http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
유홍성(Yoo, Hong-Sung),남승균(Nam, Seung-Kyun),신진영(Shin, Chin-Young),임영숙(Lim, Young-Sook) 인천대학교 인천학연구원 2014 인천학연구 Vol.21 No.-
본 연구는 주민참여예산제도 활성화 방안에 대한 요인을 도출하고 도출된 요인을 관련 공무원과 주민참여예산 위 원들의 설문조사를 통해 실증분석 하고, 또한 인천 남구 주민참여예산제도 운영에 대한 분석을 하였다. 연구결과 주민참여예산에 관한 요인은 ‘주민참여예산제도 기반형성’, ‘주민참여예산제도 성공요인’으로 구분됨을??확인하였고 이들 차원과 주민참여예산제도 시행효과의 인과관계와 각 요인에 대해 관련 공무원과 주민참여예산??위원들 두 집단이 차이가 있는지를 살펴본 결과 주민참여예산제도 기반형성과 주민참여예산제도 성공요인이 주민 참여예산제도 시행효과에 통계적으로 유의하게 나타났다. 또한 각 요인에 대한 관련 공무원과 주민참여예산 위원 들 두 집단에 대한 차이분석 결과 통계적으로 유의하게 차이가 있음을 확인하였다. 추가적으로 공무원과 주민참여 예산 위원들 각각 회귀분석 비교분석 결과 공무원은 주민참여예산제도 성공요인을 중요하게 생각하고 있으며, 위 원들은 기반형성 구축이 주민참여예산제도 시행효과에 더 중요하게 영향을 미치는 것으로 인식하고 있다, 주민참 여예산제도의 활성화를 위해서는 참여가치에 대한 공감대, 지역사회나 관련조직의 의견수렴, 교류를 위한 네트워 크 구축 등의 기반형성과 주민참여예산제도의 범위를 예산편성에서 예산 전반의 참여권한 확대가 필요하고, 공무 원의 적극적인 지원 활동 등 주민참여예산제도 성공요인 관리가 필요하다. This study derived factors related to the activation of citizen participatory budgeting, analyzed the factors??positively through a questionnaire survey of involved civil servants and participatory budgeting committee??members, and made analysis of participatory budgeting system for operation in the Incheon Nam-Gu area. According to the results of this study, factors related to participating budgeting were largely divided into??‘footing of citizen participatory budgeting’ and ‘success factors of citizen participatory budgeting.’ In the??results of examining the causal relationship between these dimensions and the effect of citizen participatory??budgeting system and seeing if there was any difference in each factor between involved civil servants and??participatory budgeting committee members, footing of citizen participatory budgeting and the success factors??of citizen participatory budgeting were statistically significantly correlated with the effect of citizen participatory??budgeting sysytem. In addition, a statistically significant difference was observed in each factor between??involved civil servants and participatory budgeting committee members. In additional comparative regression??analysis between civil servants and participatory budgeting committee members, civil servants attached more??importance to the success factors of citizen participatory budgeting, but committee members considered the??footing of the system more important for the effect of citizen participatory budgeting. What are required for the??activation of citizen participatory budgeting system are consensus on the value of participation, opinion??collection from communities and related organizations, construction of networks for exchange, and the??extension of the scope of participatory budgeting from budgeting to the whole range of budget?related areas.??What is more, the success factors of participatory budgeting including civil servants’ active support need to be??managed properly.
Nam, Se Hyun,Choi, Hyun Jin,Kang, Woo Dae,Kim, Seok Mo,Lim, Myong Cheol,Park, Sang-Yoon,Kim, Jung-Sup,Kim, Byoung-Gie,Bae, Duk-Soo,Lee, Jeong-won,Kim, Tae-Joong,Song, Taejong The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.12
<P>Given the growing number of cancer patients and the resulting increase in the administration of chemotherapeutic agents, convenient and effective methods for measuring the symptoms and quality of life associated with the hand-foot syndrome (HFS) are needed. Therefore, the aim of this study was to develop and validate the Korean version of the hand-foot skin reaction and quality of life questionnaire (HF-QoL-K), comprising a 20-item symptom domain and an 18-item daily activity domain. After we developed the HF-QoL-K, 209 Korean patients with gynecologic cancer who were undergoing chemotherapeutic agents relating the HFS were asked to fill in the questionnaire. The content validity, internal consistency reliability, and test-retest reliability were evaluated. The internal validity index, Cronbach’s alpha coefficient, and intra-class correlation coefficient of the HF-QoL-K were 0.90, 0.958, and 0.825 (95% confidence interval [CI], 0.774–0.865), respectively. The scatter plot (Pearson correlation coefficient, 0.826) and the Bland-Altman plot for test-retest reliability were also acceptable. The HF-QoL-K instrument is a valid and reliable questionnaire for the measurement of the symptoms and quality of life in Korean cancer patients suffering HFS.</P>
( Sung Won Lee ),( Hae Lim Lee ),( Nam Ik Han ),( Hee Yeon Kim ),( Chang Wook Kim ),( Chan Ran You ),( Sang Wook Choi ),( Se Hyun Cho ),( Joon-Yeol Han ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: We have evaluated the efficacy and safety of the sofosbuvir (SOF) and weight-based ribavirin (RBV) therapy in genotype 2 hepatitis C virus (HCV) infected Korean patients in real clinical settings. Methods: A total of 323 patients who received SOF plus RBV between May 2016 and February 2017 at the liver unit of the Catholic University of Korea were consecutively recruited and analyzed. Patients with chronic hepatitis and cirrhosis underwent 12 weeks and 16 weeks of antiviral therapy, respectively. The primary endpoint was sustained virologic response 12 weeks after the end of treatment (SVR12). Results: The mean age was 61.6±11.8 years and 36% of the patients were male. 238 (73.7%) patients had chronic hepatitis, 78 (24.1%) compensated cirrhosis, and 7 (2.2%) decompensated cirrhosis. 17 (5.3%) patients had a history of hepatocellular carcinoma treatment. 52 (16.1%) patients were treatment experienced (7 non-responders, 33 prior relapse, and 12 intolerable to interferon based treatment). 95.1% (293/308) of the patients achieved undetectable HCV RNA at week 4, 99.6% (255/256) end of treatment response and 96.6% (141/146) SVR12. No difference was observed according to age, previous treatment experience, viral load and cirrhosis (P>0.05). Overall, the SOF plus RBV regimen was well-tolerated but 4 patient discontinued treatment due to possible drug-related side effects. The most frequently observed adverse event was anemia and 15.9% (47/296), 5.4% (16/296) of the patients experienced grade 2 and grade 3 anemia, respectively. The doses of RBV were reduced to median 825mg and 577mg daily in grade 2 and 3 anemia groups, respectively but the SVR12 were 100% in both groups. Conclusions: Sofosbuvir and ribavirin regimen resulted in a high SVR rate and was tolerable in genotype 2 HCV infected Korean patients in real clinical practice.
Auxin response factor 2 (ARF2) plays a major role in regulating auxin-mediated leaf longevity
Lim, Pyung Ok,Lee, In Chul,Kim, Junyoung,Kim, Hyo Jung,Ryu, Jong Sang,Woo, Hye Ryun,Nam, Hong Gil Oxford University Press 2010 Journal of experimental botany Vol.61 No.5
<P>Auxin regulates a variety of physiological and developmental processes in plants. Although auxin acts as a suppressor of leaf senescence, its exact role in this respect has not been clearly defined, aside from circumstantial evidence. It was found here that <I>ARF2</I> functions in the auxin-mediated control of <I>Arabidopsis</I> leaf longevity, as discovered by screening EMS mutant pools for a delayed leaf senescence phenotype. Two allelic mutations, <I>ore14-1</I> and <I>14-2</I>, caused a highly significant delay in all senescence parameters examined, including chlorophyll content, the photochemical efficiency of photosystem II, membrane ion leakage, and the expression of senescence-associated genes. A delay of senescence symptoms was also observed under various senescence-accelerating conditions, where detached leaves were treated with darkness, phytohormones, or oxidative stress. These results indicate that the gene defined by these mutations might be a key regulatory genetic component controlling functional leaf senescence. Map-based cloning of <I>ORE14</I> revealed that it encodes ARF2, a member of the auxin response factor (ARF) protein family, which modulates early auxin-induced gene expression in plants. The <I>ore14/arf2</I> mutation also conferred an increased sensitivity to exogenous auxin in hypocotyl growth inhibition, thereby demonstrating that ARF2 is a repressor of auxin signalling. Therefore, the <I>ore14/arf2</I> lesion appears to cause reduced repression of auxin signalling with increased auxin sensitivity, leading to delayed senescence. Altogether, our data suggest that ARF2 positively regulates leaf senescence in <I>Arabidopsis</I>.</P>
( Sung Won Lee ),( Hae Lim Lee ),( Nam Ik Han ),( Hee Yeon Kim ),( Chang Wook Kim ),( Chan Ran You ),( Sang Wook Choi ),( Se Hyun Cho ),( Joon-Yeol Han ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The aim of this study was to determine the factors associated with the development of major clinical adverse events in genotype 1 hepatitis C virus (HCV) infected Korean patients who received direct-acting antiviral (DAA) therapy in real clinical settings. Methods: A total of 648 genotype 1 HCV infected patients who received DAA therapy between May 2016 and January 2018 at the liver units of the Catholic University of Korea were analyzed. Primary endpoints were hepatic decompensation and/or treatment discontinuation due to adverse events and the development of de novo hepatocellular carcinoma (HCC). Results: The median follow-up period was 12.8 months (range, 1.3~34.8). 70.7% of the patients had chronic hepatitis and 29.3% compensated cirrhosis. Treatment discontinuation due to adverse events occurred in 2.8% (18/648), hepatic decompensation in 1.4% (9/648) and de novo HCC developed in 3.1% (19/620) of the patients. In multivariate analysis, baseline platelet count less than 150,000/㎣ (P=0.022), estimated glomerular filtration rate (eGFR) less than 50 mL/min/1.73㎡ (P=0.037) and baseline serum albumin less than 3.5g/dL (P=0.035) were independently associated with hepatic decompensation and/or treatment discontinuation due to adverse events. Also, platelet count less than 150,000/㎣ was independently associated with the development of de novo HCC (P=0.048). Conclusions: Patients with low platelet count and serum albumin level, which are indicators of portal hypertension, and patients with renal impairment were more likely to experience hepatic decompensation and/or treatment discontinuation due to adverse events. Low platelet count was associated with de novo HCC development. These patients should be meticulously followed up during and after the DAA therapy.
Lim, Yeong-Min,Yang, Pil-Sung,Jang, Eunsun,Yu, Hee Tae,Kim, Tae-Hoon,Uhm, Jae-Sun,Kim, Jong-Youn,Pak, Hui-Nam,Lee, Moon-Hyoung,Joung, Boyoung,Lip, Gregory Y.H. Elsevier 2019 Mayo Clinic proceedings Vol.94 No.2
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>To assess the effects of body mass index (BMI) variability on the incidence of new-onset atrial fibrillation (AF), stroke, cardiovascular (CV) risk factors, and CV outcomes in a general Asian population.</P> <P><B>Patients and Methods</B></P> <P>Data from the National Health Insurance Service–Health Screening cohort in Korea were used: 171,324 patients without AF were included, and BMI measurements occurred biennially from January 1, 2002, through December 31, 2009. Patient outcomes were followed through 2013. The BMI intraindividual variability between visits was measured.</P> <P><B>Results</B></P> <P>During mean ± SD follow-up of 47.4±3.9 months, 1959 patients (1.1%) developed new-onset AF. Overweight or obesity (BMI ≥25) had a greater risk of new-onset AF compared with BMI of 20 to 22.5, with a hazard ratio (HR) of 1.24 (95% CI, 1.10-1.41; <I>P</I><.001). In underweight or normal-weight participants (initial BMI <25), a 1-kg/m<SUP>2</SUP> increase of BMI variability increased the risk of new-onset AF, with an adjusted HR (aHR) of 1.13 (95% CI, 1.01-1.25; <I>P</I>=.02). Weight gain increased the risk of new-onset AF (aHR, 1.32; 95% CI, 1.01-1.71; <I>P</I>=.04) and myocardial infarction (aHR, 1.52; 95% CI, 1.06-2.18; <I>P</I>=.02) but not stroke. In this group, blood pressure, glucose level, and total cholesterol level were higher in individuals with the greatest BMI variability compared with those with stable BMI.</P> <P><B>Conclusion</B></P> <P>In the underweight and normal-weight Asian population, BMI variability, especially weight gain, was related to increased risk of new-onset AF and myocardial infarction. Avoiding weight gain is important to improve CV outcomes.</P>