폐외소세포암

선길홍,윤찬영,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Background: Small cell carcinomas (SCC) are most commonly seen in the lung, approximately 2.5-4% of all SCC occur in extrapulmonary sites. This study aimed to review the clinical features, therapy and natural course of patients with extrapulmonary small cell carcinoma (EPSCC) in single-institution series. Methods: We retrospectively reviewed the medical records of patients with SCC between December 2002 and November 2005. Study eligibility required that patients had pathologically proven SCC in sites other than lung with normal radiological findings of the chest and normal sputum cytology or negative bronchoscopic findings. Result: Eight patients with EPSCC were identified and their primary sites were various such as esophagus (4 cases), kidney (1 case), thymus (1 case), stomach (1 case) and unknown primary supraclavicular lymph node (1 case). The 4 patients were classified as limited disease (LD) and 2 patients were as extended disease (ED) at initial staging work-up. But 2 patients were undetermined. The 3 patients with EPSCC of LD were treated with operation and adjuvant chemotherapy or chemotherapy and radiotherapy and one received only supportive care. They showed favorable clinical courses with a median overall survival of 23 months. EPSCC of ED and undetermined group received only supportive care. They had aggressive clinical courses with a median overall survival of 3 months, Conclusions: EPSCC was identified in various sites with the most common primary site being the esophagus, It was predominantly occurred in old male patients and associated with smoking like as SCC of the lung. Since EPSCC is a relalively rare disease that mimics SCC of the lung in its response to treatment and survival pattern, it would appear advisable to follow similar treatment guidelines. Although recurrence within short terms was observed, a significant survival benefit was obtained in EPSCC of LD received treatment (chemotherapy, operation and radiation therapy). Thus, EPSCC is usually a fatal disease with meidan overall survival of 18 months. 연구배경: 소세포암의 가장 흔한 발생부위는 폐이며, 폐외소세포암은 전체 소세포암의 2.5~4%를 차지하는 매우 드문질환이다. 본 연구의 목적은 단일 기관에서 진단된 폐외소세포암의 임상적 특징, 치료와 자연경과를 보고하고자 하였다. 방법: 조선대학교부속병원에서 2002년 12월 부터 2005년 11월 사이에 소세포암으로 진단된 66명의 의무기록을 검토하였다. 폐외소세포암은 흉부 단순 몇 전산화단층 촬영, 객담세포 검사, 기관지경 검사에서 폐병번이 없으면서 폐와 병변의 조직학적 생검에서 소세포암으로 증명된 경우로 하였으며, 총 8명이였다. 결과: 본 연구에서 식도가 전체 폐외소세포 암 환자의 50%(4례)로 가장 많은 원발병소를 보였으며 그 외 흉선, 신장, 위가 1례씩 있었으며 쇄곧상부 림프절에서 소세포암이 발견되었으나 원발 병소를 발견 못한 경우가 1례 관찰되었다. 4명의 환자는 제한 병기를 보였으며 2명은 광범위 병기를 보였지만 나머지 2명은 위내시경으로 식도에서 소세포암이 조직학적으로 진단되었으나 보전적 치료만을 받길 원하여 병기결정을 위한 검사는 시행할 수 없었다. 제한 병기의 폐외소세포암 환자는 4명이었다. 2명은 수술적 절제후 보조항암화학요법을 받았으며, 1명은 항암화학요법후 방사션치료를 받았고, 나머지 한명은 보전적 치료만 시행하였다. 제한 병기의 폐외소세포암 환자틀은 양호한 임상 경과를 보였으며 중앙 생존기간은 23개월이었다. 하지만 광범위 병기의 폐외소세포암 환자와 병기를 분류할 수 없던 환자에 대해서는 항암화학요법 등의 적극적 치료는 시행하지 않고 보존적 치료만 시행하였다. 그들의 임상경과는 빠르게 악화되었으며 중앙 생존 기간은 3개월이었다. 결론: 본 연구에서 폐외소세포암은 다양한 장기에서 발견될 수 있으나 가장 흔한 곳은 식도였다. 소세포폐암과 유사하게 고령, 남성 및 흡연과 관련을 보였었다. 제한 병기에서 국소 치료, 항암화학요법은 생존기간의 연장을 보였으나 쉽게 다른 장기로 전이가 되거나 재발하는 매우 치명적인 질환임을 확인할 수 있었다. 전체 중앙 생존기간은 18개월 이었고 항암 화학요법등의 치료를 받은 군이 보존적 치료를 받은 군에 비해 의미있는 생존기간 (p=0.040)의 연장을 보였다. 본 연구는 단일기관의 상대적으로 적은 수의 소규모 연구이지만 폐외소세포암의 제한 병기에서 국소치료 및 항암화학요법은 생존기간의 연장을 보였고 쉽게 다른 장기로 전이가 되거나 재발하는 매우 치명적인 질환임을 확인 할 수 있었다.

혼합형 자가면역성용혈성빈혈과 동반된 Evans 증후군 1례

선길홍,윤찬영,박상곤,박경희,우정주,한경택,김진화,김영훈,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Evans syndrome is defined as a simultaneous or sequential occurrence of autoimmune hemolytic anemia and autoimmune thrombocytopenia. Autoimmune hemolytic anemia (AIHA) is usually induced by IgG warm autoantibody or cold-active IgM antibodies reacting specifically with antigens associated with a patient's RBC. AIHA is a fairly uncommon disorder, with estimates of the incidence at 1 to 3 cases per 100,000 per year. Mixed-type AIHA is a relatively uncommon form of AIHA, with studies noting the incidence of 7-8% among cases of AIHA. We experienced a patient, 46-year-old woman who was diagnosed having a very rare clinical presentation of mixed warm and cold antibody mediated Evans syndrome. She was treated with corticosteroid therapy only and has been maintaining a complete response for 15 weeks. 저자들은 혼합형의 자가면역성 용혈성 빈혈과 자가면역성 혈소판 감소증이 동시에 발생한 혼합형 Evans 증후군으로 진단하고 스테로이드 요법 후 혈액학적으로 회복된 상태로 15주가 지난 현재 steroid 5 mg/일 까지 감량한 상태에서 추적 관찰 치료중인 46세 여자 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

추출조건에 따른 다시마 추출액의 특성에 미치는 물리적 특성의 영향

허상선,정재용*,박영호,주길재,최용희* 경북대학교 농업과학기술연구소 1999 慶北大農學誌 Vol.17 No.-

The objective of this research was to characterize viscosity of sea tangle extract isolated from sea tangles in Korea to obtain basic data for production of dietary fiber materials with new functional properties. The viscosity of sea tangle extract was increased as the the extraction time increased. However, these values increased inginficantly up to 1 hour of extraction time and then slow increased in case of hot water extraction and enzymatic hydrolyzed sea tangle extract. As for addition of sugar and salts, the values of viscosity of sea tangle extract was very low in the additon of EDTA-2Na regardless of concentration. But in case of sucrose and NaCl, the viscosity of sea tangle extract were tended to decreased up to 2.5% concentration.

Duchenne형 進行性 筋異養症 保因者 檢出에 Restriction Fragment Length Polymorphism 이용에 관한 硏究

李美正,朴吉洪,朴善華,柳總根 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.3

We performed genetic analysis for detection of carrier state of Duchenne's muscular dystrophy (DMD). As genetic markers of the disorder, We used DNA-sequence polymorphisms detected with 6 different DNA probes derived from the vicinity of the DMD locus at genetic distance less than 15 cmo or from within the gene. on the short arm of X chromosome. In the family we studied. a consultand was a 29 years old woman whose maternal grandfather was a DMD patient who was unavailable. Therefore, all of her maternal aunts were DMD carriers whose next generations were requested for DNA studies. On the basis of linkage analysis. a proband and her niece were deemed to be unaffected with an accuracy of more than 99%, and we anticipated another two femals and one malt to be unaffected with 98% probability (normal serum creatine kinase level) where crossover events between intragenic(pERT 87.30) and flanking probes(pXUT23) were detected. but carrire risk of a female with the same haplotype was elevated to 41% taking account of an increased serum creatine kinase level. Two other females were predicted to be affected with 99.9 and 97.1% probabilities each. However. a genetic interpretation was impossible for one male in which a crossover breakpoint could not be determinied because of his mother's homozygosity of the alleles between crossovered alleles where hitherto pessibility of intragenic crossover could not be ruled out Our experience suggests that genetic diagnosis based on recombinant deoxyribonucleic acid techniques are assuming increasing importance. and provide a highly accurate method for carrier detection and prenatal diagnosis of DMD. By the way, despite the large number of intragenic and flanking DNA polymorhpisms available, uncertainties often remain in the genetic diagnosis of DMD. Pitfalls are presented by the large size of the region in which Duchenne's mutations can occur. Crossover events in this region. especially intragenic ones, which result in an exchange of DNA between two X chromosomes, can,rener DNA-marker studies inaccurate.

온도상승에 따른 마감재의 세공구조 특성에 관한 연구 : 석고보드를 중심으로 Focusing on Gypsum Boards

김광기,박선길,김근허,송병창,정상진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

On fire, the most significant materials influencing the rise of temperature are finishing materials, and highly combustible materials become the reason of magnifying fires compared to incombustible materials. Recently, gypsum boards are widely used as interior finishing boards for constructions because of their features of absorbing heats and little temperature rising at the early stage of fire. Therefore, in this research, basic data were suggested to secure fireproof stability by investigating interior processing features, which change together with the backside temperature of test materials from Flash Over(within 30 minutes after firing), at which temperature reaches its highest point, to survey the features of materials due to rising temperature in the chase of gypsum boards (general and fireproof gypsum board)

Establishment of the Extraction Process by Evaluation of Morroniside, Loganin, and Cornin Contents of Sansuyu (Corni fructus) Extracts

Ji-Suk Jeong,No-Jin Park1,Byeong-Gil Son,Kyung-Il Kim,Bok-Sun Shim,Yung Hyun Choi 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

혈액투석 환자에게서 발생한 재생불량성 빈혈 1예

정지용,윤나라,강대웅,오종찬,장재현,선길홍,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Aplastic anemia is a disease characterized by pancytopenia in the peripheral blood and hypocellular bone marrow with the fatty infiltration. The causes of the acquired aplastic anemia were usually related to drugs and immune-related diseases. A 34-years old man was admitted due to general weakness. He has been going hemodialysis for 2 years because of end stage renal disease (ESRD) due to chronic glomerulonephritis. At admission, laboratory tests showed hemoglobin 6.2 g/dL, hematocrit 18.0 %, WBC 5,710mm (neutrophil 71.8%, lymphocyte 19.1%, monocyte 5.9%), reticulocyte 1.9%, platelet 93,000/mm, Fe 12.8 ug/dL, TIBC 204 ug/dL, ferritin 941.47 ng /ml, haptoglobin 0.72 g/L, vitamin B12 508.17 pmol/L, folate 24 ng/mL, total protein 6.54 g/dL, albumin 3.76 g/dL, Alk. pohsphatase 79 IU/L, AST 30.0 IU/L, ALT 39.7 IU/L, total bilirubin 0.57 mg/dl, BUN 79.4 mg/dl and creatinine 10.18 mg/dl. Peripheral blood smear showed the normocytic normochromic anemia with anisocytosis. Anemia was diagnosed but it was irresponsive to the recombinant human erythropoietin (EPO) and blood transfusion. In the bone marrow aspiration smear were there the hypoplastic myeloid and erythroid precursors. The bone marrow biopsy section showed the hypoplasia of all components (10-20%) and the fatty infiltration. We have experienced one case of the idiopathic aplastic anemia in a patient going through hemodialysis and we just report it with documentary records. 저자들은 혈액 투석 중인 환자에서 약물, 면역계 이상등의 원인을 발견할 수 없었음에도 재생 불량성 빈혈이 발생한 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

A preliminary study for the development of indices and the current state of surgical site infections (SSIs) in Korea

Sun Jin Park,Kil Yeon Lee,Ji Won Park,Jae Gil Lee,Hee Jung Choi,Hee Kyung Chun,Jung Gu Kang 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.3

Purpose: We aimed to develop an effective system for surgical site infection (SSI) surveillance and examine the current domestic state of SSIs for common abdominal surgeries in Korea. Methods: The Korean Surgical Site Infection Surveillance (KOSSIS) program was developed as an SSI surveillance system. A prospective multicenter study in nine university-affiliated or general hospitals was conducted for patients who underwent gastrectomy, cholecystectomy, appendectomy, colectomy, or proctectomy between August 16 and September 30 in 2012. Patients were monitored for up to 30 days by combining direct observation and a postdischarge surgeon survey. Data on SSIs were prospectively collected with KOSSIS secretarial support according to a common protocol. Operation-specific SSI rates were stratified according to risk factors and compared with data from the Korean Nosocomial Infections Surveillance System (KONIS) and National Healthcare Safety Network. A focus group interview was conducted with participating hospitals for feedback. Results: A total of 1,088 operations were monitored: 207 gastrectomies, 318 cholecystectomies, 270 appendectomies, 197 colectomies, and 96 proctectomies. Operation-specific SSI rates determined by the KOSSIS program were substantially higher than those found in KONIS (7.73% [95% confidence interval, 4.5%?12.3%] vs. 3.4% for gastrectomies, 10.15% [95% confidence interval, 6.1%?15.2%] vs. 4.0% for colectomy, and 13.5% [95% confidence interval, 7.4%?22.0%] vs. 4.2% for proctectomy). Conclusion: Despite a short surveillance period and heterogenous group of hospitals, our results suggest that KOSSIS could be a useful program to enhance SSI surveillance in Korea.

Survey on Dental Caries Experience of Students in Vientiane Province, Laos

Sun-Gil Park,Ja-Won Cho,Hyun-Jun Yoo,Phommavongsa Nitthasack,Ji-Hyeon Park 대한예방치과학회 2023 International Journal of Clinical Preventive Denti Vol.19 No.4

Objective: The purpose of this study is to assess the prevalence of dental caries among students in the Vientiane area of Laos. Methods: We conducted an analysis of the oral examination outcomes for a cohort of 344 children in Vientiane, including 121 in primary school, 138 in middle school, and 85 in high school, to evaluate the prevalence of dental caries in this group. Results: For 12-year-olds, equivalent to the first year of middle school, the index of experienced decay in permanent teeth was 3.30, with a decayed permanent tooth surface index of 6.01. The rate of caries experience in permanent teeth was 86.13%, the decay rate in permanent teeth was 92.09%, the treatment rate for permanent teeth was 1.98%, and the caries fatality rate was determined to be 12.09%. Conclusion: The prevalence of dental caries experience among most age groups was significantly higher compared to other regions, with a permanent tooth decay rate ranging from approximately 88% to 91%. Notably, the primary tooth decay rate was found to be around 99%, indicating an exceptionally high level. The dental caries fatality rate was also estimated to be in the range of 5% to 12%, underscoring the need for simultaneous preventive measures and treatment programs in Laos to halt the progression of dental caries and reduce the dental caries fatality rate.

Long-term follow-up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report

Park, Jung Gil,Tak, Won Young,Park, Soo Young,Kweon, Young Oh,Jang, Se Young,Lee, Soo Hyun,Lee, Yu Rim,Jang, Sun Kyung,Hur, Keun,Lee, Heon Ju Spandidos Publications 2017 Oncology letters Vol.14 No.4