항원 흡입에 의한 비특이적 기관지과민성: II. 화분

김미경,엄재호,이동호,조명찬,이상도,윤세진,궁성수,김승택,이복희 충북대학교 의과대학 충북대학교 의학연구소 1992 忠北醫大學術誌 Vol.2 No.1

피부단자검사, RAST 및 항원 기관지유발검사(allergen bronchial provocation test, ABPT)결과 쑥, 잔듸, 나무화분에 감작된 기관지 천식 환자 13명을 대상으로 이들 화분이 비특이적 기관지과민도(non-specific bronchial hyperresponsiveness, NSBR)에 미치는 영향을 알아보고, ABPT시의 조기 및 후기 천식반응(early, late asthmatic response, EAR, LAR)이 NSBR 생성에 관여하는지와 각각 화분의 항원성을 비교하고자, 감작된 화분으로 ABPT를 시행하고, 이를 전후하여 메타콜린 기관지유발검사(methacholine bronchial provocation test, MBPT)를 시행하여 아래와 같은 결과를 얻었다. 기저 폐기능상 기도 폐색을 보인 환자는 없었으며, 알레르기성 비염만을 호소하였던 환자 11명 중 4명(31%)은 MBPT에 양성반응을 나타내었으나, ABPT에는 11명 모두 양성반응을 보인 천식 환자였다. ABPT상 3명은 EAR, 2명은 ILAR, 8명은 LAR이였다. EAR만을 나타낸 경우는 ABPT 24시간 후 PC20이 감소하지 않고, 오히려 다소 증가하였으나, ILAR을 나타낸 환자들은 24시간 후 PC20가 감소하여 3일 후 기저치로 환원된 반면, LAR에서는 24시간 후 PC20가 현저히 감소하여, 2주 내지 6주 후에야 기저치로 환원되었다. LAR을 보인 환자들 중 쑥에 감작된 환자들이 목초 화분에 감작된 환자에 비해 Pc20의 감소기간이 유의하게 길었다. 이상의 결과를 종합해 보면 화분 흡입에 의한 LAR에 의해 NSBR이 악화되며 지속기간이 상당히 긴 것을 알 수 있다. 또한 화분 중 쑥의 항원성이 목초보다 상당히 강한 것도 알 수 있다. 더불어 화분에 감작된 알레르기성 비염 환자들의 대부분에서 천식이 잠재해 있음도 알 수 있다. 그러므로 향후 천식의 증상이 없는 화분에 감작된 비염환자라 할지라도 MBPT 및 ABPT를 시행하여 정확한 진단을 해야겠다. 본 연구에서 종래의 다른 연구 결과들과는 달리 쑥의 경우 ILAR의 경우도 NSBR을 악화시킴을 관찰하였는데, ILAR과 LAR의 차이가 단순한 기도폐색의 정도 차이인지, 기도 내에서 염증반응에 차이가 있는지는 향후 기관지 페포세척이나 조직 검사등을 통해 밝힘으로써, ABPT에 의한 NSBR의 발생 및 악화의 기전을 보다 확실히 규명할 수 있을 것으로 사료된다. Bronchial hyperresponsiveness is a fundamental characteristics in bronchial asthma. The pathogenesis of bronchial hyperreactivity has not been clearly understood, yet. We studied non-specific bronchial hyperresponsiveness with methacholine inhalation sequentially afterallergen provocation in pollen such as, alder, grass and mugwort-sensitzed allergic asthma and/or allergic rhinitis to investigate if there is any relation between allergen exposure and bronchial hyperreactivity, and compare the allergenicity of each pollen. 3 of 13 study subjects showed early asthmatic reaction, but 8 of them showed late(dual) asthmatic reaction, and the other 2 showed intermediate late asthmatic reaction. Non-specific bronchial hyperreactivity was not increased in early asthmatic responder, however, it was increased upto 45 days after allergen inhalation in all late asthmatic responder and in intermediate late reactor, upto 3 days. In mugwort-sensitized late asthmatic responder NSBR decreased much longer than any others. Taken together, pollen-induced late asthmatic reaction is one factor which contributes NSBR in pollinosis patients.

종골 골절 치료에 있어서의 전산화 단층 촬영의 유용성

김학준,하권익,윤정로,심재익,김택선,김영배,이우승,최재혁 대한골절학회 2003 대한골절학회지 Vol.16 No.4

제주도 목야지내 독초의 분포상황 및 그 성분에 관한 조사 연구

양기천,김승호,이정택 제주대학교 1974 논문집 Vol.6 No.-

We, investigators made a survey on the species, regional distribution and toxic chemical components of the poisonous plants in Cheju island from March to Nov. 1974. The results obtained were as follows : 1. If not all, 86 species(65 spp. of herbs(inbolvlng ergot), 21 spp. of shrubs) within 42 families of the poisonous plants distributed in this Cheju area were classified. 2. According to their regional distribution, 36 spp, were in wild, field, 34 spp. in jungle area, 21 spp. in inhabited region, 15 spp. in a region of seashore, 5 spp. in a mountainous area. 3. And according to their toxic chemical components or poisoning types, they were classified as 7 spp. of cyanogenetic plants, 8 spp. of photosensitization, 6 spp. of oxalate-producing plants, 3 spp. of producing a thiamine deficiency, 2 spp. of teratogenetic effect, 1 sp (ergot) of gangrene production and 59 spp. of the other activities. 4. Actually, the bracken fern(Pteridium nquilinum) is a most problematic poisonous plant in livestock, because it is so high in frequecy or in this Cheju island. But, of course, it will be a nonsense to despise lots of the other poisonous plants.

외상성 뇌실질 손상의 MRI

김성택,오창진,홍승관,문명선 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.8

The authors retrospectively analyzed the MRI findings of the 8 head-injured patients who had showed persistent unconsciousness and severe neurologic deficite after trauma. T2-weighted MR images disclosed high signal intensity lesions of various size and shape at lobar white matter and corpus callosum, subcortical gray matter, brain stem, and cerebral cortex, and assisted greatly in understanding the neurologic deficits of the corresponding patients. The lesions were mostly multiple and involved multiple structures CT's revealed in those patients only small hemorrhages, suspicious low densities, such nonspecific findings as slit ventricles and diffuse brain atrophy, or no abnormality at all. Post-traumatic parenchymatous lesions detected by MR images were either missed or quite underestimated on CT's. MRI was very superior to CT in the detection and anatomic localization of nonhemorrhagic intraaxial cerebral injuries, especially in the cases of small cortical contusions. CT is indicated in order to fastly detect intracranial hematomas which may need emergent surgical evacuation. If CT findings does not explain the neurologic degicits of the patients, especially in the late stage. MRI is indicated, MRI is expected to play a major role in the diagnosis of shear injuries involving white matter and brainstem where CT has been of little contribution or misleading.

무한증을 동반한 선천성 동통 무감각증 : 1예 보고 Report of A Case

김진영,송석환,조성일,공준택 최신의학사 1991 最新醫學 Vol.34 No.1

뇌의 미만성 축삭 손상 정도, 지능 지수 그리고 예후와의 상호관계

양승민,김영백,권정택,박승원,황성남,최덕영 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.2

Diffuse axonal injury (DAI) is defined as posttraumatic coma for over 24 hours without intracranial mass lesion. the purpose of this study was to examine the neurologic state of the patient and to evaluate the psychiatric sequela after DAI by psychometric analysis.Twenty eight patients with DAI were analyzed by a psychoanalyzer. Electroencephalography and magnetic resonance(MR) imaging were performed on eighteen patients. The ratio of male to female was about 6 to 1 and the major cause was traffic accident followed by fall down. Radiologic abnormality in MR image was predictors of poor outcome and early neurologic state was one of the most significant prognostic factor. Psychometric anlysis revealed that lntelligence Quotient was correlated with outcomes and most of patients with DAI were in normal range of lntelligence Quotient(67.9%) but they have suffered from variable psychologic problems, such as depression, anziety, phobia and dementia. Previous studies in DAI have been based principally on the prognostic factors and treatment without a systemic apporach to their meurologic and psychologic problems. Psychometric analysis can reveal psychologic symptom in the patients with DAI and appropriate management of their psychiatric problems may carry important implications for management of patients with moderate or servere DAI and improve rehabilitation outcomes.

優秀工業系 實科敎員養成을 위한 工業敎育大學 敎育課程 改善에 關한 硏究 : 工業敎育學部를 中心으로

李廷玟,任洪彬,李載元,李來然,金澤基,劉承坤 충남대학교 공업교육연구소 1983 論文集 Vol.6 No.2(A)

This paper is studied to improve the curriculum of the College of Industrial Education of Chungnam National University, which is more helpful for the students to become a competent teacher of technical high school. The thesis includes the curriculum of general, professional, technical subjects and so on. The main conclusions are summarized as follows; 1) The current curriculum of the College of Industrial Education was formed on a wholesale manner following the basis of standard courses for some characterized engineering colleges. But the suggested is conformed to the curriculum system of CNU in credits and hours. 2) The current technical subjects are mainly based on the curriculum of college of engineering, but the newly suggested technical subjects are conformed to the curriculum of technical high school as following that some departments of engineering are founded in the College of Industrial Education. 3) In current curriculum, the ratio of reguired technical subjects to elective technical subjects is 85:15. In suggested curriculum, the ratio of it is largely changed to 45:55 for effective operation of minor cousres. And the lists of the subjects for minor courses are changed from subjects for College of Science to subjects for College of Engineering.

컴퓨터를 이용한 혈액학 교육시스템의 개발

이기형,손보라,윤희석,조원덕,김승택 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.1

연구목적 : 전통적인 의학교육 시스템은 최근 개발되고 있는 여러 가지 영상 진단법 등 시각적 자료를 전달하는데 한계가 있으며, 이러한 한계는 모든 분야에 걸쳐서 나타나지만 특히 혈액학이나 심장학 등 시각적인 자료가 진단에 필수적인 분양에서 두드러진다고 할 수 있다.본 연구는 혈액학 교육에 사용되던 기존의 강의실 교육에 시각적 자료가 첨부된 CD-ROM을 개발하여 혈액학 교육 시스템을 개선하기 위한 것이다. 대상 및 방법 : 기존의 혈액학 교육에 있어서 필수적으로 강의 되어오던 자료를 수집하여 체계적으로 정리하였다.강의 자료에 따라서 필요한 영상 자료를 충북대학교 병원에 입원한 혈액질환 환자들의 검사 자료로부터 수집하여 컴퓨터를 기반으로 한 의학영상 처리 및 분석시스템을 통하여 이미지 파일로 변형하였다.또한 입원 환자들 중 대표적인 증례들을 수집하여 실제 임상 진료와 유사한 형태의 증례를 통한 학습을 할 수 있도록 하였다. 결과: 본 CD-ROM은 혈액학 교육에 필요한 대부분의 영역을 포함한다 각 질환의 병태생리, 진단, 임상양상, 치료 및 예후 등 전통적으로 강의되어 오던 강의록에 이미지 파일로 변형된 영상 자료를 필요한 곳마다 링크시켰다.따라서 학습자는 특별한 장치 없이 텍스트 및 영상을 한 화면에서 볼 수 있어 전통적인 교육 시스템에 비하여 시,공간적인 장점을 갖는다 할 수 있다.또한 입원 환자들로부터 수집된 증례를 통하여 실제 임상 진료와 매우 유사한 경험을 하도록하여 교육효과를 증대시켰다. 결론: 혈액학 교육에 있어서 멀티미디어적 효과를 극대화시켜 질환의 병태생리 등 강의실 교육자료뿐 아니라 진단에 필수적인 시각적 자료를 손쉽게 접할 수 있는 CD-ROM의 개발로 전통적인 강의방법이 갖는 한계를 개선시킬 수 있을 것으로 기대된다. Purpose : The traditional medical education system has its limitations in effectiveness of conveying informations in multiple modalities used in diagnosis of patients with hematologic diseases.This study was performed to develop such a multimedia system using computer based CD-ROM, which includes visual assistant systems, several hematological case studies as well as the traditional text-wise education systems. Materials and Methods: The informations about hematologic diseases were compiled and organized.The main visual data was peripheral blood smears, bone marrow data, and several laboratory results accrued from patients admitted to Chungbuk National University Hospital.Each visual data were transformed through computer-based medical image processing and analyzing system and saved as to JPEG files.Case studies were also acquired from admitted patients and the laboratory data of that patients were used unmodified as possible as. Results : The CD-ROM covers almost all kinds of hematologic diseases that must be included in ordinary medical education courses.The text part includes pathophysiology, diagnosis, clinical features, treatment and prognosis of each hematologic diseases.The essential visual data were linked to each text part and accessible with ease, by one click.Case studies were simulated to actual clinical settings and presented step by step from diagnoses to treatments. Conclusion: A multimedia approach for the study of hematologic diseases has been developed and available in CO-ROM format.This system has advantage over traditional education system in conveying all kinds of visual data which is essential in educating hematologic disorders.

Inhibitory Effect of <i>Poncirus trifoliate</i> on Acetylcholinesterase and Attenuating Activity against Trimethyltin-Induced Learning and Memory Impairment

KIM, Jae Kyeom,BAE, Heyri,KIM, Mi-Jeong,CHOI, Soo Jung,CHO, Hong Yon,HWANG, Han-Joon,KIM, Young Jun,LIM, Seung Taik,KIM, Eun Ki,KIM, Hye Kyung,KIM, Bok Yong,SHIN, Dong-Hoon Japan Society for Bioscience, Biotechnology, and A 2009 Bioscience, biotechnology, and biochemistry Vol.73 No.5

<P>Various native Korean plants were screened to find an effective acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer’s disease (AD). Among these plants, the ethanol extract of <I>Poncirus trifoliate</I> was selected for isolating the AChE inhibitor because it exhibited the highest inhibitory activity (47.31%). To separate the active compound from <I>Poncirus trifoliate</I>, solvent partition, open column chromatography, thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) were utilized. The putative chemical structure of the AChE inhibitor was identified as <I>methoxsalen</I> by successive analysis with electron ionization mass spectrometry (EI-MS) and <SUP>13</SUP>C/<SUP>1</SUP>H-nuclear magnetic resonance (NMR). To confirm the attenuating effect of the <I>Poncirus trifoliate</I> extract against trimethyltin (TMT)-induced neurotoxicity, <I>in vivo</I> behavior tests were carried out. Our findings suggest that the <I>Poncirus trifoliate</I> extract significantly reversed TMT-induced learning and memory impairment. These results demonstrate that the <I>Poncirus trifoliate</I> extract could possess a wide range of beneficial activities for neurodegenerative disorders, notably AD.</P>

Zeatin Supplement Improves Scopolamine-Induced Memory Impairment in Mice

KIM, Mi Jeong,CHOI, Soo Jung,LIM, Seung-Taik,KIM, Hye Kyung,KIM, Young Jun,YOON, Ho-Geun,SHIN, Dong-Hoon Japan Society for Bioscience, Biotechnology, and A 2008 Bioscience, biotechnology, and biochemistry Vol.72 No.2

<P>In this study, our aim was to clarify the ameliorative effects of zeatin, a development hormone in plants. Zeatin mitigated cognitive deficits and showed AChE inhibition in scopolamine (Scop)-induced mice following 21 d of zeatin treatment. After administration of Scop for 30 min, each mouse performed Y-maze and step-down latency tasks as a check on immediate against cognitive function. The results showed that zeatin administration attenuated Scop-induced memory damage and decreased AChE activity in the mice. This suggests that zeatin might be useful for protecting cognitive dysfunction, as well as for reducing the activation of AChE in dementia.</P>