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장지면(Ji Myun Jang),이명철(Myung Chul Lee),신준수(Joon Su Shin),정재훈(Jae Hoon Cheong),김양배(Yang Bae Kim),김박광(Bak Kwang Kim) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.1
N/A The derivative of chrysin 7-O-cyclopropanecarboxylate was synthesized by condensing cyclopropanecarboxylic acid with chrysin in organic solvent, and its structure was identified by NMR, MS, UV, IR etc. We also investigated the physico-chemical properties, anti-diabetic effect and set up the quantitative analytical method of this compound. The correlation coefficient of calibration curve on this compound was approximately 0.9985 by absorption spectrophotometry. And, this study was carried out to investigate the hair-growth effect of chrysin derivative to the black mouse (C57BL/6). When this derivative in ethanol solution was administered to the back of mouse by method of skin paste, this derivative promoted the hair growth of mouse.
Phytochemical Constituents from the Herba of Artemisia apiacea
Lee, Sang-Hyun,Kim, Kyoung-Soon,Jang, Ji-Myun,Park, You-Mie,Kim, Yang-Bae,Kim, Bak-Kwang The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.3
Four compounds of a coumarin, a steroid and two flavonoids were isolated from the herba of Artemisia apiacea by open column chromatography. Their structures were elucidated as artemicapin C, apigenin, daucosterol and cacticin by chemical and spectroscopic analysis. This is the first report of the isolation of these compounds from this plant.
식용 식물자원으로부터 활성물질의 탐색-V. -상추(Lactuca sativa L.)의 ACAT 억제 Diterpenoid, Phytol-
장태오,방면호,송명종,홍윤희,김지영,정대균,배동근,권병목,김영국,이현선,김인호,백남인,Jang, Tae-O,Bang, Myun-Ho,Song, Myoung-Chong,Hong, Yoon-Hee,Kim, Ji-Young,Chung, Dae-Kyun,Pai, Tong-Kun,Kwon, Byung-Mok,Kim, Young-Kuk,Lee, Hyun-Sun,Kim 한국응용생명화학회 2003 한국농화학회지 Vol.46 No.1
황석연(Seock-Yeon Hwang),권운(Woon Kwon),채희열(Hee-Youl Chai),조영민(Young-Min Cho),이남진(Nam Jin Lee),류재면(Jae Myun Ryu),신지순(Ji Soon Sin),김태명(Tae Myung Kim),조정희(Jung-Hee Cho),장자영(Ja Young Jang),박정휘(Jung-Hui Park) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
The purpose of this study was to confirm the safety of the water extract of Mori folium single (MFS) or mixed (MFM) compound. Male Sprague-Dawley rats were orally administered with MFS or MFM at dose levels of 0.5, 1.0 or 2.0 g/㎏/day for 4 weeks. As results, there were no significant differences in the body weight gain between vehicle control and MFS or MFM-treated rats. Also, significant changes in daily feed intake and water consumption were not observed during the experimental period. In hematological analysis, there was a trend of decrease in prothrombin time, in contrast to a slight delay in activated partial thromboplastin time following MFS or MFM treatment. And white blood cells (WBC), especially lymphocytes, somewhat increased. In serum biochemical analysis, aspartate transaminase, alanine transaminase and alkaline phosphatase, related to hepatic injuries, decreased. Also, renal and pancreatic toxicity parameters such as blood urea nitrogen, creatinine and amylase decreased by MFS or MFM treatment. Interestingly, serum globulin fraction in total proteins increased, suggestive of an immunopotentiation effect, in accordance with the increase in WBC. There were no significant changes in organ weights, and no gross and histopathological lesions were observed. Taken all together, it is proposed that repeated treatment with the extract of Mori folium or its mixture, available in oriental clinics, may not exert considerable adverse effects, and that rather protect against tissue injuries and enhance immune functions.