Pseudomonas stain HK-6에 의한 폭발물 RDX(Hexahydro-1,3,5-Trinitro-1,3,5-Triazine)의 생분해

정관구,차민석,오계헌 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.2

The feasibility using an isolate derived from the enriched microbial consortium for explosive degradation was explored. The present study reports on the isolate which was developed to grow aerobically with RDX (hesahydro-1,3,5-trinitro-1,3,5-triazine) as the sole sources of carbon and nitrogen. Complete depletion of RDX a the initial concentration of 15 mg per liter was achieved within 24 days of incubation in bench-scale bioreactors. Addition of supplemental carbons (e.g., succinate, glucose, fructose) stimulated the degradation of RDX. The isolate also could degrade structurally related explosive 2,4,6-trinitrotoluene. Degradation of RDX was verified by HPLC analysis of the residual RDX concentration in the test culture. Microscopic examination of this degrader, HK-6 revealed a Gram-negative and coccobacillus shaped cell. Strain HK-6 was characterized by using the Biolog system and an analysis of the total cellular fatty acids. The strain indicated that the bacterium could be identified and designated as pseudomonas putida HK-6

EG-모드 마이크로스트립 아이소레이터에 관한 연구

田啓石,丁寬秀,金容平 慶熙大學校 1980 論文集 Vol.10 No.-

In X-band, a edge-guided(EG) mode microstrip isolator is designed in which nonreciprocal attenuation is due to the ferromagnetic resonance absorption caused by a strong d-e magnetic field applied locally at the shorted edge of a ferrite microstrip. From modal analysis. the dominant EG mode has been shown to propagate alone the microstrip with one edge shorted to the ground plane. Dispersion relations and rf electric field distributions have been calculated numerically. And the upper limit and the cutoff frequency of band width have been discussed with several design parameters. A practical EG-mode microstrip isolator based on these results has been successfully designed, which has more than 25dB isolation.

한국 프로야구 선수들이 지각한 감독의 리더십과 선수들의 스트레스 및 생활 만족도에 관한 연구

이상호,이계윤,김갑룡,원유병,이해권 창원대학교 체육과학연구소 2002 경남 체육연구 Vol.7 No.1

현장에 적용하여, 한국 프로야구 감독자들의 리더 역할이 효율적 또는 비효율적 프로파일 중에서 어느 프로파일에 해당하는지 알아보고, 그리고 감독자들의 6개 리더 역할과 선수들의 스트레스 및 생활만족도 간에 상관 관계를 분석하였다. 조사대상은 해태 야구 선수를 포함하여 해태 야구 선수들과 시합을 하기 위해 어웨이 경기차 광주를 방문한 7개 구단 선수들을 본 연구자가 직접 숙소로 찾아가 조사 목적과 설문 내용을 설명하고, 본 설문지에 응답토록 하였다. 조사된 설문지 중에서 성의없이 응답했거나, 전체 문항중 10%이상 응답을 하지 않은 자료에 대해서는 연구 대상에서 제외한 결과 최종 145명을 연구자료로 확정하였다. 측정도구는 하형주(1996)가 개발한 스포츠 지도자의 대응가치 리더십 검사지(CVLQS:Competing V alues Leadership Questionnaire for Scale)를 사용하였다. 스트레스를 알아보기 위해 첫째, 한국 스트레스 매니지먼트 연구소에서 개발한 심리적, 신체적 스트레스 척도(1990)를 사용하였고, 둘째, 운동 스트레스는 이계윤(1997)이 개발한 프로야구 선수들의 스트레스 척도를 사용하였다. 자료분석은 먼저 선행 연구에서 밝힌 스포츠 지도자의 효율적인 리더십 프로파일을 제시한 후, 각 구단별 프로야구 감독들의 리더 역할에 대해 Z점수를 구하고, Quinn(1988)이제안한 리더십 프로파일에 적용하여 비교 분석하였다. 마지막으로 한국 프로야구 감독들의 6개 리더 역할과 선수들의 스트레스, 생활 만족도 간에 상관 분석을 하였다. 이상과 같은 연구과정을 통해 도출된 결론은 다음과 같다. 첫째, 효율적인 리더역할 프로파일에 해당한 감독은 8개 구단 감독 중 감독 2, 3, 4, 7, 8로 나타났고, 비효율적인 리더역할 프로파일에 해당한 감독은 감독 1, 5, 6으로 나타났다. 둘째, 한국 프로야구 감독들의 리더역할과 운동선수들의 스트레스, 생활만족도 간의 상관분석은 감독의 리더역할과 운동선수들의 신체적 스트레스, 운동 스트레스, 생활만족도 간에 유의한 상관으로 나타났다.

인공 산성비 용액 함침 및 경사평면법에 의한 옥외용 실리콘 고무의 열화 특성 평가

김정호,정규원,유영식,양계준,박용관 成均館大學校 科學技術硏究所 1999 論文集 Vol.50 No.1

We investigated the effect of acid rain on the surface aging, and resistance to tracking and erosion of silicone rubber materials : First, we measured the contact angle, SEM, EDX, and weight reduction to investigate the surface aging caused by immersion in the artificial acid rain solution. From the results of a series of experiments, we concluded that the acid rain attacked the base polymer of the surface, and lead to the depolymerization. Second, we adopted Inclined-Plane Method to measure the resistance to tracking and erosion of silicone rubber, and rather not observably affected the immersed specimen in the tracking resistance than in the erosion resistance.

수면량과 집중력의 상관관계

김병우,류지근,박우진,박계원,김미정,임지은,백대현,최재덕,최윤호,이가현,이관,김덕수 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

수면, 기억 그리고 학습의 연관성은 실제 매우 복잡하다. 많은 연구에도 불구하고 명확한 연구결과는 아직 없다. 우리는 이 연구에서 평소와는 달리 시험 전날 수면 변화 양상이 집중력에 어느 정도 영향력을 미치는지 알아보고자 하였고, 이를 이용해 효율적인 수면 관리를 할 수 있는 기초자료로 삼고자 하였다. 동국대 의대 본과 1학년생 중 지원자 30명과 본과 2학년생 10명을 대상으로 평상시 상태와 시험 직후 수면이 부족한 상태에서 각각 K-PES TEST를 실시하여 총 8항목에 걸쳐 암기력, 판단력, 단순반응의 변화정도를 검사하였다. 또 설문조사를 병행하여 결과에 영향을 미칠 수 있는 다른 인자들도 파악하였다. 수면량에 대한 부호 숫자 짝짓기(순간 판단력)을 검사한 결과, 인간의 최대 생리학적 기능은 꼭 수면부족에 의해 좌우되는 것은 아니다. 그러나, 수면감소는 피로를 증가시키고, 동기부여를 감소시키나 단, 새로운 사실을 학습하는 데에는 큰 영향을 끼치지 않는다. 즉, 수면부족으로 장시간 깨어있는 것은 정확성과 반응성을 떨어뜨린다. 흡연에 대한 부호 숫자 짝짓기(순간 판단력)을 검사한 결과, 니코틴의 수면에 대한 상호관계는 알려지지 않았고, 인간의 감정이나 의식, 인식에 영향을 주는 것으로 알고있지만, 장기적은 측면에서 흡연이나 알코올은 인식능력과 무관한 것 같다. 카페인에 대한 숫자 외우기(암기력)검사 결과, 카페인은 spacial selective attention에는 특별한 영향을 주지 않지만 지각과정이나 주의 집중에 큰 효과를 주며, 인간의 의식 수행에 긍정적인 효과를 준다. 즉 카페인은 활력, 혼란, 피로상태를 변화시키고 visual analog scales에서 휴식상태에 가까운 양상을 나타낸다. 또 48시간 동안 수면을 취하지 않은 사람에게 카페인은 집중력과 장시간의 좋은 기분을 유지하게 하였다. 그러나 규칙적, 비규칙적으로 먹는 사람간에는 인지수행력의 차이를 보이지 않으며 상용자에서는 상당한 내성이 보인다. 수면패턴에 대한 숫자 더하기(순간 판단력)검사 결과, 집중력은 수면패턴에 의해서도 영향을 받고, 수면패턴이 바뀌게 되면 순간판단력을 저하시킨다. This study was performed to evaluate relationship of sleep and attention, and to control sleep effectively. We conducted a K-PES test of 40 medical students. K-PES contains eight elements, for example, simple response, selective response, color pairing, OddEven discrimination, number addition, number-symbol matching, memory, right-tapping, left tapping. Through these, we tested changes of memory, judgement, simple response. And we conducted a questionnaire survey to exclude bias. Results are as follows. As a results of number-symbol matching test, we know that sleeplessness is not complete responsible for physiologic function for humans. But, decreased sleep increases fatigue and decreases motivation, but no influence on learning new materials. So, long term sleeplessness decreases precision and responsibility. As a results of number-symbol matching test on smoking, a relationship of nicotine and sleep is not certain. A point of view in long term period, smoking and drinking is not related cognition, even if we know that those influence mood, consciousness and cognition. As a results of memory work test on caffeine, caffeine does not influence spacial selective attention, but mainly does perception, attention and consiousness process. Namely caffeine changes energetic activities, chaos, fatigue states and shows resting state in visual analog scales In sleeplessness for 48 hours, caffeine produced attention and good mood for a long time. But, in case of cognitive process no significance shows in regular or irregular diet. Regular diet shows high resistance. As a results of number addition test on sleep patterns, seep patterns influence attention, changes of sleep patterns decrease a moment judgement.

The minimal chiral Schwinger model with the minimal Wess-Zumino action

Kye, Won Ho,Kim, Won Tae,Kim, Jae Kwan 서울대학교 이론물리학연구센터 1992 연구논문집 Vol.1 No.-

Gefitinib in Selected Patients with Pre-Treated Non-Small-Cell Lung Cancer: Results from a Phase IV, Multicenter, Non-Randomized Study (SELINE)

( Kwan Ho Lee ),( Kye Young Lee ),( Young June Jeon ),( Maan Hong Jung ),( Choon Hee Son ),( Min Ki Lee ),( Jeong Seon Ryu ),( Sei Hoon Yang ),( Jae Cheol Lee ),( Young Chul Kim ),( Sun Young Kim ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.73 No.6

Background: This study was designed to analyze the efficacy of gefitinib as a second-line therapy, according to the clinical characteristics in Korean patients with non-small-cell lung cancer (NSCLC). Methods: In this Phase IV observational study, we recruited patients, previously failed first-line chemotherapy, who had locally advanced or metastatic NSCLC, and who were found to be either epidermal growth factor receptor (EGFR) mutation-positive or satisfied 2 or more of the 3 characteristics: adenocarcinoma, female, and non-smoker. These patients were administered with gefitinib 250 mg/day, orally. The primary endpoints were to evaluate the objective response rate (ORR) and to determine the relationship of ORRs, depending on each patient``s characteristics of modified intent-to-treat population. Results: A total of 138 patients participated in this study. One subject achieved complete response, and 42 subjects achieved partial response (ORR, 31.2%). The subgroup analysis demonstrated that the ORR was significantly higher in patients with EGFR mutation-positive, compared to that of EGFR mutation-negative (45.8% vs. 14.0%, p=0.0004). In a secondary efficacy variable, the median progression-free survival (PFS) was 5.7 months (95% confidence interval, 3.9∼8.4 months) and the 6-month PFS and overall survival were 49.6% and 87.9%, respectively. The most common reported adverse events were rash (34.4%), diarrhea (26.6%), pruritus (17.5%), and cough (15.6%). Conclusion: Gefitinib was observed in anti-tumor activity with favorable tolerability profile as a second-line therapy in these selected patients. When looking at EGFR mutation status, EGFR mutation-positive showed strong association with gefitinib by greater response and prolonged PFS, compared with that of EGFR mutation-negative.

Effects of a Cancer Prevention Advertisement on Beliefs and Knowledge about Cancer Prevention

Kye, Su Yeon,Yoo, Jisu,Lee, Min Hee,Jun, Jae Kwan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Background: Outcome-expectation beliefs and knowledge may ultimately influence behavior for cancer prevention. The aims of this study were to measure changes in knowledge and beliefs about cancer prevention before and after viewing a television advertisement and identify the factors affecting receptivity to its messages. Materials and Methods: A one-group pretest-posttest design was used in this study of 1,000 individuals aged 20 to 65 years who were recruited online in November 2014. The outcome variables included cancer prevention beliefs based on the Health Belief Model (five items) and knowledge about risk factors for cancer (seven items). Results: Perceived susceptibility, perceived benefits, and self-efficacy increased significantly and their perceived severity and perceived barriers decreased significantly, after participants viewed the television advertisement. Correct responses to questions about risk factors also increased significantly, except for smoking. The main factors affecting changes in the outcome variables were age, interest in cancer prevention, social network, satisfaction with the ad, and pretest scores. Conclusions: Television advertisements with positive frameworks can be an efficient channel of improving beliefs and knowledge about cancer prevention in a short period. The continuous development of intervention materials that consider the demographics, needs, and satisfaction of the target group will be necessary for future studies.

Systemic Nicardipine과 Intracisternal Nicardipine이 뇌혈관 연축에 미치는 효과에 대한 실험적 연구

유계희,박윤관,정용구,정흥섭,서중근,이훈갑,이기찬,주정화 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.8-9

This study reports the protective effect of systemic nicardipine and intracisternal nicardipine administration in the three-hemorrhage canine model of chronic cerebral vasospasm. Twenty-one dogs were assigned to one of three groups : control, intravenous nicardipine and intracisternal nicardipine. All animals received a total of 12ml of fresh unheparinized autologous blood via three cisternal injection. Selective vertebral angiograms were obtained before and 8 days after the initial subarachnoid blood injection. Seven animals were treated by intravenous nicardipine for 7 days continuously, the other seven were treated by intracisternal nicardipine for 7 days, and the remaining were not treated. Animals were sacrificed at day 9. Comparisons were based on the percentage of reduction in basilar artery diameter(% RBAD). The ultrastructural changes were studied by transmission electron microscopy(TEM). There was a mean reduction(± standard deviation) of 54±6% in control dogs. 35±4% in dogs with intravenous nicardipine, 32±6% in dogs with intracisternal nicardipine (difference significant, t-test. P<0.05). The preventive effects of intracisternal nicardipine was superior to those of intravenous nicardipine. There was a strong trend toward reduction of medial necrosis in the basilar artery in dogs with intravenous and intracisternal group compared to control dogs. All basilar arteries showed structural changes with electron microscopic examination ; these included medial necrosis, lysosome, intimal changes, endothelial cell vacuoles, and adventitial erythrocytes, leukocytes. Intimal proliferation was unusual in all three groups, but reduction of intimal proliferation was found in dogs with treatment, and it was believed that vasospasm in this stage is due to long-standing smooth muscle contraction and not to arterial wall thickening. There was significant reduction of blood clot in intracisternal nicardipine group, which may be due to inhibitory action on platelet aggregation of nicardipine. These investigations support the hypothesis that the presence of clotted blood around the intracranial arteries is the cause of vasospasm.

Gefitinib in Selected Patients with Pre-Treated Non-Small-Cell Lung Cancer: Results from a Phase IV, Multicenter, Non-Randomized Study (SELINE)

Lee, Kwan-Ho,Lee, Kye-Young,Jeon, Young-June,Jung, Maan-Hong,Son, Choonhee,Lee, Min-Ki,Ryu, Jeong-Seon,Yang, Sei-Hoon,Lee, Jae-Cheol,Kim, Young-Chul,Kim, Sun-Young The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.73 No.6

Background: This study was designed to analyze the efficacy of gefitinib as a second-line therapy, according to the clinical characteristics in Korean patients with non-small-cell lung cancer (NSCLC). Methods: In this Phase IV observational study, we recruited patients, previously failed first-line chemotherapy, who had locally advanced or metastatic NSCLC, and who were found to be either epidermal growth factor receptor (EGFR) mutation-positive or satisfied 2 or more of the 3 characteristics: adenocarcinoma, female, and non-smoker. These patients were administered with gefitinib 250 mg/day, orally. The primary endpoints were to evaluate the objective response rate (ORR) and to determine the relationship of ORRs, depending on each patient's characteristics of modified intent-to-treat population. Results: A total of 138 patients participated in this study. One subject achieved complete response, and 42 subjects achieved partial response (ORR, 31.2%). The subgroup analysis demonstrated that the ORR was significantly higher in patients with EGFR mutation-positive, compared to that of EGFR mutation-negative (45.8% vs. 14.0%, p=0.0004). In a secondary efficacy variable, the median progression-free survival (PFS) was 5.7 months (95% confidence interval, 3.9~8.4 months) and the 6-month PFS and overall survival were 49.6% and 87.9%, respectively. The most common reported adverse events were rash (34.4%), diarrhea (26.6%), pruritus (17.5%), and cough (15.6%). Conclusion: Gefitinib was observed in anti-tumor activity with favorable tolerability profile as a second-line therapy in these selected patients. When looking at EGFR mutation status, EGFR mutation-positive showed strong association with gefitinib by greater response and prolonged PFS, compared with that of EGFR mutation-negative.