자료포락분석(DEA)를 이용한 보건의료의 효율성 측정

김남송,박홍섭,김은진,김설화,김정숙,김현아,김경숙,신지혜,최은정,양은진,유선미,유수진 圓光大學校 醫科學硏究所 2007 圓光醫科學 Vol.22 No.1

고추 탄저병 저항성 중간모본 ‘원예 100005호 ’,‘원예 100006호’ 육성

양은영,김수,채영,채수영,조명철,문지혜,박태성,이우문,곽정호 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

Owing to frequent heavy rain due to abnormal weather, the occurrence of pepper anthracnose has recently increased, which affects the supply and demand of pepper. As a result, the price of red pepper powder in 2011, for example, increased three times compared to the average year. Although anthracnose of pepper plants has been controlled by fungicides until now, it is important to develop new resistant cultivars because of the reduction of the labor force in rural area and occurrence of new anthracnose strains resistant to fungicides. National Institute of Horticultural and Herbal Science developed two pepper lines, ‘Wonye 100005’ and ‘Wonye 100006’ that are resistant to pepper anthracnose. These lines were developed by continuous selection of progenies from a cross between ‘Wonye AR1’, which were developed from interspecific hybridization and ‘TF68’. The anthracnose resistance level of the two lines was higher than that of commercial cultivars and similar to check varieties showing highest level of anthracnose resistance.

폐암으로 오인된 이물질에 의한 기관지 육아종증 1예

정종훈,김소영,김휘정,김학렬,양세훈,정은택 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

신경병증성 통증 모델쥐 뒤뿌리신경절의 Nitric Oxide Synthase 아형 및 NADPH-diaphorase 발현에 관한 연구

정성균,김수일,양은진,류택근,권오유,박경란,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

Injury to peripheral nerve somtimes lead to neuropathic pain. Nitric oxide(NO) is increased in the dorsal root ganglia (DRG) of neuropathic pain models, and L-NAME, a nitric oxide synthase (NOS) inhibitor, reduces neuropathic pain. However, it is not known that underlying mechanism of NO involvement in development and maintanence of neuropathic pain. It was found that there were three NOS isoforms-nNOS, eNOS, and iNOS. It is also necessary to investigate NOS isoforms in neuropathic pain. The aim of this study is to investigate NOS isoforms and NADPH-diaphorase expressions and underlying mechanism of NO involvement in neuropathic pain. The 5^th lambar (L5) DRG were obtaind after tight ligation of L5 an L6 spinal nerves for 7 days. Toluidine blue stain, immunohistochemistry for nNOS, eNOS, and iNOS, and NADPH-diaphorase histochemistry were performed. All specimens were observed under light microscope. nNOS expression was increased significantly in the cytoplasm of the DRG of ligated side at 7 day post-ligation (7D PL). eNOS expression was also increased in the blood vessel, a few neurons or satellite cells, and cell membrane of Schwann cells in the DRG of ligated side at 7D PL. iNOS expression was increased in a few blood vessels and cytoplasm of small neurons in the DRG of ligated side at 7D PL. NADPH-diaphorase expression was increased significantly in the neurons of the DRG of ligate side at 7D PL, but NADPH-diaphorase expressions were weak or absent in the blood vessel and Schwann cell in the contralateral DRG and the DRG of ligated side at 7D PL. It is suggested that NOS isoforms may be closely related to development and mantanence of neuropathic pain in order of nNOS>eNOS>iNOS.

S. cerevisiae에서 세포주기의 진행에 관련된 COS28과 COS46 유전자의 클로닝

박정은,임선희,선우양일 동아대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.17 No.1

본 연구에서는 효모의 돌연변이주를 분리하여 G1/S기에서 세포주기 진행에 관련된 유전자의기작을 이해하기 위해 연구를 수행하였다. 먼저, cos28과 cos46 돌연변이주의 MMS(methylmethane sulfonate)와 HU(hydroxyurea)에 대한 감수성을 조사하였다. 이들 돌연변이주들은 MMS와 HU에 대해서 감수성을 보이므로, S기 checkpoint에 관련되었다고 생각된다. 다음으로 cos28과 cos46 돌연변이를 상보하는 유전자를 클로닝하였고, 서열화하였다. 그리고 클론된 유전자는 데이터 베이스 분석을 통해 조사하였다. cos28 변이주를 상보하는 DNA 단편은 전체 6개의 ORF를 가지며 그 중 기능이 알려진 ORF로는 RPS21B와 LCB3와 MRS3가 있고, 기능이 알려지지 않은 ORF로는 YJL131와 YJL132와 YJL135의 세개를 포함하고 있었다. cos46 유전자는 전체 6개의 ORF를 가지며, 그 중 기능이 알려진 CYP5와 HNT2와 SRB7와 GIC2를 가지고, 기능이 알려지지 않은 ORF로 YDR306, YDR307를 포함하고 있음이 확인되었다. In this study, to understand the mechanisms of genes which related in cell cycle progression at G1/S phase, using the isolated mutants in S. cerevisiae were investigated. First of all, cos28 and cos46 were examined the sensitive to MMS(methylmethane sulfonate) and HU(hydroxyurea). These mutants were showed MMS, HU sensitivities and might be a act at a checkpoint pathway during S phase. These mutants were carried out gene cloning for the gene which were complemented the cos mutants. As a result, the DNA fragments which complement with the cos28 and cos46 mutants, were cloned and sequenced. And then cloned genes were surveyed though data base analysis. Complemented DNA fragment of COS28 contained six ORF which were consisted RPS21B, LCB3, MRS3, YJL131, YJL132, and YJL135. Complemented DNA fragment of COS46 contained six ORF which were consisted CYP5, HNT2, SRB7, GIC2, YDR306 and YDR307.

사회성 훈련 프로그램이 발달장애아동의 사회성 및 적응행동에 미치는 효과

유은희,양정남,이숙자 동신대학교 2005 論文集 Vol.15 No.-

The Effects of a Social Skills Program on Improving Sociability, and Adaptive Behaviors of Children with Developmental Disabilities. The purpose of this study was to investigate the effects of a social skills program on improving social skills, and adaptive behaviors of children with developmental disabilities. A total of nine children at the Language Therapy Center for children and adolescents in Gwangju Metropolitan City participated in this study with the consent from their parents. The research was conducted following one-group pretest-posttest design, a preexperimental design. A social skills program was implemented once a week with 90 minutes per session for 15 weeks. The effects of the program were evaluated by administering Social Maturity Scale, and Adaptive Behavior Scale before and after the program. The results showed that the scores in social maturity, and adaptive behavior scales, respectively, increased from pretest to posttest. This study concluded with a discussion on the implications of social skill programs for improving social skills, and adaptive behaviors of children with developmental disabilities in the field of social welfare. Implications and suggestion for future studies was discussed.

골격성 Ⅲ급 부정교합자의 양악수술후 연조직 변화의 평가

조은정,양원식 대한치과교정학회 1996 대한치과교정학회지 Vol.26 No.1

본 연구는 골격성 Ⅲ급 부정교합 환자에서 상악골 전방이동수술과 하악골 후방이동수술을 동시에 시행하였을 때 경,연조직 측모 및 연조직 후경의 변화를 관찰하고 경,연조직 변화의 상관성과 그 비율을 산출하여 교정-악교정 수술 복합 치료 계획의 수립과 결과의 예측에 이용하고자 하였다. 서울대학교병원 치과진료부 교정과에 내원하여 상, 하악골의 수직적 골격 부조화는 경미하고 전후방적 골격 부조화가 심한 골격성 Ⅲ급 부정교합으로 진단되어 술전 교정치료를 받고 1990년 7월부터 1995년 4월 중에 Le Fort I 골절 단술 또는 Le Fort Ⅱ골절단술로 상악골을 전방이동시키는 동시에 시상분할 골절단술로 하악골을 후방이동시킨 성인 환자 25명(남자 13명, 여자 12명)을 대상으로 수술전, 후 측모두부방사선사진을 계측, 분석하여 다음과 같은 결과를 얻었다. 1. 상악골의 전방이동에 따른 상순부 연조직의 수평적 변화는 Stms를 제외하면 상관성이 높았으며 A point의 전방이동에 따라 Sn, SLS, LS 는 각각 71%,67% 37%의 비율로 전방이동하였다. 2. 하악골의 후방이동에 따른 하순부 연조직의 수평적 변화는 상관성이 상당히 높았으며 ID, B Point,Pog, Gn의 후방 이동에 따라 LI, ILS, Pog', Gn'은 각각 84%, 107%, 96%, 97%의 비율로 후방이동하였다. 3. 하악골의 후방이동에 따라 SLS, LS, Stm, LI 는 중등도의 산관성을 가지며 하방이동하였다. 4. 경조직의 전후안면고경비율과 연조직의 상,하안면고경은 수술전후 유의한 차이가 없었으나 수술후 Stm의 하방이동으로 하순고경에 대한 상순고경의 비율은 유의성있게 증가하였다(p<0.001). 5. 연조직 후경은 수술후 LI-LIH에서는 증가하고 LS-LSH에서는 감소하였으며 LS-LSH의 수술후 변화량과 수술전 후경은 역상관관계를 나타내었다(p<0.001). The purpose of this study was to evaluate the amount and interrelationship of the soft and hard tissue changes after simultaneous maxillary advancement and mandibular setback surgery in skeletal Class Ⅲ malocclusion. The sample consisted of 25 adult patients(13 males and 12 females) who had severe anteroposterior skeletal discrepancy. These patients had received presurgical orthodontic treatment and surgical treatment which consisted of simultaneous Le Fort I or Le Fort Ⅱ osteotomy and bilateral sagittal split ramus osteotomy. The presurgical and postsurgical lateral cephalograms were evaluated. The computerized statistical analysis was carried out with SPSS/PC program. The results were as follows: 1. The correlation of maxillary hard and soft tissue horizontal changes were high and the rations for soft tissue to A point were 71% at Sn, 67% at SLS and 37% at LS. 2. The correlation of mandibular hard and soft tissue horizontal changes were very high and the rations were 84% at LI, 107% AT ILS, 96% at Pog' and 97% at Gn'. 3. The correlation of mandibular hard tissue horizontal changes and soft tissue vertical changes were moderate. 4. The upper to lower lip length were increased(P<0.01). 5. The soft tissue thickness were decreased in upper lip and increased in lower lip(p<0.001). The postsurgical changes were reversely correlated with initial thickness in upper lip.

중안면부 함몰과 하악전돌을 동반한 Ⅲ 급 부정교합자의 교정-악교정수술 복합치료

조은정,김종태,양원식 대한치과교정학회 1996 대한치과교정학회지 Vol.26 No.5

성장이 완료된 골격성 III급 부정교합의 치료는 골격 부조화의 심도, 절치 치축, overbite와 연조직 측모의 심미성 등을 고려하여 필요한 경우 교정치료와 악교정수술을 병행하여 골격과 치아관계 개선에 따른 기능의 증진외에도 안모의 심미성을 증진시킬 수 있다. 특히 전후방적, 수직적, 횡적인 골격 부조화가 크거나 안면비대칭이 있는 경우, 또한 악교정수술후의 안정성이나 보다 이상적인 안모를 위하여 양악수술을 시행한다. 중안면부 함몰환자에서 안와하연과 관골부는 보존하며 비상악체를 전방이동하는 pyramidal Le Fort II osteotomy를 시행할 수 있으며, 안와하연과 관골부의 전방이동을 필요로 할 때는 quadrangular Le Fort II osteotomy를 시행할 수 있다. 이 수술법은 안와하연의 위치를 변화시켜 안와체적에 영향을 미치므로 상악골의 횡적, 수직적 이동량이 5mm 이상일 때는 시행할 수 없다. 서울대학교병원 치과진료부 교정과에 내원하여 중안면부 함몰과 하악전돌을 골격성 III급 부정교합으로 진단되어 교정-악교정수술(Le Fort II osteotomy 와 BSSRO) 복합치료를 받은 2명의 환자에 대해 살펴보고자 한다. In non-growing Class III malocclusion, the critical aspects which determine the need of orthognathic surgery are the severity of skeletal discrepancy, incisor inclination, overbite and soft tissue profile. Two-jaw surgery is more effective in correcting severe sagittal, vertical, transverse skeletal discrepancies and facial asymmetry. And more esthetic and stable profile can be achieved by two-jaw surgery. Some midfacial deficiency patients can be treated by pyramidal Le Fort II osteotomy to maintain infraorbital rim and malar complex and to advance nasomaxillary complex. Others who require advancement of infraorbital rim and malar complex can be treated by quadrangular Le Fort II osteotomy. On the following cases, patients who had represented midfacial deficiency and mandibular prognathism were treated with combined orthodontic-surgical therapy by Le Fort II osteotomy and BSSRO.

네오스트그민 독성에 대한 디펜히드라민 및 프로메사진의 효과

박은희,양근해,전민정 숙명여자대학교 약학연구소 1998 약학논문집-숙명여자대학교 Vol.14 No.-

This study was designed to examine the effects of diphehydramine and promethazine on the toxic manifestation of neostigmine. It was found that diphenhydramine and promethazine increase acetylcholinesterase activity in liver of mice. When diphenhydramine and promethazine was treated before administration of neostigmine, it significantly extend the onset latency in the signs of toxicities which were characteristically produced by neostigmine and it also prevented lethality in all of the animals.

방광의 이행상피암에서 p53과 PCNA 분포에 관한 연구

최은정,강상균,양승하,김대중,김의한 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

Immunohistochemical studies were carried out to observe the expression of p53 protein and PCNA in transitional cell carcinoma (TCC), then analyzed according to the tumor grade and progression. 38 cases of TCC consist of 13 cases grade Ⅰ, 12 cases grade Ⅱ and 13 cases grade Ⅲ respectively. Results obtained are as follows. 1. p53 protein expression was seen in 60% of cases(15 out of 38 cases) In the poorly differentiated area and infiltrated lesion, tumor cell showed more strong positive reaction of p53 protein compared with well differentiated area. 2. All of 38 cases of TCC showed PCNA positive expression. The more strong positivity was seen in the poorly differentiated area and the more intense positive reaction was noted in the basal layer of the tumor nests. 3. The above results showed that positivity of p53 protein and PCNA are closely related with tumor cell differentiation(grade) and progression. It is concluded that positive reaction of p53 protein and PCNA may contribute to detection of tumor growth and prognosis of patient.