전기투석법에서의 구리 및 황산의 이동에 관한 연구

홍지형,최윤,이승무 한국화학공학회 1988 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.26 No.4

구리이온의 flux에 대한 실험식을 만들어 전류밀도, 도입유속에 따른 구리이온 제거효율을 계산하여 실험값과 비교하였다. 구리이온의 flux에 대한 식은 feed중 구리이온 농도에 비례하였고 확산과 대류영향을 제외한 경우 구리이온 flux는 전류밀도에 선형적으로 비례하였다. 연속식 실험에서 구리이온 및 환산의 제거효율은 도입유속 2.3㎖/min, 전류밀도 285.7A/㎡에서 구리이온은 65% 이상, 황산은 70% 이상이었다. 황산에 대한 전류효율은 도입유속이 클수록 전류가 낮을수록 높게 나타났으며 실험범위 3. 1∼15.0㎖/min, 0.3A∼1.2A 중에시 유속 15.0㎖/min, 전류 0.3A에서 황산의 전류효율은 75.4%로 가장 높게 나타났다. An experimental formula is proposed and the calculated ion removal efficiencies have been compared with experimentally measured ones with variation of current density and input flow rate. The copper ion flux has been found to be proportional to the copper ion concentration in feed. The copper ion flux without diffusion and convection has been found to be linearly proportional to the current density. When the input flow rate was 2.3 ㎖/min and the current density was 285.7 A/㎡ in the continuous system, the removal efficiencies of copper ion and sulfuric acid were 65% and 70% respectively. Current efficiency of sulfuric acid showed the highest value in the flow rate of 15.0 ㎖/min and the current of 0.3A, in the experimental range of 3.1-15.0 ㎖/min for the flow rate and of 0.3-1.2A for the current.

Total Lesion Glycolysis Using 18F-FDG PET/CT as a Prognostic Factor for Locally Advanced Esophageal Cancer

홍지형,김현호,한은지,변재호,장홍석,최은경,강진형,유이령 대한의학회 2016 Journal of Korean medical science Vol.31 No.1

Standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) have been considered prognostic factors for survival in many cancers. However, their prognostic value for radiotherapy-treated squamous esophageal cancer has not been evaluated. In this study, SUV, MTV, and TLG were measured to predict their prognostic role in overall survival (OS) in 38 esophageal cancer patients who had undergone 18F-FDG PET/CT before radiotherapy. TLG demonstrated higher sensitivity and specificity for predicting OS than MTV and SUV; and a better OS was observed in patients with low TLG compared to those with high TLG in locally advanced disease (OS, 46.9 months; 95% confidence interval [CI], 33.50-60.26 vs. 25.3 months; 95% CI, 8.37- 42.28; P = 0.003). Multivariate analyses in these patients determined that TLG and the use of combination chemotherapy were the independent prognostic factors for OS (hazard ratio [HR], 7.12; 95% CI, 2.038-24.857; P = 0.002 and HR, 6.76; 95% CI, 2.149-21.248; P = 0.001, respectively). These results suggest that TLG is an independent prognostic factor for OS and a better predictor of survival than MTV and SUV in patients with locally advanced esophageal cancer treated with radiotherapy.

수도권 대기환경개선대책의 기술적 과제와 전망

홍지형,정동일,김정수,김대곤,김지영,이용미 한국대기환경학회 2006 한국대기환경학회 학술대회논문집 Vol.- No.-

세포독성 항암치료의 부작용 관리: 일차의료기관을 중심으로

홍지형 대한의사협회 2023 대한의사협회지 Vol.66 No.2

Background: Despite the increased incidence of cancer, more effective cancer drugs are being developed and cancer patient survival expectancy has been prolonged. Here, we discuss the contribution of primary healthcare clinics to managing the side effects of cytotoxic chemotherapy and provide a compilation of what is currently being used in this field. Current Concepts: Loperamide is recommended for active use when diarrhea occurs. In severe cases, octreotide can help control diarrhea by reducing small bowel fluid secretion. Mouthwash mixed with salt and sodium bicarbonate is helpful for controlling mucositis, and transdermal fentanyl patches can be used for severe pain. Limited evidence suggests that pilocarpine may be helpful for xerostomia. Neurokinin-1 receptor antagonists, serotonin receptor antagonists, glucocorticoids, metoclopramide, and olanzapine are used for nausea and vomiting. Opioid-related constipation can be relieved without counteracting the analgesic effect of opioids via peripherally acting μ-opioid receptor antagonists. Granulocyte colony-stimulating factor is recommended to treat neutropenic fever. In cases with neutropenia but no fever, the decision to use it should be based on the patient’s condition. Minoxidil can be used for hair loss, and scalp cooling can also be considered, but its practical applications are limited. Topical steroid ointments are used to treat hand-foot syndrome. Selective serotonin re uptake inhibitors are recommended for depression in cancer patients because they have little interaction with other drugs and are well tolerated. Discussion and Conclusion: Due to an increased cancer patient management burden and limited medical resources, primary healthcare practitioners should know these management strategies for cancer patients receiving cytotoxic chemotherapy.

다이옥신 처리기술

홍지형 한국공기청정협회 1998 空氣淸淨技術 Vol.11 No.3

가축 슬러리의 액상 콤포스트화 시스템 (1)

홍지형 한국축산시설환경학회 1998 축산시설환경학회지 Vol.4 No.1

The dramatic increase in both swine and cattle production in Korea has presented problems related to protection of water resources. Animal wastes are a potentially valuable source of plant nutrients. Modern liquid waste management plans for a livestock housing need to focus on the slurry aeration and composting control methods and cost effective equipments. Recent developments in the animal manure liquid composting make it possible to improve the manure more easier to handle, reduce the odorous, labors and bedding materials, kill the weed seeds etc. However, there are some disadvantages, the aerator consumes much electrical power and initial cost is high. To solve these problems, this study is intended to develop a key points such as slurry aeration and dilution, liquid waste composting equipments.

낙농시설의 사양관리시스템의 현장과 전망

홍지형,오동환 한국농업기계학회 1994 바이오시스템공학 Vol.19 No.2

가네코 미쓰하루(金子光晴)의 작품 속 전쟁과 중국

홍지형 한국일본학회 2016 한국일본학회 학술대회 Vol.2016 No.02

Clinical Features of Male Breast Cancer: Experiences from Seven Institutions Over 20 Years

홍지형,하경선,정윤화,원혜성,안호정,이국진,강동훈,박지찬,박사라,변재호,서영진,김정수,박우찬,정상설,박일영,정수미,우인숙 대한암학회 2016 Cancer Research and Treatment Vol.48 No.4

Purpose Breast cancer treatment has progressed significantly over the past 20 years. However, knowledge regarding male breast cancer (MBC) is sparse because of its rarity. This study is an investigation of the clinicopathologic features, treatments, and clinical outcomes of MBC. Materials and Methods Clinical records of 59 MBC patients diagnosed during 1995-2014 from seven institutions in Korea were reviewed retrospectively. Results Over a 20-year period, MBC patients accounted for 0.98% among total breast cancer patients, and increased every 5 years. The median age of MBC patients was 66 years (range, 24 to 87 years). Forty-three patients (73%) complained of a palpable breast mass initially. The median symptom duration was 5 months (range, 1 to 36 months). Mastectomy was performed in 96% of the patients. The most frequent histology was infiltrating ductal carcinoma (75%). Ninety-one percent of tumors (38/43) were estrogen receptor–positive, and 28% (11/40) showed epidermal growth factor receptor 2 (HER-2) overexpression. After curative surgery, 42% of patients (19/45) received adjuvant chemotherapy; 77% (27/35) received hormone therapy. Five out of ten patients with HER-2 overexpressing tumors did not receive adjuvant anti–HER-2 therapy, while two out of four patients with HER-2 overexpressing tumors received palliative trastuzumab for recurrent and metastatic disease. Letrozole was used for one patient in the palliative setting. The median overall survival durations were 7.2 years (range, 0.6 to 17.0 years) in patients with localized disease and 2.9 years (range, 0.6 to 4.3 years) in those with recurrent or metastatic disease. Conclusion Anti–HER-2 and hormonal therapy, except tamoxifen, have been underutilized in Korean MBC patients compared to female breast cancer patients. With the development of precision medicine, active treatment with targeted agents should be applied. Further investigation of the unique pathobiology of MBC is clinically warranted.

환경공해와 신 농업기술

홍지형 한국농업기계학회 1993 바이오시스템공학 Vol.18 No.4