삼출성 중이염 환자에서의 혈중 및 아데노이드 면역글로불린 E의 면역혈청학적 연구

장혁순,강성호,유창수,김성현,이병돈,박영진,윤세동,안희영,강주원 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Otitis media with effusion (OME) is one of the most common disease in children but its pathogenesis is not clear. In particular the role of allergy has revealed conflicting support with widely varing opinions as to its importance. Within recent years, striking biochemical and immunochemical analytic techniques have opened a new approach the study of otitis media with effusion. So we focused on distributions of IgE in adenoid tissue and serum IgE levels. Authors compared the serum IgE and the distribution of IgE in adenoid tissue between the 20 patients underwent tonsillectomy, adenoidectomy and ventilating tube insertion and control group of 11 patients underwent tonsillectomy and adenoidectomy. The results were as follows; 1. In the distribution of IgE in adenoid tissue, there was a significant increase in the group of patients with OME compared to the control group (P<0.01). 2. In the analysis of serum IgE levels, the levels of IgE in the OME patients an control group were higher than normal level, although the level of IgE in the OME patients were less than that of control group, there was no significance P>0.05).

자궁탈의 임상적 고찰

김동원,노형균,안태규,최상준,송창훈,정혁 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

The purpose of this study was to evaluate clinical aspects of prolape uteri. This clinical and statistical study was attempted to analyze 369 cases of uterine prolapse(328 cases -operated, the other cases - not operated) from Jan. 1994 to Dec. 1998 at the Department of Obstetrics and Gynecology, Chosun University Hospital. The results were as follows. 1. The incidences of uterine prolapse was 0.62% of the total admitted gynecologic patients during the study period. 2. Age distribution at the time of operation showed that 184 cases(25.6%) were 60 to 65 years of age, and 62 cases(18.2%) were 56 to 60 years of age. 3. Age distribution at the time of development of prolapse uteri showed that 134 cases(36.3%) were 21 to 30 years of age, 126 cases(34.1%) were 31 to 40 years of age. 4. 228 cases(61.7%) were those who had suffered from uterine prolapse for more 11 years and the mean durations were 15.6 years. 5. The degree of prolapse uteri showed that 281 cases(76.1%) were 3rd degree and 61 cases(16.5%) were 2nd degree. 6. The parity showed that 297 cases(80.2%) were over 4 times and 2 cases(0.27%) was nullipara. 7. The delivery place was at home in 318 cases(86.1%) and in hospital in 51 cases(13.9%). 8. The main symptoms comprised prolapse in 311 cases(84.2%), urinary frequency in 259 cases(70.1%), and bearing down sensation in 242 cases (65.8%). 9. An operation in 328 cases was carried out of 369 cases of prolapse uteri, 301 cases were treated by the vaginal hysterectomy with either anterior &osterior repair or posterior repair, 23 cases were treated by anterior &osterior repair. 10. The postoperative complications were urinary tract infection in 7 cases(2.1%), urinary retention in 4 cases(1.2%), vaginal vault prolapse in 2 cases(0.6%). 11. The indwelling foley catheter was kept for 7 days in 279 cases and the average postoperative hospitalization was around 9 days. 12. The postoperative pathologic findings were chronic cervicitis in 211 cases(67.8%), squamous metaplasia of the cervical gland in 98 cases(31.5%), adenomyosis in 69 cases, leiomyoma in 47 cases, and dysplasia of cervix, cervical polyp, endometrial polyp were also resulted. In conclusion, clinical features of uterine prolapse were studied. The clinical evaluation of uterine prolapse include age, parity, degree of prolapse, delivery site, age of onset, symptomatology, type of operation, complications, the results of histopathological examinations. Further study is necessary before these aspects can be implicated in the clinical evaluation of uterine prolapse.

관상동맥내 스텐트 시술시 Aspirin과 Cilostazol 2개월 병합요법

윤명호,탁승제,염철훈,장혁재,최소연,유상용,안성균,고종훈,신준한,김한수,최병일 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

Recent Trend Changes in Clinical Features, Treatment, and Survival from Korean Patients with Hepatocellular Carcinoma

( Jem Ma Ahn ),( Soon Ho Um ),( Dae Hoe Ku ),( Jung Mi Chang ),( Han Ah Lee ),( Tae Hyung Kim ),( Hyuk Soon Choi ),( Young Kul Jung ),( Eun Sun Kim ),( Bora Keum ),( Ji Hoon Kim ),( Yeon Seok Seo ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: There were limited data regarding recent changes from patients with hepatocellular carcinoma (HCC). Our study aimed to evaluate recent time-trends in etiology, stage, treatment and overall survival in Korean patients with HCC. Methods: We consecutively enrolled 1367 patients who were diagnosed as HCC for the first time in Korea University Anam hospital between 2004.3 and 2015.12. These patients were categorized into four groups based on the date of HCC diagnosis with a 3-year interval as follows: P1, 2004.3 - 2007.2 (n = 321); P2, 2007.3 - 2010.2 (n= 348); P3, 2010.3 - 2013.2 (n = 368); P4, 2013.3 - 2015.12 (n = 330). Results: Over the median 19.0 months of follow-up duration, 68.0% of all patients died. Regarding secular trends from 2004 to 2015, HCC had become diagnosed with better liver function (Child-Pugh stage, P = 0.022). Etiology of HCC were changed; proportion of chronic hepatitis B decreased, while cryptogenic etiology increased (P= 0.004, P = 0.024). The proportion of early stage HCC increased (Barcelona Clinic Liver Cancer staging system, P = 0.001; modified UICC staging system, P = 0.005). More patients tended to receive treatment for HCC other than conservative treatment (P = 0.05); either operation or chemotherapy gradually increased as the first treatment modality, while locoregional therapy decreased (P = 0.012). The 1-, 3-, 5-year overall survival rates also increased from 2004 to 2015 (p < 0.001). Conclusions: Over recent 10 years, HCC had become to be diagnosed at earlier stages with better liver function. In addition, the proportion of chronic hepatitis B in HCC etiology decreased, and operation and chemotherapy were more performed as the first treatment. Thus, the overall survival rates could gradually improve with these changes, which might be derived from advance in treatment as well as improvement of HCC surveillance and wide-spread use of anti-viral therapy.

Effects of blood flow to the prefrontal cortex on high-intensity exercise combined with high-decibel music

( Hyuk Ki Chang ),( Kyun Gae Kim ),( Yu Jin Jung ),( Na Ri Ahn ),( Wi Young So ),( Morimasa Kat ) 한국운동영양학회 2013 Physical Activity and Nutrition (Phys Act Nutr) Vol.17 No.4

We studied the effects of high-intensity exercise (70-75% of VO2 max) combined with high-decibel music (100 dB) on cognitive function (measured by the Stroop test) and related blood flow changes to the prefrontal cortex (measured by Oxy-hemoglobin (Hb), Deoxy-Hb, tissue oxygen index (TOI), and normalized tissue hemoglobin index (nTHI)). The subjects of the study were 28 healthy female university students in their early 20s. Subjects were categorized into control group (CG), music group (MG), exercise group (Ex), and music and exercise group (MnEx). A crossover design was implemented so that all subjects participated in all test groups. We found no significant difference in reaction time between CG and MG for the neutral and incongruent tasks of Stroop test. However, there were significant improvements in the neutral and incongruent tasks for both the Ex (p < 0.01) and MnEx (p < 0.01) groups. Oxy-Hb measurements in the prefrontal cortex of the brain supported the Stroop test data. We found no difference between Ex and MnEx in the TOI; however, there was a significant decrease (p < 0.05) in MnEx compared to Ex. In addition, Ex resulted in a significant increase (p < 0.05) in nTHI as compared to CG. These results indicate that high decibel music could negatively affect prefrontal cortex activation of the brain during exercise.

Surgical Management of Mechanical Valve Thrombosis: Twenty-Six Years' Experience

Hyuk Ahn,Kyung Hwan Kim,Kwan Chang Kim,Chang Young Kim 대한의학회 2008 Journal of Korean medical science Vol.23 No.3

In the present study, the authors investigated the management of mechanical valve thrombosis (MVT). From January 1981 through March 2006, 2,908 mechanical valve replacements were performed in 2,298 patients at our institution. Twenty (0.87%) patients presented with MVT, 14 (70.0%) were women, and the mean age of the patients was 42.0±14.0 (27-66) yr. Thrombosis involved mitral in 14 (70.0%), aortic in 2 (10.0%), tricuspid/aortic in 1 (5%), and tricuspid in 3 (15%). The interval from first operation to valve thrombosis was 121.8±75.4 (0.9-284.7) months. The most frequent clinical presentation was heart failure (13/20, 65%), and predisposing causes of MVT were: poor compliance with warfarin (7), pregnancy (5), drug interaction (2), and unknown (6). All 20 patients underwent valve replacement: mitral (14, 70.0%), tricuspid (3, 15.0%), aortic (2, 10%) and tricuspid/aortic (1, 5%). One early death occurred due to left ventricular failure, but no late mortality occurred during 63.3±49.9 (0.5-165.1) months of follow-up. MVT was treated successfully, and pregnancy and inadequate anticoagulation were found to influence the occurrence of this rare complication.

Nanowire FET Biosensors on a Bulk Silicon Substrate

Ahn, Jae-Hyuk,Kim, Jee-Yeon,Choi, Kyungyong,Moon, Dong-Il,Kim, Chang-Hoon,Seol, Myeong-Lok,Park, Tae Jung,Lee, Sang Yup,Choi, Yang-Kyu IEEE 2012 IEEE transactions on electron devices Vol.59 No.8

<P>A biosensor based on a nanowire field-effect transistor is demonstrated on a bulk silicon wafer for low-cost applications. The silicon nanowire is fabricated using a simple reactive-ion etching technique known as the Bosch process. The sensor operation of the fabricated device is confirmed as a proof of concept by detecting the negatively and positively charged polymers on the nanowire surface in real time. The drain current of the device is clearly modulated by the charge polarity of the polymers. In addition, the specific binding of the antigen and the antibody for avian influenza is also detected by a real-time label-free electrical method for practical applications. Control experiments support that a charged species only on the nanowire surface leads to a significant change in the drain current of the sensor. The proposed approach in bulk nanowire biosensors paves the way for the application of complementary metal–oxide–semiconductor technology for low-cost and miniaturized biosensors without external transducers; this approach is attractive in disposable and portable applications.</P>

연구논문 : 포식압력 하에 치어 보호 구조물이 피식자의 생존율에 미치는 영향에 관한 실험적 연구

안창혁 ( Chang Hyuk Ahn ),주진철 ( Jin Chul Joo ),이새로미 ( Sae Ro Mi Lee ),안호상 ( Ho Sang Ahn ),박재로 ( Jae Roh Park ),송호면 ( Ho Myeon Song ) 한국물환경학회(구 한국수질보전학회) 2013 한국물환경학회지 Vol.29 No.6

The aim of this study was to evaluate artificial fish shelter, which was known to increase prey survival and ex[and habitat space to improve species diversity and fish communities in a freshwater ecosystem. The experiment was performed at an outdoor test-bed for three months from 2011 by comparing the responses to adjustments in the volume of the artificial patch (juvenile fish shelter, JFS) in the control and experimental groups. Analysis of the environmental conditions over two periods (Period 1~2) showed minor differences in the physichemical characteristics of water quality, phytoplankton, and zooplankton biomass, thus, allowing comparative analysis of feeding ecology. However, high water temperature conditions in Period 1 (25.6 ± 2.0℃), affected the predation activity of piscivorous fishes, Coreoperca herzi (C. herzi, size 89 ± 4 mm). Survival rates of the prey fishes, Rhynchocypris oxycephalus (R. oxycephalus, size 29±1 mm), improved as the patch volume increased and were higher than those of the control group by 35.0 ~ 46.7%. Analysis showed that JFS reduced the chances of predator-prey encounter, and thereby minimized prey vulnerability.

부착조류를 활용한 도시물순환시스템 인공수로 내 수질관리 연구

안창혁 ( Chang Hyuk Ahn ),주진철 ( Jin Chul Joo ),권재형 ( Jae Hyeong Kwon ),송호면 ( Ho Myeon Song ) 한국물환경학회 ( 구 한국수질보전학회 ) 2012 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2012 No.-

생물보전지수(IBI) 및 서식지 평가지수(QHEI)를 활용한 지하 매립형 방틀둠벙의 어류 서식처 기능 평가

안창혁(Ahn Chang Hyuk),주진철(Joo Jin Chul),권재형(Kwon Jae Hyeong),송호면(Song Ho Myeon) 대한토목학회 2011 대한토목학회논문집 B Vol.31 No.6B

본 연구는 다변수 접근방식인 서식지평가 정성지수(Qualitative Habitat Evaluation Index QHEI)와 생물보전지수(Index of Biological Integrity IBI)의 적용방법 도입과 어류 서식 및 피신처 확보용 인공구조물인 방틀둠벙의 정량적인 평가를 목적으로 하였다. 또한 안동시 남후면 하아리에 소재한 한국건설기술연구원 수자원·환경실험센터의 실외 실험장을 활용하여 실규모로 생물 평가와 검증을 실시하였다. 본 평가기법의 적용을 위해 구성한 실험수로 및 방틀둠벙 시설은 국내 하천의 조건을 최대한 반영하여 조성하였으며 흐름상태와 정체상태로 구분하여 유속 0.0~1.5 m s⁻¹ 폭 1.0~3.0 m 수심 0.05~0.70 m 다양한 하상재료를 조성하여 2010년 5월~12월의 8개월간 모니터링 하였다. QHEI는 실험수로의 E~F지점이 평균 83.1로 가장 높게 나타났고 B~C지점에서 78.1로 가장 낮게 나타났다. 하지만 방틀둠벙은 시·공간적 구분 없이 98.9 이상의 값을 나타내어 전체 지점 중 가장 높은 양호상태(Good)의 서식처 조건을 유지하였다. IBI는 전반적으로 QHEI와 비슷한 패턴을 나타내었으나 겨울 갈수기에 양호상태(Good)인 44.2를 보여 32.8을 나타낸 실험수로와 비교되었다. 또한 흐름과 정체상태 조건에서 방틀둠벙의 IBI 값은 실험수로보다 각각 5.7~11.4% 18.7~34.8% 높은 평가 값을 나타내어 유량이 적거나 흐름이 없는 갈수기에 어류 서식처 확보 가능성을 정량적으로 시사하였다. 종합적인 수생태계 건강성 평가에서 실험하천은 보통과 양호상태(Fair~Good) 범위를 나타낸 반면 방틀둠벙은 대부분 양호상태(Good)를 보여 수생태계 건강성 확보에 적용 가능함을 도출하였다. The purpose of this study was to quantitatively evaluate the expression of both multi-metric qualitative habitat evaluation index (QHEI) and biological integrity index (IBI) for artificial structures eco-artificial fish reef (EAFR) for fishes asylum and habitat. Especially both experimental evaluation and biological verification were performed in Water and Environmental Center's outdoor test-bed of Korea Institute of Construction Technology located in Andong-city Gyeongsangbuk-do. The experimental conditions reflecting the situation of domestic river include the flow rate (e.g. 0.0~1.5 m s⁻¹) the width (e.g. 1.0~3,0 m) the depth (e.g. 0.05~0.70 m) and variable bed materials. Both QHEI and IBI were monitored for 8 months from May to December 2010. Whereas QHEI values were highest at experimental points of the E~F with an average of 83.1 those were lowest at B~C with an average of 78.1. However QHEI values inside EAFR were more than 98.9 regardelss of space and time and indicated more than the highest good of the state (Good) in the habitat. Overally IBI values showed similar trend with QHEI but were 44.2 in the winter dry season compared to 32.8 of QHEI values. IBI values Also IBI values inside EAFR were greater than those at the experimental channel by 5.7 to 11.4% and 18.7 to 34.8% in flow and stagnant conditions respectively indicating that EAFR can secure asylum and habitat for fish during the dry season. For comprehensive aquatic ecosystem assessment the experimental channel showed generally fair conditions (Fair~Good) whereas EAFR showed good conditions (Good) suggesting that EAFR can be applied to aquatic ecosystem restoration and improvement.