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김승남,구영,류인철,함병도,배기환,한수부,정종평,최상묵,Kim, Seung-Nam,Ku, Young,Rhyu, In-Cheol,Hahm, Byung-Do,Bae, Ki-Hwan,Han, Soo-Boo,Chung, Chong-Pyoung,Choi, Sang-Mook 대한치주과학회 2000 Journal of Periodontal & Implant Science Vol.30 No.1
The purpose of this study was to evaluate the antimicrobial activity of Crassirhzimae rhizoma and its possible use as an oral antiseptics for prevention of periodontitis. Its antibacterial activity against periodontopathic microorganisms including Actinobacillus actiomycetem - comitans, Capnocytophaga ochracea, Streptococcus mutans, Porphyromonas gingivalis, Prevotella intermedia, Actinomyces viscosus, Fusobacterium nucleatumwas evaluated via modified stab culture method. The cytotoxicity against gingival fibroblasts and rat osteoblasts was investigated via [$^3H$]thymidine incorporation and cellular activity was investigated via MTT assay. Chlorhexidine was used as control group. Crassirhizomae rhizoma was prepared at concentrations of 0.2, 0.15, 0.1, 0.05%. Chlorhexidine was also prepared at the same concentration. Crassirhizomae rhizoma showed lower antimicrobial antivity against these microorganism than chlorhexidine, but this difference was not significant. And, Crassirhzomae rhizoma showed more cellular activity and less cytotoxicity than chlorhexidine on human gingival fibrablast and rat osteoblast. This study suggests that Crassirhzomae rhizoma might be a candidate for a safe oral antiseptic for the prevention and treatment of periodontal disease.
$MPP^+$로 유도된 SH-SY5Y신경세포 사멸에 대한 고분자성분제거 봉독약침액의 신경보호 효과 연구
배광록,두아름,김승남,박지연,박히준,이혜정,권기록,Bae, Kwang-Rok,Doo, Ah-Reum,Kim, Seung-Nam,Park, Ji-Yeon,Park, Hi-Joon,Lee, Hye-Jung,Kwon, Ki-Rok 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.2
Objectives : The neuroprotective effects of bee venom (BV) have been demonstrated in many studies, but bee venom has many side effects. So we used sweet bee venom (SBV), which has high molecular elements removed to reduce the side effects. I examined the neuroprotective effect of sweet bee venom in 1-methyl-4-phenylpyridine ($MPP^+$)-induced human neuroblastoma SH-SY5Y cells. Methods : To observe the possible toxicity of SBV itself, SH-SY5Y cells were treated with SBV in various concentrations for 3 h and $MPP^+$ in concentrations (1 and 5mM) for 24h. To investigate the protective effect of SBV against $MPP^+$ toxicity, SH-SY5Y cells were pretreated with vehicle or nontoxic concentrations of SBV for 3h and the cells were not washed, followed by incubation with respective concentrations of SBV and 1 mM $MPP^+$ for 24h. To investigate the protective effect of SBV against $MPP^+$ toxicity, SH-SY5Y cells were pretreated with vehicle or nontoxic concentrations of SBV for 3h and the cells were not washed, followed by incubation with respective of SBV(0.5%), 1 mM $MPP^+$, 5uM AKT inhibitor(LY984002) and 10uM ERK inhibitor(PD98059) for 24 h. The protective effect was measured by cell viability assay. To investigate the degree of apoptosis, caspase-3 enzyme activity was measured in control, $MPP^+$, SBV+$MPP^+$. Results : SBV (0.5%) pretreatment protected the SH-SY5Y cells against $MPP^+$-induced apoptotic cell death. The cell viability was higher in the SH-SY5Y cells that were pretreated with vehicle or nontoxic concentrations of SBV than those not pretreated. The caspase-3 activity was lower in the pretreated groups than these not pretreated. ERK and AKT enzymes have a role in the neuroprotective effects of the sweet bee venom. Conclusions : The results demonstrate that SBV has a protective effect on dopaminergic neurons against $MPP^+$ toxicity. This data suggest that SBV could be a potential therapeutic tool for neurodegenerative diseases such as Parkinson's disease(PD).
저층 조적채움벽 철근콘크리트 골조의 내진보강 전후 동특성 변화
유은종,김민재,김승남,김지영,최기선,Yu, Eunjong,Kim, Min-Jae,Kim, Seung-Nam,Kim, Ji-Young,Choi, Ki-Sun 한국전산구조공학회 2015 한국전산구조공학회논문집 Vol.28 No.3
In this study, a series of forced vibration testing and ambient vibration measurement were performed at a lowrise masonry-infilled reinforced concrete frame structure before and after seismic retrofit and its dynamic properties were extracted using system identification techniques. Also, analytical models which show similar dynamic properties to the measures ones were constructed. The system identification results showed that damping ratios in x direction along which the dampers were installed has been increased. From the comparison between the analytical models, the effective stiffness of post-installed member and post-reinforced members(shear walls and damper frames) were only 50% of gross sectional stiffness of the members, which indicates that the these members were not fully integrated with the existing structure or members. In addition, support condition of post-installed footing has to be pinned in y direction to match the dynamic properties, which is seemingly caused by the change of fixity of the soil due to the installation of new footing. 본 연구에서는 저층 조적채움벽 철근콘크리트 골조 구조물의 내진보강 전과 후에 대하여 강제 진동 실험과 상시 진동 계측을 수행하였으며 시스템 식별과정을 통하여 구조물의 동특성을 구하고 해당 구조물과 유사한 동특성을 보이는 해석 모델을 만들었다. 시스템 식별 결과 댐퍼가 설치된 x방향의 감쇠비가 증가되었으며, 해석 모델과 비교한 결과 추가 설치된 부재들(전단벽과 댐퍼)의 유효 강성은 부재의 총단면 강성의 50%만이 발현되어 해당 부재들이 기존의 구조물이나 부재와 완전히 일체화되지는 않음을 알 수 있었다. 또한, 추가 설치된 기초의 y방향 구속조건을 핀으로 하여야 동특성을 일치시킬 수 있었는데, 이는 새로운 기초가 설치되며 해당 지질의 특성이 변화되었기 때문으로 보인다.
한해에 강하고 불시출수에 둔감한 맥주용 2조 겉보리 품종 ‘광맥’
강천식(Chon-Sik Kang),김양길(Yang-Kil Kim),윤영미(Young-Mi Yoon),손재한(Jae-Han Son),최진경(Jin-Gyung Cho),송재기(Jae-Ki Song),김승남(Seung-Nam Kim),박태일(Tae-Il Park),김경호(Kyong-Ho Kim),정영근(Young-Keun Cheong),김보경(Bo-Kyeong 한국육종학회 2017 한국육종학회지 Vol.49 No.4
We developed new two-rowed covered barley ‘Gwangmaeg’ superior to ‘Hopum’ that has been widely cultivated in Korea for using beer-materials. ‘Gwanngmaeg’ was related from the line named as ‘Iksan149’ in 2010 after yield trials test in conducted for three years from 2008. And then it was registered to ‘Plant protection right, No. 5847’ in 2016 after field experiment by KSVS(Korea Seed & Variety Service). ‘Gwangmaeg’ has distinct characteristics in winter type (IV) and mid-tall culm length which makes reduce damage by off-season heading and lodging comparing to those of ‘Hopum’. ‘Gwangmaeg’ have characteristics of cold tolerance and disease resistance to BaYMV(Barley yellow mosaic virus) and Net blotch(Pyrenophora teres). Yield of ‘Gwangmaeg’ was about 611kg/10a and 524kg/10a in upland and paddy field condition, respectively, which higher 2-4% than ‘Hopum’, however, it has no significant difference. In quality examination for beer usage, ‘Gwangmaeg’ has lager grain and higher assortment ratio than those of ‘Hopum’. In malt quality, ‘Gwangmaeg’ showed higher and better quality in malt extract rate and diastatic power than those of ‘Hopum’. ‘Gwangmaeg’ would be suitable for the area above -4℃ of daily minimum temperature in January in Korean peninsula.