구강점막 부착용 케토프로펜 고분자 필름의 제조 및 평가

박진석,이상은,강봉석,이경록,이은주,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract – The objective of this study was to prepare ketoprofen-loaded buccal adhesive patch. The adhesive patch was formulated by casting method using aqueous soluble polymer povidone K17 (PVP 17PF) as film-forming agent and hydroxypropylmethylcellulose (HPMC) as adhesive agent. To compare the effect of HPMC type, different molecular weight of K4M and K15M HPMC was used. The physicochemical properties of patches such as appearance, thickness, in vitro release, and adhesiveness were investigated. The concentration of ketoprofen was determined spectrophotometrically at a wavelength of 233 nm. The appearance of prepared patches was semi-transparent, light-yellow or almost colorless, and odorless. Thickness of each patches (n=6) was 0.895 ± 0.033 mm for K4M patch and 0.727 ± 0.036 mm for K15M patch. In vitro release test, both K4M and K15M patches showed over 20% release within 30 min. At 120 min, K4M and K15M patches demonstrated 95% and 67.5% release of ketoprofen, respectively, and up to 240 min, both patches released drug completely. Maximum adhesive force of K4M and K15M patches was 6.571 ± 2.703 gf and 2.735 ± 1.151 gf, respectively. Moreover, it took 28.29 ± 0.38 sec and 28.30 ± 0.34 sec for K4M and K15M patch to peel off them after adhesion, showing no significant difference. In conclusion, thickness, in vitro release, and maximum adhesive force could be modulated by alteration of polymer types.

초등학교 교사들의 직무스트레스와 건강 수준

조현숙,이종태,손혜숙,박진국 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : The purpose of this study was to assess the effect of job strain on stress and health status among elementary school teachers. Methods and Material : The subjects in this study were 300 teachers who were selected from among 588 teachers in 13 out of 42 elementary schools in the city of Gimhae. Through the questionnaire, demographic characteristics, Karasek's Job Content Questionnaire(JCQ) and the Psychosocial Well-being Index (PWI) to assess their occupational characteristics and psychosocial stress level were surveyed. Medical checkup results of them were adopted to measure their Health status. Results : 24.9 percent of the general teachers were low strain group, and 16.3 percent of them were high strain group. In the senior teachers, 19.7 percent belonged to a low strain group and 21.3 percent belonged to a high strain group. In regard to health status, more senior teachers than junior teachers suffered from obesity(24.6%) and diabetes(11.5%) (p<0.O5), and they also were higher in DBP(p<0.057), total cholesterol(p=0.039) and blood sugar level(p=0.000), the low strain group perceived more social support(p=0.000), and the high strain group felt bigger physical overload(p=0.000). Concerning psychosocial stress, the low strain group was more aware of teacher social role and put more confidence in themselves(p=0.004). The high strain group was more depressed(p=0.001), but no difference was detected in health status. The health status difference between the high strain and low strain groups was significant in depression of psychosocial stress(OR=3.823, 95%CI=1.584-9.224). Conclusion : The senior teachers group was more morbid to obesity, diabetes and hyperlipidemia, which implies that some measure should be studied to help senior teachers manage those diseases properly. The high strain group suffered more from physical overload and was high 'Social support'. Therefore it's required for high strain group to be given more support from colleagues and supervisors, and a stress management program should be implemented to reduce their psychosocial stress.

Apollonius의 점의 성질과 복소수

박진석,김향숙,김영미 경북대학교사범대학부속 중등교육연구소 2005 중등교육연구 Vol.53 No.1

내각의 크기가 모두 120° 보다 작은 삼각형에 대해서 Apollonius의 점이 정의되어 있으며, 더욱이 Apollonius의 점은 삼각형의 내부와 외부에 각각 한 개씩 생기지만 수학사에서는 삼각형의 내부에 나타나는 점만을 Apollonius의 점이라 부르고 있다. 본고에서는 삼각형의 외부에 나타나는 점도 Apollonius의 점이라 부르기로 하고, 아울러 이점에 관한 초등기하적인 성질들을 복소수를 활용하여 연구하였다. Let △ABC be a triangle whose angles are all less than 120° . Then there are two points P_(1), P_(2) which satisfy ?? · ?? = ?? · ?? = ?? · ?? ············ (*) as shown in Fig 1. We denote by D_(1), E_(1), F_(1)(resp. D_(2), E_(2), F_(2)) the pedal points from P_(1) (resp. P_(2)) to the sides BC, CA, AB, respectively. Especially the point P_(1) is called the Apllonius point of △ABC. It is well known (cf. [2,3,4]) that P_(1) is the unique point in △ABC such that the pedals D_(1), E_(1), F_(1) from P_(1) to three sides BC, CA, AB makes equilateral triangle. In this paper we investigate some geometric properties concerning the pedals D_(2), E_(2), F_(2) from P_(2) to three sides and prove tha △D_(2)E_(2)F_(2) is also equilateral triangle by using complex numbers. We also find the position of the point P satisfying (*) in △ABC with ∠A=120° .

피로와 의료이용, 업무상 사고 및 질병결근

장세진,고상백,강동묵,김성아,정진주,이철갑,강명근,현숙정,조정진,차봉석,박종구 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study examined the relationship of fatigue to medical utilization, occupational accident and sickness absence. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project, 2002~2004). A total of 30,146 employees categorized within the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were recruited. A structured-questionnaire was used to assess the participants' sociodemo-graphics, job-related factors, health-related behaviors, personality trait, self=perceived fatigue (MFS) and the frequency of medical utilization, occupational accident and sickness absence. Data on medical utilization and occupational accident were confirmed from company health records. Chi-square test and logistic regression analysis were used to elucidate the relationship of self-perceived fatigue to medical utilization, occupational accident and sickness absence. Results: In logistic regression analyses, self-perceived fatigue was associated with medical utilization (outpatient), occupational accident and sickness absence although the strength of the associations was higher in the blue collar workers except for medical utilization. For medical utilization, the white collar worker's adjusted odds ratios of outpatient utilization for workers scoring in the third quartile and the highest quartile, compared to workers scoring in the lowest quartile were 1.50 (95% CI: 1.20-1.87) and 2.16 (95% CI: 1.69-2.75), respectively. The blue collar workers' adjusted odds ratios of outpatient utilization for workers scoring in the second (OR: 1.23, 95% CI: 1.06-1.43), third (OR: 1.42, 95% CI: 1.22-1.66) and highest quartile (OR:1.83, 95% CI: 1.55-2.17), respectively, compared to workers scoring in the lowest quartile were statistically significant. However, no associations were found between fatigue and inpatient utilization for either the white or blue collar workers. The blue collar workers' adjusted odds ratios of being injured for workers scoring in the second, third and highest quartile were 1.41 (95% CI: 1.00-2.00), 1.57 (95% CI: 1.10-2.22) and 2.41 (95% CI: 1.69-3.44), respectively, compared to those scoring in the lowest quartile, but, those of the white collar workers were not significant. There was more likely to an increased risk of sickness absence in workers scoring in the second, third and highest quartile compared to those scoring in the lowest quartile in both white and blue collar workers, but the magnitudes of risk were higher in the blue collar workers than the white collars workers. Conclusion: This result suggests that fatigue is a determinant predictor of medical utilization, occupational accident and sickness absence, and that the pattern of risks for the three outcomes differs according to the occupational type. Some limitations of this study and considerations for future study were also discussed.

인장력을 받는 ㄷ형강 고력볼트 접합부의 감소계수 U값에 관한 연구

김진숙,표영석,나승욱,신영록,김보영,최문식 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

The purpose of this paper is to examine the influence of reduction coefficient according to the limit state design of steel structures in the bolted joints of tension members. It was carried out the tensile testing about high strength bolted connections performed in structural steel channels. Considered parameters are the number and row of bolts, the connection length, connection eccentricity of the specimen. The test results showed that failures generally came (a) classic net section, (b) block shear failures. We found that the professional factor, obtained by calculating the test failure load divided by the nominal specification strength, is lower than 1.00. We thought that the reason was the moment produced by eccentric loading depends upon the connection geometry as well as the rotational stiffness of the connection.

부모와 교사간의 연계교육 및 유아-교사간의 상호작용의 질에 따른 유아의 적응에 대한 연구

손인숙,송진숙 한국영유아보육학회 2004 한국영유아보육학 Vol.0 No.39

본 연구는 유아의 변수인 유아의 성별, 연령, 이전의 교육경험유무와 교사의 변수인 교사의 연령과 교사경력 등의 변수, 부모와 교사간의 연계교육과 유아와 교사간의 상호작용의 질에 따른 유아 적응의 차이를 알아보기 위하여 실시되었다. 본 연구의 대상은 전라북도 익산시와 전주시 그리고 군산시 소재 11곳의 유치원에 재원중인 아이를 둔 부모 612명과 교사 37명을 대상으로 실시하였다. 본 연구결과는 첫째, 유아의 적응에 있어 전반적으로 여아보다 남아가 유치원 적응을 잘하고 있는 것으로 나타났고, 이전 교육경험 유무에서는 전반적으로 이전 교육경험이 없는 유아보다 교육 경험이 있는 유아가 잘 적응하는 것으로 나타났다. 둘째, 교사의 특성에 따른 유아의 적응의 대한 결과는 교사가 30세 이하이고, 교사경력이 10년 이하일 때 유아가 안정성 측면에서 적응을 잘 하는 것으로 나타났다. 셋째, 부모와 교사간의 연계교육이 잘 수행될수록 유아의 적응이 잘 되는 것으로 나타났다. 넷째, 교사와 유아간의 상호작용의 질에 따라서는 교사-유아간의 상호작용의 질이 높을수록 유치원에서 유아의 적응이 잘 이루어지는 것으로 나타났다. The purpose of this study was to 1) investigate the differences between teacher and child's relationship, parent-teacher's partnership. 3) and its related variables - age of child, gender of child, educational experience of teacher, and so on - in kindergarten. Subjects were 612 parents and 37 teachers in Iksan, Junju, and Gunsan. The mean, percentile, t-test, and one-way ANOVA, were used. The results were as follows: First, there were significant difference among age of child, gender of child, and prior experience and child's adjustment in kindergarten. Second, there was significant difference between educational experience of teacher, age of teacher and child's adjustment in kindergarten. Third, there was significant difference between parent-teacher partnership and child's adjustment in kindergarten. Fourth, there was significant difference between child-teacher relationship and child's adjustment in kindergarten.

기관지 결핵의 치료 중 발생한 다발성 기관지-늑막루 1예

김인숙,용석중,진춘조,신표진,정낙영,강소은,박학천,김정주,리원연,신계철 연세대학교 원주의과대학 2000 원주의대논문집 Vol.13 No.1

트리암시놀론 아세토니드를 함유한 구강점막 부착성 패치의 제조 및 평가

엥흐자야,여동기,박진석,이은주,이경록,박정숙 충남대학교 약학대학 의약품개발연구소 2013 藥學論文集 Vol.28 No.-

The objective of this study was to prepare triamcinolone acetonide-loaded buccal adhesive patch. The adhesive patch was formulated by casting method using aqueous soluble polymer povidone K17 (PVP 17PF) as a film-forming agent and hydroxypropylmethylcellulose (HPMC) as an adhesive agent. To compare the effect of HPMC type, different molecular weight of K4M and K15M HPMC was used. The physicochemical properties of patches such as appearance, thickness, in vitro release, and adhesiveness were investigated. The concentration of triamcinolone acetonide was determined spectrophotometrically at a wavelength of 240 nm. The appearance of prepared patches was semi-transparent, light-yellow or almost colorless, and odorless. Thickness of each patches (n=6) was 0.942 ± 0.026 mm for K4M patch and 0.703 ± 0.036 mm for K15M patch, respectively. In vitro release test, both K4M and K15M patches showed over 20% release within 30 min. At 120 min, K4M and K15M patches demonstrated 80% and 76% release of triamcinolone acetonide, respectively, and up to 240 min, both patches released drug completely. Maximum adhesive force of K4M and K15M patches was 4.66 ± 0.76 gf and 2.69 ± 0.90 gf, respectively. Moreover, it took 28.73 ± 0.44 sec and 28.68 ± 0.61 sec for K4M and K15M patch to peel off them after adhesion, showing no significant difference. In conclusion, thickness, in vitro release, and maximum adhesive force could be modulated by alteration of polymer types.

알지네이트 비드를 이용한 메틸 오렌지의 봉입 및 방출에 미치는 키토산의 영향

변종찬, 이상은. 장우석, 이은주, 최진석, 박정숙 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

In this study, methyl orange-loaded alginate beads were prepared and compared to investigate the effect of chitosan on the encapsulation and release of hydrophilic methyl orange in alginate beads. Particle size and encapsulation efficiency of alginated beads were determined. Swelling ratio and disintegration of al-ginate beads were investigated in gastrointestinal environment. Particle size of beads was 1.1-1.5 mm and shape was spherical. Weight of beads was increased depending on the content of chitosan. Content of chitosan affected on the encapsulation of methyl orange. Encapsulation of methyl orange in alginate beads without chitosan was 15%, while encapsulation efficiency was increased with addition of chitosan. Beads were not disintegrated in HCl solution (pH 1.2) within 4 h, with floating and swelling. Swelling ratio of beads was in-creased to 222%. Release of methyl orange from alginate beads without chitosan was up to 70% within 2 h in HCl solution (pH 1.2). When chitosan was added to the alginate beads, release of methyl range from beads was significantly reduced. It is supposed that release of methyl orange from beads is resulted from diffusion and erosion of beads, which is pH-dependent. In condusion, chitosan-alginate beads have potentials to control release of small hydrophilic drugs by the addition of chitosan.

사무직 근로자들의 직무 스트레스와 피로

차경태,김일희,고상백,현숙정,박준호,박종구,차봉석,장세진 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.3

목적: 이 연구는 전국 규모의 조사 연구에서 수집된 자료 중 사무직 근로자들을 대상으로,사회인구학적 특성,직업 특성,건강행태,직무 스트레스와 피로수준 간의 관련성을 분석하는 데 있다. 방법:‘한국인 직무스트레스 측정도구의 표준화 전국 조사연구National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002∼2004)’를 위해 2002년 5월 1일부터 2003년 5윌 30일 까지 수행되었으며,전국의 사업장에 근무하는 근로자 30,146명(남자: 84%,여자: 16%) 중 사무직 근로자 4,457명(남자: 68.9%,여자 31.1%)을 연구 대상으로 하였다. 자료수집방법은 사업장을 방문하여 보건 및 안전관리자 등에게 연구의 취지를 알린 후 설문조사에 대한 협조를 구하고 응답자 직접 기입법을 이용 하였으며,사회인구학적 특성,직업적 특성,건강관련 요인,KOSS-SF를 이용한 7개의 직무 스트레스 요인,그리고 MFS를 이용하여 피로 수준에 영향을 주는 요인에 대해 분석하였다. 결과: 일반적 특성,작업관련 특성,건강행태관련 특성 및 직무 스트레스 요인이 근로자들의 피로와 강한 관련성이 있음이 입증되었으며,특히 직무 스트레스의 하부 요인 중에서도 피로와 관련성을 보이는 요인이 남녀별로 다소 상이 하게 관련된다는 것을 발견할 수 있었다. 남자의 경우는 직무 스트레스의 하부 영역 중 직무 요구도,직무 불안정성,보상부적절 등이 영향력이 높은 주요 직무 스트레스 요인이었던 반면,여자는 직무 요구도,보상부적절,직장문화가 주요한 직무 스트레스 요인이었다. 결론: 직장인 피로가 갖는 보건학적 의학적 경제학적 중요성을 감안할 때,조직의 생산성 향상과 근로자 개개인의 삶의 질 향상 및 건강증진을 위해선 직무 스트레스 관리 프로그램이 절실히 요청된다고 볼 수 있다. Background & Objectives: A growing body of research has documented that occupational stress is closely associated with increased risk of fatigue. This study was conducted in an effort to assess the relationship of occupational stress to self-perceived fatigue among Korean white collar employees. Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project, 2002-2004). Among them, a total of 4,502 white collar employees were recruited. A structured questionnaire was employed to evaluate the participants' sociodemographics, job-related factors, health-related behaviors, occupational stress, and self-perceived fatigue. Occupational stress and self-perceived fatigue were assessed using the Korean Occupational Stress ScaleShort form (KOSS-SF) and the Multidimensional Fatigue Scale (MFS), respectively. Results: In logistic regression analyses, occupational stress was associated with an increased risk of fatigue, and some domains of occupational stress had different effects on fatigue by gender (job demand, job insecurity, and lack of reward for men, job demand, lack of reward, and discomfort in occupational climate for women), which indicates that occupational stress may perform a slightly different role in increasing the risk of fatigue by gender. Conclusion: The results of this study suggest that occupational stress is a determinant predictor of self-perceived fatigue. Thus, a stress management program for the reduction of occupational stress, and the promotion of white collar worker's health and quality of life is strongly recommended. Some limitations of this study and considerations for future studies were also discussed.