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S-539 : A Case of Oral Allergy Syndrome caused by Crown Daisy and Sesame
( Ga Na Hong ),( Mi Ae Kim ),( Moon Kyung Yoon ),( Si Yeon Kim ),( Hae Sim Park ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Background: Oral allergy syndrome (OAS) is a subtype of food allergy, and has been commonly associated with pollen allergy. Crown daisy and sesame leaf are popular vegetables in our country, but food allergy related with these two vegetables has been rarely reported. Here, we experienced a rare case of OAS induced by both crown daisy and sesame leaf, and evaluated their pathogenic mechanisms. Case history: A 33-year-old female visited our clinic to evaluate numbness of tongue and gingiva after eating fresh crown daisy and sesame leaf for 2 years. The patient had suffered from allergic rhinitis and atopic dermatitis for 20 years and took medications intermittently. She had also a history of food allergy to crab and shrimp. Results: White blood cell counts were 8,600/μL (eosinophil 6.5%) and other routine laboratory tests were unremarkable. Total serum IgE level was 404 KU/L with 68.50KU/L of D.pteronyssinus specific IgE and 69.40 KU/L of D. farinae specific IgE, measured by immunoCAP®. Skin prick test showed strong positive reactions to tree and weed pollens-Hop Japanese (8+), pine (5+), plane tree (3+), sh and willow (3+). Serum specific IgE to crude extracts of crown daisy and sesame leaf were not detected, while high serum specific IgG4 antibodies to two extracts wered detected by ELISA. Basophil activation test (BAT) was performed with additions of two extracts, together with anti-IgG4, anti-IgE antibody and, Ca2+. The BAT showed significant upregulations of both CD63 and CD203c expressions with additions of both extracts in dose dependent manners. Conclusion: We confirmed a case of OAS induced by both crown daisy and sesame leaf, in which non-IgE mediated mechanisms were suggested based on detection of high serum specific IgG4 antibodies and positive results on BAT to each extract.
홍가나 ( Ga Na Hong ),김미애 ( Mi Ae Kim ),윤문경 ( Moon Kyung Yoon ),이소희 ( So Hee Lee ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.4
Oral allergy syndrome (OAS) is a subtype of food allergy composing of itching sense and edema in the oral cavity, lips, throat, pharynx, and larynx following ingestion of some fresh fruits or vegetables. Although the major pathogenic mechanism of OAS is known to be IgE-mediated response, here we experienced a case of OAS due to crown daisy (CD) and sesame leaf (SL) mediated by a non-IgE antibody mediated mechanism. A 33-year-old female visited our clinic to evaluate numbness of the tongue and gingiva after eating fresh CD and SL for 2 years. The patient had suffered from allergic rhinitis and atopic dermatitis for 20 years and took medications intermittently. There had been a history of food allergy to crab and shrimp. The serum total IgE level was elevated (404 kU/mL). The skin prick test showed strong positive reactions to tree and weed pollens, but not to CD and SL extracts. Enzyme-linked immunosorbant assay for detecting serum specific IgE to crude extracts of CD and SL showed negative results. The basophil activation test performed with crude extracts of CD or SL showed significant up-regulation of CD63-positive basophils by both CD and SL. In conclusion, we report a case of OAS due to CD and SL, not associated with pollen allergy, which is shown to be mediated by a non-IgE mediated mechanism.
홍은순,박진아,신태림,서기열,우가은,이나영,김미선,맹선희,조영주 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.1
Buckwheat belongs to the Polygonacea or buckwheat family and is not a true cereral since it does not belong to the Graminiae, or grain family. Its products have long been considered excellent foods for both human and animal consumption. The earlist reference to case of buckwheat sensitivity was a report by Smith in 1909. He accurately described a case of angionerotic edema and urticaria in a young man upon ingestion accurately described a case of angionerotic edema and urticaria in a young man upon ingestion of small amounts of buckwheat, and violent asthma on the ingestion of moderate quantities of buckwheat. The authors have experienced one case of buckwheat allergy. The chief complaints were wheezing and dyspnea for several years. The skin tests showed positive reaction to the extracts of buckwheat flour and buckwheat husk. The buckwheat allergy is considered to be the model of the typeⅠallergy(that is lgE dependent type) proposed by Cooms and Gell. The antigenicity of buckwheat is extremely string, so oral provocation test must not easily be applied for fear of severe and dangerous reaction.
( Ga Ram Ahn ),( Joon Seok ),( Jungtae Na ),( Beom Joon Kim ),( Chang Kwun Hong ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Botulinum toxin A (BTX-A) is clinically used for muscular disorders, migraine, hyperhidrosis and cosmetics by preventing the release of neurotransmitter acetylcholine into synaptic cleft. Objectives: The aim of this study is to investigate the efficacy and safety of newly developed BTX-A product (Korea) compared to conventional BTX-A (USA) for the reduction of muscle hypertrophy in Myostatin-deficient (Mstn<sup>-/-</sup>) mouse. Methods: Two different BTX-As were injected on the hindlimb of Mstn<sup>-/-</sup>mouse. Since then, serial sciatic nerve conduction study (NCS), X-ray, 3D micro-CT and muscle biopsy was done. Results: Administration of BTX-A in both product group induced denervation-mediated atrophy and alleviated muscle hypertrophy generated in Mstn<sup>-/-</sup> mice. On day 56, newly developed BTX-A product group showed significant suppression in NCS compared with conventional BTX-A product group. Conclusion: In this study, the results suggest that both BTX-A regulate skeletal muscle size and the number and diameter of myofibers. Also, newly developed BTX-A product seems to have longer duration compared with conventional BTX-A product in the ability to act in a local area.
한국전통발효식품인 청국장에서 분리한 Bacillus methylotrophicus에 의한 항산화물질의 생산
이나리 ( Na Ri Lee ),우가영 ( Ga Young Woo ),장준혁 ( Jun Hyeok Jang ),이상미 ( Sang Mee Lee ),고태훈 ( Tae Hun Go ),이희섭 ( Hee Sup Lee ),황대연 ( Dae Youn Hwang ),손홍주 ( Hong Joo Son ) 한국환경과학회 2013 한국환경과학회지 Vol.22 No.7
Although antioxidant activities of Korean traditional fermented foods were reported by many researchers, study on antioxidant activity of microorganism originated from Korean traditional fermented foods was little. Therefore, we improved condition for antioxidant production by a bacterium isolated from home-made Chungkookjang. We selected a bacterial strain, which showed the highest antioxidative activity, from Chungkookjang and then named GJ. The selected GJ strain was identified as Bacillus methylotrophicus by alignment data of 16S rRNA gene nucleotide sequences. Improved medium compositions for DPPH radical scavenging activity were 0.25% sucrose, 1% peptone, 0.01% MgSO4ㆍ7H2O and initial pH 6.5, respectively. Optimal culture conditions were 30℃, 200 rpm and 4% inoculum volume, respectively. In improved conditions, DPPH radical scavenging activity of GJ reached to 91% in a short time. The strain GJ also possessed ACE inhibition and other antioxidative activities; ACE inhibition activity (49.4%), ABTS radical scavenging activity (99.8%), metal chelating activity (67.9%), SOD-like activity (36.5%) and reducing power (A700=5.982) were observed, respectively. Therefore, our results suggest that B. methylotrophicus Gj strain may be potential candidate for functional foods, cosmetic products for anti-aging and medicine for diseases caused by oxidative stress.
AER(Asan Entrepreneur Review)사례를 통한 창업 초기와 창업 성장기 스타트업 기업의 성공요인 분석
김대홍(Dae Hong Kim),나지현(Ji Hyun Na),유춘규(Chun Gyu Yoo),이필립(Pil Lip Lee),김혜민(Hye Min Kim),김가연(Ga Yeon Kim),김순찬(Soon Chan Kim),김정음(Jeung Eum Kim),고유미(Yumi Ko),구애란(Ae Ran Gu),길창군(Chang Goon Ghil),박민석(Min Se 한국과학기술실용화학회 2023 과학기술융합연구 Vol.2 No.2