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Phosphodiesterase inhibitor improves renal tubulointerstitial Hypoxia of the Diabetic rat Kidney
( Hui Kyoung Sun ),( Yun Mi Lee ),( Kum Hyun Han ),( Han Seong Kim ),( Seon Ho Ahn ),( Sang Youb Han ) 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.2
Background/Aims: Renal hypoxia is involved in the pathogenesis of diabetic nephropathy. Pentoxifyllin (PTX), a nonselective phosphodiesterase inhibitor, is used to attenuate peripheral vascular diseases. To determine whether PTX can improve renal hypoxia, we investigated its effect in the streptozocin (STZ)-induced diabetic kidney. Methods: PTX (40 mg/kg, PO) was administered to STZ-induced diabetic rats for 8 weeks. To determine tissue hypoxia, we examined hypoxic inducible factor-1α (HIF-1α), heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), and glucose transporter-1 (GLUT-1) levels. We also tested the effect of PTX on HIF-1α in renal tubule cells. Results: PTX reduced the increased protein creatinine ratio in diabetic rats at 8 weeks. HIF-1α, VEGF, and GLUT-1 mRNA expression increased significantly, and the expression of HO-1 also tended to increase in diabetic rats. PTX significantly decreased mRNA expression of HIF-1α and VEGF at 4 and 8 weeks, and decreased HO-1 and GLUT-1 at 4 weeks. The expression of HIF-1α protein was significantly increased at 4 and 8 weeks in tubules in the diabetic rat kidney. PTX tended to decrease HIF-1α protein expression at 8 weeks. To examine whether PTX had a direct effect on renal tubules, normal rat kidney cells were stimulated with CoCl2 (100 μM), which enhanced HIF-1α mRNA and protein levels under low glucose conditions (5.5 mM). Their expressions were similar even after high glucose (30 mM) treatment. PTX had no effect on HIF-1α expression. Conclusions: PTX attenuates tubular hypoxia in the diabetic kidney.
투석 중인 말기신부전 환자에서 관동맥 우회로술과 관동맥 중재술의 장기 성적 비교
선휘경 ( Hui Kyoung Sun ),김나경 ( Na Kyoung Kim ),조유정 ( Yu Jung Cho ),강승대 ( Seung Dae Kang ),김태완 ( Tae Wan Kim ),한금현 ( Kum Hyun Han ),도준형 ( Joon Hyung Doh ),이성윤 ( Sung Yun Lee ),김창영 ( Chang Young Kim ),장우익 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.4
Purpose: Coronary artery disease is the main cause of morbidity and mortality in dialysis patients. Some observational studies proposed that coronary artery bypass graft (CABG) might provide higher survival benefit than percutaneous coronary intervention (PCI) in dialysis patients. There were not many studies of the comparison between the methods of coronary artery reperfusion therapy. Therefore, we compared the long term survival between PCI and CABG groups in dialysis patients. Methods: We selected 104 patients with end stage renal disease (ESRD) who had PCI (N=75) or CABG (N=29) in Ilsan-Paik Hospital from December 1999 to February 2010. We collected data from medical records and performed a retrospective analysis in ESRD patients hospitalized for the first coronary revascularization procedure. Results: There was no difference in the basic characteristics between the two groups. However, the frequency of more than 3-vessel lesions or less than 30% ejection fraction was higher in the group of CABG than that of PCI. One and three-year survival rates were higher in the PCI group than those in the CABG group. However, there was no difference in the 5 year survival rate between the groups. In subgroup analysis for severe patients with 3-vessel coronary diseases or less than 30% of ejection fraction, there were no statistical differences in the 1, 3 and 5 year survival rates between the groups. In subgroup analysis for the patients maintaining dialysis more than three months, 1, 3, and 5 year survival rates were not statistically different. Conclusion: In ESRD and dialysis patients, there was no difference in the long-term survival between PCI and CABG.
Safety and Immunogenicity of Salmonella enterica Serovar Typhimurium LlaB in Mice
( Sun A Cho ),( In Soo Lee ),( Jong Hwan Park ),( Seung Hyeok Seok ),( Hui Young Lee ),( Dong Jae Kim ),( Min Won Back ),( Seok Ho Lee ),( Sook Jin Hur ),( Sang Ja Ban ),( Yoo Kyoung Lee ),( Jae Hak P 한국미생물생명공학회 2005 Journal of microbiology and biotechnology Vol.15 No.3
( Sun Hwa Park ),( Ji Sun Park ),( Kyoung-hee Han ),( San-hui Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: To assess the feasibility of robotic single-site hysterectomy in clinical and economic aspects. Methods: Total 91 patients who underwent robotic hysterectomy in Wonju Severance Christian Hospital from July 2018 to July 2019 was enrolled retrospectively. All patients underwent total hysterectomy or subtotal hysterectomy with or without adnexal surgery using da Vinci Xi® system. Of total 91 patients, 31 patients underwent robotic single-site hysterectomy(RSSH) using Lapsingle® single port channel system, and 60 patients underwent robotic multi-port hysterectomy(RH) using 4-port system. Results: No cases of RSSH were converted to multi-port, laparoscopy or laparotomy. The patients characteristics showed no significant difference between RSSH group and RH group. The uterine weight of RSSH group was 323g [120-720g] and of RH group was 317g [80-653g], it had no significant difference (p=.286). Clinical outcomes except docking time (RSSH; 7.5 min [3-20 min] vs. RH; 10 min [5-26 min], p=.011) had no significant difference between 2 groups; including postoperative pain score on 2, 4, 6, 8, 12 hours after surgery, total operation time, console time, total hospital day, postoperative hemoglolin change. And the overall cost and actual cost paid by patients also had no significant difference. Conclusion: Robotic single-site hysterectomy is feasible in both clinical and economic aspects. Further prospective study should be needed.
Hypersensitivity Reactions to Oxaliplatin
Kyoung-Hwan Lee,Yong Jai Park,Eun Sun Kim,Hui Jeong Hwang,Byoung Yong Shim,Hoon-Kyo Kim 대한암학회 2006 Cancer Research and Treatment Vol.38 No.4
Oxaliplatin is a third-generation platinum compound that is used as a single agent and in combination with fluorouracil (5-FU) to treat colorectal and gastric carcinoma. The patients treated with oxaliplatin may develop hypersensitivity and idiosyncratic reactions, although these complications are known to be rare. We report here on two patients who suffered with metastatic colorectal cancer and who underwent palliative combination chemotherapy with oxaliplatin; they then developed hypersensitivity reactions to oxaliplatin. The first case had an anaphylatic reaction immediately after the beginning of the 7th to 8th cycle infusion of oxaliplatin. The second case developed repeated febrile episodes from the 4th to 8th cycles of oxaliplatin infusion. With the increasing use of oxaliplatin in clinical practice, we are now encountering an increasing incidence of suspected hypersensitivity reactions. Physicians should keep their eyes wide open and carefully observe for the clinical manifestations of these hypersensitivity reactions. (Cancer Res Treat. 2006; 38:240-241)
Sun-Joo Yoon,Kyung-Hui Moon,Ji-Young Lee,Mi-Kyoung Jeong 대한예방치과학회 2017 International Journal of Clinical Preventive Denti Vol.13 No.3
Objective: This study was conducted to compare the effects of dentifrice containing dentifrice components such as Panax notoginseng, Magnoliae Cortex and tranexamic acid and bamboo salt on the periodontal tissues such as relief of initial gingivitis and mitigation of gingival bleeding. I would like to use it as a reference for the development of dentifrice for patients with periodontal diseases. Methods: 20 applicants who had a slight gingivitis have participated in this study by dividing 4 groups as using the dentifrice in the Panax notoginseng, Magnoliae Cortex, tranexamic acid and bamboo salt, were used for four weeks. PHP (patient hygiene performance) index, GBI (gingival bleeding) index, coated tongue check, oral moisture check were performed on before the experiment, a week later, 2 weeks and 4 weeks later. The data were analyse in order to compare the results for the gingival subside effect. Results: GBI index, and coated tongue index were significantly different in all experimental groups (p<0.05), and there was a significant difference in PHP index between the control and experimental 3 groups after one week (p<0.01). oral moisture index was significantly different between the control group and the experimental 3 group (p<0.05). There was no significant difference between two weeks (p>0.05). Halitosis index was not significantly different in all groups (p>0.05). Conclusion: Using dentifrice containing Panax notoginseng, Magnoliae Cortex, tranexamic acid and bamboo salt were recommended to relieve slight gingivitis.
Sun-Joo Yoon,Kyung-Hui Moon,Ji-Young Lee,Mi-Kyoung Jeong 대한예방치과학회 2017 International Journal of Clinical Preventive Denti Vol.13 No.4
Objective: This study was conducted to compare the effects of dentifrice containing dentifrice components such as Panax notoginseng, Magnoliae Cortex and tranexamic acid and bamboo salt on the periodontal tissues such as relief of initial gingivitis and mitigation of gingival bleeding. I would like to use it as a reference for the development of dentifrice for patients with periodontal diseases. Methods: 20 applicants who had a slight gingivitis have participated in this study by dividing 4 groups as using the dentifrice in the Panax notoginseng, Magnoliae Cortex, tranexamic acid and bamboo salt, were used for four weeks. PHP (patient hygiene performance) index, GBI (gingival bleeding) index, coated tongue check, oral moisture check were performed on before the experiment, a week later, 2 weeks and 4 weeks later. The data were analyse in order to compare the results for the gingival subside effect. Results: GBI index, and coated tongue index were significantly different in all experimental groups (p<0.05), and there was a significant difference in PHP index between the control and experimental 3 groups after one week (p<0.01). oral moisture index was significantly different between the control group and the experimental 3 group (p<0.05). There was no significant difference between two weeks (p>0.05). Halitosis index was not significantly different in all groups (p>0.05). Conclusion: Using dentifrice containing Panax notoginseng, Magnoliae Cortex, tranexamic acid and bamboo salt were recommended to relieve slight gingivitis.
Lee, Sun Kyoung,Choi, Beom Kyu,Kang, Woo Jin,Kim, Young Ho,Park, Hye Young,Kim, Kwang Hui,Kwon, Byoung S Korean Society for Molecular Biology 2008 Molecules and cells Vol.26 No.1
<P>Herpetic stromal keratitis (HSK) is an inflammatory disorder induced by HSV-1 infection and characterized by T cell-dependent destruction of corneal tissues. It is not known what triggers CD4(+) T cell migration into the stroma of HSV-1-infected corneas. The keratocyte is a fibroblast-like cell that can function as an antigen-presenting cell in the mouse cornea by expressing MHC class II and costimulatory molecules after HSV-1 infection. We hypothesized that chemokines produced by stromal keratocytes are involved in CD4(+) T cell infiltration into the cornea. We found that keratocytes produce several cytokines and chemokines, including MCP-1, RANTES, and T cell activation (TCA)-3. HSV-1 infection increased the production of MCP-1 and RANTES by keratocytes, and these acted as chemoattractants for HSV-1-primed CD4(+) T cells expressing CCR2 and CCR5. Expression of MCP-1 in the corneal stroma was confirmed in vivo. Finally, when HSV-1-primed CD4(+) T cells were adoptively transferred into wild type and MCP-1-deficient mice that had been sublethally irradiated to minimize chemokine production from immune cells, infiltration of CD4(+) T cells was markedly reduced in the MCP-1-deficient mice, suggesting that it is the MCP-1 from HSV-1-infected keratocytes that attracts CD4(+) T cells into the cornea.</P>