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김봉룡 ( Bong Roung Kim ),김진오 ( Jin O Kim ),김성환 ( Seong Hwan Kim ),이상호 ( Sang Ho Lee ),정인섭 ( In Seop Jung ),홍수진 ( Su Jin Hong ),유창범 ( Chang Byum Ryu ),조주영 ( Joo Yung Cho ),이준성,이문성 ( Moon Sung Lee ),심찬섭 ( 대한장연구학회 2003 Intestinal Research Vol.1 No.1
Backgrounds/Aims: The aim of this study was to analyze clinicopathologic feature of early colon cancer diagnosed by endoscopic resection. Methods: 41 early colon cancers from 22 patients endoscopically removed during the period from 2001.1~2002.6 were analysed. Results: 22 patients who were diagnoised as early colon cancer patient had totally 210 colonic polyps and 41 early colonic cancers. Most common age of distributuion was 6th decade. Of the 41 early colon cancers, malignant polyps less than 5 mm in size were in 43%, 6~10 mm in 10%, 11~20 mm in 21%, >21 mm in 26%. Malignant polyps were more common in left side colon than right side colon (7:3). Endoscopic shapes of early colon cancers were mostly sessile type (sessile type were in 90.2%). Conclusions: Significant fraction of early colon cancers were less than 1 cm in size. To detect and treat early colon cancers more earlier, It is advisable to remove all of the colon polyps even though small polyps. (Intestinal Research 2003;1:51-54)
유지 혈액투석환자에서의 우울증 발생의 위험인자 및 우울증이 영양지표에 미치는 영향
김진철(Jin Cheol Kim),조성태(Sung Tae Jo),윤종우(Jong Yoo Yoon),김근호(Gheun Ho Kim),전노원(Rho Won Jeon),김형직(Hyung Jig Kim),채동완(Dong Wan Chae),노정우(Jung Woo Noh),손봉기(Bong Ki Son),구자룡(Ja Roung Koo) 대한내과학회 2002 대한내과학회지 Vol.62 No.1
N/A Background: Depression is common in chronic renal failure patients and usually associated with poor appetite. Malnutrition with poor appetite is known to be associated with increased mortality in chronic hemodialysis (HD) patients. So we evaluated the prevalence, risk factors of depression and effects of depression to nutritional status in chronic HD patients. Methods: Sixty two HD patients (age 48.8±11.1 years, diabetes 29%) were investigated. Each patients were interviewed and completed the Beck depression inventory (BDI, 21 items, 0-3 point). To exclude the possible confounding effects of illness and treatment symptoms, cognitive depression index (CDI, a cognitive subset of 15 items selected from BDI) was used as a measure of depression. KT/V and nutritional parameters such as serum albumin, normalized protein catabolic rate (nPCR), subjective global assesment (SGA), body mass index (BMI), triceps skinfold thickness (TSF) and midarm muscle circumference (MAMC) were also measured. Results: Corrected BDI score (CDI score multiplied by 21/15) was 24.9±12.7 and the prevalence of depression (corrected BDI score≥21) was 64.5%. DM patient s had higher CDI score than non DM patient (22.9±7.2 vs 15.6±9.0). In univariate analysis, CDI score was correlated with age (r =0.39, p <0.01), serum albumin (r =- 0.37, p <0.005), nPCR (r =- 0.30, p <0.05), SGA (r =- 0.42, p <0.05), BMI (r =- 0.28, p <0.05), TSF (r =- 0.41, p <0.05) and MAMC (r =- 0.50, p <0.01). In multivariate analysis, CDI score was the strongest correlate of nPCR, SGA, BMI, TSF and MAMC. But KT/V, hematocrit, erythropoietin usage, plasma bicarbonate, serum parathyroid hormone, c-reactive protein concentration and HD duration had no relationship with CDI score. Conclusion: The prevalence of depression in chronic HD patients was high. Diabetes and old age were import ant risk factors for depression. It was also concluded that severity of depression was correlated with markers of malnutrition and depression could be a independent risk factors of malnutrition in chronic HD patients.(Korean J Med 62:77-82, 2002)
김인수,박영호,강진훈,김선봉,도정룡 한국수산학회 1987 한국수산과학회지 Vol.20 No.4
魚油의 酸化에 의한 DNA損傷作用機構를 밝히는 연구의 일환으로 고등어에서 抽出한 脂質을 다시 極性 및 非極性脂質로 分劃하여 이들을 각각 plasmid DNA와 37℃에서 反應시키면서 이들 脂質의 酸化에 의한 DNA 損傷作用을 1% agarose gel 電氣泳動을 통하여 調査하였는데 그 結果를 요약하면 다음과 같다. 極性脂質을 DNA와 反應시킨 경우에는 가장 적은 농도에서도 DNA損傷作用이 크게 나타나 反應 1日째에 Form I DNA가 완전히 切斷되어 Form Ⅱ 및 Form Ⅲ DNA로서 檢出되었다. 極性脂質의 酸化에 의하여 그 농도가 증가함에 따라 POV의 증가가 빠르게 이루어졌으나 反應 4日동안 POV가 100mi11ieq./㎏ 以下에서 DNA損傷作用이 일어나는 것을 알 수 있었고, 한편, 極性脂質의 酸化에 의한 DNA 損傷作用에 대한 活性酸素種의 영향에서는 總脂質의 경우처럼 一重項酸素 (¹O₂)와 superoxide anion (·O₂^-)의 영향이 가장 컸으며 水酸 radical(·OH)과 過酸化水素(H₂O₂)는 그다지 뚜렷한 영향을 나타내지 않았다. 非極性脂質의 경우에서도 極性脂質과 마찬가지로 농도에 따라 DNA 損傷能이 커졌으나 極性脂質과 總脂質에 비하여 그 程度가 훨씬 떨어지는 것을 알 수 있었으며, 이상의 DNA 損傷作用에 대한 活性酸素種의 영향에 있어서도 極性脂質과 同一한 경향을 나타내었다. The present study was investigated on the DNA damage by the peroxidation of polar and non-polar lipid fractionated from mackerel lipid to elucidate the DNA damage mechanism by fish oil peroxidation. The degree of DNA damage by polar lipid peroxidation became greater with the increase of its concentration, and such DNA damage was induced below 100 millieq./㎏ in POV for 4 days incubation. Among the polar lipid peroxidation products, singlet oxygen (¹O₂) and superoxide anion (·O₂^-) greatly affected to the DNA damage than hydrogen peroxide (H₂O₂) and hydroxyl radical (·OH). Non-polar lipid peroxidation also induced the DNA damage with the increase of its concentration, but such effect was lower than the case of total lipid and polar lipid. And, the effects of active oxygens on the DNA damage by non-polar lipid peroxidation was the same as in the case of total and polar lipid peroxidation.
비후폐쇄성 심근증 환자에게서 세균성 심내막염에 병발된 심근경색증 1예
이상민,설상훈,이상봉,정명교,정수룡,조길현,김대경,김두일,김동수 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2
Hypertrophic cardiomyopathy has the complications of ischemic heart disease, arrhythmia, heart failure, sudden death, and infectious endocarditis. The case-report of an infective endocarditis complicating myocardial infarction in hypertophic cardiomyopathy is rare. We experienced a case of case acute myocardial infarction with infective endocarditis in hypertrophic cardiomyopthy. This case is reported in a 52 years old Korean woman with dyspnea, chest rain and drowsy mentality. Echocardiography revealed asymmetric septal hypertrophy, systolic motion of anterior mitral leaflet and the vegetation of mitral valve. In blood culture, streptococcus viridans was isolated. In coronary angiogram, there is no evidence of an obstruction or a narrowing finding. The patient was treated antibiotics and was resulted in the good clinical outcome.
( Jin Kyeong Cho ),( Ji Hwan Lim ),( Jun Yong Bae ),( Hye Won Park ),( Jang Eon Kim ),( Bong Roung Kim ),( Yoo Hyun Jang ),( Kye Heui Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Case Description: We experienced a case of metachronous four primary malignancies. The patient was 76-year-old man with mild wall thickening of GB (gall bladder) fundus and he had laparoscopic cholecystectomy and it revealed adenocarcinoma with invasion of lamina propria of GB. On Regular follow up of abdominal CT (computerized tomography) after 7 months of his cholecystectomy, his prostate was enlarged and hypervascular and the PSA (prostate specifi c antigen) level was high up to 119.9 ng/dL. He had hormonal therapy with goserelin acetate and leuprorelin acetate. 3 years after the diagnosis of his prostate cancer, multiple colon polyps were noticed at his colonoscopy for screening of outside clinic. He came to our hospital and had polypectomy. One of them on his sigmoid colon included focal intramucosal carcinoma, and others were tubular adenoma with low grade dysplasia. He got esophagogastroduodenoscopy and ulcerofungated mass was seen on greater curvature of distal antrum, which is suggesting malignancy. Biopsy showed some atypical glands, and distal gastrectomy was done. It was early gastric cancer of moderately differentiated adenocarcinoma with submucosal invasion and no involvement of lymph node and another organ (stage IA). He underwent no adjuvant therapy and is has been on regular follow up till this time.