스코폴라민의 흰쥐 피부투과에 대한 투과촉진제들의 영향

정재영,감성훈,김건남,지상철,박은석 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

The transdermal therapeutic system (TTS) of scopolamine has various advantages over its oral dosage forms. The ideal scopolamine TTS requires high skin permeation rate in short time after it is applied on the skin. In order to increase the initial skin permeation rate of scopolamine from TTS, various permeation enhancers were employed. Enhancers employed were fatty acids(oleic and linolenic acids), cyclic monoterpenes(menthol, camphor, cineole and limonene) and others(isopropyl myristate, sodium lauryl sulfate and glyceryl monostearate). The concentration of enhancers in the base were fixed to 5% (w/w). While fatty acids had little enhancing effect on the skin permeation of scopolamine, cyclic monoterpenes, isopropyl myristate and sodium lauryl sulfate resulted in 1.5∼2.36-fold higher skin permeation rate of the drug compared to the control. However, lag time was not affected by enhancers studied.

신체형장애와 정신신체장애 간의 임상증상 및 자아기능에 관한 비교 : SCL-90-R와 Bellak의 자아기능척도를 이용한 Using SCL-90-R and Bellak's Ego Function Scale

은흥석,안정숙,김학렬 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.6

The purpose of this study was to investigate the difference in clinical symptoms and ego function between somatoform disorder and psychosomatic disorder by using Symptom Check List-90-Revision(SCL-90-R) and Bellak's Ego function Scale(EFS). The sample consisted of 30 somatoform disorder patients, 30 psychosomatic disorder patients, and 30 normal controls. The results were as follows: 1) In SCL-90-R 7 sacle, mean T-scores on each subscale were within normal range in all groups, but scores of somatoform group were significantly higher than other groups. Somatoform and psychosomatic group had similar profiles and clinical symptoms however somatoform group showed severe symptom and tended to amplify symptoms. Anxiety and interpersonal sensitivity subscale did not show significant differences, but somatization, depression, obsessive-compulsive, hostility, phobic anxiety and paranoid ideation subscale showed significant differences between somatoform and psychosomatic groups(P<.05) 2) In EFS, mean scores of somatoform group were significantly lower than psychosomatic group in all EFS-subscales except object relations(P<.01). Mean scores of Psychosomatic group did not show significant differences from those of normal control group and profiles of psychosomatic group were similar to those of normal control group.

무균성 뇌막염에 있어 뇌척수액 추적검사에 대한 재평가

정은경,김경석,김갑승,문경래,박상기 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

The author evaluated the clinical manifestation of forty cases of aseptic meningitis who were admitted in the pediatric department of the Chosun University Hospital from March 1990 to September 1990, and also observed the clinical course of two groups of aseptic meningitis divided by admitting time and reevaluated the needness of follow-up lumbar puncture for CSF examination. The author performed follow-up lumbar puncture for CSF examination to the first group, on the 7th hospital day by conventional way, otherwise only observed the clinical course without follow-up lumbar puncture for CSF examination to the 2nd group. There was no difference between both groups, and clinical improvement was seen in both groups. In conclusion, the author considers that if clinical and laboratory finding were compatible with aseptic meningitis, there may be no need for follow-up lumbar puncture for CSF exmenation.

이트라코나졸의 경구용 액제 처방화

정기섭,홍지웅,최기송,지상철,박은석 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

The oral bioavailability of itraconazole is variable and low in fasting state. This is mainly due to the low solubility of this drug. Bioavailability can be improved by changing the formulation and it is general that the liquid preparations show greater bioavailability than the solid dosage forms such as tablets and capsules do. Benzyl alcohol-water binary mixture showed the excellent solubilizing capacity for itraconazole but the release of the drug from the preparation needs to be enhanced. In this study, various nonionic surfactants and hydrophilic polymers, poloxamers, were screened to investigate their effects on the release of itraconazole from the liquid preparations. Poloxamer 407 showed the most enhancing effect on the drug release and the release rate was proportional to the amount of poloxamer 407 added. A liquid preparation of itraconazole, consisting of benzyl alcohol/water/poloxamer 407 ternary solvent system, released more than 80% of the total drug amount at 5 min and showed the possibility of a new formulation development.

장내의 탄수화물과 지방 흡수 억제를 통한 체지방 및 비만 개선 효과에 관한 연구

정은희,윤승원,이홍석,윤유식,유경미,황인경 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.1

In a previous study, a dietary supplement was developed in our lab using natural herbal extracts against digest enzyme activity in GI tract for weight control. This natural herbal extracts could regulate absorption of glucose and lipid by the inhibition of digest enzyme activity. In this study, we screened the natural herbs that inhibit glucoamylase activity and developed an water extract of cinnamon. The cinnamon extract delayed and decreased the increment of carbohydrate degradation through the inhibition of glucoamylase activity in vitro. Fifty volunteers were subjected to the intake of the herbal extracts by taking twice a day for 60 days. As a result, the treated subjects lost 3kg of body weight and 3.5kg of body fat mass after the treatment. Furthermore, the body mass index and waist size were significantly decreased during the experimental period. Above results suggested that the administration of the dietary additives composed of cinnamon and natural herbal extract improves the obesity by the decrement of body weight and body fat mass.

폐굴껍질과 천연제올라이트를 이용한 피혁폐수 중의 질소 제거에 관한 연구

김은호,정유진,박성현,고현웅,성낙창,정왕석 東亞大學校 建設技術硏究所 1999 硏究論文集 Vol.23 No.1

In Korea, waste-oyster shells discharged from oyster culture industry cause a serious ocean environmental pollution. There is a need for developing low cost, easily and abundantly available adsorbent. So, waste-oyster shells could be recycled as a nitrogen adsorbent because of those large specific surface area. And natural zeolites are known as a good adsorbent of NH^(4+) ion. Thus, the objective of this research is to observe removal trends of nitrogen from tannery wastewater with waste-oyster shells and natural zeolite using continuous fixed bed reactors. 피혁폐수는 다양한 유기물을 함유하고 있을 뿐만 아니라, 가공공정상 질소화합물이 많이 사용되기 때문에 고농도의 유기질소 및 암모니아성 질소가 함유되어 있어 적절한 처리 없이 주변수계로 방류될 경우 자연정화작용을 방해하여 수계의 부영양화가 진행되어 남조 및 적조의 원인이 되고있다. 일반적으로 수역의 제한요인은 대개의 수역에서 질소 제한, 인 제한,질소·인 동시제한 중 어느 하나이며 계절이나 시대 추이에 따라 변화하므로 부영양화 대책으로 질소·인 모두 제거해야 한다. 최근에 천연제올라이트가 암모니아성 질소제거에 효과적인 것으로 보고되면서 이에 대한 연구가 많이 수행되었다. 암모니아를 포함하는 폐수를 침전 처리한 다음 2차 처리 공정에서 주로 활성탄 및 이온 교환수지 충전탑이 이용되고 있다. 이 중에서 활성탄 홉착은 간편성, 확실성 등으로 아주 효과적인 방법으로 각광받고 있지만 고가라는 단점을 가지고 있다. 이에 비해 상대적으로 저가인 천연 제올라이트에 의한 암모니아 제거공청은 다른 공정에 비하여 제거속도가 크고 수온의 변화에 영향이 적으며, 고농도 뿐만 아니라 저농도의 암모니아에 대해서도 안정적인 처리효율을 보이는 것으로 알려져 있다.또한 공정자체가 간단하며 기존의 정수 및 폐수 처리시설에 적용하기가 용이하며, 처리후 발생하는 물리, 화학, 생물학적 부작용이 거의 없는 것으로 알려져 있다. 한편, 국내 해안 양식업 중에 비중이 높은 굴양식업에서 부산물로 다량 발생하고 있는 폐굴껍질은 28만톤에 달하고 있고 그 중에 약 10%만이 종패 부착용(2만5천톤), 비료(2천톤)로 가공처리 되고 있을뿐 해양수산 폐기물인 굴 껍질의 처리방법과 자원으로 재활용 하기 위한 연구가 필요한 실정이다.

체외수정시술을 위한 과배란유도시 Nafarelin 과 Triptorelin 사용에 따른 임상성적의 비교

목정은,김낙연,김정훈,강병문,장윤석 울산대학교 의과대학 1996 울산의대학술지 Vol.5 No.1

Gonadotropin-releasing hormone agonists(GnRH-a) vary in structure and route of administration. We performed this study to compare patient response to intranasal nafarelin acetate versus subcutaneous triptorelin as adjuncts to ovulation induction for in vitro fertilization(IVF). From October 1995 to May 1996, sixty-four patients with tubal factor infertility entering their 79 cycles of IVF were randomized to receive either intranasal nafarelin acetate(Group Ⅰ, 38 cycles) or subcutaneous triptorelin(Group Ⅱ, 41 cycles). Controlled ovarian hyperstimulation(COH) using luteal long protocol of GnRH-a was used in all patients. Patient characteristics in the two groups did not differ significantly, nor did sperm parameters or endocrine profiles. There was no significant difference in ovarian response as indicated by duration of GnRH-a administration before ovarian stimulation, number of ampules of gonadotropin used and duration of gonadotropin administration in ovarian stimulation, and serum E( ) level and number of follicles(≥14mm) on the day of hCG administration between the two groups. There were no significant differences in clinical results of oocyte and embryo obtained such as number of oocytes retrieved, oocytes fertilized, embryos cleaved, embryos frozen, and embryos transfered between the two groups. There were also no significant differences between group Ⅰ and group Ⅱ in clinical pregnancy rate(31.6% versus 34.1%) and abortion rate per clinical pregnancy(8.3% versus 14.3%). This study suggests that intranasal nafarelin acetate as well as subcutaneous triptorelin can be used successfully in ovulation induction using luteal long protocol of GnRH-a.

로드셀을 이용한 직물의 신축성 측정에 관한 연구

최정수,김은석,주기세,왕지남 한국경영과학회 2002 한국경영과학회 학술대회논문집 Vol.- No.1(1)

So far, the common elasticity data of textile fabrics has not been present because the method depends on the knowledge of measurement operators. In this paper, the new measurement equipment using road cell is presented to measure the coefficient of textile fabrics in real time. The measurement method is based on the volt: among textile fabrics. The textiles with strong elasticity are high voltage produced from others are low. The presented method can be applied to visualize the textile, sew the cloth, contrc textile fabrics. Also, these measurement datum are used to B2B electronic trading system.

고령자를 위한 주거시설 치수 표준화 연구

김석준,권순정,오은진,김노석,김상길,이특구 한국의료복지시설학회 2008 의료·복지 건축 Vol.14 No.3

As the elderly population is growing rapidly, guidelines for planning and designing of the elderly housing are required for improving housing environment of the elderly. The purpose of this study is making the basic dimensional standardization of residential spaces for the elderly. The dimensional standard of spaces suggested in this guideline considers characteristics of both aged and the general users. The spaces studied in this research include bedroom, living room, bathroom, kitchen and other circulation spaces in the elderly housing. The design guidelines of furniture, equipment for the aged with sizing of the areas are provided. Finally, applicability of the output is reexamined by implementing this guidelines to the sample planning and design of the elderly housing

노인요양시설의 적정 침실 면적에 관한 연구

권순정,한정한,오은진,김석준,김노석,이특구 한국의료복지시설학회 2008 의료·복지 건축 Vol.14 No.3

The purpose of this study is to suggest optimum size of residents' bedrooms in nursing homes. Bedroom is an essential part of nursing homes because nursing home residents spend most of their times in bedrooms and occupy the largest part of facility area. Therefore it is necessary to set an adequate standard related to resident room area in nursing facilities, which have a great effect on planning longterm care facilities for the elderly. The body dimensions of elderly people and care givers have been collected from the previous study. Based on the body dimensions data, the behaviors of elderly as well as care givers have been analysed. The minimum areas-exclusive of toilets, closets, vestibules and so on - have been proposed from the results of the behavior analysis.