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박계원,유호성,김주연,정선주 대한파킨슨병및이상운동질환학회 2017 Journal Of Movement Disorders Vol.10 No.3
Oculodentodigital dysplasia (ODDD) is a rare autosomal dominant inherited disease caused by mutations of the human gap junction alpha 1 gene, which encodes the protein Connexin-43. Patients with ODDD may present with neurological deficits with a typical pleiotropic combination of characteristic craniofacial, ophthalmological, phalangeal, and dental anomalies. In this report, we describe the first genetically confirmed Korean ODDD patient, who presented with spastic paraparesis. We will also review the neurological aspects of ODDD as reported in the literature.
In vitro and in vivo Anti-tumor Effects of Oriental Herbal Mixtures
박계원,Su-hyang Ye,Young-jun Kim,So-Ra Jung,Min-hyuk Bang,이한웅,박기문 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.4
To identify antitumor materials, oriental herb extracts were investigated in the present study. The effects of individual oriental herb extracts (OHE) and a mixture of these extracts (MOHE) for antioxidant, free radical scavenging,and tumoricidal activities were determined. The OHEs and MOHE exhibited relatively high free radical scavenging and antioxidant activities, in a concentration dependent manner. The total phenolic contents of the extracts suggest that these compounds may have played a role, at least in part, in the free radical scavenging and antioxidant effects. Since the MOHE showed the highest toxicity against tumor cell lines, the MOHE was administrated in cancer mice models. Consistent with the in vitro studies, the MOHE resulted in prolonged life spans in cancer mice possibly by combination of its anticancer and antioxidant activities. Our data indicate the possibilities of using the MOHE to counteract carcinogenesis as well as other forms of electrophilic toxicity.
중소형 화재시험(ISO 5660-1 및 EN 13823)을 이용한 샌드위치패널 연소성능 분석
박계원,김운형,정재군,임홍순 한국화재소방학회 2009 한국화재소방학회논문지 Vol.23 No.1
In this study, the combustion properties, which are called the reaction-to-fire’s performance, of sandwich panels were tested and analyzed according to both ISO 5660 (cone calorimeter method) and EN 13823 (SBI). Several variables including ignition time, mass loss, heat release rate, smoke production rate and O2 density about four sandwich panels and four core materials (thermal insulation material) were evaluated. Combustion properties’ similarity and difference of sandwich panels and core materials were compared by materials and test methods respectively. Finally test results were evaluated by Japanese standard building code, National Building code of Canada and EN 13501-1 as well. 본 연구에서는 ISO 5660-1(cone calorimeter test)과 EN 13823(Single Burning Item;SBI)에 의해 샌 드위치패널에 대한 화재연소성능이 비교·분석되었다. 4종의 국내 샌드위치패널(심재 및 패널재)에 대해 착화시간, 열방출율, 연기발생율, 산소소모율 등과 같은 변수들이 측정되었다. 또한, 각 종류의 패널에 대 한 연소특성이 시험방법별 및 소재별로 분석되었으며, 최종적으로 일본, 캐나다, 유럽 EN 1350-1의 화재 성능 등급분류기준에 의해 검증되었다.
박계원,김성희,이건호 대한임상건강증진학회 2009 Korean Journal of Health Promotion Vol.9 No.4
연구배경 : 항산화제인 carotenoids와 심혈관질환 위험인자인 대사증후군의 관련성을 알아보고자 하였다. 방 법 : 2005년 9월-12월 사이, 일개 대학병원에서 40세 이상의 검강 검진 수검자 533명을 대상으로 대사증후군 및 위험요소에 따른 혈중 carotenoids 농도를 비교하고 (ANCOVA), carotenoids 농도가 대사증후군에 미치는 영향을 분석하였다(multiple logistic regression analysis). 통계분석은 SPSS 12.0을 이용하였으며, carotenoids 측정값은 나이, 성별, 흡연, 음주, 육체적 활동량, 과일 및 채소의 섭취량, 비타민 및 미네랄 보충제 복용량에 대해 보정하였다. 결 과 : 대사증후군에서 일부 혈중 carotenoids의 농도가 저하되었다(p<0.05). β-carotene은 대부분의 대사증후군 항목에서 유의한 농도저하를 보이고(p<0.05) 대사증후군 항목 수 증가에 따른 음의 용량-반응 관계가 있었으며(p<0.01), β-carotene농도 1사분위에서 대사증후군의 위험도가 5.35배 증가하였고(p<0.01). 복부비만이 동반된 대사증후군에서 농도가 가장 낮았다(p<0.01). 혈중 carotenoids 농도는 남자가 여자보다 낮게 측정되었다(Lutein 제외). 결 론 : 본 연구에서 carotenoids는 대사증후군을 예방하는 경향을 보이었으며 특히, β-carotene에서 유의하였다. Background : This study investigated the association between serum carotenoids as antioxidants and metabolic syndrome as a risk factor of cardiovascular disease. In addition, the relationships among oxidative stress, metabolic syndrome and antioxidants were assessed. Methods : From September to December, 533 subjects (>40 yrs, men: 342, women: 181) from one general hospital joined this study. They were grouped into: normal (460), metabolic syndrome without central obesity (13) and metabolic syndrome with central obesity (60). We analyzed associations among 1) serum carotenoids and metabolic syndrome considering central obesity and gender (ANCOVA), 2) serum carotenoids and the 5 components of metabolic syndrome (ANOVA, ANCOVA) and 3) serum carotenoids and risk factors for cardiovascular disease (correlation test) by SPSS 12.0. Serum carotenoid concentrations were adjusted for age, gender, smoking, alcohol use, physical activity, intake of fruits and vegetables and supplement use (vitamins and minerals). Results : Serum carotenoid levels were lower in the presence of metabolic syndrome, with the lowest levels seen in metabolic syndrome with central obesity. Serum levels of β-carotene were lower with most components of the metabolic syndrome and decreased according to increasing numbers of components (negative dose-response relationship, p<0.05). Conclusions : This study showed that serum carotenoids are associated with the metabolic syndrome.