경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

연령에 따른 한국인 손 피부색 차이 분석

홍다검ㆍ이희경ㆍ이정현(Da Geom HongㆍHee kyung LeeㆍJeong Hyun Lee) 한국인체미용예술학회 2016 한국인체미용예술학회지 Vol.17 No.1

Recently, nail industry trends have been shifting from polish nail to gel nail. Because of the popularity of gel nail, the criteria for customers to choose colors have significantly changed. Therefore, there has been a rising demand for a nail color which goes well with skin color, not with the color of clothes, makes the hand more beautiful. Unlike a face, hand skin color isn’t corrected through makeup. Therefore, it is more difficult to find a color which is well matched with the skin tone. In this sense, the accurate analysis and classification of hand skin color which is the first step in the selection of nail color are required. However, it’s still very hard to find studies on hand skin color. To figure out the characteristics of Koreans’ hand skin color by age, this study analyzed differences in hand skin color by age after measuring the tone of the back of the hand and conducting quantitative analysis against 300 women living in Busan, Ulsan and Gyeongnam. The results revealed statistically significant difference (p.001). As the respondents were younger, a bright skin tone was observed. According to analysis on the distribution by the rank, ‘20s’ was the highest with 46% among those with a bright skin tone within top 100 ranks. In top 300 ranks, in contrast, ‘50s’ was the highest with 46% while ‘20s (8%)’ was the lowest. In terms of a skin tone, there was a considerable difference between ‘20s’ and ‘50s.’ Even though no big difference was found between ‘30s’ and ‘40s,’ a skin tone was brighter in the latter.

XML 문서의 관계형 데이터베이스 게이트웨이 설계 및 구현

홍동현,김정희,곽호영 제주대학교 공과대학 첨단기술연구소 2002 尖端技術硏究所論文集 Vol.13 No.1

In this paper, using the characteristics of XML document, the method that separately stores the structures and contents of XML documents, is proposed for the relational database(RDB), which is representative of the industrial world. The design of the storage architectures to efficiently store XML documents and easily reconstruct the original documents in RDB, is based on E-R modeling. In order to practically store XML documents in RDB, XML Parser and Inserter that handle XML documents according to the proposed storage architecture, were implemented. And when the structures and the contents of XML documents are separately queried, to turn out a complete result, Extractor and XML Composer were also implemented. Moreover, the convenient user interface was designed to easily store and query XML documents.

3'-Methyl-4-dimethylaminoazobenzene이 백서의 정상 및 재생간의 EGF Receptor 변동에 미치는 영향

홍장희,허강민,석정호,이재흔 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

To study the changes of EGF receptors in the rat liver regeneration and hepatic carcinogenesis, ^125I-EGF binding sites were measured in the regenerated liver cell membrane after partial hepatectomy of normal rat and 3-methyl-4-dimethylaminoazobenzene treated rat. 1. EGF binding sites (Bmax) in the normal rat liver cell membrane were 553.8fmole/mg protein and were markedly decreased at the 1st day after partial hepatectomy. These sites were increased at the 3rd day(Bmax-161.0fmole/mg protein) and were 29% of the normal liver EGF binding sites. 2. EGF binding sites (Bmax) in the normal cell membrane of the 3-methyl-4-dimethylaminoazobenzene-treated rat, were 72.8fmole/mg protein and were significantly less than those in the normal rat live cell membrane. At the 1st day after partial hepatectomy, EGF binding sites were markedly decreased and increased at the 3rd day (Bmax=155.8fmole/mg protein). 3. Kd values in EGF receptor binding were not much altered in both liver cell membranes of the normal rat and the 3-methyl-4-dimethylaminoazobenzene treated rat. From these result, it is suggested that decreased EGF binding sites in the liver cell membrane of regenerating rat liver and 3-methyl-4-dimethylaminoazobenzene treated rat may be due to the alteration of EGF receptor number.

都市計劃 用度地區 指定 및 都市設計에 관한 硏究 : 新都市에 있어서 地域施設의 供給計劃에 관하여 On the Supply Plan of Regional Facilities in New Town

丁泰燮,洪熙澤 全北大學校 附設 都市및環境硏究所 1996 都市 및 環境硏究 Vol.11 No.1

This study aims to investigate actual conditions of the supply of community facilities of cities in Korea and Japan, by surveying the number of facilities per unit population, and to obtain the fundamental data for regional planning in Korea through comparative analyses. Followings are the results of this investigation : 1) High correlations are found between the population and the number of facilities. 2) The original unit of facilities are classified into four types according to the size of the population and the population density. 3) In general the original unit of facilities and the population per unit facilities hold higher level in Japan than in Korea, but some kinds of facilities stand approximately the same level in both countries.

골수, 제대혈 및 가동화된 말초혈액에서 Megakaryocyte 집락의 형성능력 비교

홍대식,김정아,김숙자,박성규,서원석,박희숙 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.2

연구배경 : MK 집락배양은 적절한 배양조건과 배양후 MK 집락을 확인하기 어려워 다른 집락배양에 비하여 늦게 시작하였다. 하지만 이러한 문제들이 해결되면서 최근에는 체외에서 MK를 증폭하거나 TPO, IL-11등과 같은 사이토카인의 사용으로 이식 후 혈소판의 감소를 극복하려는 시도들이 활발하게 진행되고 있다. 저자들은 MegaCult^(TM)(Stem Cell Technologies Inc, Vancouver, Canada)를 이용하여 제대혈, 가동화된 말초혈액, 골수를 이용하여, 조혈원 간의 MK 집락 형성능력을 비교하였으며, 앞으로 이러한 방법을 생체 외 MK 증폭 실험 뿐만 아니라 혈소판질환의 병태생리를 연구하는 기초적인 자료로 사용하고자 한다. 방법 : 말초 조혈모세포는 정상인에게 G-CSF 300㎍을 5일간 피하 주사 한 후 혈액분반기를 이용하여 채취하였다. 골수는 동종 골수이식 시 공여자로부터 동의를 얻은 후 채취하였으며, 제대혈액은 정상 분만 후 태반과 제대로부터 얻었다. 단핵구와 CD34^(+) 세포를 분리하여 MegaCult^(TM)를 이용하여 MK 집락을 배양하고, 항 GPIIb/IIIa를 이용하여 이를 확인하고 도립현미경하에서 집락수를 관찰하였다. 결과 : 1) 단핵구를 이용한 MK 집락 비교에서 순수 MK, 혼합 MK 집락 모두 제대혈에서 가장 많은 집락 형성능을 보였고, 골수, 말초 조혈모세포 순이었다. 2) CD34^(+) 세포를 이용한 MK 집락은 각 조혈원에서 양호하게 형성됨이 관찰되었고, 단핵구를 이용한 MK 집락 배양에서처럼 제대혈, 골수, 말초혈액 순으로 제대혈액내에서 가장 많은 집락 형성을 보였다. 3) 단핵구 또는 CD34^(+) 세포를 이용한 집락 배양 시에도 MK를 포함한 전체 집락이 제대혈액에서 가장 많이 형성되었다. 결론 : 각 조혈원의 MK배양에 IL-3, IL-6, TPO가 포함된 MegaCult^(TM)를 사용하였으며 배양된 집락중 megakaryocyte를 확인하기 위하여 항GPIIb/IⅡa 항체를 이용한 면역 조직학적 염색을 시행하였다. 저자들이 시행한 MK집락 배양과 GPIIb/IⅡa를 이용한 면역조직학적 염색은 혈소판의 병태 생리를 이해하고, MK 증폭을 포함한 이식 후 혈소판 회복을 증진시키기 위한 여러 가지 실험의 기초적인 자료가 될 것이다. Background: In vitro colony assay procedures for detecting human erythroid and granulocyte-macrophage progenitors have been in widespread use for many years. However, the development of reproducible assay methods for human megakaryocyte (MK) progenitors lagged considerably behind. There are two main reasons for this: First, the growth conditions initially optimized for other blood cell lineages are not optimal for MK progenitor cell growth. Secondly, the specific recognition of MK colonies requires fixation of the cultures and immunocytochemical staining of the cells for MK-specific antigens. The Methocult^(TM) system for detcting human clonogenic MK progenitors uses a medium containing a defined serum substitude to minimize the inhibitory effects of factors like TGF-β that are found in most sera. Three categories of colonies can be identified in cultures set up with Methocult^(TM): pure MK colonies; mixed MK colonies (containing other lineages as well as MK); and non-MK colonies (containing only other lineages of cells). Methods: This assay has been used to determine the range of MK progenitors present in a series of umbilical cord blood, peripheral blood and bone marrow samples. The MK colonies are detected by staining of the cells with a primary antibody to the MK-specific antigen GPIIb/IIIa (CD41). Results: We enumerated pure CFU-MKs in G-CSF mobilized peripheral blood (MPB), BM and umbilical cord blood (UCB). CFU-MK were detected in MPB, BM, and UCB at incidences of 1.00±0.82, 6.75±2.22, 8.00±1.83 of 5×10⁴mononuclear cells and at incidences of 19.00±03.37, 40.33±17.21, 99.00±54.76 of 5×10³ CD34^(+) cells. The highest number of pure CFU-MK was seen in UCB. The other colony counts (mixed CFU-MK, non-MK CFU) were also higher in UCB than in MPB and BM. Conclusion: We speculate that UCB should be better source of CFU-MK than any other stem cell sources.

장중첩증을 동반한 맹장 지방종 1예

홍의실,나병규,김민옥,유일영,채지영,채희복,윤세진,이상전,송형근,박길선,정현용 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

대장 지방종은 주로 우측 결장에 호발하고 특히 회맹판 부위와 맹장 부위에 호발한다. 또한 50~60대에 빈도가 높고 증상이 있는 환자에서 장중첩증이 높게는 40~50%에서 보고되고 있어 성인 장중첩증의 원인으로 중요한 비중을 차지한다. 특히 성인 장중첩증 및 장폐쇄의 중요 원인인 악성 종양과 임상 양상이 유사하여 감별진단이 중요하다. 저자들은 반복적인 복통을 주소로 내원한 환자에서 맹장의 4×5㎝의 점막하 지방종이 말단 회장부위와 반복적인 장중첩중이 발생했던 1례를 부분 절제술로 치료하여 양호한 임상 경과를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Lipomas are one of the most common benign nonepithelial tumors of the colon which are often detected incidentally by radiologic investigation or on operation. These tumors are usually without specific symptoms. Colonic lipomas occur most often in the right colon, particularly in the ileocecal valve and the cecum. Most patients are asymptomatic. but tumors larger than 2 cm tend to produce a change in bowel habit. abdominal pain. rectorrhagia and complications including luminal obstruction or intestinal intussusception. Diagnosis can be made by colonoscopy abdominal CT. MRI, or barium enema. We report a case of lipoma of the cecum that originated in the submucosa and presented as a intussusception in a 50-year-old woman with a brief review of the literature.

유아에서 발생한 재발성 외음부 콘딜로마 1례의 치료

홍정희,문성택,김윤숙,전섭,최승도,선우재근,배동한 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

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Mossbauer 분광법을 이용한 제주 화산암의 미시적 연구와 그 응용

홍성락,고정대,김순희 濟州大學校 基礎科學硏究所 1994 基礎科學硏究 Vol.7 No.1

제주도 전 지역의 특정위치를 선정하여 그 위치에 따라 지하 60m, 61m, 87m, 99.5m, 220m까지 깊이별로 화산암 시료를 채취하여, 이 시료에 대한 SIMS, XPS와 Mossbauer spectroscopy의 실험결과를 보고한다. UHV chamber에서 분리 이온화에 의해 생겨 난 parent 이온들로부터 cracking pattern들에 대해 연구하였고, 그 parent 이온들은 Si??, Al??, Ca??, Mg??, Fe??, Fe??, Na?, k?등으로 나타났다. 이 시료들에 대한 XPS 실험에서 wide scan analysis를 통하여 시료 표면에서 Al, Si, Ca, O, Fe, Na 등의 원소가 존재하고 있음을 알 수 있었으며, narrow scan analysis를 통하여 이들 대부분이 single compound state를 나타내고 있음을 발견할 수 있었다. 화산암에 대한 Mossbauer spectrum으로부터 olivine, pyroxene, ilmenite에 의한 세쌍의 quadrupole splitting을 얻었으며, 각 광물에 함유된 Fe는 약간의 Fe??를 제외하고는 거의 모두 Fe??상태임을 확인하였다. We are reporting the results of measurements of the SIMS, XPS, and ??Fe Mossbauer spectrum for powder samples of volcanic rock which has been distributed throughout different areas on Cheju island, each in different depth beginning at 60m then 61m than 61m, 87m, 99.5m, and 220m. We have studied the cracking patterns from parent ions which are created by dissociative ionization in the UHV chamber. The parent ions were Si??, Al??, Ca??, Mg??, Fe??, Fe??, Na??, and k??. In the XPS results for these samples, we find the existence of elements Al, Si, Ca, O, Fe, Na on their surfaces through the wide scan analysis. Also, the single compound state has appeared in a greater percentage of the them through the narrow scan analysis. The Mossbauer spectrum consists of well defined quadrupole doublets having a dominant 2+ charge state with a small percent having a 3+ charge state. These indicate the presense of olivine, pyroxene, and ilmenite.

Bacillus subtilis SS103으로 제조한 된장의 품질 특성 및 Angiotensin 전환효소 저해 활성

홍지수,박정륭,전정례,차명화,김진,김정희 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.4

Three different doengjang(fermented soybean paste) were prepared by using B. subtilis SS103 with high angiotensin converting enzyme(ACE) inhibitory activity, Asp. oryzae and mixed culture of two organisms, respectively. Quality characteristics and the inhibitory activity were compared. β-Amylase activity rapidly increased during 30 days of fermentation, but lower activity was found in doenjang prepared with B. subtilis. However, α-Galactosidase activity decreased for 15 days of fermentation and little activity was observed after that fermentation period. Protease production tended to increase during the fermentation. High protease activity was found only in doengjang prepared with Asp. oryzae, but the doengjang prepared with B. subtilis SS103 showed very low activity. Total isoflavone content at 90 day fermentation was the highest in doengjang prepared with mixture of Asp. oryzae and B. subtilis. ACE inhibitory activity increased during the fermentation period. The highest activity was found in doengjang made with mixture of Asp. oryzae and B. subtilis. Sensory evaluation on doengjang itself and its soup indicated that doengjang made with mixture of Asp. oryzae and B. subtilis showed higher acceptability on taste, flavor and color than those prepared with only Asp. oryzae or B. subtilis, respectively.