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강은경,조성환,류시윤,손화영 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Fracture healing is a complex physiological process that involves the coordinated participation of several cell types. Unlike other tissues that heal by the formation of poorly organized scar, in fracture healing the original tissue, bone, is regenerated and the properties of the preexisting tissue largely are restored. Fracture healing generally proceeds in an orderly fashion when appropriate biological and mechanical component are present. Many complications may occur with repair and subsequent healing of fracture, including osteomyelitis, implant loosening, and fracture instability. All of these complications may result in delayed union, nonunion or malunion of the fracture. A 1-year-old male, Collie sustained a closed, transverse femoral fracture in a mortor vehicle accident. His initial treatment with open reduction and bone plating was failed. A second surgery was done to remove the plate and perform corrective osteotomy, and bone grafting. Histopathological observation of the bone fragment from fracture end was carried.
운동부하 방법에 따른 수영선수들의 LT 및 OBLA에서의 심박수 반응 분석
류경화 ( Kyoung Hwa Ryu ),박동호 ( Dong Ho Park ),윤성원 ( Sung Won Youn ),정동식 ( Dong Sik Chung ) 한국스포츠정책과학원(구 한국스포츠개발원) 2003 체육과학연구 Vol.14 No.2
본 연구는 수영과 트레드밀에서 각각 최대 점증부하 테스트를 실시하여 두 가지 각기 다른 형태의 테스트에서 얻은 LT와 OBLA(2.0mM/L, 4.0mM/L) 지점에서의 심박수 범위를 산출, 비교함으로서 트레드밀에서 얻은 LT 혹은 OBLA를 실제 수영 훈련의 운동강도 설정에 이용할 수 있는지를 규명하고자 7명의 고등학교 수영 선수를 대상으로 점증적 운동부하 검사를 실시하였다. 수영에서는 200m 구간의 최고 속도에서 얻은 기록에 35초를 더한 기록을 1단계로 설정한 후, 다음 단계부터는 5초씩 줄여가며 속도를 증가하여 총 7단계를 마쳤고, 트레드밀에서는 경사도를 0˚로 고정한 상태에서 초기속도는 150m/min으로 각 단계마다 20m/min의 속도를 증가시켜 총 7단계를 실시하였다. LT와 OBLA에 상응하는 심박수와 운동부하 방법간의 속도의 범위차를 검증하기 위해 paired t-test를 이용하였다. 연구 결과로서 LT점에서의 심박수는 수영과 트레드밀간에 유의한 차이를 보였고(수영=123.29bpm, 트레드밀=137.00bpm), 2.0mM/L에서의 심박수도 수영과 트레드밀간에 통계적으로 유의한 차이를 보였으나(수영=118.86bpm, 트레드밀=130.00bpm), 4.0mM/L에서의 심박수는 통계적으로 유의한 차이가 나타나지 않았으며(수영=145.10bpm, 트레드밀=151.43bpm, 3.62%차이), 심박수의 반응이 두 개의 각기 다른 형태의 테스트(트레드밀 vs 수영 테스트)에서 비슷하게 나타났다. 따라서 점증부하 테스트 방법이 다르더라도 수영선수들의 유산소성 운동능력을 향상시키기 위해 트레드밀에서 얻은 특정 혈중 젖산농도(4.0mM/L)를 운동강도 기준으로 설정하여 그에 상응하는 심박수를 산출하여 적용함으로써 수영선수에게 수중에서의 트레이닝뿐만 아니라 지상에서의 트레이닝에 적용하여 활용할 수 있을 것이다. The purpose of this study to identify whether the lactate threshold(LT) or onset of blood lactate accumulation (OBLA: 2.0mM/L and 4.0mM/L of lactate concentrations) obtained from the graded exercise test(GXT) of treadmill as the use of a training intensity for swimming or not. Seven swimming players in "S" high school were recruited and conducted GXT both on the treadmill and in the swimming pool: 1) swimming test (SW): the stage I of swimming protocol was determined by adding 35 seconds(s) to a record obtained from 200 meter` top velocity. The velocity of swimming continuously was increased by subtracting 5 s from each subsequent stage until 7 stages. 2) treadmill test (TM): treadmill protocol was a continuous, graded, horizontal run test. Each stage was 2min in duration, with an initial velocity of 150mㆍmin-l which increased 20mㆍmin-l for each subsequent stage. The grade of the treadmill remained unaltered during the test. The paired t-test was used to identify the differences of heart rates per min at the intensities of LT and OBLA obtained from both GXT of treadmill and swimming pool. Significant differences existed between exercise modalities(SW vs. TM) for heart rates per minute values at LT (SW: 123.29bpm vs. TM: 137.00bpm, p<.05), 2.omM(SW: 118.86bpm vs. TM: 130.00bpm, p<.05) and maximal exercise(SW: 183.l0bpm vs. TM: 195.70bpm, p<.001), respectively. However, no significant difference was found between exercise modalities(SW vs. TM) for heart rates per minute values at 4.0mM/L(SW: 145.lbpm vs. TM: I 51.43bpm, 3.62% difference). It was concluded that exercise modality may do not affect the heart rate per min at 4.0mM/L and that a similar heart rate response exists between the two modalities. Therefore, the heart rate value at 4.0mM/L obtained from the TM could be applied to a criterion of swimming players` exercise intensity for improving their performance.
Simple Evaluation of Listeria monocytogenes Pathogenesis Using Caenorhabditis elegans Animal Model
Kyoung Hee Yang,Bohyun Yun,Hye Jin Choi,Sangdon Ryu,Woong Ji Lee,Mi-Hwa Oh,Min-Ho Song,Jong Nam Kim,Sangnam Oh,Younghoon Kim,Young Jun Kim 한국축산식품학회 2019 한국축산식품학회지 Vol.39 No.1
Listeria monocytogenes is a major cause of serious foodborne illness in the dairy foods. Although Caenorhabditis elegans model is well established as a virulence model of pathogenic bacteria, its application on L. monocytogenes is critically unclear. The objective of this study was to carry out an evaluation of L. monocytogenes toxicity using C. elegans nematode as a simple host model. We found that C. elegans nematodes have high susceptibility to L. monocytogenes infection, as a consequence of accumulation of bacteria in the worms’ intestine. However, L. innocua, which is known to be non-toxic, is not accumulate in the intestine of worms and is not toxic similarly to Escherichia coli OP50 known as the normal feed source of C. elegans. Importantly, immune-associated genes of C. elegans were intensely upregulated more than 3.0-fold when they exposed to L. monocytogenes. In conclusion, we established that C. elegans is an effective model for studying the toxicity of L. monocytogenes and we anticipate that this system will result in the discovery of many potential anti-listeria agents for dairy foods.
( Kyoung Hwa Lee ),( Mi Ryoung Seo ),( Hee Jung Ryu ),( Hyo Jin Choi ),( Han Joo Baek ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Systemic lupus erythematosus (SLE) is a chronic in. ammatory disease that can affect any part of the body including the central and peripheral nervous systems. However, neurogenic bladder associated with SLE has rarely been reported. We experienced a case of neurogenic bladder in a female patient with SLE treated with intravenous cyclophosphamide and glucocorticoid pulse therapy. A 46-year-old female visited the hospital because of voiding dif. culty developed 3 days before. She had been diagnosed with SLE in 2005 and treated with maintenance doses of hydroxychloroquine (200mg/day) and prednisolone (5mg/day). She could not urinate almost at all and residual bladder volume was 400ml checked by Foley catheterization. Blood tests displayed positive antinuclear antibody and anti-double stranded DNA antibody. ESR (57 mm/hour) and CRP (1.07 mg/dL) were elevated but complement level was normal. CT showed distended bladder with bilateral hydroureteronephrosis. Detrusor muscle contractility was decreased by uro. owmetry study. There was nothing remarkable by brain and spine MRI except small cystic lesion of posterior fossa that did not change in size compared to 10 years before. Her bladder dysfunction was presumed to be complicated by peripheral neuron disease associated with SLE. Intravenous methylpredisolone (1g/day) for 3 days and cyclophosphosphamide pulse therapy (1g/day) followed by high doses of prednisolone (40mg/day) were administered. After that her urinary retention was gradually improved. She was able to urinate a month later and had no voiding dif. culty at 10-month follow-up.
류경귀,이준화 서울시립대학교 산업기술연구소 1997 산업기술연구소논문집 Vol.5 No.-
In order to obtain the positioning data from the GPS satellite signal, carrier synchronization must be maintained by the GPS receiver. In this paper, we propose several second and third order loop filters for the carrier synchronization of the GPS receiver. The static and dynamic tracking performances of the proposed loop filters are analyzed and compared.
Hwa-Ja Ryu,Hee-Kyoung Kang,Eun-Seung Seo,Than Hanh,Go-Eun Kim,Hea-Jin Woo,Nahyun Kim,Young-Min Kim,Doman Kim 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1
In this seminar I will briefly introduce about current research progress in our Lab related with glycoside synthesis using glycansucrases and carbohydase inhibitor screening using Grid. We are synthesizing various glycosides of the hydroquinone for the improvement of antioxidant activity. Hydroquinone (HQ) functions as a skin whitening agent, but it has the potential to cause dermatitis. We synthesized a novel HQ fructoside (HF), HQ galactoside and HQ glucoside as potential skin whitening agents by reacting glycansucrases from Leuconostoc mesenteroides with HQ as an acceptor and sucrose as a donor. The product was purified using butanol partition and silica-gel column chromatography. One of them HF synthesis was determined using a response surface methodology and the final optimum condition was 350-mM HQ, 115-mM sucrose, and 0.70 U/ml levansucrase, and the final HF produced was 1.09 g/l. HF showed anti-oxidation activities and inhibition against tyrosinase. The IC50 of DPPH scavenging activity was 5.83-mM, showing higher anti-oxidant activity compared to β-arbutin (IC50 = 6.04-mM). The Ki value of HF (0.67-mM) against tyrosinase was smaller than that of β-arbutin (Ki = 2.8-mM). The inhibition of lipid peroxidation by HF was 108.12% that of HQ (100%) and much higher than that of β–arbutin (0.81% of HQ). Virtual screening (VS) was applied for discovery of new inhibitors for the human intestinal maltase (HMA) enzyme. VS of 308 307 compounds was performed with HMA using 4700 CPUs and AutoDock 3.0.5 in a WISDOM (Wide In Silico Docking On Malaria) production environment. The 42 best ranked compounds containing hydrogen bond interaction with key residues from VS were tested in vitro for their inhibitory activities against the recombinant HMA from Pichia pastoris. Compounds 17 and 18 were identified as competitive inhibitors for enzyme inhibition with Ki values of 19.8 and 19.6 μM, respectively. In contrast to acarbose, the two compounds showed no inhibition on human pancreatic α-amylase, suggesting potential inhibitors with fewer side effects, including abdominal discomforts.