성인에서 Nutcracker Syndrome의 임상양상

노미오 ( Mi Oh Roh ),최수정 ( Soo Jeong Choi ),최은숙 ( En Suk Choi ),신현주 ( Hyun Joo Shin ),박무용 ( Moo Yong Park ),김진국 ( Jin Kuk Kim ),황승덕 ( Seung Duk Hwang ),박성진 ( Seong Jin Park ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.2

목적: 성인에서 Nutcracker 증후군의 임상상과 경과를 알아봄으로써 진단과 예후 판단에 도움을 주기 위해 본 연구를 시행하였다. 방법: 2003년 8월부터 2006년 8월까지 순천향대학교 부천병원에서 Nutcracker 증후군을 진단받은 15세 이상 성인 환자 22명을 대상으로 임상기록 및 검사 소견을 후향적 방법으로 분석 하였다. 결과: 진단 당시 연령은 평균 24.0±12.0세 (15-59세)였고, 남자가 13명 여자가 9명이었다. 총 22명 중 20명이 혈뇨를 주소로 내원하였다. 그 외 증상으로 배부통 7명, 요통 2명, 복통 2명, 거품뇨 3명, 체중감소 1명, 그리고 피로감이 1명에게서 동반되었다. 요검사에서 현미경적 혈뇨는 18명, 단백뇨와 혈뇨 모두 있는 경우는 6명, 고립성 단백뇨가 1명이었으며, 3명의 소변은 정상이었다. 24시간 소변검사를 시행한 10명의 단백뇨는 평균 496.3±387.5 mg/일이었다. 도플러 초음파로 17명, 복부 컴퓨터 단층촬영으로 8명, 혈관 조영술로 1명이 진단되었다. 초음파로 측정한 좌신문 부위와 대동맥 상장간동맥 부위의 좌신정맥 혈관 직경비는 평균 8.25±3.05이고, 협착 부위와 확장 부위의 평균 혈류 속도비는 평균 6.09±1.47이었다. 신 생검을 시행한 3명의 환자의 조직소견은 각각 막성 사구체염 1명, IgA 신병증 1명, 정상이 1명이었다. 평균 9.9±7.9개월을 추적한 8명의 환자 중, 1예에서만 혈뇨가 호전되었다. 결론: 성인의 Nutcracker 증후군은 혈뇨 이외의 증상이 호발하며, 단백뇨를 보일 때는 사구체 신염의 동반 가능성도 배제해야 한다. Purpose: This study was designed to aid the diagnosis and predict the prognosis of Nutcracker syndrome in adults by understanding its clinical course. Methods: We reviewed the records of 22 adult patients diagnosed with Nutcracker syndrome from August 2003 to August 2006 at Soonchunhyang university Bucheon hospital. Results: The mean age was 24.0±12.0 years (15-59) including 13 males and 9 females. Twenty of 22 patients visited our hospital due to hematuria. Combined symptoms were flank pain (7 patients), back pain (2), abdominal pain (2), foamy urine (3), weight loss (1) and fatigue (1). Urine analysis showed hematuria (18 patients), isolated proteinuria (1), combined form (6), and normal findings (3). The mean level of proteinuria was 496.3±387.5 mg/d. Patients were diagnosed by doppler ultrasonography (17), abdominal computed tomography (8), and renal angiography (1). The mean ratio of the anterioposterior diameter of the left renal vein (LRV) between the hilar portion and the aortomesenteric (AM) portion was 8.25±3.05. The mean peak velocity ratio in the LRV between the AM and hilar portion was 6.09±1.47. Renal biopsy was done in the 3 patients with proteinuria >500 mg/day, and revealed membranous glomerulonephritis, IgA nephropathy and normal finding, respectively. Eight patients were followed up in 9.9±7.9 months. Only 1 patient showed improvement of hematuria. Conclusion: In the adults with Nutcracker syndrome, other symptoms beyond hematuria occurs. And when proteinuria is presented, the possibility of combined glomerulonephritis must be avoided.

연령관련황반변성에 의한 맥락막하신생혈관에서 광역학치료와 유리체강내 스테로이드주입술의 치료효과

오현섭,노미인,오상준,이성철,이원영,권오웅,Hyun-Sub Oh,M,D,Mi-In Roh,M,D,Sang-Joon Oh,M,D,Sung-Chul Lee,M,D,Won-Young Lee,M,D,Oh-Woong Kwon,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.8

Purpose: To evaluate the safety and visual outcome of intravitreal triamcinolone acetonide combined with photodynamic therapy for subfoveal choroidal neovascularization in patients with age-related macular degeneration. Methods: We evaluated 32 eyes of 32 patients with choroidal neovascularization due to age-related macular degeneration. The study group received photodynamic therapy and intravitreal triamcinolone acetonide (combined group), while the control group received photodynamic therapy only (PDT group). Results: Three months after treatment, no difference was detected between the two groups in visual acuity changes (p>0.05), but the leakage in fluorescein angiography and macular edema in optical coherent tomography decreased (p<0.05) in the combined group. The retreatment rate in the combined group (6.0%) after 3 months was lower than that of the PDT group (53.3%). Conclusions: Photodynamic therapy with intravitreal triamcinolone acetonide to choroidal neovascularization reduced the retreatment rate at 3 months significantly. These results may have been be due to the short-term anti-inflammatory effect of steroids.

교사들의 반성적 글쓰기를 통해 본 배움중심수업의 특징과 의미

남미자 ( Mi Ja Nam ),길현주 ( Hyun Joo Ghil ),오춘옥 ( Chun Ock Oh ),노시구 ( Si Ku Roh ) 한국사회과교육학회 2014 시민교육연구 Vol.46 No.1

본 연구의 목적은 배움중심수업을 실천하는 교사들의 반성적 글쓰기를 통해 배움중심수업의 특징과 의미를 이해하는 것이다. 경기도 교육청에서는 학교혁신의 방향으로 수업혁신을 꼽았고, 수업혁신의 청사진을 배움중심수업으로 구체화하고 있다. 그러나 배움중심수업은 특정한 수업 방법이나 일정한 매뉴얼을 가진 수업이 아니기 때문에 현장의 교사들이 배움중심 수업을 개념적으로 또는 실천적으로 이해하는 데 어려움을 겪고 있는 상황이다. 본 연구에서는 배움중심수업을 실천하고 있는 초.중.고등학교 교사 39명의 반성적 글쓰기 자료, 수업관찰, 초점집단면담 자료를 분석하여 배움중심수업의 특징과 의미를 드러내었다. 배움중심수업의 특징은 다음과 같다. 첫째, 배움중심수업 실천교사들은 교실을 역동적 공간이라고 이해하고 있었다. 교사가 수업을 설계하나 교사의 수업 의도와 설계 그대로 학생들이 배움을 경험하지 않고 있으며, 학생들은 자신들의 방식대로 배움을 스스로 만들어가고 있었다. 둘째, 교사들은 수업에서 교과서나 학습 내용을 가르치기 앞서 관계성에 주목하고 있었다. 학생들에게 배움이 일어나기 위해서는 교사와 학생간의 관계, 학생과 학생간의 신뢰와 협력의 관계가 선행되어야 하며, 교사들은 수업에서 이러한 관계를 만들기 위해서 수업 밖에서 교사와 교사 간의 신뢰와 협력을 경험해야 함을 강조하고 있었다. 즉 수업 내의 관계성은 수업 밖의 관계성에 기반하고 있음을 이야기하고 있었다. 셋째, 배움중심수업 실천 교사들은 배움이 수업 시간에 하는 학습 활동으로 끝나지 않고, 학생들의 구체적이고 일상적인 삶으로 이어지길 바라고 있었다. 배움중심수업에서의 배움은 교과서에 갇혀있지 않고 학생들의 구체적인 삶과 연결되어 지속적으로 새롭게 탄생하고 있었으며, 교사들은 수업에 대한 성찰을 통해 자신의 삶을 성찰하게 되었고, 이를 바탕으로 교사도 함께 성장하고 있었다. 본 연구를 통해 교사, 학부모, 학생들이 배움중심수업을 이해하는 데 도움이 되고, 특히 수업혁신과 관련한 실천적 실마리를 얻을 수 있기를 기대한다. The purpose of this study is to understand the feature and meaning of Learning Oriented Class through teachers` reflective writing. Gyeonggi Provincial Office of Education push forward to reform class for school reform and the key point of reforming class is the Learning Oriented Class. But Teachers have difficulties in practicing Learning Oriented Class because it is not the method of teaching or manual. This study conducts a qualitative study, adopting reflective writing, on 39 teachers at primary schools, middle schools and high schools. As a result of these analyses, following have appeared as key findings. First, the teacher recognized classroom as dynamic space of unpredictability. Second, teachers pay attention to the relationship between teachers and students. The confidential relationship between teachers and students, students and students must be preceded to students` learning. The such confidential relationship between teachers and students is based on the relationship of the outside class. Third, teachers recognized learning not activities in a classroom but activities in students` daily life. Therefore learning is not tied up knowledge of school subject, but newly borned as connecting students` life. Also teachers are growing by introspecting their life. Through this study teachers can find the clue to improve their class and we expect that teachers, parents, and students can understand the Learning Oriented Class.

공중 유·무인복합체계 개발동향 및 발전방안

김미선(Mi-Seon Kim),노유찬(Yu-Chan Roh),오주영(Juyoung Oh) 한국항공우주학회 2021 한국항공우주학회 학술발표회 논문집 Vol.2021 No.11

Thioacetamide로 유발한 간손상 모델에서 계혈등(鷄血藤)의 간보호 효과

오민혁 ( Min Hyuck Oh ),신미래 ( Mi-rae Shin ),노성수 ( Seong-soo Roh ) 대한본초학회 2021 大韓本草學會誌 Vol.36 No.2

Objectives : This study was undertaken to investigate the hepatoprotective effect of Spatholobi Caulis water extract (SC) to thioacetamide (TAA)-induced acute liver injury (ALI) in rats. Methods : The rats were injected intraperitoneally with TAA (200 ㎎/㎏ body weight) and orally administered SC (100 or 200 ㎎/㎏ b.w.) daily for 3 days. Liver biomarkers were assessed by serum glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and ammonia levels. Malondialdehyde (MDA) was measured both serum and liver tissue. In addition, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, anti-oxidant, and inflammation-related proteins were investigated by western blot analysis. Histological examination further confirmed though hematoxylin and eosin stain. Results : The SC treatment reduced liver function markers like GOT and GPT and also remarkably decreased ammonia level. Moreover, the elevated MDA level in TAA-induced group was significantly reduced by SC treatment. NADPH oxidase expression associated with oxidative stress including NOX2, NOX4, and p47^phox markedly inhibited by SC administration. SC treatment exerted anti-oxidant effect through the increase of anti-oxidant enzyme including superoxide dismutase (SOD), Catalase, and heme oxygenase-1 (HO-1). The protein expressions of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), IL-6, and IL-1β induced by nuclear factor-kappa B (NF-κB) activation were modulated through blocking the phosphorylation of inhibitor of nuclear factor κBα (IκB)α. SC treatment also improved histological alterations. Conclusion : These findings suggested that SC administration may be a potential candidate for the prevention or treatment of ALI.

증례 : 급성 A형 간염 후 발생한 전격성 제1형 당뇨병 1예

권지연 ( Ji Yeon Kwon ),노미오 ( Mi Oh Roh ),송민수 ( Min Soo Song ),정찬희 ( Chan Hee Jung ),박형규 ( Hyeong Kyu Park ),김여주 ( Yeo Ju Kim ),목지오 ( Ji Oh Mok ),김상진 ( Sang Jin Kim ),김철희 ( Chul Hee Kim ),변동원 ( Dong Won 대한당뇨병학회 2009 임상당뇨병 Vol.10 No.2

전격성 제1형 당뇨병은 췌도에서 급격히 베타세포와 알파세포가 파괴되는 특징을 가진 당뇨병으로 그 기전은 명확하지 않으나 유전적 감수성이 있는 개체에서 바이러스 감염 등의 환경적인 인자와의 연관성이 가능한 병태생리로 제시되고 있으며 이에 대한 추가적인 연구가 필요하다. 저자들은 최근 급증하는 A형 간염 후에 발생한 전격성 제1형 당뇨병 1예를 경험하여 전격성 제1형 당뇨병과 바이러스 감염의 관련성에 대한 근거를 제시하고 이에 대해 보고하는 바이다. Fulminant type 1 diabetes mellitus is a novel subtype of type 1 diabetes, which is characterized by a remarkably abrupt onset, metabolic derangement such as diabetic ketoacidosis at diagnosis, low HbA1c level at onset and negative islet-related autoantibodies. The pathogenesis of this disease remains to be clarified, but the involvement of both genetic background and viruses have been suggested. We recently encountered a case of fulminant type 1 diabetes mellitus in 32-year-old male patient who was diagnosed with acute hepatitis A a month ago. Laboratory findings revealed high blood glucose level as well as evidence of diabetic ketoacidosis, but the HbA1c level was normal. The low level of plasma C-peptide indicated the loss of endogenous insulin secretion. This patient`s laboratory results met the criteria for the diagnosis of fulminant type 1 diabetes. We consider that this report can add to the body of evidence of a viral etiology of fulminant type 1 diabetes. Further study is needed to elucidate the exact pathogenesis. (Korean Clinical Diabetes J 10:118-122, 2009)

안면홍조에 대한 임상시험 참가자의 증상 발현 양상에 관한 연구

김동일 ( Dong Il Kim ),노진주 ( Jin Ju Roh ),정수경 ( Su Kyoung Jung ),성준호 ( Jun Ho Seung ),이승덕 ( Seung Deok Lee ),안홍엽 ( Hong Yup Ahn ),오달석 ( Dal Seok Oh ),최선미 ( Sun Mi Choi ) 대한한방부인과학회 2006 大韓韓方婦人科學會誌 Vol.19 No.4

소시호탕(小柴胡湯)이 thioacetamide로 유발된 간섬유증 동물 모델에 미치는 영향

이세희,오민혁,신미래,이지혜,노성수,Lee, Se Hui,Oh, Min Hyuck,Shin, Mi-Rae,Lee, Ji Hye,Roh, Seong-Soo 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.6

Objectives: The aim of the current study was to investigate the effect of Sosiho-tang on thioacetamide (TAA)-induced liver fibrosis in mice and to elucidate its underlying mechanisms. Methods: The mice were divided into 4 groups: Normal mice (Normal), TAA-induced control mice (Control), TAA-induced and silymarin-treated (50 mg/kg) mice (Silymarin), and TAA-induced and Sosiho-tang treated (200 mg/kg) mice (SSHT). Liver fibrosis was induced via intraperitoneal injection of TAA three times a week for 8 weeks. Silymarin and Sosiho-tang were concomitantly administered for 8 weeks. Serum and liver tissues were then collected and the anti-oxidant and inflammatory protein levels in the liver tissues were evaluated using western blotting. Results: SSHT administration significantly reduced the levels of AST, ALT, ammonia, and MPO in the serum. SSHT also significantly down-regulated liver NADPH oxidase and regulated the Nrf2/Keap1 signaling pathway. SSHT treatment downregulated the liver NF-κB levels and suppressed inflammatory cytokines. SSHT treatment also decreased bile acid-related factors, such as CYP7A1 and NTCP, and fibrosis-related factors, such as α-SMA and Collagen I. Conclusions: Taken together, these data suggest that SSHT administration suppressed the progression of liver fibrosis by activating the Nrf2/Keap1 pathway and inhibiting NF-κB.

계혈등 추출물이 급성 간 손상에 미치는 효과

오민혁(Min Hyuck Oh),박해진(Hae-Jin Park),신미래(Mi-Rae Shin),노성수(Seong-Soo Roh) 대한약학회 2021 약학회지 Vol.65 No.4

This study aimed to examine the protective effect of the water extract from Spatholobi Caulis (SC) on rats with acute liver injury (ALI) induced by thioacetamide (TAA) and its underlying mechanism. ALI was induced by intraperitoneal injection with TAA for 3 days in a row and the rats were administered SC (100 or 200 mg/kg) 1 h 30 min prior to the TAA treatment. Myeloperoxidase (MPO) was measured in serum and malondialdehyde (MDA) was measured in serum and liver tissue, as markers related to oxidative stress. Further, inflammation-related proteins and apoptosis proteins were investigated using western blot analysis. SC treatment significantly reduced the levels of MPO and MDA. Further, SC treatment significantly reduces the mitogen-activated protein kinase (MAPK) signaling pathway, including p-JNK, p-ERK, and p-p38, and reduces the expression of pro-inflammatory signaling factors. Furthermore, it effectively decreased the expression of Bax, Cytochrome C, and Cleaved Caspase-3 in liver tissue. Taken together, SC treatment alleviate0d the severity of ALI via inhibition of inflammation through both the MAPK pathway and Matrix metalloproteinase (MMPs)-dependent apoptosis.

대황-황금 혼합물이 만성 역류성 식도염에 미치는 효과

이진아,오민혁,신미래,노성수,박해진,Lee, Jin A,Oh, Min Hyuck,Shin, Mi-Rae,Roh, Seong-Soo,Park, Hae-Jin 한국생약학회 2022 생약학회지 Vol.53 No.1