SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner

Lee, Ji-Seon,Park, Jeong-Rak,Kwon, Ok-Seon,Lee, Tae-Hee,Nakano, Ichiro,Miyoshi, Hiroyuki,Chun, Kwang-Hoon,Park, Myung-Jin,Lee, Hong Jun,Kim, Seung U.,Cha, Hyuk-Jin Oxford University Press 2015 Neuro-oncology Vol.17 No.1

<P><B>Background</B></P><P>Cancer stemness, observed in several types of glioma stem cells (GSCs), has been demonstrated to be an important barrier for efficient cancer therapy. We have previously reported that cancerous neural stem cells (F3.Ras.CNSCs), derived from immortalized human neural stem cells by a single oncogenic stimulation, form glial tumors in vivo.</P><P><B>Method</B></P><P>We searched for a commonly expressed stress modulator in both F3.Ras.CNSCs and GSCs and identified silent mating type information regulation 2, homolog (SIRT1) as a key factor in maintaining cancer stemness.</P><P><B>Result</B></P><P>We demonstrate that the expression of SIRT1, expressed in “cancer cells with neural stemness,” is critical not only for the maintenance of stem cells, but also for oncogenic transformation. Interestingly, SIRT1 is essential for the survival and tumorigenicity of F3.Ras.CNSCs and GSCs but not for the U87 glioma cell line.</P><P><B>Conclusion</B></P><P>These results indicate that expression of SIRT1 in cancer cells with neural stemness plays an important role in suppressing p53-dependent tumor surveillance, the abrogation of which may be responsible not only for inducing oncogenic transformation but also for retaining the neural cancer stemness of the cells, suggesting that SIRT1 may be a putative therapeutic target in GSCs.</P>

家畜排泄物 콤포스트化 有效利用에 關한 硏究

洪志亨,全炯柱,朴又龍,崔秉旻,金在煐 順天大學校 1983 論文集 Vol.2 No.1

家畜排泄物의 堆肥化 작업체계의 工學的인 局面은 畜産經營의 畜産物 生産性, 에너지保存, 公害防力및 勞動力 節約에 密接한 關係를 갖고 있는 바이다. 그러나 韓國에 있어서 現在 畜産業의 飼養規模와 飼育頭數는 每年 增加하는 傾向을 나타내고 있으나, 傳統的인 家畜排泄物의 堆肥化處理 加工作業上의 問題點에 關한 硏究資料는 거의 없는 實情으로 堆肥化 작업체계 改善確立이 切實히 要求되고 있다. 따라서, 本硏究의 目的은 家畜排泄物 堆肥化 작업체계상의 工學的인 諸問題點을 調査分析하고 이에 對한 現況을 評價하여 改善方案을 模索하기 위한 基本資料를 提供하기 위해 遂行되었으며 調査分析 結果를 要約하면 다음과 같다. 1. 畜産農家의 家畜排泄物 處分方法으로는 大部分이 自然乾燥, 堆積, 嫌氣的 固形堆肥化에 依하여 遂行되고 있어 家畜糞尿에 의한 公害가 深刻해 지고 있었다. 2. 野積堆肥化 가공작업체계에 있어서는 트랙터에 附着된 前後作動式 로우더가 바람직하다. 3. 好氣性 野積堆肥化 加工作業에 따른 良質의 腐熟堆肥를 얻기 위해서는 外部氣溫에 따라 適正通氣量을 維持하기 위해 3∼7日 間隔으로 混合攪拌해야 되며 氣象條件에 의한 影響을 防止하기 위하여 堆肥作業物質의 表面을 비닐 等으로 덮거나, 더운날에는 加水를 해야할 것이 要望된다. 4. 堆肥化 加工作業體系의 基本段階別로 이루어지는 畜産農家는 거의 찾아 볼 수가 없었다. 5. 堆肥化加工 過程은 畜産農家周圍의 콤포스트센타에서 全體農家가 地力增進과 公害防止를 위해 參與할 수 있는 總合的이고 協同的인 加工作業體系로서 一貫性있게 遂行되어야 할 것으로 思料된다. There was almost no livestock farms to follow the basic stage in composting operation system. Composting disposal process should be performed successively an integrate cooperative operation system at compost center which is participated in all farmers near the livestock farms for the purpose of land improvement and pollution abatement. Well matured compost which is resulted from aerobic windrow solid composting should be turned at 3 to 7 days to insure abequate aeration according to the ambient temperature. The compost material should be covered with vinyl sheets etc. to avoid the effect of climatic condition.

송이의 증산에 관한 연구

이지열,류천인,남성우,이송규 한국균학회 1980 韓國菌學會誌 Vol.8 No.1

To increase production of Tricholoma matsutake, experiments were carried out in a mountain located in Keumma 2-ri, Joocheon-myun, Yongwol-gun, Kangwon-do, Korea during the period from April to November 1979. The area of the experiment showed pH 6.55 of soil acidity`and the rock was found to be granite. Among its vegetation, the major growths were Pinus densiflora Siebold et Zuccarini, Rhododerulron mucronulatum Turcz., Rhododendron schlippenbachii Max., Lespedesa bicolor and Pteridium aquilinum (Linne) Kuhn var. japonicum Nakai. Of two equally divided areas of A and B in which pine mushrooms grew, artificial methods such as thinning the upper portion of land raking and water-spraying were applied to area B only, where 21% increase of the production was obtained as compared with the control area A.

주5일 수업제의 성공적인 도입을 위한 선결과제

최관경,이명우,김지혜 부산교육대학교 초등교육연구소 2004 초등교육연구 Vol.19 No.-

The purpose of this study is to examine the function and problem of five-day school-week system and to build the desirable image of elementary school-teacher in the era of five-day work-week. As is generally known, the issue of the five-day work-week system was first raised in 1998 and banks were the first to implement it in July, 2002. However, the five-day work-week system was officially adapted July, 2004. As of July 2004, companies with more-than 1,000 employees adapted this system. This involves 1.8million workers, although some companies still have issues to work out such as holiday and pay adjustments. Five-day work-week system will be put into force in small and medium-sized businesses with more than 300 employees starting from July, 2005. The new working hours will also be fully introduced to the governmental and public sectors. Civil servants will start working five days a week from second half of 2005, while the remaining work places will only do so in 2011. Breathing in a more leisurely lifestyle, people are expected more and more to seek diverse and new ways to spend their extra time. The phases in which people may adapt to a leisurely lifestyle can be categorized into three types : cocoon, active and practical. The first describes individuals who will pass their time at home enjoying hobbies or watching television. The second refers to those who will take pace in activities outside the home and the third to those who will use the extra time to expand their knowledge and seek ways to increase their income. At the present time when there is serious talk of a five-day work-week, a number of thoughtful people are pointing out that without increased emphasis on education for leisure time, it could be very dangerous to so shorten the time that man must labor. It is no simple matter for man to learn how to utilize his leisure hours in ways that are, at best, socially beneficial and, at least, not injurious to others and to himself. In this context, five-day school-week system will be put into force in all elementary, middle and high schools nationwide once a month starting from March, 2005. Regretfully, we have traditional obsessions that 'working is a virtue' but not 'working is a vice', 'school is the only place of learning' but 'home is the place of playing', and 'the days of going to school are the only days of learning' but 'the day of not going to school is the day of playing to the full. First of all, teachers should become model persons to demolish such as fixed ideas thoroughly and to become habitual learners. As a matter of fact, man is born to live, not to prepare for life. It is urgent for us to have new ways of thinking which every place of staying is the place of learning and every day after day is the day of learning constantly. In addition, the prerequisites of successful operating of five-day school-week system are as follows : 1) the structural improvement of curriculum, 2) the flexible operation of curriculum adjusting to five-day school-week system, 3) new curriculum-development suited to the efficient reduction of curriculum and activities on holidays, 4) the constructing of various educational infrastructure, and 5) the program development for parents of students to participate voluntarily and positively. In conclusion, I suggest that teachers and parent of students make concerted efforts to introduce five-day school-week system successfully in all nation-wide schools.

과아밀라제혈증을 동반한 갈색세포종

김소양 ( Kim So Yang ),김지훈 ( Kim Ji Hun ),김창환 ( Kim Chang Hwan ),남순우 ( Nam Sun U ),김윤정 ( Kim Yun Jeong ),김진일 ( Kim Jin Il ),박수헌 ( Park Su Heon ),한준열 ( Han Jun Yeol ),김재광 ( Kim Jae Gwang ),정규원 ( Jeong Gyu 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2

Pheochromocytoma, a catecholamine-producing tumor of the chromaffin tissue, may present with various features. Herein, we report case of 66-year-old woman with pheochromocytoma accompanying hyperamylasemia and acute abdomen. She was admitted to another hospital due to myocardial infarction 5 months ago. At that time, pheochromocytoma was suggested on the basis of hormonal studies, but she refused surgical resection. When she came to our hospital, serum amylase level was 703 U/L. Subsequent studies revealed pancreatic type isoenzyme, and elevated lipase level. After normalization of serum amylase level, she undertook laparoscopic adrenalectomy. On pathologic examination, pheochromocytoma was confirmed. There are several cases of pheochromocytoma with hyperamylasemia. In general, the source of hyperamylasemia was thought to be pulmonary endothelial cells under ischemic damage caused by potent vasoconstrictive action of circulating catecholamines. In our case, analysis of isoenzymes and serum lipase level suggest that hyperamylasemia can originate from the pancreas. Thus, pancreatitis also should be considered when serum amylase level is elevated in pheochromocytoma. (Korean J Gastroenterol 2003;42:172-175)

남자대학생의 정신건강, 부모양육태도, 애착이 도박중독에 미치는 영향

김혜진,박재희,유지원,이수현,이지은,임소정,장우주,지연주,최민정,김석선,박향진 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50

Objectives: The purpose of this research was to identify the effect of mental health, parenting attitude and attachment on gambling addiction severity among male college students. Methods: Subjects of the research were 292 students recruited from colleges in Seoul, Korea. The questionnaires were composed of CPGI, DASS-21, PBI, ECR-R. The data was statistically analyzed by Chi-square, ANOVA, Scheffe test and Pearson’s correlation. Results: The proportion of moderate-risk gambling and high-risk gambling group was reported 28.1%. There a statistically significant difference between gambling addiction severity groups in Anxiety(F=3.19, p<.05). Statistically significant linear relationship was found between Anxiety and gambling addiction score(r=.15, p<.05). There was statistically significant difference between gambling addiction severity groups in Caring(F=4.74, p<.01). Statistically significant linear relationship was found between Caring and gambling addiction score(r=-2.14, p<.01). There was statistically significant difference between gambling addiction severity groups in Overprotection(F=4.74, p<.01). Statistically significant linear relationship was examined between Overprotection and gambling addiction score(r=.20, p<.01). Significant difference was examined between gambling addiction severity in Attachment Anxiety(F=3.76, p<.05). Attachment Anxiety showed significant linear relationship with gambling addiction score(r=-.17, p<.01). Significant differences were examined between gambling addiction severity in Attachment avoidance (F=3.46, p<.05). Attachment avoidance showed no significant relationship with gambling addiction score(r=-.09, p=.12). Conclusions: This study showed the effect of mental health, parenting attitude and attachment on gambling addiction severity among male college students. Based on the result, it is recommend for nurses to develop intervention to prevent gambling addiction among college students by lowering anxiety, stabilizing attachment through desirable caring attitude from parents.

Analysis of morphological relations between orbital rim and the eyebrow

Ji-su Yun,Ki-su Park,Min-ji Kim,Won-Joon Lee,U-Young Lee 대한체질인류학회 2018 대한체질인류학회 학술대회 연제 초록 Vol.61 No.-

Research : Aesthetic Characteristics of Glocalism in Flight Attendants` Uniform Design

( Ji U Kim ),( Jang Hyeon Kim ),( Young Sam Kim ) 한국의류산업학회 2015 한국의류산업학회지 Vol.17 No.1

This study considers the expressive types of ``Glocalism`` trends and its inherent aesthetic characteristics through the analysis of flight attendants’ uniform design. The following is the conclusions regarding the glocalism trend according to the analysis of airline uniform design that reflect it. First, the design approach was developed appropriating the whole or parts of traditional attire and applying decorative items in terms of a formal aspect. Secondly, the colors of the airline’s homeland symbols or natural environment were used while, thirdly, the fabrics represent glocalism by employing folk elements of the region and patterns of nature for a uniform design. Induced from these design analyses, the aesthetic characteristics of airline uniforms reflecting glocalism are traditionality, naturality, and compromisability. To begin with, traditionality is what is realized in interpreting the historical aesthetics in a contemporary perspective, contributing in inspiring the historical value of the homeland and contributing to the establishment of identity by applying forms and colors of traditional garments with folk patterns on a uniform design. In addition, naturality means the reorganization of unprocessed pure nature, expressing the image of nature through colors taken from the natural environment or motifs of the regional plants. Finally, combining general sensibilities with diverse cultural features, compromisability is realized as a modern design which combines a standardized uniform with the aesthetic components of the local environment and traditional garments.

Magnetic Levitation Force of YBCO superconductors at 77 K

Ji U Kim,Ye Bin Jo,Young Hwan Lee,Jah Ho Lee,Chan Joong Kim 한국자기학회 2018 한국자기학회 학술연구발표회 논문개요집 Vol.2018 No.11

Sediment Flushing at the Nakdong River Estuary Barrage

Ji, U.,Julien, P. Y.,Park, S. K. American Society of Civil Engineers 2011 Journal of hydraulic engineering Vol.137 No.11