단풍취 분획물이 알콜대사효소에 미치는 영향

문형인,지옥표,문세훈,신말식 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Spraque-Dawley계 수컷랫트에 계통분획한 단풍취의 각 분획물을 경구투여하고 혈청 ethanol농도와 간의 ADH활성에 미치는 효과를 검색 추적한 결과 알코올대사를 촉진시키는 성분은 주로 에탄올가용부에, 억제시키는 성분은 에탄올불용부에 주로 존재함을 추정할 수 있었고 현재 활성성분을 분리중에 있다.(1998년 9월 25일 접수, 1998년 10월 14일 수리) Effects of organic solvents fraction from Ainsliaea acerifolia ethanol extract on alcohol metabolism in rats were examined and the results were as follows: Ethanol souble fraction, after a single oral administration to rats, was found to cause a significant decrease in the serum ethanol concentration as well as enhancement of liver cytosolic alcohol dehydrogenase(ADH) activity, on the other hand, the fraction insouble in ethanol was found to cause an increase ethanol concentration in the blood and inhibit ADH activity.

중증 객혈환자의 구명을 위한 새로운 외과적 접근 : 흉골 정중절개에 의한 폐엽의 기관지-혈관 격리술

박형주,이철세,고정관 순천향대학교 1994 논문집 Vol.17 No.4

Major hemoptysis is not only a clinical challenge but also the most critical situation when it is aspirated into the tracheobronchial tree especially in the chronic debilitated patients. Recently, bronchial artery embolization(BAE) is the most effective measure for the primary conservative management and salvages a lot of lives in the emergency situations. However, as the recurrence rate of hemoptysis after embolization is significant and there are very poor cases that cannot be controlled by every medical efforts, emergency surgical resection is the only way of lifesaving. In these high risk group of patients, standard lobectomy resulted in high mortality and morbidity. Since October, 1993, we introduced a new surgical approach of "Broncho-vascular Isolation Lobectomy" for the lifesaving of medically failed life-threatening hemoptysis. Now we report 3 cases treated by this approach and would like to suggest future implications in the treatment of major hemoptysis.

개의 하악에서 막성골 중첩이식후 신연골 형성에 관한 연구

박세정,이동훈,이정형,조병채,백봉수 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

The purpose of this study was to investigate the possibility of distraction osteogenesis in membranous onlay bone graft on the mandible and to clarify the histology of bone repair during distraction osteogenesis in the membranous onlay bone in a dog model. Four dogs, 5 months of age at the beginning of the experiment, were used for this study. The zygomatic arch was exposed in the subperiosteal plane and the full-thickness zygomatic arch was harvested to 3 centimeters in length. The lateral surface of the mandibular body was exposed in the subperiosteal plane and the membranous onlay bone graft was performed with firm contact using screws. The osteotomy on the membranous onlay bone graft and underlying mandibular body was carried down week 1 in dog 1, week 2 in dog 2, week 3 in dog 3, and week 4 in dog 4 after membranous onlay bone graft. The external distraction device was applied to the mandibular body. Mandibular distraction was started 7 days after the operation at a rate of 1mm per day for a total of 10 mm distraction over 10 days. After completion of distraction, the distraction device was left in place for 6 weeks bony consolidation of the distracted area. Radiographs were carried out at 2 weeks, 4 weeks and 6 weeks after distraction. New bone between the native underlying mandibular segments was generated in the distracted zone in all dogs. The new bone between the native underlying mandibular segments was generated in the distracted zone in all dogs. The new bone between segments of membranous onlay bone graft was not generated in dog 1, but it was generated in dogs 2, 3 and 4. However, in dog 2 and 3, the new bone between segments of the distracted membranous onlay bone graft presented less firmness with fibrous tissue than that of the native underlying mandibular segment. Histologically, the distracted gap between segments of the membranous onlay bone graft was composed of much fibrous tissue in the central zone while activated osteoblastic cells formed new bone in the margins of the distracted gap in dogs 2 and 3. In dog 4, there were abundant osteoblastic activities in the distracted gap and the new bone appeared as nearly-normal cortical bone. In conclusion, these findings suggested that membranous onlay bone graft had an osteogenic capacity and that distraction osteogenesis was possible in membranous onlay bone graft.

충남대학교병원 마취발전의 경향에 관한 분석 : 1967년부터 - 1996년까지 from 1967 to 1996

최세진,김상수,정규돈,윤석화,신용섭,손수창,이원형,김혜자,이정은 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

To evaluate the specificity and historical trends of the anesthesia in Chungnam National University Hospital, anesthetic experiences of 83,572 in total performed at Chungnam National University Hospital from January 1967 to December 1996 were analyzed statistically and clinically according to age, sex, surgical department, physical status, elective and emergency surgery, premedicants, IV anesthetics, anesthetic methods, inhalational anesthetics, muscle relaxants. The results were as follows : 1. The number of cases has been steadily increased year by year. 2. The ratio of male to female was 52.8% : 47.2%. 3. According to the age, There were 44,905 cases (54%) in the group of 13-45 years. 4. According to the ASA classification of physical status, most of the cases were belonged to the class 1 & 2 (72.5%). 5. The ratio of elective to emergency was 79.4% to 20.6%. 6. Recently, glycopyrrolate has been used increasingly. 7. Thiopental sodium has been mainly used for intravenous induction agent. 8. General anesthesia has been used mainly. 9. Enflurane is the most common inhalational anesthetic agent. but Isoflurane has been used increasingly. 10. Most of muscle relaxants are Pancuronium & Vecuronium(84.5%).

춤의 대중화를 위한 춤 스폰서십의 이론적 고찰

김인형,김세정,이근모 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-

The purpose of this study was to provide a grounding model on the activation of dance sponsorship for the popularization of dance as researcher examined a social function of dance, the need of dance sponsorship, and a benefit of dance organization or enterprise by the dance sponsorship. The dance sponsorship can offer a chance which can approach to the general public with a guarantee of financial stabilization to the dance organization. Also, the enterprise can attain a image enhancement, an advertising impact, a sales promotion, or a development of regional economy as well as a profit pursuit of enterprise. On the idea of mutual benefit, the enterprise be able to sponsor a dance in two ways. First, the enterprise is to offer a human or material resources in culture event related dance. Second, the enterprise is to manage directly the dance organization. Therefore, the enterprise can contribute the popularization of dance and play a role of priming for a development of dance culture inducing an interest and participation of the general public at the market of dance arts through a substantial sponsorship like above ways.

모낭의 하부 1/2을 이식시 모낭의 재생

박세정,류형호,서정민,김정철 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

We have examined the regenerative capabilities of the human scalp hair follicle after grafting the lower half of the follicle. Twenty-eight of 32 intact whole-hair follicles isolated from the human scalp regenerated hairs when grafted onto the forehead of the same person. Seven of the 15 lower-half follicles regenerated complete hair follicles 8 months after grafting showed that the lower-half follicle implant reconstituted the complete hair follicle. The sebaceous gland was not regenerated, but there was an outgrowth in the sebaceous gland region. Some grafts formed epithelial cysts. Two years after grafting, the histological examination of the regenerated follicle from the lower-half implant showed that the sebaceous gland was completely regenerated. While an intact follicle shows prominent naked shaft outgrowth, the sheath grows concomitantly with the shaft in lower-half follicles in culture. If grafted lower-half follicles were located too deep, the regrown sheath could not reach the epidermal layer. In this situation, the formation of an epidermal cyst was likely.

본태성 고혈압이 동반된 당뇨병환자의 혈중 인슐린 농도

양동호,홍세용,성기범,안무영,윤신구,박형국,양광익,황주호,신현길 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Multiple lines of evidence link elevated blood pressure with diabetes mellitus. Specifically, it has been proposed that resistance to insulin-stimulated glucose uptake and hyperinsulinemia may play a central role in the cause and clinical course of hypertension. In diabetes mellitus, insulin resistance and/or hyperinsulinemia is an common finding and it is interesting whether the hyperinsulinemia may play a signigicant role in hypertension with DM in the same way as in essential hypertension without diabetes mellitus. The object of this study was to compare insulin and c-peptide levels between age, sex, and obesity matched two groups(DM with DM without hypertension). Method The study group consisted of 55 male diabetes mellitus patients, aged between 45-55 (years). Patients with obesity (body mass index · 30 ㎏/m2), renal disease (proteinuria · 300 ㎎/24hr urine), and secondary hypertension were excluded. Insulin and c-peptide were measured in overnight fasting state and after oral administration of glucose(75 gm). In the fasting, venous plasma glucose levels were similar in the hypertensive and control group(132 ±7 ㎎/dl vs 135 ±8 ㎎/dl). In the fasting, venous plasma insulin levels were higher in the hypertensive than in the control group (10.9 ±5.3 μIU/ml vs 5.5 ±3.9 μIU/ml, p = 0.0001). After loading with 75 gm glucose, venous plasma insulin level seems to be higher in the hypertensive patients than in the control patients, but the difference was not signigicant statistically (27.2 ±17.5 μIU/ml vs 19.9 ±18.9 μIU/ml, p = 0.1297). The mean insulin concentration of the essential hypertensive patients with diabetes mellitus was twice that of the normotensive patients with diabetes mellitus. In control group, there was a direct relations between insulin level and c-peptide, in both fasting state (R = 0.617, p = 0.0001) and glucose-loaded state (R = 0.531, p = 0.001). But in hypertensive group, there was no relations between insulin level and c-peptide, in both fasting state (R = 0.257, p = 0.2738) and glucose-loaded state (R = 0.307, p = 0.1885).

한국재래산양 태자의 위장관에서 Chromogranin A 면역반응세포에 대한 분포 및 출현빈도에 관한 연구

이형식,구세광,이재현 慶山大學校 基礎科學硏究所 1997 基礎科學 Vol.1 No.2

임신 180일령의 한국재래산양 태자의 위장관에서 chromogranin A(CgA) 면역반응세포의 각 부위별 출현 분포와 빈도를 면역조직화학적으로 관찰하였던 바, CgA 면역반응세포는 위장관 전 부위에서 관찰되었다. 부위별 분포는 직장(104.0/1㎟)에서 가장 높은 빈도로 출현하였고, 회장(66.6/1㎟), 십이지장(62.1/1㎟), 위저부(53.3/1㎟), 유문부(46.0/1㎟), 결장(34.9/1㎟) 및 공장(30.0/1㎟)의 순으로 관찰되었다. 이들 면역반응세포들은 주로 위저부, 유문부, 십이지장, 회장 및 결장부위에서는 점막샘에 다수, 점막 상피에 소수 분포하였으며, 공장과 결장에서는 점막 전체에 산재되어 있었다. The regional distribution and relative frequency of chromogranin A(CgA)-immunoreactive cells in gastrointestinal tract of the fetus(180 days of gestation) of the Korean native goat were studied with immunohistochemical methods. CgA-immunoreactive cells were detected throughout the gastrointestinal tract and they were situated to the mucosal glands and mucosal epithelia. These cells were most predominant in the rectum(104.0/1㎟), and ileum(66.6/1㎟), duodenum (62.1/1㎟), fundus(53.3/1㎟), pylorus(46.0/1㎟), colon(34.9/1㎟), and jejunum(30.0/1㎟) were followed in that order.

문신치료의 실험적 연구

張忠鉉,李斗炯,陳世勳 大韓成形外科學會 1987 Archives of Plastic Surgery Vol.14 No.1

In general social opinions of developed cultural state, tattoos induced psychological and social problems. Since Hellenic times, the removal of unwanted tattoos has been a challenge: for example, salabrasion, dermabrasion, LASER surgery, skin graft and cryosugery, etc. But the availability of manay methods for the removal of tattoos appears to indicate that there is no one absolute method. So we studied macroscopical color changes and microscopical histological changes in tattooed rabbits and rats, and overtattooed rabbits and rats. The results were as following: 1. Inflammatory reactions was nearly almost disapperared within 3 weeks. 2. The major fade―out of tattooed color was occurred from post―tattooing 5 days to 3 weeks. 3. Dye particle was located mainly in upper & mid dermis and it was not relafted with tattooing depth. 4. Masking effect of black colored tattoos was definitely improved in the overtattooing group. But complete masking was impossible.

외상성 기관지 가성류

이승진,이석열,박형주,이철세 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Rupture of the main bronchus followed by blunt chest trauma is relatively rare but, with increasing traffic accidents, the incidence has been increasing recently. Early diagnosis and management for the traumatic bronchial rupture is essential to reduce morbidity, mortality and late complication but often, it is comcealed in cases of blunt chest trauma and particularly it is associated with multiple other organ injuires. Especially, bronchial pseudoaneurysm which maintains airway patency after complete transection of the bronchus by blunt chest trauma is very unusual case. We report a case of a 15 year old male who had complete bronchial transection with bronchial pseudoaneurysm.The bronchial rupture was comfirmed by spiral chest CT and 3D reconstruction. In the operation, right main bronchus was completely transected and separated but the airway was patent to the right lung by pseudoaneurysm of the bronchus. Resection of the pseudoaneurysm and end to end anastomosis of the bronchus was performed successfully.