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Theophylline(Etheophyl(R))에 의한 약물 유발성 간염 1 예
이동기,김태헌,권상옥,박용순,김태헌,백순구,임대욱,서정인,박학천,조미연,신계철,리원연,용석중 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.2
Theophylline has been widely used in the treatment of asthma and chronic obstructive lung disease. To date, there have been very few reports on hepatotoxicity due to theophylline. We diagnosed, through biochemical testing and a liver biopsy, a case of acute cholestatic hepatitis developed after oral consumption of theophylline. A 43 year-old man was admitted to the department of internal medicine due to jaundice and pruritus which developed after ten days administration of oral theophylline (Etheophyl). Liver function tests showed elevated serum bilirubin at 13.2 mg/dL with AST and ALT of 71 U/L and 194 U/L. Alkaline phosphatase and γ - GTP were also elevated at 175 U/L and 301 U/L. There was no evidence of viral or autoimmune hepatitis in laboratory tests. The patients symptoms and liver function tests were improved after conservative treatment. After 9 months oral theophylline was readministered for the control of relapsed asthma. Then, jaundice and pruritus again developed again. A liver biopsy showed a fw lymphocytes and eosinophilic inflammatory cell infiltration in portal tract and cholestasis in the lobule. Drug - induced hepatitis was diagnosed with a typical clinical course, the exclusion of all possible causes of acute hepatic dysfunction,' and a positive response to accidental readministration of drug. We report this case with a review of the literature.(Korean J Hepatol 2001;7:213-215)
외음부의 실리콘액 주사에 의한 폐출혈 및 급성 호흡 곤란 증후군 2예
강소은 ( Kang So Eun ),용석중 ( Yong Seog Jung ),이원연 ( Lee Won Yeon ),신표진 ( Sin Pyo Jin ),김미혜 ( Kim Mi Hye ),박학천 ( Park Hag Cheon ),심명숙 ( Sim Myeong Sug ),최현민 ( Choe Hyeon Min ),신계철 ( Sin Gye Cheol ),임미애 ( 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.51 No.2