심한 낙타혹(Hump)의 형성을 동반한 제 2 형 막증식성 사구체신염(Dense Deposit Disease) 1예

오희정,유민아,이영숙,김미연,김승정,강덕희,윤견일,최규복,성순희 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.1

Dense deposit disease (DDD), known as type Ⅱ MPGN, is an uncommon form of glomerulonephritis. It is an acquired primary glomerular disease, characterised by electron microscopic evidence of a continous, dense membrane deposition replacing the lamina densa. There is associated alternative pathway complement activation and a C3 nephritic factor maybe present. Patients with dense deposit disease tend to be young at clincal onset and more commonly have persistent nephrotic syndrome, gross hematuria, and acute nephritis episode and persistent depression of the serum complement level. The prognosis of dense deposit disease is worse than that of typeⅠMPGN. We experienced a patient with dense deposit disease that presenting persistent nephrotic syndrome, gross hematuria and having subepithelial hump. It is a first report of dense deposit disease having subepithelial hump in Korea, therefore we report this case with the review of relevant literatures.

중년여성의 강인성, 스트레스와 사회적 지지에 관한 연구

김미희,오현이,나덕미 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

This study was designed to identify the relationship between hardiness, stress and social support of middle-aged women. The subjects were 139 women between 40 and 64 years of age. Data were collected by questionnaire from September 6 to 27, 1994. The instruments used for this study were the Health Related Hardiness Scale by Pollock, the Perceived Stress Scale by Cohen and the Social Support Questionnaire by Norbeck. The data were analyzed by t-test, ANOVA, and Pearson’s Correlation Coefficient. The results obtained from this study were summarized as follows : 1. There was no significant correlation between hardiness and stress (r= .076, p= .19). 2. There was no significant correlation between social support and stress (r= - .084, p= .16). 3. There was no significant correlation between hardiness and social support(r= - .107, p=.21). 4. The middle aged women’s control differed according to their frequency of delivery(F=2.80, p= .04) and marital status (F=3.89, p= .01). 5. The middle aged women's perceived stress differed according to their marital satisfaction (F=4.95, p= .00) 6. The middle aged women’s social support differed according to their marital satisfaction (F=2.60, p= .04) and monthly income (F=2.63, p= .03).<참고문헌참조 actuate="onRequest" inline="true" rid="ref1" show="replace" xml:link="simple">[1]</참고문헌참조>

소규모 베이커리에서의 HACCP적용을 위한 미생물학적 위해도 평가

엄애선,권성희,정덕화,오상석,이헌옥 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.4

Recently, the HACCP(Hazard Analysis Critical Control Point) system has been emphasized in food processing industries throughout the world. However, the system has, as yet, not been applied very well to domestic food industries. Due to the increase in the consumption of bakery products, more studies are required on the application of HACCP to establish the system in small-scale bakeries. This study was designed to provide basic data for setting management standards for HACCP, based on microbiological hazard evaluations of bakery products. Red bean paste filled breads, custard cream filled breads and cakes covered with fresh whipping cream were collected, and microbiological evaluations conducted on the raw materials, the manufacturing processes and potential hazards. The result showed the presence of coliforms in fresh cream of cakes and the soybean paste of soybean paste breads at levels as high as 105 CFU/g on the hazard analysis of the raw materials. Moreover, the general levels of bacteria and coliforms were over those of the standards during the intermediate fermentation and molding processes. Furthermore, high levels of coliforms were detected on the hands of the salesmen and bakers themselves. This suggests that the CCPs (Critical Control Points), such as fresh cream and red bean paste manufacturing process desperately require better management. There is also a requirement for education relating to personal hygiene for the production of hygienic bakery products and for the publics health.

사후장기제공 찬성대학생, 사후장기등록자 및 신장공여자 집단의 심리적 특성

김창윤,한오수,이철,박인호,한덕종,유희정,김헌수 울산대학교 의과대학 1994 울산의대학술지 Vol.3 No.2

This study is composed of three sections : First, questionnaires were administered to 350 university student to investigate attitudes related to organ donation. Three groups(agreed(15.4%, N=54), undecided(76%, N=266), opposed(8.6%, N=30)) were identified. Second, the subjects were composed of 30 students who agreed for organ donation with 30 disagreed students for organ donation and those subjects were administered cognition toward health, anticipatory pain for operation, anticipatory discomfort for operation, Beck Depression Inventory (BDI), Hostility scale, social desirability scale, altruism scale, internal-external control scale, self-esteem scale, death anxiety scale, psychological well-being scale, life satisfaction and affect scale. In comparing difference between the agreed and the disagreed for organ donation, the agreed group exhibited higher scores on social desirability, altruism, psychological well-being than the disagreed group. On the contrary, there were significantly higher scores on anticipatory discomfort for operation and negative affect on the disagreed organ donation group than the a greed group. These results indicated that the agreed group for organ donation was more similar to the real organ donation group than the disagreed group. Third, the subjects were composed of 30 kidney donors, 30 kidney donors, 30 potential donors who signed donor cards and 30 agreed student group for organ donation. In comparing among three groups, kidney donor group showed the highest scores on cognition toward health and life satisfaction variables. Consummated kidney donor and potential donor group showed higher scores on internal control, psychological well-being and positive affect variables than the agreed student group. But on social desirability, self-esteem and affect balance, there was no significant difference among three groups. These results suggested that significant factor in willingness to donate were influenced by social desirability, altruism and self-esteem.

신장수여자의 수술경과시간에 따른 자기존경감, 희망감, 염려 및 스트레스원의 차이

이 철,김창윤,한오수,박인호,유희정,한덕종 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.2

This study attempted to examine the differences of self - esteem, hopes, concerns and total stress scores of 110 kidney recipients in before(N=32) and fellowing kidney transplantation [1 to 6 months(N=29), 6 to 12 months(N=23), 12 to 36 months(N=26)] and utilizing severity rating scale of 44 potential stressors on a 5-point scale of 110 kidney recipients in before(N=32) and following kidney transplantation operation [1 to 6 months(N=29), 6 to 12 months(N=23), 12 to 24 months(N=15) and 24 to 36 months(N=11)]. On scores of hopes and total stress, pretransplant group exhibited significantly higher scores than three posttransplant recipient groups. But, it was found that there was no significant differences among four transplant kidney recipient groups on the scores of self - esteem and concerns. In the pretransplant group, craving for foods was identified as the most stressful event, on the contrary, changes in friends was identified as the lowest stressful events. In the 1 to 6 months posttransplant group, side effect of medications was identified as the most stressful event, however, loss of contact with dialysis patients was identified as the lowest stressful event. In the 6 to 12 months posttransplant group, cost of medication, changes in body appearance were identified as the most stressful event, on the other hand, managing of medications at home was identified as the lowest stressful event. In the 12 to 24 months posttransplant group, cost of medication and insurance coverage were identified as the most stressful event, but possibility of dying and competence of nursing staff were identified as the lowest stressful event. In the 24 to 36 months posttransplant group, changes of body appearance was identified as the most stressful event, on the contrary, possibility of infection was identified as the lowest stressful event. Insurance coverage was a continuing concern throughout posttransplant period.

Poster Session 2 : DNA Replication, Recombination, and Repair Transcription, RNA Processing and Translation Protein Structure and Function ; Antioxidative Effects of Human Metallothionein-3 to Oxygen Radicals

( Duck Hee Oh ),( Ho Jin You ),( Chung Yung Choi ),( Dong Gun Lee ),( Kyung Soo Hahm ),( Hye Gwang Jeong ) 한국생화학분자생물학회 (구 한국생화학회) 2002 생화학분자생물학회 춘계학술발표논문집 Vol.2002 No.-

Fimasartan attenuates renal ischemia-reperfusion injury by modulating inflammation-related apoptosis

Jang-Hee Cho,Soon-Youn Choi,Hye-Myung Ryu,Eun-Joo Oh,Ju-Min Yook,Ji-Sun Ahn,Hee-Yeon Jung,Ji-Young Choi,Sun -Hee Park,Chan-Duck Kim,Yong-Lim Kim 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.6

Fimasartan, a new angiotensin II receptor antagonist, reduces myocyte damage and stabilizes atherosclerotic plaque through its anti-inflammatory effect in animal studies. We investigated the protective effects of pretreatment with fimasartan on ischemia-reperfusion injury (IRI) in a mouse model of ischemic renal damage. C57BL/6 mice were pretreated with or without 5 (IR-F5) or 10 (IR-F10) mg/kg/day fimasartan for 3 days. Renal ischemia was induced by clamping bilateral renal vascular pedicles for 30 min. Histology, pro-inflammatory cytokines, and apoptosis assays were evaluated 24 h after IRI. Compared to the untreated group, blood urea nitrogen and serum creatinine levels were significantly lower in the IR-F10 group. IR-F10 kidneys showed less tubular necrosis and interstitial fibrosis than untreated kidneys. The expression of F4/80, a macrophage infiltration marker, and tumor necrosis factor (TNF)-α, decreased in the IR-F10 group. High-dose fimasartan treatment attenuated the upregulation of TNF-α, interleukin (IL)-1β, and IL-6 in ischemic kidneys. Fewer TUNEL positive cells were observed in IR-F10 compared to control mice. Fimasartan caused a significant decrease in caspase-3 activity and the level of Bax, and increased the Bcl-2 level. Fimasartan preserved renal function and tubular architecture from IRI in a mouse ischemic renal injury model. Fimasartan also attenuated upregulation of inflammatory cytokines and decreased apoptosis of renal tubular cells. Our results suggest that fimasartan inhibited the process of tubular injury by preventing apoptosis induced by the inflammatory pathway.

MICRO WAVE OVEN용 마그네트론 구동을 위한 전원장치개발에 관한 연구

오덕진(Duck-Jin Oh),김희준(Hee-Jun Kim),오원석(Won-Seak Oh),정진홍(Jin-Hong Jung),김석기(Seak-Gi Kim),송종화(Jung-Hwa Song) 전력전자학회 1999 전력전자학술대회 논문집 Vol.- No.-

HVT<High Voltage Transformer) have been used to drive a magnetron in a microwave oven, but they have some problems such as heavy weight and low efficiency. To solve such problems of microwave oven power source, voltage resonant ZVS-PFM inverters have been developed. This paper presents a high-frequency high-voltage AC-DC converter incorporating high-frequency transformer resonant ZVS-PFM inverter with three-wmdmg transformer and voltage doubler type rectifier for drive high power magnetron. The new power supply makes it possible to realize light weight and high efficiency

과거 60년 간 한반도에 영향을 미친 태풍의 강도 및 지속기간의 경향 분석

오지희(Oh Ji Hee),서경덕(Suh Kyung-Duck),김영오(Kim Young-Oh) 대한토목학회 2011 대한토목학회논문집 B Vol.31 No.2B

본 연구에서는 과거 60년 간 한반도에 영향을 미친 태풍의 강도(중심기압)와 지속기간에 대한 경향 분석을 실시하였다. 경향 성분 추출을 위해 Singular Spectrum Analysis(SSA)를 사용하였고 경향 성분에 대한 선형회귀분석 결과 태풍의 강도가 약간 증가하는 것을 볼 수 있었다. 또한 약 30년의 장주기 변화를 발견하였고, 이에 따라 전체 시계열을 30년 기간의 두 개의 하위 기간으로 나눠서 태풍의 중심기압 및 지속기간에 대한 정규분포 및 Gumbel 분포를 추정하였다. 그 결과 두 번째 기간에 평균적인 태풍의 중심기압은 감소하지만 수퍼 태풍에 해당하는 매우 큰 태풍의 비율은 거의 변화가 없음을 발견하였다. 지속기간에 대해서도 두 번째 기간에 뚜렷한 증가가 있음을 발견하였다. The paper presents trend analyses of the past 60-year-data of intensity (central pressure) and duration of the typhoons that influenced the Korean Peninsula. The singular spectrum analysis was employed to extract the trends. The result of linear regression of the trend component shows that the intensity of typhoons is slightly increased. A long-term change with period of about 30 years was detected, and thus the original series were separated into two sub-periods of 30 years. For these sub-periods, normal and Gumbel distributions of central pressure and duration of typhoons were estimated. The results show that during the second sub-period the overall intensity of typhoon was increased but the occurrence of extreme typhoons remains unchanged. The duration also showed an obvious increase during the second sub-period.

Effects of Losartan and Pentoxifylline on Renal Dimethylarginine Dimethylaminohydrolase-1 Expression in Proteinuric Nephropathy

Park, Sun-Hee,Hyun, Seung Hyea,Ryu, Hye-Myung,Ahn, Ji-Sun,Oh, Se-Hyun,Oh, Eun-Joo,Yoon, Se-Hee,Choi, Ji-Young,Cho, Jang-Hee,Kim, Chan-Duck,Kim, Yong-Lim S. Karger AG 2013 American journal of nephrology Vol.37 No.5

<P>Abstract</P><P><B><I>Background/Aims:</I></B> Circulatory asymmetric dimethylarginine (ADMA) is correlated with proteinuria and endothelial dysfunction in patients with proteinuric renal diseases. However, it is not known whether proteinuria itself affects expression of dimethylarginine dimethylaminohydrolase (DDAH), a degrading enzyme of ADMA, in kidney. The aim of this study is to evaluate the direct effects of losartan and/or pentoxifylline on expression of renal DDAH-1 and its relation to oxidative stress in the setting of albuminuria. <B><I>Methods:</I></B> Using NRK52E cells, DDAH-1 mRNA and protein were determined after exposure to albumin with losartan and/or pentoxifylline. Reactive oxygen species (ROS), PKC activity, and NOX-4 mRNA were also measured. In addition, the effect of losartan and/or pentoxifylline on renal expression of DDAH-1 and serum ADMA were evaluated in a rat model of proteinuric nephropathy. <B><I>Results</I></B>: Exposure to albumin resulted in increased release of N-acetyl-β-<smlcap>D</smlcap>-glucosaminidase along with an increase of TNF-α, 8-hydroxy-2′-deoxyguanosine, and angiotensin II in NRK52E cells. Losartan and pentoxifylline reversed albumin-induced decrease of DDAH-1 mRNA and protein expression and DDAH-1 activity. The effects of losartan and pentoxifylline on DDAH-1 mRNA were associated with reduction of ROS. In addition, treatment with losartan and pentoxifylline resulted in an attenuated change of renal DDAH-1 protein expression and serum ADMA levels in vivo. <B><I>Conclusion:</I></B> DDAH-1 was positively regulated by losartan and pentoxifylline with its antioxidative effect in albumin-exposed renal proximal tubular cells. Combined treatment with losartan and pentoxifylline has a direct beneficial effect on expression of renal DDAH-1, and, thus, at least in part, modulates the circulatory levels of ADMA in proteinuric nephropathy.</P><P>Copyright © 2013 S. Karger AG, Basel</P>