입원 기간 중 발생한 첫 경련발작

이훈복,김종흥,김제,이애영,김재문 대한신경과학회 1997 대한신경과학회지 Vol.15 No.2

^(7)Li, ^(87)Rb과 ^(27)Al NMR을 이용한 (K_(1-x)Li_(x))_(2)SnCl_(6), (K_(1-x)Rb_(x))_(2)SnCl_(6)와 K_(2)SnCl_(6):Al^(3+)의 상전이 근처에서의 결정 동력학 연구

김복수,김영훈,강재필,백아영,차유정,김민경,서용문,송승기 명지대학교 자연과학연구소 2004 자연과학논문집 Vol.23 No.-

K_(2)SnCl_(6)는 antifluoride계에 속하는 결정으로서 K_(2)SnCl_(6)에 Li^(+)를 첨가하여 ^(7)Li 핵자기공명(NMR)을 측정하여 동형(isomorphic) 혼합결정(K_(1-x)Rb_(x))_(2)SnCl_(6)와 비동형(nonisomorphic) 혼합결정 K_(2)SnCl_(6):Al^(3+)에서의 핵자기공명(NMR), ^(87)Rb NMR과 ^(27)Al NMR의 측정값과 비교하였다. Rb^(+) 이온은 K_(2)SnCl_(6)의 K^(+)이온을 대신해 동형 결정을 이루며, Al^(3+)이온은 Sn^(4+)이온을 대치하면서 비동형 결정을 이루는데 Li^(+)이온 또한 K^(+)이온을 대신하는 동형 혼합결정과 유사한 결과 값을 얻을 수 있었다. 이 연구 결과는 종래의 Cl-NQR 연구 결과와 비교함으로서 K_(2)SnCl_(6)의 동력학적 특성과 구조 상전이 근처에서의 임계현상을 새로운 관점에서 볼 수 있는 가능성을 보여주었다. ^(7)Li, ^(87)Rb and ^(27)Al NMR have been investigated in the isomorphic and nonisomorphic impurity doped crystals (K_(1-x)Li_(x))_(2)SnCl_(6), (K_(1-x)Rb_(x))_(2)SnCl_(6) and K_(2)SnCl_(6):Al^(3+) as a supplementary to the previous Cl NQR studies in these crystals. The results yielded that the features of NMR spectra for both types of crystals are roughly in line with the systematic trends shown in the Cl NQR in these crystals, though the outstanding characteristics exhibited in the Cl NQR become in the case of the NMR of the doped impurities in crystals somewhat weakend. This is due to the degradation of the role of the local field from the main hamiltonian in NQR to the subsidiary in NMR. Each NMR result of the iso/nonisomorphic crystals has been analyzed in terms of the 'impurity induced dynamic lattice defects' for K_(2)SnCl_(6):Al^(3+) and the 'static primary impurity effects' for (K_(1-x)Rb_(x))_(2)SnCl_(6) and (K_(1-x)Li_(x))_(2)SnCl_(6) respectlvely.

국내 설사환자로부터 분리된 Escherichia coli 균의 혈청군 및 Verocytotoxin 생성능

김호훈,강연호,김성한,박미선,유재연,이복권 대한감염학회 1998 감염 Vol.30 No.5

목적: 국내 설사 환자에게서 분리 동정된 인체 감염 유래 E. coli 균의 혈청군, verocytotoxin 생성능을 구명하여 EHEC 균의 인체 감염 실태를 구명하고, 동물 및 식품 유래 분리균주의 성상과 비교 검토하여 인체 감염 위험성에 대한 기초적 자료를 의학계에 제공하고자 하였다. 방법: EHEC 감염의심 설사 환자 분변 검체로부터 분리된 균주 중 생화확적 성상에 따라 대장균을 분리하였고 이들 균주 중 E. coli O157:H7를 분리하기 위해서는 Dsorbitol 음성균을 선별하였으며, 분리균에 대하여 항혈청으로 응집 시험을 실시하여 혈청군을 구명하였다. 혈청군이 확인된 균주에 대하여 중합효소 연쇄반응 (PCR) 및 역수동라텍스 응집시험 (Reversed Passive Latex Agglutination:RPLA) 으로 verocytotoxin 생성능을 구명하였다. 결과: 장출혈성 대장균 감염 의심설사 환자의 분변검체로부터 25주의 E. coli 균을 분리 동정하였으나 이들 균주는 모두 verocytotoxin을 생성하지 않았다. 분리 동정된 대장균으로부터 확인된 혈청군은 16종으로서 E. coli O1, O6, O8, O15, O20, O25 O26, O28, O29, O44, O86a, O119, O126, O128, O152, 및 O157:H-였으며 E. coli O157:H-혈청형 균주와 E.coli O25 혈청군 균주가 각각 3주씩 분리되어 비교적 높은 분리율을 보였다. 결론: 장출혈성 대장균 감염 의심설사 환자 분변 가검물로부터 총 25주의 E. coli균을 분리 동정하였으나 verocytotoxin을 모두 생산하지 않았다. Background: Since 1982, many countries has reported outbreaks or sporadic cases caused by enterohaemorrhagic Escherichia coli (EHEC) serogroup strains, mainly E. coli O157:H7 type strain. However, systemic investigation about EHEC agents, including E. coli O157:H7, have not been done in Korea. Therefore, we investigated serogroup and verotoxin productivity of E. coli strains isolated from diarrheal patients and estimated risk of human infection in comparison with EHEC strains isolated from cow, pig, and food material in Korea. Methods: Diarrheal patient stool samples were collected and E. coli strains were isolated, according to biochemical characteristics. In order to isolate E. coli O157:H7, D-Sorbitol negative strains were selected. Serogrouping of the E. coli isolates was done by agglutination test. Verocytotoxin productivity was investigated by polymerase chain reaction (PCR) and reversed passive latex agglutination (RPLA). Human infection risk was estimated in comparison with EHEC strains isolated from cow, pig and food materials in Korea. Results: Twenty-five E. coli strains were isolated from the diarrheal patients who were suspected to be infected with EHEC. However, none of these E. coli strains produced verocytotoxin. Out of 25 E. coli isolates, 16 serogroups of E. coli O1, O6, O8, O15, O20, O25, O26, O28, O29, O44, O86a, O119, O126, O128, O152 and 157:H-were found. In each of the E. coli O157:H-and O25 serogroups 3 strains were found. Conclusion: None of 25 E. coli isolated from diarrheal patients who were suspected of EHEC infection produced verocytotoxin producing E. coli have been reported recently in Korea.

두경부 유리피판 26례 분석

정복성,윤근철,심경보,고경석,한상훈 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.3

Twenty four patients(21 males and 3 females) aged 14 to 70 years underwent 26 microvascular free tissue transfers in head and neck reconstructions from April 1990 to July 1992 (27 months) . Nineteen cases were tumors in head and neck area, and four were acquired deformities such as burn alopecia, burn scar contracture of the neck, Romberg disease and frontal sinus infection, and one was hemifaclal microsomia. The free flaps were executed successfully in 15 upper aerodigestive tracts, in 2 scalps and 3 skull bases and in contouring and resurfacing six facial and cervical lesions. The selection of donor site was bases upon the location of defect and the volume of tissue required : the forearm free flap was used in 11 cases, the rectus abdominis in 5, the groin in 2, the jejunum in 2, the occipital scalp in one, the first toe web space in one, the latissimus dorsi in one, the serratus anterior in one, the parietotemporalis fascia in one and the omentum in one. The free tissue transfers were primarily indicated in all patients in our series and there was no flap failure. The complications were minimal and the morbidities low. A free flap in the head and neck area is not only the most expedient method of reconstruction but also either the most reliable or the only available one in some clinical situations.

수컷 생쥐의 정자두부 미세구조에 대한 Chlorambucil의 영향

김덕훈,고복현 동국대학교 2007 慶州大學論文集 Vol.9 No.-

Generic BOM에서의 미입력 파라미터에 관한 연구

김훈태,이영복 대진대학교 생산기술연구소 2000 생산기술연구소 논문집 Vol.3 No.-

The adaptation of the range of products within an enterprises to the today customers demands results in an exploding number of different variant parts and variant bills of material. The mentioned problem can be solved from representing one general BOM for all product variants. That is, Generic BOM includes explaining variants of components. Each variant is represented as a pair of parameter and value. When there are unknown parameter values, this paper explains the methodology for mentioned problem, describes problems, types and specifications owing to existence of unknown parameters. If one more unknown parameter values are exited, determining handling orders of unknown parameters is cause of a different result BOM and constraints to still unknown parameter values, So this paper represents a method for handling order of unknown parameter values. The method is composed of two steps. First step is use of inclusion rule, and second step is exclusion rule. The final specification is the result of the decision of BOM administrator. This paper is expected to reduce laborious work of BOM administrator 주요기술용어 : Generic BOM, unknown parameter value(미입력 파라미터), rule(규칙), specification(명세)

수컷 생쥐의 정자두부 미세구조에 대한 Chlorambucil의 영향

김덕훈,고복현 동국대학교 경주대학 1990 論文集 Vol.9 No.-

The study was carried out to investigate the effect of Chlorambucil on the mouse sperm head by electron microscopy. Chlorambucil was injected intraperitoneum at a dosage of level 16mg/kg for one weeks, 3weeks and 5weeks, respectively. The result obtained were as follows 1. One week after the administration, Most plasma membrane of late spermatid were swollen and dilation. and the acrosomal membrane was normal. 2. After 3 weeks, the condensation of nucleus was presented at some late spermatids. The nucleus membrane was mostly loss, But the dilation of nucleus membrane was partly observed. The acrosome and the plasma membrane was mostly disrupted. 3. After 5 weeks, most nucleus membrane, acrosome membrane, acrosome, and necleus membrane were severely disrupted. The nucleus was severely condensed and the shape of nucleus was very queer. But, in some late spermatids, the heterochromathin was observed. The membrane whorl in acrosome region was presented at some late spermatids.

충주시 농촌지역 주민들에 대한 보건교육 평가

권복규,양준호,송진범,이건세,이원진,장성훈 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

The aim of this study was to evaluate the effect of health education program in Choongju rural area which had conducted by Public Health Doctor during winter in 1994 and 1995. We used two step sampling method for a household survey. First, six were selected from 12 Myuns, which were stratified by the level of health education activity. Second, we applied convenient sample method. Of the 307 respondents, most of them knew Health-subcenter's existence in their region. However, only 149 persons(45%) visited it during last year. They visited Health-subcenter because it was easy to travel and convenient. Some of them thought that Health-subcenter had very poorly equipped and supplied. About 32∼34% of respondents participated the health education program for hypertension and diabetes mellitus which was done last winter, and 59∼70% of participants of the program answered that it was very, moderately helpful. 82∼83% of participants recognized complications of hypertension and diabetes mellitus, and 18∼20% of them did not know that medications of hypertension and diabetes mellitus should be continued one's whole life. The respondents want to receive health educations for cancer, arthritis, viral hepatitis and AIDS in orders. Many of rural residents utilize Health-subcenters because health clinics in Choongju rural area are very few.

고용량 및 저용량 ticlopidine의 혈소판 응집억제 효과 비교: 예비연구

김제,이훈복,송희정,이태용,김재문 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

지속형 항응고성 살서제 중독에 기인한 뇌실질출형 1예

양충용,이진훈,이서울,정복희,노상균,신용일 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

저자들은 brodifacoum성분의 지속형 효과를 갖은 항응고제인 쿠마린계 살서제를 정확한 용량을 추정할 수는 없지만 다회의 약물 복용 17일 후 뇌실질출혈이 발생한 증례를 문헌 고찰과 함께 보고하는 바이다. 지금껏 쿠마린계의 지속형 항응고성 살서제의 약물 중독이 알려져 있다. 이러한 약물은 vitamin K₁ 2,3-epoxide 환원효소를 억제하여 vitamin K₁과 연속적으로 vitamin K₁ 의존성 응고인자 Ⅱ, Ⅶ, Ⅸ, Ⅹ의 합성을 억제하고 이로써 출혈 경향을 증가시킨다. 이 증례를 토대로 향후 출혈성 환자 특히 선행 질환이 없는 젊은 뇌실질출혈 환자에서 원인을 감별진단 함에 있어 환자의 약물 중독 가능성과 치료에 대한세심한 주의가 필요할 것으로 생각한다. Spontaneous intracerebral hemorrhage is one-tenth of all strokes and represents relatively high frequency and morbidity. Hypertension is the most common cause of spontaneous intracerebral hemorrhage and other causes are vascular malformation, intracerebral amyloid angiopathy, hemorrhagic infarction, blood diseases and drug abuse. Some peoples have the intoxication of drug such as long-acting anticoagulant of rodenticides, family of cumarin, that inhibit vitamin K₁ 2,3-epoxide reductase, the synthesis of vitamin K₁ and subsequently vitamin K₁ dependent clotting factors Ⅱ, Ⅶ, Ⅸ, and Ⅹ. Finally these make prolonged PT, INR and aPTT, which are prone to trigger bleeding tendency. We report a rare case of intracerebral hemorrhage maybe caused by after frequent intended ingestion of long-acting anticoagulant rodenticide(brodifacoum) for suicide.