Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

사회복지사의 기업복지 유형이 삶의 질과의 관계에서 직무몰입의 조절효과

김효선(Kim, Hyo-Seon),조주복(Cho, Joo-Bog) 한국경영교육학회 2020 경영교육연구 Vol.35 No.2

[연구목적] 본 연구는 사회복지시설에 종사하는 사회복지사의 직무몰입과 삶의 질의 향상을 위한 선택적 복지제도의 정착에 대한 기초자료를 제공하여 사회복지국가 발전에 기여하는데 그 목적이 있다. [연구방법] 본 연구의 자료 수집은 대구 · 경북지역 사회복지사를 대상으로 총 300부 설문지를 배분하여 이 중 298부를 분석 자료로 활용되었다. 실증분석을 위해 요인분석, 신뢰도분석, 분산분석, t-test, ANOVA분석, SAS 등을 이용하였다. [연구결과] 첫째, 기업복지유형에 따른 선택적 복지제도가 직무몰입에 미치는 영향을 검증한 결과, 유의한 차이가 없어서 기각되었다. 둘째, 기업복지유형과 사회복지사의 삶의 질과의 차이 검증 결과, 통계적으로 유의미한 차이가 없는 것으로 나타났다. 셋째, 기업복지의 유형과 삶의 질과의 관계에서 사회복지사의 직무몰입의 조절효과를 검증한 결과, 통계적으로 유의한 조절효과가 있는 것으로 나타났다. [연구의 시사점] 본 연구는 사회복지사의 기업복지유형에 따른 선택적 복지제도는 삶의 질과의 관계에서 직무몰입이 조절효과가 있는 것으로 나타났다. 따라서 사회복지시설에서 선택적 복지제도 정착에 필요한 직무교육프로그램을 개발하고 예산편성에 반영하여 사회복지서비스를 향상시켜야 할 것이다. [Purpose] The purpose of this study is to contribute to the development of the social welfare state by providing basic data on the corporate welfare types for the improvement of job quality and quality of life of social workers in social welfare facilities. [Methodology] The data collection of this study was divided into 300 questionnaires for social workers in Daegu and Gyeongbuk, and 298 of them were used as analytical data. Factor analysis, reliability analysis, analysis of variance, t-test, ANOVA analysis, SAS were used for the empirical analysis. [Findings] First, as a result of verifying the effect on job commitment according to corporate welfare type, it was rejected because there was no significant difference. Second, as a result of verifying the difference between the corporate welfare type and the social worker’s quality of life, there was no statistically significant difference. Third, as a result of verifying the moderating effect of job involvement of social workers in the relationship between the type of corporate welfare and the quality of life, there was a statistically significant moderating effect. [Implications] This study found that job involvement had a moderating effect on the social worker’s corporate welfare type in relation to quality of life. Therefore, the social welfare service should be improved by developing job training programs necessary for the Cafeteria Plan in social welfare facilities and reflecting them in budgeting.

국내외 저명학술지에 발표된 무작위대조연구 초록의 질적 연구

김효선,김은영 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-

In this study, the quality of reporting the Randomized Controlled Trial (RCT) abstracts was investigated. It was compared between abstracts in four major Korean medical journals, covered by SCI(E), and in the New England Journal of Medicine (NEJM), the most cited medical journal in 2010 (IF=53.484), published from 2007/01 to 2011/06. There were 57 abstracts in Korean SCIs and 50 in NEJM included in the investigation; among them, three from Korean SCIs and one from NEJM were excluded. A modification of CONSORT for abstract was used as criteria, including 16 checklist items. The conformity of the abstracts to each item was assessed, and the χ2 (chi-square) analysis was used to analyze the significance of difference between the two. As a result, the two groups of journals were statistically equivalent in six items; Korean journals were significantly better in two items, and NEJM were in eight. In conclusion, the quality of reporting of RCT abstracts was better in general in NEJM than in Korean SCIs. This does not mean the full RCT reports of NEJM are superior to that of Korean SCI; rather, it highlights the need for Korean journals to adopt the CONSORT for abstracts in reporting of RCT in abstracts.

유산소 리듬 운동프로그램이 노인의 혈압, 심박수 및 생활만족도에 미치는 효과

우선혜,김효정,박영숙 대한보건협회 2001 대한보건연구 Vol.27 No.3

The purpose of this study was to test the effects of aerobic rhythmical exercise program on blood pressure, pulse and the life satisfaction of the elderly. This quai-experimental study was designed as a non-equivalent control group pretest-posttest study. The subjects were 36 subjects(experimental group: 19 subjects, control group: 17 subjects), aged between 65 and 73 years who have normal cognition, sensory function and cerebellum function. Aerobic rhythmical exercise program was developed on the basis of aerobic exercise, Korean tradititional dance and music by the author. The blood pressure, pulse rate and life satisfaction were measured prior to and following the experimental treatment. Data were analyzed with x^2-test, t-test, mean, standard deviation, percentage of change and ANCOVA test using SAS program. The results were as follows. 1. There was no significant difference of systolic blood pressure between experimental and control group following the aerobic rhythmical exercise program(F=1.39, P=0.247). 2. The diastolic blood pressure of the experimental group was significantly lower than that of control group following the aerobic rhythmical exercise program(F=2.96, p<0.1). 3. There was no significant difference of resting heart rate between experimental and control group following the aerobic rhythmical exercise program(F=0.07, P=0.793). 4. The life satisfaction of the experimental group was significantly higher than that of control group following the aerobic rhythmical exercise program(F=9.94, p<0.01). On the basis of the above findings, aerobic rhythmical exercise program is effective in reducing diastolic blood pressure and promoting life satisfaction of the elderly. Thus, this program can be recommended as an effective nursing intervention for the elderly.

컴퓨터의 키보드와 마우스, 휴대폰, 자판기 음료캔 표면에서의 미생물 오염 분석

황선영,장효원,오계헌 순천향대학교 기초과학연구소 2001 순천향자연과학연구 논문집 Vol.7 No.2

We investigated the degree of microbiological contamination about keyboard and mouse of computer, cellular phone, and surface of can of drinks clooected from vending machine. In this study, it showed that keyboard and mouse of computer in PC game room, cellular phone, and the surface of can of drinks from vending machine were contaminated by various microorganisms. In the case of keyboard and mouse of computer, various kinds of bacteria and fungi including Staphylococcus aureus, Staphyolcoccus epidermidis, Streptococcus mitis, streptococcus salivarius, Escherichia coli, Enterobacter sp., β- hemolytic Bacillus, Pseudomonas sp., salmonella sp., Candida sp. were isolated on solid selective media. keyboards and mouses of computers in PC game rooms located nearby hospitals showed higher contamination than those of PC game rooms located around colleges or apartments. In the case of cellular phone and phone in the office, the results were quite similar to the previous work. Cellular phone was more contaminated than phone in the office. Many bacteria and fungi were distributed on the surface of can of drinks collected from vending machine. Cans from vending machines located near hospitals were proven to be more contaminated. fungi were isolated predominantly. As the results, we confirmed that keyboard and mouse of computer, cellular phone, and the surface of can of drinks collected from vending machine were seriously contaminated by various microorganisms.

特用資源植物의 硏究 : 한국임학회지에 게재된 논문을 중심으로 Based on the Articles Published in the Journal of Korean Forestry

이재선,김철우,배찬호,송재모,강효진,황석인,문흥규 江原大學校 森林科學硏究所 2003 Journal of Forest Science Vol.19 No.-

한국임학회지 (1962년의 1호~2002년의 91권 6호)에 게재된 특용자원식물 관련 논문에서 식·음용식물, 약용식물, 사료식물, 조경식물, 섬유식물, 산업용식물 및 밀원식물로 분류하고 그 내용에 따라 입지환경, 생태, 생리, 번식, 조림(또는 무육, 재배), 유전·육종, 분류(또는 식별), 병·충해와 방제, 동물피해와 방제, 성분분석, 식생정보, 생물공학, 경영·경제 및 총설로 나누었다. 총 1,434편의 발표 논문 중 유용식물자원을 대상으로 한 논문은 27.6%를 차지하는 396편이었고, 내용은 식생정보 60편(15.2%), 생리 56편(14.1%), 유전·육종 56편(14.1%), 번식 53편(13.4%) 및 생태 37편(9.3%)이었다. 조림(무육·재배)은 11편(2.8%)으로 특용자원식물의 규모경영이 이루어지지 않고 있음을 시사하고 있으며, 이것은 경영·경제 분야가 6편(1.5%)인 것과 맥을 같이 하고 있었다. 연구대상 식물은 잣나무(42편), 아까시나무(23편), 밤나무(14편) 및 은행나무(14편) 순으로 높았고, 이 식물들과 관련한 연구내용은 번식, 생리, 유전·육종, 생태 및 병·충해 순이었다. 연구의 목적, 내용, 결과 및 대상식물 등을 고려하여 보면, 1) 초본식물에 대한 보다 많은 연구, 2) 타산업 또는 학분 분야와의 공동연구, 3) 자원 보전적 연구 및 4) 연구주체자 간의 연구결과의 공유 등이 매우 요망된다. The articles, published in the Journal of Korean Forestry from Number 1(1962) to number 6, Volume 91(2002), were surveyed and investigated for the research trend analysis about resource-plants for special use or purpose, i.e edible plants, medicinal plants, feed resource, landscape plants, fiber plants, industrial usage, and bee plants. If the purpose or subject matter of the research was construction or furniture timber production, mushrooms and/or pulp and Paper, such research was not included in this study. These articles were classified again depending on the content of research into 14 categories : habitat environment, ecology, physiology, propagation, silviculture(tending and culture), genetics and breeding, identification, insect and disease control, animal-related research, cemponent analysis, vegetation survey, biotechnology, management, and review. Among the total 1,434 articles published, 396 ones (27,6%) were related with plants for special use or purpose. Vegetation survey was 60(15.2%) ; physiology 56(04.1%) ; genetics and breeding 56(14.1%) ; propagation 53(13.4%) ; and ecology 37(9.3%). Siviculture research field included 11 articles (2.8%), which indicates that the management of resource-plants is to far from economic income as seen in the low number of management research filed articles, i. e., only 6 reports(1.5%). Korean white Pine was most popular for research and included 42 articles ; Robinia pseudoacacia 23 Castanea crenata 14 : and ginkgo tree 14, Research related with these species had focused mainly or propagation, physiotogy, genetics and breeding, ecology and pest control. Based on this survey and analysis, the followings are suggested : 1. More research is required on forest herbaceous plants. 2. Cooperative research work with other industrial and/or scientific area is recommendable for commercialization including medicine, cosmetics, and food etc. 3. Research resource-plant conservation. which includes biology, social education and policy, should be supported for next generation. 4. Mutual correspondence and information exchange about the research results between researchers and institutes is more necessary than now.

인용구문'-다고 하는'과 '-다는'의 특성

김선효 서울대학교 언어교육원 2004 語學硏究 Vol.40 No.1

The two goals of this thesis are to ascertain syntactic and semantic differ- ences between '-dako hanin' and '-danin' of the Korean quotation construction markers and to reveal that '-danin' can be a syntactic unit after grammaticalizational processes. First of all, we examined that '-danin' was abbreviated into '-dako hanin' synchronically.'-dako hanin' combines with the compliment head noun, which have communicative meanings. Second, the semantic meaning of '-dako hanin' has an indirectness of the statements, '-donin' has probability of the statements. Third, '-danin' can be one of the adnominal endings in Korean, because '-danin' and adnominal ending'-(i)n' have same syntactic phenomena.

초등학교 학생들의 공기에 대한 선개념 조사

조선형,유효진 청주교육대학교 과학교육연구소 2001 科學과 數學敎育論文集 Vol.22 No.-

The preconception is socalled the naive theories was made according to the general experience, direct investigation, wrong explanation on textbook or bibliography material and different of culture. By Champagne and klopfer(1983) find out that the preconception are latent in those blains long time, so they cause serious influences to the general teaching method without special healing. The researches on the air unit in primary school are first, the concept of air volume and its weight, secondly the difference of concepts between urban and local area, and third the distinction of sex. In this work, there are formed preconception in the third grade children primary school, urban children thought are more than local, and last male children have more right thought than female both urban and local area.

韓國 經濟成長과 에너지 資源의 需給 政策에 관한 小考

李孝善 檀國大學校 地域硏究所 1986 地域硏究 Vol.7 No.-

자기성장 집단상담이 초등 특수학급 아동의 자아개념에 미치는 효과

임효선 이화여자대학교 교육대학원 2003 이화교육논총 Vol.13 No.-

This study is to investigate the effect of the self-growth group counseling which was regarded to have an effect on formation of positive self-concept, and the members of the group are the students in special classes in an elementary school. The subject for this study is as follows. Does the experiment group show more effect in group counseling than the control group in terms of the self concept? The research hypotheses: The hypothesis : After executing the self-growth group counseling, the self concept of the experiment group will be increased significantly more than that of the control group. 1-1 The physical self concept of the experiment group will be increased significantly more than that of the control group. 1-2 The social self concept of the experiment group will be increased significantly more than that of the control group. 1-3 The human nature self concept of the experiment group will be increased significantly more than that of the control group. 1-4 The academic self concept of the experiment group will be increased significantly more than that of the control group. This study was carried out with two groups which were experiment group and control group. The experiment group was composed of 10 students from the special classes in 3rd, 4th, 5th, and 6th grade in one elementary school, and the 10 students of control group were chosen from the special classes in the same grades in the other elementary school. For the experiment group, the program was put into practice 15 times for 50-70 minutes twice a week. In the other hand, for the control group, regular lessons from the normal curriculum were provided. The Self-Concept Test was used as tools, which was developed by Yun, Hee Jun(1984), and revised by Thae, Moung Wha(1998). The result of this study is analysed by t-test using SPSS/PC+Windows(ver 10.0) program. In addition to the statistical analysis, the Sentence Completion Test was used and analyzed. And The Self Concept Test was used again to measure how the changed self-concept is being maintained. The summary of the results is as follows. First, it was shown that the self-growth group counseling is to facilitate the growth of children's self -concept in special classes in an elementary school. Second, it was shown that the self-growth group counseling is effective in formation of physical self concept, a social self concept, a human nature self concept and a academic self concept. Like the above, the results indicate that the self-growth group counseling is effective for the formation of the children's positive self concept in special classes in an elementary school. The restriction of this research is as follows: first, all the members for the groups were chosen as the students with reading comprehension ability. Therefore, it is difficult to generalize this results to all students in general special classes. Second, the students in special classes have tendency of lack in cognitive and social sensitiveness. Nevertheless, this study is only based on the self-report without another-person evaluation. Therefore, this study has some limits in this point Based on the results of this study, the suggestions are as follows. First, most researches were executed with the normal students, and the researches for special children are scarce. Consequently researches on the special children should be done more. Second, it is said generally that special children's self concept is lower than the normal children according to many scholars. Therefore, it will be necessary to compare the difference in effectiveness of the group counseling between special children and normal children. Third, in general special children's family situations are poor, so it is necessary to provide family counseling or social welfare program for them. Finally, this program needs to be applied widely for improving special children's self concept in special classes.