필라델피아 염색체 양성 급성골수성백혈병에서 Imatinib Mesylate로 분자학적 관해를 유도한 후 성공적인 자가 말초혈액 조혈모세포이식이 시행되었던 1예

김여경,이제중,이병환,변정래,조덕,이일권,정익주,양동욱,김형준 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1

저자들은 필라델피아 염색체 양성 급성골수성백혈병 환자에서 복합항암화학요법으로 혈액학적 완전관해를 유도하고, imatinib mesylate를 이용하여 분자학적 관해를 유도한 후, 성공적으로 자가 말초혈액조혈모세포이식을 시행하였던 1예를 경험하였기에 이를 보고하는 바이다. Philadelphia chromosome (Ph¹)-positive acute myeloid leukemia (AML) is very rare disease, comprising 3~4% of the AML, and is a clinically distinct entity with poor clinical outcome with conventional chemotherapy. We report a case of Ph¹-positive AML who underwent successful autologous peripheral blood stem cell transplantation after achieving a molecular remission with imatinib mesylate.

아동기 가정 내 스트레스가 공동의존성에 미치는 영향 및 공동의존성과 정신병리와의 관련성

곽운환,손지욱,한규희,박철수,김장락,김붕년,김봉조,강여화,하형래 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.1

연구목적: 본 연구는 공동의존성에 영향을 미치는 아동기 가정내 스트레스 요인과 공동의존성과 다른 병리와의 연관성을 규명하고자 하였다. 더불어 특정한 질환에서의 공동의존성의 평가가 가지는 의의를 탐색해 보고자 하였다. 방 법: 연구 대상은 정상 일반인 남성집단 88명과 알코올리즘 남성 집단 76명으로 구성되어 있다. 평가도구는 본 저자가 직접 작성한 '아동기 가정내 스트레스 요인 측정용 설문'과 공동의존 척도(RPS), 간이증상 진단검사(SCL-90-R)를 사용하였다. 통계적 분석은 Mann-Whitmey test, Kruskall- Wallis test, Multiple linear regression analysis, Spearman correlation analysis를 이용하였다. 결 과: 1) 정상 일반인 군과 알코올리즘 군의 공동의존성 평균값은 각각 49.12점(표준편차=15.41)과 88.31점(표준편차=17.48)이었다. 2) 정상 일반인 군에서는 '아동기 부모 사별'(p<0.01) '부모의 알코올리즘'(p<0.01) '부모의 상습적 구타'(p<0.01)의 3가지 요인에서, 알코올리즘 군에서는 '어린시절 부모 사별'(p<0.01) '부모의 알코올리즘'(p<0.01) '부모의 상습적 구타'(p<0.01) '부도의 도박'(p<0.01) '사회 병질자 부모의 존재'(p<0.05)의 5가지 요인에서 스트레스 유무에 따라 공동의존성에 유의한 차이를 보였다. 3) 두 집단 동시에 SCR-90-R의 8개 소척도 중 '대인관계 예민성'이 공동의존성과 가장 높은 연관성(rs>0.06, p<0.01)을 보였다. 이외에도 '우울증' '불안증'등이 두 집단 모두에서 통계적으로 유의한 연관성을 보였다. 결 론: 본 연구는 부모의 알코올리즘뿐만 아니라 여러 가정 내 스트레스 요인이 공동의존성의 발생에 영향을 미칠 수 있음과 공동의존성이 높은 집단이 다른 정신과 질환을 동반할 가능성이 높음을 증명한다고 할 수 있다. Objectives : The aim of this study was to examine the relationships of codependency with family stressors in childhood and psychopathology. Methods : Subjects were a group of 88 normal adult males and a group of 76 alcoholic males. The degree of codependency was assessed with the Korean version of Recovery Potential Survey(RPS). All subjects filled out questionnaires regarding demographic information and family stressors. The psychopathology was measured by self-administred questionnaires using Symptom Check List-90-Revision(SCL-90-R). Results : 1) There were no significant differences in codependency levels by sociodemographic characteristics in two groups, but obvious difference in mean of codependency scores(normal group : 49.12±15.41, alcoholism group : 88.31±17.48). 2) There were significant differences in codependency levels between the presence and absence of parental physical abuse, parental death, and parental alcoholism(p<0.01) in both groups. 3) Among family stressors, parental physical abuse had the largest contribution to codependency level in multiple linear regression. 4) There were significant correlations between the codependency levels and the scores of SCL-90-R's subscales of interpersonal sensitivity, depression, and anxiety in both groups. Conclusion : The codependency levels were related to some family stressors such as parental physical abuse, parental death, and parental alcoholism and the high-level codependency was correlated with higher level of psychopathology in both normal and alcoholism group. These results suggested that various family stressors, as well as parental alcoholism may be predictors of codependency, and codependency also may be a predictor of other psychiatric disorders.

Mg이 흡착된 Si(111)7×7 표면 재배열 구조

안기석,여환욱,이경원,이순보,박종윤 성균관대학교 기초과학연구소 1993 論文集 Vol.44 No.1

Si(111)7×7 위에 Mg을 흡착시켜 표면 구조의 변화를 RHEED(Reflection High Energy electron Diffraction)와 XPS(X-ray Photoelectron Spectroscopy)를 이용하여 연구하였다. RT∼200℃까지의 기판온도에서 증착량의 증가에 따라 표면구조는 7×7에서 diffused 1×1, 그리고 2√3/3×2√3/3-R30° 구조로 변화하였다. 이를 thermal annealing하여 3-Domain 3×1 구조를 관측하였고, 이 결과는 J. Quinn등의 결과와 일치함을 알 수 있다. 또한, 기판온도를 증가시킴에 따라 diffuse 1×1, Single domain 3×1구조(450℃)에 대하여 Mg(KLL)/Si(2p) peak intensity ratio를 증착량 증가에 따라 측정하여 각기 다른 온도에서의 Mg 흡착에 대한 mechanism을 제시하였다. Change of the Si(111)7×7 surface structure upon Mg adsorption was studied by RHEED(Reflection HI호 Energy Electron Diffraction) and XPS(X-ray Photoelectron Spectrocopy). The RHEED patterns of Si(111)7×7 were changed to the diffuse 1×1 and 2√3/3×2√3/3-R30° patterns with increasing the deposition times of Mg at RT. The diffuse 1×1, 3-domain, and single domain 3×1 structures appeared successively at the adsorption temperature of 300, 350 and 450℃, respectively. We could find the relative coverages of these structures by measuring Mg(KLL)/Si2p XPS intensity ratio.

白鼠感染 肝吸蟲의 幼蟲 및 成蟲에 대한 국산 praziquantel(Distocide^(�))의 殺蟲效果

林漢鍾,李駿商,朱炅煥,朴升圭,嚴基善,呂煥旭 최신의학사 1985 最新醫學 Vol.28 No.7

재조합 인간 상피세포성장인자(DWP401)의 흰쥐에서의 in vivo와 in vitro 대사

고여욱(Yeo Wook Koh),남권호(Kouen Ho Nam),정주영(Ju Young Jung),박승국(Seung Kook Park),유영효(Young Hyo Yu),김재환(Jae Hwan Kim),한건(Kun Han),박명환(Myung Hwan Park),심창구(Chang Koo Shim) 대한약학회 1997 약학회지 Vol.41 No.3

Metabolism of DWP401, recombinant juman epidermal growth factor, was examined in vivo and in vitro in rats. When 125I-labeled DWP401 was administered at a dose of 50 mcg/kg by i.v. injection. 125I-labeled DWP401 was rapidly degraded within 30 minytes above 93%. Thin layer chromatography analysis of urine collected for 24 hr after i.v. administration of 125I-labeled DWP401 showed ohly one spot on a X-ray film which was considered as diiodo-tyrosine. This result suggests tha 125I-labeled DWP401 was completely digested into free amino acids without any specific intermediate polypeptides. About 42.1% of the administered iodine was recovered in 24 hr. For in vitro degradation study, 125I-labeled DWP401 was added to plama and tissue homogenates of rats and incubated at 37oC. Almost 98% of the added radioactivity recovered from the protein fraction of the liver, kidey, small intestine, stomach and spleen decreased rapidly. For examplem the recovery rates of 125I-labeled DWP401 were 58.6, 63.2, 39.9, 52.9 and 66.8% after 4hrs of incubation in respective organ homogenates.

Secretory Production of Biologically Active Human Thrombopoietin by Baculovirus Expression System

Koh, Yeo-Wook,Lim, Seung-Wook,Park, Seung-Kook,Park, Myung-Hwan,Na, Doe-Sun,Yang, Jai-Myung Korean Society for Biochemistry and Molecular Biol 1998 Journal of biochemistry and molecular biology Vol.31 No.5

Human thrombopoietin (hTPO) was expressed to high levels in insect cells using the baculovirus expression system. Full-length hTPO cDNA containing a native signal peptide sequence was amplified by PCR from a human fetal liver cDNA library and cloned into the Autographa californica nuclear polyhedrosis virus (AcNPV) expression vector. Immunoblot analysis with antiserum against hTPO indicated that an approximately 55 kDa protein was produced in recombinant AcNPV infected insect cells. Recombinant hTPO was produced 4-fold higher in Trichoplusia ni (Tn5) cells than in Spodoptera frugiperda (Sf9) cells. with most of the hTPO produced in Tn5 cells secreted into the culture medium. Addition of tunicamycin in the culture medium resulted in the reduction of the size of hTPO to 35-38 kDa, and most of the protein remained within the cell. These results suggest that N-glycosylation of hTPO is required for the secretion of the protein into the culture medium in insect cells. hTPO produced in insect cells induced proliferation and maturation of megakaryocyte progenitors, indicating that it is in a biologically active form.

Radial and Circumferential Variations in Hygroscopicity and Diffusion Coefficients within a Tree Disk

Wook Kang,Woo Yang Chung,Chang Deuk Eom,Yeon Jung Han,Hwan Myeong Yeo,Hee Suk Jung 한국목재공학회 2007 목재공학 Vol.35 No.2

A case of annular elastolytic giant cell granuloma after amiodarone medication

( Yeo-rye Cho ),( Jung-hwan Kim ),( Ho-jin Kim ),( Gun-wook Kim ),( Ki-ho Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Annular elastolytic giant cell granuloma (AEGCG) is an uncommon condition belonging to the family of elastolytic granuloma disease. Almost always it occurs on sun-exposed area, such as the face, neck, dorsa of hands, arms, hence previously named as actinic granuloma. Objectives: A 59-year-old man presented with erythematous annular plaques on both dorsa of hands. Patient has history of implantable cardioverter defibrillator insertion after acute MI 2 years ago and was taking amiodarone, an antiarrhythmic agent. A total of 85 to 90 g of amiodarone was administered to him, and so phototoxicity by amiodarone was considered. Methods: Histopathologic examination revealed annular elastolytic giant cell granuloma. Results: Histopathologic examination revealed a finding of annular elastolytic giant cell granuloma. The skin lesions improved clinically after 3 month of systemic & topical steroid treatment. Conclusion: AEGCG, as a relatively rare disease, is clinically similar to granuloma annulare. This case is very interesting at the point of development after chronic medication of phototoxic drug such as amiodarone. Despite some possibilities of co-occurrence of AEGCG and amiodarone phototoxicity, we suspect that medication of amiodarone may cause phototoxicity that initiated the granulomatous cascade after fragmentation of elastic fiber. We report herein this case as an AEGCG caused by Amiodarone.

Rapid, One‐Step, Digital Selective Growth of ZnO Nanowires on 3D Structures Using Laser Induced Hydrothermal Growth

Yeo, Junyeob,Hong, Sukjoon,Wanit, Manorotkul,Kang, Hyun Wook,Lee, Daeho,Grigoropoulos, Costas P.,Sung, Hyung Jin,Ko, Seung Hwan WILEY‐VCH Verlag 2013 Advanced functional materials Vol.23 No.26

<P><B>Abstract</B></P><P>For functional nanowire based electronics fabrication, conventionally, combination of complex multiple steps, such as (1) chemical vapor deposition (CVD) growth of nanowire, (2) harvesting of nanowire, (3) manipulation and placement of individual nanowires, and (4) integration of nanowire to circuit are necessary. Each step is very time consuming, expensive, and environmentally unfriendly, and only a very low yield is achieved through the multiple steps. As an alternative to conventional complex multistep approach, original findings are presented on the first demonstration of rapid, one step, digital selective growth of nanowires directly on 3D micro/nanostructures by developing a novel approach; laser induced hydrothermal growth (LIHG) without any complex integration of series of multiple process steps such as using any conventional photolithography process or CVD. The LIHG process can grow nanowires by scanning a focused laser beam as a local heat source in a fully digital manner to grow nanowires on arbitrary patterns and even on the non‐flat, 3D micro/nano structures in a safer liquid environment, as opposed to a gas environment. The LIHG process can greatly reduce the processing lead time and simplify the nanowire‐based nanofabrication process by removing multiple steps for growth, harvest, manipulation/placement, and integration of the nanowires. LIHG process can grow nanowire directly on 3D micro/nano structures, which will be extremely challenging even for the conventional nanowire integration processes. LIHG does not need a vacuum environment to grow nanowires but can be performed in a solution environment which is safer and cheaper. LIHG can also be used for flexible substrates such as temperature‐sensitive polymers due to the low processing temperature. Most of all, the LIHG process is a digital process that does not require conventional vacuum deposition or a photolithography mask.</P>

The effect of openings on combined bound water and water vapor diffusion in wood

( Wook Kang ),( Chun Won Kang ),( Woo Yang Chung ),( Chang Deuk Eom ),( Hwan Myeong Yeo ) 韓國木材工學會 2008 한국목재공학회 학술발표논문집 Vol.2008 No.-