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권오훈 ( Oh Hoon Kwon ),윤희관 ( Huy Kwan Yun ),한성국 ( Seong Kuk Han ),안대현 ( Dae Hyun Ahn ),심명진 ( Myeong Jin Shim ),조성운 ( Sung Woon Cho ),박종순 ( Jong Soon Park ),김재용 ( Jae Yong Kim ) 한국공업화학회 2010 공업화학 Vol.21 No.5
기존 단열재의 주된 기능은 단지 열전달을 차단하는 기능과 건물로부터 열손실을 줄여주는 기능만을 수행했다. 반면, 축열재는 특정온도 범위 내에서 열에너지를 저장 또는 방출함으로써 건물에너지 사용량을 절감할 수 있다. 축열 건자재는 실내 공기온도 변화주기를 효과적으로 조절하여 일정하게 온도를 유지시킬 수 있다. 결과적으로 냉난방시스템기능을 효율적으로 향상시킬 수 있다. 본 연구는 건축자재로 많이 이용되고 있는 석고보드에 상변화잠열물질을 축열재로 첨가하여 그 물성과 열환경 특성을 파악하였다. 또한 축열 건자재를 활용할 때 발생가능한 문제점을 확인하였다. 마지막으로 TVOC와 HCHO 함량 분석으로부터 오염물질의 배출가능성을 조사하여 축열 건자재의 환경 친화도를 검토하였다. The main function of conventional insulation materials is only to block the heat transfer and reduce heat loss from the building. On the other hand, thermal storage materials can work as an energy saver by absorbing or emitting heat within a specific temperature range. Thermal storage materials for building can maintain a constant temperature by effectively regulating the cycle of indoor temperature. As a result, we can enhance the performance of a cooling and heating system efficiently. In this study, phase change materials (PCMs) were added as thermal storage materials into gypsum boards which are extensively used for building material and we found out the thermal environmental characteristics. In addition, we checked out some problems when applying the thermal storage materials to buildings. Finally, This study set out to examine the degree of environmental-friendly characteristics of thermal storage building materials by analyzing the amount of TVOC and HCHO contents with the possibility of pollutants emission.
고콜레스테롤혈증 토끼에서 녹차추출물의 동맥경화 치료효과
채희열(Hee-Youl Chai),권운(Woon Kwon),김태명(Tae Myoung Kim),김한얼(Haneul Kim),이남진(Nam Jin Lee),신지순(Ji-Soon Sin),이덕근(Deok Keun Lee),박종범(Jong Bum Park),박승경(Sung-Kyeong Park),황석연(Seock-Yeon Hwang),김윤배(Yun-Bae Kim 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
Cholesterol-lowering and antiatherosclerotic effects of green tea extract were evaluated in hypercholesterolemic rabbits produced by feeding on high-cholesterol diet. Male New Zealand White rabbits were fed on only hypercholesterol diet containing 1% cholesterol and 2% corn oil for 2 weeks, and then green tea extract (1%) or lovastatin (0.002 %) were added to the diet for additional 8 weeks. Blood cholesterol level was greatly increased by 2-week feeding on the hypercholesterol diet to 25 fold (mean 1,057.8 ㎎/㎗) of control level (42.5 ㎎/㎗), and maintained high for additional 8 weeks, in spite of slight reduction to 92.2 % of initial hypercholesterolemia. Such a hypercholesterolemia was significantly reduced by 8-week feeding on green tea extract and lovastatin to 62.6% and 67.4% of initial levels, respectively. Low-density lipoproteins were also markedly enhanced by hypercholesterol diet for 2 weeks to 34 fold (mean 533.3 ㎎/㎗) of control (15.8 ㎎/㎗), and increased further by 181.9 ㎎/㎗ during 8-week feeding on the diet. Compared to no effect of green tea extract (181.3 ㎎/㎗), lovastatin (63.0 ㎎/㎗) significantly attenuated the increase in the level of low-density lipoproteins during 8 weeks. On the other hand, triglycerides were not affected by hypercholesterol diet, and the level of high-density lipoproteins, which had been increased (3.6 fold of control) by hypercholesterol diet, were not considerably affected by green tea extract or lovastatin. Interestingly, thick atheromatous plaques on the wall of aorta of rabbits fed on hypercholesterol diet were markedly attenuated by green tea extract or lovastatin, leading to the decreases in athrosclerosis indices to 1.75 and 1.25, respectively, from 2.25 of rabbits fed on hypercholestrol diet alone. In addition, green tea extract lowered lipid deposition in hepatocytes, showing restricted distribution of foamy hepatocytes. Taken together, it is suggested that green tea extract exert antiatherosclerotic effect by reducing blood cholesterol level.
황석연(Seock-Yeon Hwang),권운(Woon Kwon),채희열(Hee-Youl Chai),조영민(Young-Min Cho),이남진(Nam Jin Lee),류재면(Jae Myun Ryu),신지순(Ji Soon Sin),김태명(Tae Myung Kim),조정희(Jung-Hee Cho),장자영(Ja Young Jang),박정휘(Jung-Hui Park) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
The purpose of this study was to confirm the safety of the water extract of Mori folium single (MFS) or mixed (MFM) compound. Male Sprague-Dawley rats were orally administered with MFS or MFM at dose levels of 0.5, 1.0 or 2.0 g/㎏/day for 4 weeks. As results, there were no significant differences in the body weight gain between vehicle control and MFS or MFM-treated rats. Also, significant changes in daily feed intake and water consumption were not observed during the experimental period. In hematological analysis, there was a trend of decrease in prothrombin time, in contrast to a slight delay in activated partial thromboplastin time following MFS or MFM treatment. And white blood cells (WBC), especially lymphocytes, somewhat increased. In serum biochemical analysis, aspartate transaminase, alanine transaminase and alkaline phosphatase, related to hepatic injuries, decreased. Also, renal and pancreatic toxicity parameters such as blood urea nitrogen, creatinine and amylase decreased by MFS or MFM treatment. Interestingly, serum globulin fraction in total proteins increased, suggestive of an immunopotentiation effect, in accordance with the increase in WBC. There were no significant changes in organ weights, and no gross and histopathological lesions were observed. Taken all together, it is proposed that repeated treatment with the extract of Mori folium or its mixture, available in oriental clinics, may not exert considerable adverse effects, and that rather protect against tissue injuries and enhance immune functions.
황석연(Seock-Yeon Hwang),권운(Woon Kwon),채희열(Hee-Youl Chai),조영민(Young-Min Cho),류재면(Jae Myun Ryu),김동규(Dong Kyu Kim),신지순(Ji Soon Sin),김태명(Tae Kyung Kim),조정희(Jung-Hee Cho),신선희(Sunhee Shin),박정휘(Jung-Hui Park) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
Four-week repeated-dose toxicity of Kamiguibitang was investigated in rats. Male Sprague-Dawley rats were orally administered with Kamiguibitang at doses of 200, 800, 1,600 or 3,200 ㎎/㎏/day or its vehicle for 28 days. There were no significant differences in the body weight gain between vehicle control and Kamiguibitang-treated groups. Significant changes in daily feed intake and water consumption were not observed throughout the experimental period. There were trends of increase in platelets and white blood cells, in parallel with increases in serum globulin level and spleen weight, suggestive of inflammatory response and/or immune enhancement. Serum parameters of hepatic and renal injuries, such as aspartate transaminase, alanine transaminase, alkaline phosphatase, cholesterol, triglyceride, creatinine, phosphorus, calcium, sodium and potassium, also increased at low doses (200-800 ㎎/㎏) of Kamiguibitang, although the levels were suppressed at high doses (1,600-3,200 ㎎/㎏). However, no gross and histopathological lesions were seen at all doses. Based on the results, no observed adverse effect level (NOAEL) of Kamiguibitang was found to be lower than 200 ㎎/㎏, which is comparable with clinical dose (100 ㎎/㎏) in human. In spite of the relatively-low NOAEL, it is suggested that repeated treatment with Kamiguibitang may not exert considerable adverse effects, as inferred from that major hematological and blood biochemical changes were results of pharmacological effectiveness on immunomodulation, and that no histopathological lesions were exerted up to 32 folds of clinical dose (3,200 ㎎/㎏),
황석연(Seock-Yeon Hwang),권운(Woon Kwon),채희열(Hee-Youl Chai),조영민(Young-Min Cho),이남진(Nam Jin Lee),류재면(Jae Myun Ryu),신지순(Ji Soon Sin),김태명(Tae Myung Kim),조정희(Jung-Hee Cho),김은주(Eun Ju Kim),박정휘(Jung-Hui Park),강종 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
Four-week repeated-dose toxicity study was performed to confirm the safety of the water extract of Mori radicis cortex single (MRCS) or mixed (MRCM) compound. Male Sprague-Dawley rats were orally administered with MRCS or MRCM at doses of 0.5, 1.0 or 2.0 g/㎏/day for 28 days. In the results, there were no significant differences in the body weight gain between vehicle control and MRCS or MRCM treatment groups. Also, no significant changes in daily feed intake and water consumption were observed throughout the experimental period. In hematological analysis, there was a trend of increases in red blood cells at 0.5 and 1.0 g/㎏ of MRCM and in hemoglobin at 0.5 g/㎏ of MRCM, although such changes were in normal ranges. In addition, white blood cells, especially neutrophils, slightly increased, without statistical significance, following treatment with MRCS or MRCM. Interestingly, serum biochemical parameters including aspartate transaminase and alanine transaminase, related to hepatic injuries, decreased at all doses after 28-day treatment with MRCS or MRCM, suggestive of protective effects against tissue damage. No significant changes in organ weights were observed, in accordance with normal features in gross and microscopic findings. Taken together, it is suggested that repeated treatment with the extract of Mori radicis cortex or its mixed compound, available in oriental clinics, may not exert considerable side effects.
황석연(Seock-Yeon Hwang),신지순(Ji Soon Sin),권운(Woon Kwon),채희열(Hee-Youl Chai),조정희(Jung-Hee Cho),이남진(Nam Jin Lee),박종배(Jong Bae Park),김익수(Iksoo Kim),류강선(Kang Sun Ryu),윤치영(Chi-Young Yun),강종구(Jong-Koo Kang),김윤배 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.2
The purpose of this study was to confirm the safety of the extract of cricket, Gryllus bimaculatus. Male Sprague-Dawley rats were divided into 5 groups, 10 animals in each group, and orally administered with the cricket extract at doses of 0 (vehicle), 25, 50, 100 or 200 ㎎/㎏ for 2 weeks. In the results, there were no significant differences in the body weight gain between vehicle control and cricket-treated groups. Also, significant changes in daily food intake and water consumption were not observed through tout the experimental period. In addition, hematological parameters did not show any significant or dose-dependent alterations. Serum biochemical parameters including aspartate transaminase, alkaline phosphatase, creatine kinase, cholesterol, triglyceride, lactate dehydrogenase, pancreatic amylase, iron and magnesium decreased at high doses, in contrast to increases in glucose and potassium levels, although such changes were in normal ranges. In gross findings, no remarkable lesions were seen, except a light increase in only absolute weight, but not relative weight, of submaxillary glands at 25 ㎎/㎏ of cricket. In addition, no abnormal histopathological findings were observed. Taken together, it is suggested that repeated treatment with the extract of cricket may not exert considerable side effects.