요통 환자에서 척추후지 내측지 고주파 열응고술의 효과

정용훈,임경준,이은영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

Background: A number of patients complain of lower back pain due to facet joint problems, and radiofrequency thermocoagulation (RFTC) of medial branches is known to be an effective method of relieving pain caused by the problems. However, objective outcome assessments for this modality are limited so far. Therefore, the authors investigated the effect of the RFTC on the low back pain. Methods: The object of this study was 25 patients who had facet joint syndrome and underwent RFTC. Pain relief was estimated at 2 weeks, 6 weeks, 3 months, and 6 months after the procedure using a visual analog scale (VAS), and was regarded to be successful if pain reduction exceeded 50% on the VAS at 6 weeks. Results: Seven of the 25 patients did not respond favorably to RFTC application and their pain reduction was less than 50%. Of the 18 patients who showed a successful response, 17 had a favorable result up to 3 months and 15 patients up to 6 months after the procedure. Conclusion: Our result showed that lumbar medial branch rhizotomy using RFTC, is an effective treatment modality for patients with lumbar facet joint syndrome, and showing a successful response its effect is maintained for at least 6 months after the procedure in most patients.

백서 뇌에서 전기경련 충격에 의해 발현이 조절되는 새로운 유전자

정선주,박정은,강웅구,구영진,박주배,김용식 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 이 연구는 백서 뇌에서 전기경련 충격(Electroconvulsive shock, ECS)에 의해 발현이 조절되는 새로운 유전자를 검색하고, 발달단게 및 뇌 조직에 따른 발현양상을 관찰하기 위하여 시행되었다. 방법: 생후 7일, 21일된 어린 웅성 백서에 전기경련 충격을 가한 후 mRNS differential display-PCR(DD-PCR) 기법을 시행하여 발현의 차이를 나타내는 유전자를 검색한 후 서열분석을 실시하였다. 생후 7일 및 21일된 백서의 뇌와 성년 백서의 대뇌피질, 해마를 이용한 Northern blot 분석을 시행하여 검색된 유전자의 ECS 처치 후 시간경과에 따른 유전자 발현양상을 관찰하였다. 결과: ECS 처치군과 위충격군간에 발현의 차이를 나타낸 유전자 4개를 검색할 수 있었으며, 이중 ECS에 의해 발현이 증가되는 1개의 유전자를 선정하여 서열분석을 실시한 결과 EST 서열만이 보고된 새로운 유전자임이 밝혀졌다. 이 유전자는 생후 7일된 백서의 뇌에서는 ECS 처치 후 180분에 발현양의 증가가 최고치에 도달하였으나, 생후 21일된 백서의 뇌와 성년백서의 대뇌피질 및 해마에서는 360분 경과시까지 지속적으로 발현 양이 증가하였다. 결론: 이같은 결과는 ECS에 의해 생체 내에서 유전자 발현의 조절이 이루어짐을 시사하며, 향후 이러한 유전자의 세포 내 기능에 관한 연구를 시행함으로써, ECS에 의한 생체의 반응과 치료기전에 대한 이해를 넓힐 수 있을 것으로 기대된다. 중심단어:전기경련 충격·DD-PCR·유전자·백서 뇌. Objectives: This study was performed to identify genes regulated by electroconvulsive shock (ECS) and to observe the pattern of expression of genes according to different developmental stages and brain regions. Method: ECS(130V, 0.5 sec) was given to male Sprague-Dawley rats with age of postnatal day 7 and 21(P7, P21 respectively). After screening genes regulated by ECS with mRNA diffe-rential display-PCR(DD-PCR), we selected one clone among them and observed the induction of this gene after ECS by time-dependent Northern blot analysis of rat brain of P7, P21 and adult rat cortex and hippocampus. Results: By DD-PCR method, we have identified four clones whose expression was regulated by ECS. Among them, one(CP 10-2) was proved to be a new gene by sequencing and BLAST search. Its expression was increased after ECS in P7, P21, and adult rat brain. The expression of CP 10-2 reached peak level at 180 minutes after ECS in P7 rat brain, but was further increased until 360 minutes after ECS in P21 and adult rat brain. Conclusion: In this study, a new gene was identified in rat brain which showed up-regulated expression in response to ECS. Cloning and characterization of this new gene would be helpful to elucidate the effect of ECS in rat brain. KEY WORDS:Electroconvulsive shock·Differential display-PCR·Gene·Rat brain.

마케팅환경변화와 통합커뮤니케이션 디자인(ICD)에 관한 연구

정은주,이용우 동서대학교부설연구센터 2001 연구센터논문집 Vol.4 No.1

This research is aimed to study the change in design environment caused by being digitalized, to define the new concept and sphere in digital design, to find out the direct or indirect on design by the social and cultural changes resulted in informational technology and internet, and to find out the change and response in design world being brought about it. Powerful digital forms a new world and market. Internet world, a symbol of the power, changes the area, method, and the process of design. The unity of interior decoration and appliance caused by the digitalization of living space brings about that of interior decoration and production design. On account of the change of the electronic products resulted in the informational technology, product design area has been changed from the outward appearance of the design to the software design and the interface design of users. Converted from electronic publication to multimedia design and homepage design area, virtual design also faces the same problem. This phenomenon will also change design area. Banner advertisement, as a representative of new media, appears newly. Electronic newspaper, news broadcasting, radio, and magazine through Internet unite the existing printing media and mass media such as radio, TV. As a result, their respective characteristics disappear and design areas seem to be changed into Internet broadcasting which has equivalent position and method. This change will be much faster on account of the rapid development of information technology. But impersonality and inhumanity caused by digitalization is the problem which digital society and designers should solve together.

새우젖의 呈味成分에 關한 硏究 : Ⅰ. Degradation of Nucleotides and their Related compounds in small shrimp during Fermentation 第1報. 새우젓 熟成中의 核酸關聯物質의 變化

鄭承鏞,金恩愛 慶尙大學校 1976 論文集 Vol.15 No.-

새우젓의 呈味成分 및 微生物相을 밝혀 食品學的인 基礎資料를 얻기 위하여 西海 産 젓새우를 原料로 하여 우선 새우젓 熟成중의 核酸關聯物質의 變化를 實驗하여 다음과 같은 結果를 얻었다. 젓갈 熟成중 ADP, AMP 및 IMP는 현저히 減少하고, 反面 hypozanthine은 熟成 27日만에 월등히 增加되었다가 72日에는 약간 減少되었다. 새우젓에는 hypoxanthine의 含量이 비교적 많으므로 새우젓의 獨特한 맛에 어떤 구실을 할 것이라고 보아진다. In Korea fermented fish and shellfish have traditionally been favored and consumed as seasonings or further processed for fish sauce. Three major items in production quantity among more than thrity kinds which are presently available i the market are fermented anchovy, oyser and small shrimp. They are usually used as a seasoning mixtrue of Kimchi in order to provide a distinctive flavor. Fermented smal shrimp, Acetes chinensis is most widely and largely used and occupies an important position in food industry of this country. But no study on its taste compounds has beeen reported. This study was attempted to estblish the basic ata for evaluating taste compounds of fermented samll shrimp. The changes of such compounds during fermentation as nucleotides and their related compounds were analysed. The samples were prepared with three different salt contents of 20, 30 and 40% to obtain the proper degree of fermentation at a controlled temperature of 20+2℃. The results are summarized as follows: ADP, AMP and IMP tended to degrade rapidly while hypoxanthine incresed remarkably at 27 day fermentation but slightly decreased at 72 day fermentation. It is presumed that the chracteristic flavor of fermented small shrimp might be attribted to the relatively higher content of hypozanthine.

OMT 모델을 기반으로 한 관계형 데이타베이스 설계 시스템의 구현

정헌석,이은경,임해철,김용환 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

Database design is the base of the entire process related to the database, and the well-designed database schema has a great effect on the system performance. So, there's a growing need for the automatic schema generation system. In this paper, database design automation system is implemented which translates automatically OMT based database model to relational database table. For developing this system, transformation rules of OMT into RDB schema are suggested which satisfy normalization and integrity constraints. This automation system can be used efficiently in the area of training database system and applying database design in actual business fields.

양성 뇌종양 : 뇌 수막종 Meningioma

정상섭,박용구,조용은 한국의학사 1987 診斷과治療 Vol.7 No.4

사업장 근로자의 건강위험 평가도구 개발

정규철,이용애,홍윤철,조희숙,박혜숙,임현술,하은희 이화여자대학교 환경문제연구소 1998 이화환경연구 Vol.2 No.-

Health Risk Appraisal(HRA) is usually defined as a process by which we expect of individual's chances of acquiring specific diseases within a defined period of time. The concept of worksite as an area of health maintenance and promotion is newly developing. Our movement for health promotion of employees has been increasingly known in the worksite. The aim of this study is to develop health risk appraisal tools about health promotion at the worksite for employees. We performed this study by two steps: one step was to develop a HRA questionnaire of worksites in Korea, another was to evaluate the reliability of the questionnaire. For developing HRA questionnaire, we reviewed scientific examples at first, and then weighted the score by delphi. To evaluate the reliability of developed questionnaire, we carried out survey by test-retest method. A total of 131 employees completed HRA questionnaire on two times. The results are as follows. The total score of health risk in unhealthy workers was higher than that of healthy workers. The range of test-retest reliability of responses to the questionnaire was 0.57-0.94. Therefore it seems that this questionnaire was very suitable to assess the health behavior of workers. In conclusion, the developed HRA questionnaire can be used as a tool for evaluating health behavior and for providing health counseling materials.

두부외상 환자의 치료 : 입원 결정의 · 지침 Criterion of Hospitalization

정상섭,박용구,조용은 한국의학사 1987 診斷과治療 Vol.7 No.5

한국인에서 Lipoprotein lipase gene polymorphism의 빈도와 혈관질환과의 관계

정준용,박소영,김제,성인환,김영건,전은석 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

Background : Lipoprotein lipase(LPL) is a key enzyme in the metabolism of serum triglycerides(TG) which is utilized in the peripheral tissue as free fatty acid and stored in adipose tissue. LPL gene is consisted of 10 exons which encode 475 amino acids and over 9 LPL gene polymorphisms have been reported. It's polymorphisms are related to the lipid levels and the severity of atherosclerosis in the coronary artery disease. In Korea, LPL polymorphisms has not been reported yet. This study is purposed on the incidences of LPL gene mutations and on it's relationships with blood lipid levels and the severity of atherosclerosis. Methods : Our subjects were consisted of three groups, normal controls(n=50), coronary artery disease(CAD, n=51) and cerebrovascular disease(CVD, n=52). The PCR amplified genomic DNA from peripheral white blood cell were analyzed with restriction fragment length polymorphisms (RFLP by two different restriction enzyme(PVU II, Hind III). Results : Total cholesterol(TC) were higher in CVD than in controls and in CAD (203±60mg/ dl vs 188±37, 167±42, p<0.01). Triglyceride(TG) were also elevated in CAD(166±65mg/dl vs 122±62 in controls, p<0.05). HDL cholesterol(HDL-C) were higher in controls than in CVD and CAD(49±9mg/dl vs 36±10, 44±9, p<0.05). The incidences of Hind III RFLP and PVU II RFLP has no differences among groups. Only HDL-C was elevated in Hind III RFLP(-/-) homozygotes. Conclusions : The LPL gene mutations in intron 6 and 8 have no direct effects on the lipid profiles and the severity of coronary artery disease. Although LPL is a key enzyme in TG metabolism, two mutations in this study could not change the activity of LPL, nor were not a marker of linked other site mutations. The mutation(s) in exon which encode amino acid for enzyme activity should be detected to analyze the pathophysiology of the atherogenesis.

급성하벽심근경색에서 전흉부유도 ST절 하강의 의의

정병천,배호상,곽동훈,김영태,배용학,황종현,임현주,류재근,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 급성하벽심근경색증 환자에서 심전도상 흔히 동반되는 전흉부유도 ST절 하강의 의의를 알아보았다. 방법 : 심근경색후 24시간에서 48시간에 얻은 심전도를 기준으로 52명의 급성하벽심근경색증 환자를 전흉부유도에서 ST절의 하강이 있는 군과 없는 군으로 나누었으며 심도자, 관상동맥조영술, 심초음파도 및 방사성 핵종을 이용한 좌심구혈율 측정 등을 시행하였다. 결과 : 1) 좌심실확장기말압은 전흉부유도에서 ST절의 하강이 있는 경우에서 16.9±5.33mmHg로 없는 경우의 11.0±4.02mmHg보다 유의하게 높았다(p<0.05). 그러나 운동량 및 좌심구혈을은 흥부 유도상 ST절의 하강이 있는 경우 7.6±3.0 METs 및 53.9±9.1%로 없는 경우의 9.1±2.7 METs 및 54.6±9.5%보다 낮았으나 통계적 유의성은 없었다(p=0.180, p=0.823). 2) 관상동맥조영술상 전흉부 ST절의 하강이 동반된 군에서는 유의한 좌전하행지나 좌회선지의 협착이 있는 경우가 60.9% 및 57.9%로 ST절의 하강이 없는 군에서의 34.5% 및 7.7%와 비교해 좌관상동맥에 협착이 동반된 경우가 많았다(p=0.050, p=0.001). 3) 관상동맥조영술상 세 혈관질환의 빈도는 흉부유도상 ST절의 하강을 보인 23예에서 10예로 ST절 하강이 없었던 29예중 2예에 비하여 유의하게 많았고(P=0.007), 단 혈관질환의 빈도는 ST절의 하강을 보인 군에서 23예중 5예로 ST절 하강이 없었던 29예중 17예에 비하여 유의하게 적었다(P=0.002). 두 혈관질환의 경우에는 각각 8예와 10예로 양군간에 유의한 차이가 없었다. 4) 흉부유도상 ST절 하강의 빈도는 단 혈관질환 22예 중 5예에서, 두 혈관질환 18예중 8예, 세 혈관질환 12예 중 10예에서 관찰되어 협착이 있는 관상동맥의 수가 많을수록 ST절의 하강이 나타나는 빈도가 많음을 보였다(p=0.00308). 그러나 흉부유도상 나타난 ST절의 하강을 모두 합하여 구한 ST절 하강의 합은 협착이 있는 관상동맥의 수와 통계적인 유의성이 없었다. 5) 심초음파도상 좌심실 하벽의 벽운동은 ST절 하강을 보인 군에서는 akinesia가 83.3%, hypokinesia가 11.1%, 정상 벽운동이 5.6%로, ST절 하강이 없었던 군에서의 dyskinesia가 3.6%, akinesia가 39.3%, hypokinesia가 25.0%, 정상 벽운동이 32.1%와 비교하여 ST절의 하강이 있는 군에서 유의하게 벽운동의 장애가 빈번함을 보였다(p=0.03891). 그러나 좌심실전벽, 측벽 및 중격부위에서는 유의한 벽운동의 차이가 없었다. 결론 : 급성하벽심근경색증 환자의 전흉부유도에서 ST절의 하강이 동반되는 경우 다혈관 질환의 가능성이 높으며 좌심실확장기말압이 상승되었고 운동능력은 감소되어 있었다. 또한 심초음파도상 좌심실하벽의 벽운동장애도 심하였다. 따라서 전흉부 ST절의 하강을 동반한 급성하벽심근경색증 환자는 전흉부유도에 ST절 하강이 없는 경우보다 예후가 불량할 것으로 생각되며, 보다 적극적인 치료가 필요할 것으로 생각된다. The purpose of this study was to determine the significance of precordial ST segment depression appearing during acute inferior myocardial infarction and to assess the correlation of that with angiographic finding. 52 patients were allocated into two groups based on the existence of precordial ST segment depression : 23 patients with ST segment depression and 29 patients without ST segment depression. The extent of coronary artery disease as well as the prevalence of significant stenosis (≥70%) in left anterior descending artery were more frequent in patients showing precordial ST segment depression than in patients not showing them (p=0.050) and the result were similar in cases of left circumplex artery (p=0.001). On echocrdiographic examination of left ventricular (LV) wall motion, it showed more severely decreased inferior LV wall motion in patients showing precordial ST segment depression than in patients not showing them (p=0.03891) even though the other segment of LV wall motion didn't show the statistical difference between both groups. The other cardiac parameters such as LVEDP, exercise amount (METs) and ejection fraction were tend to showing bad profile in patients with precordial ST segment depression. From the above results, we could deduce that patients with precordial ST segment depression have relatively large infarction or concomitant left coronary artery disease, so they need more caution and intensive theraphy.