정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구

이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.

다산부에서 자간전증의 임상적 고찰

이주롱,이석민,한효상,이해혁,이임순,이권해 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

목적 : 전자간증 산모에서 초임신부와 다산부 각각의 임상적 특징을 조사하여 비교 분석하고자 하였다. 연구방법 : 1998년 1월부터 1999년 12월까지 2년간 순천향대학 서울병원에서 입원 분만한 임신성 고혈압성 질환 환자중 초임신부 106명과 다산부 50명, 총 150명을 대상으로 임상통계학적으로 조사 분석하였다. 결과 : 분만까지 임신기간의 비교시 초임신부에서는 33-36주에서 17.9%였고 다산부에서는 34.0%로, 다산부에서 조기분만의 예가 의의있게 많았다. 신생아 체중이 2500g 미만인 군이 초임신부군에서는 36.8%였고 다산부군에서는 62.0%로 다산부군에서 더 많았다. 임신성 고혈압성 질환의 중등도를 보면 중증자간전증의 초임신부에서 35.8%와 다산부에서는 44.0%로, 초임신부에 비해 다산부군의 중증 자간전증의 비율이 많았다. 결론 : 중증 임신성 고혈압성 질환이 다산부군에서 더 많았으며 적은 주수에서 제왕절개술을 시행해 출생아의 체중이 초임신부군에 비해 더 작았고 Apgar 점수도 더 낮았다. Objective : To study the clinical differences of primiparous and multiparous preeclamptic patients. Methods : We statistically analyzed 106 primiparous and 50 multiparous preeclamptic patients who were admitted to the Soonchunhyang University Hospital from January 1998 to December 1999. Results : It was statistically found that multiparae were more likely to give premature birth than primiparae: Thirty four percents of multiparae gave birth in the period between the 33rd and the 36th gestational weeks while 17.9% of primiparae did in the same period. Sixty two percents of the newborn babies of multiparae weighed less than 2500g. Among primiparae, the ratio was 36.8%. In addition, more multiparae(44.0% vs. 35.8%) suffered from severe preeclampsia. Conclusion : severe preeclampsia was found more frequently among multiparae. Since they gave birth earlier by cesarian section than primiparae, their babies weighed less and had lower apgar scores.

Pneumatosis intestinalis and portal venous gas secondary to gefitinib therapy for Lung adenocarcinoma

( Joo Young Lee1 ),( Hye-suk Han ),( Sung-nam Lim ),( Young Kwang Shim ),( Yong Hyeok Choi ),( Ok-jun Lee ),( Ki Hyeong Lee1 ),( Seung Taik Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-

육백산(강원도, 삼척시)의 거미상

김주필(Joo Pil Kim),예용택(Yong Taek Ye),오종화(Jong Hwa Oh),예성훈(Seong Hun Ye),성민규(Min Gyu Seong),이정준(Jeong Jun Lee),김태우(Tae Woo Kim),김대희(Dae Hee Kim),지승환(Seung Hwan Ji),이형민(Hyeong Min Lee) 한국거미연구소 2016 한국거미 Vol.32 No.1

2015년 8월 3일부터 5일까지 한국거미연구회 회원들은 강원도 삼척시 육백산을 채집 조사한 결과 22과 49속 63종이 채집 조사되어 이에 보고하는 바이다. The authors investigated the spiders of the Mt. Yukbaek from August 3th to August 5th, 2015. In the present paper 63 species of 49 genera belong to 22 families were identified. These specimens are deposited at the Joo-Pil Spider Museum, Namyangju-Si, Gyeonggi-Do.

정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

리조트 속성중요도에 관한 연구

이주형,이재곤 문화관광연구학회 1999 문화관광연구 Vol.1 No.1

ABSTRACTThe purpose of this study is to examine the importance of attributes in resorts and to help the managers of resort in marketing, management and sales promotion in such a competitive situation of the resort industry for member/non-member.This study adapted and modified components of a number of previously tests and validated research instruments to make the hypotheses of test. This exploratory study surveyed a random sample of 1,000 resorts tourists. After follow-up procedures were applied, responses rate of 85 percent was achieved. However, useable responses 812 of the 856 questionnaires.Findings generally indicate that through the classification of member/non-member and preferential importance-satisfaction group, each group make an assumption to understand the keynote of vital statistics and the difference of utilization circumstantial variable and a variable in the interrelation, and through the verification, they try to get useful information in the search of management strategy. In the interrelation of importance of attribute by the member/non-member tries to authorize to understand the difference between any other attributes and it.Therefor, this study presented the reform measures of management as follows. First, the vital statistical trait and utilization circumstantial variable to the product and service, institution and surroundings, promotion, scenery constitution., and regional traffic means and price should be deliberated to get rid of importance of attribute. Second, the employee and equipment of service should be developed to reinforce the customer service. Third, it is necessary to develop the new products and provide the new experience and atmosphere for tourists. Forth, the marketers have to classify the tourist into a high-demand season and a low-demand season. Fifth, there is a need to apply a competitive price strategy non-member. In other words, marketer should solve a pricing problem in dealing with non-member showing a meaningful difference, and provide service and low price in using utilities to keep star resort position.The tourist behavior in choosing resort facilities should be continued studying theoretically for managers or marketer in the resort industry.

중저가호텔의 활성화 전략

이주형 경기대학교 부설 소성종합관광연구소 2002 여가관광연구 Vol.6 No.-

The main purpose of this study is to find out the situation which we need to take customer's complaints about the current hotel products and to find out their desires and consuming patterns to make the budget hotel merchantable with new concept under the assumption of the existence of potential market and to explore a plan for marking strategy. To accomplish the purpose of this study, document investigation, the concept of budget hotel, characteristics of hotel management, marketing environment of budget hotel and marking strategy are conducted. Form this study, according to the empirical research, the findings of establishment of marketing strategy of budget hotel were ; 1. It analyzed the direct validity of the necessity of the merchantable budget hotel. 2. The standardization strategy for the merchandization of budget hotel. It presents a plan to provide lower prices for the customers than the current ones and to maintain all the services with good condition. 3. It presents a customer's behavior and marketing strategy. This survey is developed to help managing budget hotel in Korean in terms of quality management customer service, development marketing strategy.

枳實에 의한 아나필락시의 抑制效果

李彦政,朱泓炫,金炯均,宋峰根 圓光大學校 韓醫學硏究所 1996 원광한의학 Vol.6 No.1

The effect of water extract of Poncirus trifoliata fruit (ATFE) on compound 48/80 induced anaphylaxis was studied in the rat. The following results have obtained. 1. Optimal lethal dose of compound 48/80 was 8ug/gm B.W. 2. PTFE was found to exhibit an inhibitory activity on the anaphylaxis induced by compound 48/80. 3. Administration of PTFE 60 min before or 5 min after had a better result than 10 min after anaphylaxis induced by compound 48/80. 4. PTFE also inhibited significantly the serum histamine release in anaphylaxis induced by compound 48/80 in the rat. 5. Administration of PIFE before 30 min decreased PCA reaction induced by anti DNP-IgE and DNP-HSA. This result indicates that poncirus trifoliata suppresses the anaphylaxis induced by compound 48/80 with decreasing the serum histamine release.

Styrene 과 Acrylonitrile의 분산 공중합

이기창,서형주 慶尙大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.13 No.-

본 연구에서는 ethanol 분산매하에서 styrene/acrylonitrile의 분산공중합을 poly(vinyl pyrrolidone)과 AIBN을 각각 안정제와 개시제로 하여 55-70℃에서 행하였다. St/AN 단량체 조성에 대하여 생성된 입자경은 St/AN 90/10 wt.% 조성에서 가장 크며, AN함량이 증가함에 따라 입자경은 감소하였다. 생성된 P(St/AN)라텍스는 중합온도가 증가함에 따라 또는 안정제의 농도가 감소할수록 평균입자경은 증가하였다. 그리고 안정제의 농도가 증가함에 따라 생성되는 coagulum량은 감소하였다. 본 연구를 통하여 1.28-3.33㎛의 크기의 P(St/AN) 단분산 입자를 제조할 수 있었다.

분산중합에 의한 Poly(styrene-co-butyl acrylate,50/50 wt.‰)미립자 제조

이기창,서형주 慶尙大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.13 No.-

본 연구에서는 isopropanol/water 분산매하에서 styrene/butyl acrylate (50/50 in wt.%)의 분산공중합을 poly(vinyl pyrrolidone) 과 AIBN을 각각 안정제와 개시제로 하여 75℃에서 행하였다. 생성된 P(St/BA, 50/50 wt.%)라텍스는 단량체, 개시제 농도 및 중합온도가 증가함에 따라 또는 안정제의 분자량 및 농도, 초기 중합계의 극성도가 감소할수록 평균입자경은 증가하였다. 그리고 본 연구를 통하여 1.46-3.11㎛의 크기의 P(St/BA, 50/50 wt.%) 단분산 입자를 제조할 수 있었다.