數種 原發性 肝病變이 肝 및 肺의 生理學的 機能에 미치는 影響

朱永恩,李錫江,金鍾基 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.16 No.2

四鹽化炭素의 投與로서 肝組織뿐 아니라 肝組織에 미치는 中毒現象을 살펴보고 나아가서 還元型 glutathione(GSH)를 CCl_4와 倂用함으로서 肝 및 肺組織에 미치는 影響을 알기 위하여 家兎를 材料로 하고 CCl_4와 olive oil의 1:1混合液을 體重 ㎏當 0.3㎖씩 週 2回, 2週間 續續한 群과 GSH를 體重 ㎏當 20㎎ 投與한 群, 및 GSH와 CCl_4를 倂用한 群으로 나누어 投與後 1,3 및 5日에 各各 肝 및 肺組織의 蛋白質, NP-SH(non-protein sulfhydryl) 및 NP-SS(non-protein disulfide)를 定量하고 또한 肺洗滌液의 表面活性度와 蛋含量을 測定하였다. 또한 體重, 肝重量 및 左肺重量을 測定하여 肝重量 對 體重比 및 左肺重量對 體重比를 算出하고 對照群의 그것들과 서로 比較하여 다음과 같은 結果를 얻었다. 1. 對照群에 있어서 體重은 2.45±0.15㎏이었고 肝組織의 蛋白質, NP-SH 및 NP-SS는 各各 108.3±12.05㎎ wet. wt., 8.30±0.75 μ㏖/gm wet. wt. 이었다. 肺組織의 蛋白量, NP-SH 및 NP-SS는 各各 50.2±6.35㎎/gm wet. wt., 3.01±0.42 μ㏖/gm wet. wt. 및 6.02±0.50 μ㏖/gm wet. wt. 이었다. 한편 肝洗滌液의 表面活性度는 最大張力이 58.0±3.0 dyne/㎝이었고 最小張力은 6.0±2.5 dyne/㎝ 이었으며 stability index는 1.63이었다. 肺洗滌液의 蛋白量은 108.0±9.0㎎/gm wet. wt. 이었고 肝重量對 體重比는 17.76이었으며 左肺重量對 體重比는 1.31이었다. 2) CCl_4 投與群에서는 肝 및 肺組織에서 모두 蛋白量 및 SH基가 對照에 比하여 減少되었고 GSH 投與群에서는 모두 큰變化가 없었으나 GSH와 CCl_4를 倂合한 群에서는 大體로 CCl_4 單獨投與 보다는 높으나 GSH 投與群보다는 낮은값을 나타내었다. 3) 肺洗滌液의 表面活性度는 CCl_4 投與로서는 對照에 比하여 低下되었으나 GSH 投與群에서는 큰 差異가 없었고 GSH와 CCl_4를 倂用한 群에서는 大體로 CCl_4投與群 보다는 높은 傾向을 나타내었다. 4) CCl_4 投與로서 體重의 減少는 顯著하였고 反面 肝重量은 相當히 增加되어 그 結果 肝重量對 體重比는 增加하였고 左肺重量對 體重比는 큰 差異가 없었다. GSH 投與로서는 體重, 肝重量, 左肺重量, 肝重量對 體重比 및 左肺重量對體 中比가 對照에 比하여 差異를 나타내지 않았으나 GSH와 CCl_4의 倂用으로서는 各 値가 大體로 CCl_4 單獨投與群보다는 높은 傾向을 나타내었다. The fact that the liver functions decrease when the liver is damaged is well established, but little has been reported whether the primary liver damage causes the decreased metabolism of other organs, particularly the lung. In the present study, carbon tetrachlorid (CCl_4) was injected intraperiteneally to the rabbit, and the changes of protein, NP-SH and NP-SS levels of the liver and lung were observed. Also, the pulmenary surfactant activities as well as the protein content of the lung washings were studied. The changes of the body weight, left lung weight and the liver weight were also measured and the left lung wt: BW ratio as well as the liver wt: BW ratio were calculated. CCl_4 was mainly used as the mixture with olive oil(1:1) in the dose of 0.5㎖ per ㎏ BW, and the experiment was performed at 1,3 and 5 days after the CCl_4 injection. Reduced glutathione (GSH) in the dose of 20㎎ per ㎏ BW was used either singularly or in combination with CCl_4 in order to elucidate the effectiveness of GSH on the CCl_4 intoxicated animal. The results thus obtained are summarized as follows: 1) In the normal (control) group, the protein, NP-SH and NP-SS of the liver was 108.3±2.05㎎/gm wet wt., 8.30±0.75㎛ol/gm wet wt. and 6.80±0.55㎛ol/gm wet. wt., respectively. In the lung tissue, the protein, NP-SH and NP-SS level was 50.2±6.35㎎/gm wet wt., 3.01±0.42㎛ol/gm wet wt. and 6.02±0.50㎛ol/gm wet wt., respectively. The maximun surface tension, minmum surface tension and stability index of the lung washings was 58.0±3.0dyne/㎝, 6.0±2.5dyne/㎝ and 1.63, respectively, and protein content of the lung washings was 108.0±9.0㎎/gm wet wt. The body weight was 2.45±0.15㎏, and the liver wt: BW ratio was 17.76 while the left lung wt: BW ration was 1.31. 2) The protein and sulfhydryl(SH) levels of the liver and lung in the CCl_4 injected proup were decreased comparing to the control, and when GSH alone was injected, there was no noticeable change. However, when GSH and CCl_4 were combinded, both the liver and lumg showed generally higher values of the protein and SH levels than CCI_4 injected group, and lower levels than the GSH injected group. 3) The surfactant activities of the lung washings were decreased when CCl_4 was used, and the injection of GSH alone produced no significant change from the control. When GSH and CCl_4 were combined, the surfactant activities showed a tendency of increased levels than the CCl_4 injected group. 4) The decrease of the body weight was prominent when CCl_4 was injected but the liver weight increased noticeablly with the result of the increased liver wt: BW ratio. The left lung wt: BW ratio did not, however, change much in the CCl_4 injected group. When GSH alone was injected, the body weight, liver wt, left lung wt, liver wt: BW ratio as well as the left lung wt: BW ratio did not change noticeablly from the control. When GSH and CCl_4 were combined, the above values showed a general tendency of increase comparing with the CCl_4 injected group.

도로기반 수치지도의 수정 및 갱신을 위한 GPS-Van 적용에 관한 연구

주영은,이형석 한국지리정보학회 2005 한국지리정보학회지 Vol.8 No.3

Agenesis of the Dorsal Pancreas: A Case Report and Review of the Literature

주영은,강호철,김현수,최성규,유종선,정민영,김세종 대한내과학회 2006 The Korean Journal of Internal Medicine Vol.21 No.4

Partial or complete agenesis of the dorsal pancreas is a rare congenital anomaly that results from the embryological failure of the dorsal pancreatic bud to form the body and tail of the pancreas. To date, four cases have been reported in Korea. We report an additional case; a 25-year-old woman presented with diabetes mellitus and abdominal pain. Abdominal computed tomography (CT) revealed a normal-appearing pancreatic head, but the body and tail were not visualized. Endoscopic cholangiopancreatogram (ERCP) revealed a short pancreatic duct in the uncinate process and the head and the duct of Santorini draining into the minor papilla. Abdominal magnetic resonance imaging (MRI) findings were similar to the CT and ERCP results. The patient was diagnosed with partial agenesis of the dorsal pancreas by CT, ERCP and MRI.

Expression of Cyclooxygenase-2, p53 and Ki-67 in Gastric Cancer

주영은,정익주,박영규,Yang-Seok Koh,이재혁,박창환,이완식,김현수,최성규,유종선,박창수,김세종 대한의학회 2006 Journal of Korean medical science Vol.21 No.5

실버유아보조강사교육 만족도 조사

주영은 한국보육학회 2006 한국보육학회지 Vol.6 No.2

A Preschool Teacher Assistant Education Program for Senior Citizens which was intended to systematically and professionally support the elderly labor force was developed and operated. Then, by examining whether this program appropriately satisfied the demands of the senior citizen, this study aims to further complement and develop the Preschool Teacher Assistant Education Program for Senior Citizens and to provide a important basic data on the characteristics of the elderly labor force to be applied to the field of Preschool educational institutions when senior citizens are sent to work as Preschool Teacher Assistants. The findings of this study are as follows. Research subjects" general characteristics such as sex and age showed that the percentage of men(52%) was a little higher than that of women(48%), and the mid-old population between ages 65 to 74 was the largest group(74%)In terms of co-habitants, the percentage of those who live with their spouses was highest(49%). Regarding educational attainment and occupation, most subjects(82%) had high school diplomas or more including some senior citizens with postgraduate education(92%). When asked about their motives of participating the Preschool Teacher Assistant Education Program for Senior Citizens, 41% of research subjects answered because they were interested in preschool children and 36% of them said "because they want to learn new information and knowledge," Regarding participation paths, the highest rate of subjects(63%) found the path to participate in the program through local Social Welfare Centers. After attending the Preschool Teacher Assistant Education Program for Senior Citizens, almost all research participants(97%) expressed that they were satisfied with the program "because they were able to learn new information"(33%) and "because they could spend their leisure time usefully"(26%). Thus, through the education program, most research subjects could have "meaningful leisure time"(33%) and "acquirement of new knowledge"(28%). For a future Preschool Teacher Assistant Education Program for Senior Citizens, the research subjects requested that the program last within 10 days(45%) and 4 hours a day(87%). The most desired number of working days was three days a week(82%) and the desired number of working hours was two or three hours a day(62%). Also, 97/% of research subjects expressed that, they want to be employed after the Preschool Teacher Assistant Education Program for Senior Citizens, indicating that most elderly labor force wish to work as Preschool Teacher Assistants. 본 연구에서는 노인 인력을 체계적이고 전문적으로 지원하는 실버유아보조강사교육 프로그램이 노인들의 요구를 적절하게 만족시켰는지 조사하여 실버유아보조강사교육 프로그램을 보완하고 발전시키고자 할뿐만 아니라 실버유아보조강사 파견 근무 시 유아교육기관 현장에서 노인들의 특성을 적용할 수 있는 중요한 기초 자료를 제시하고자 한다. 본 연구의 결과를 보면 첫째, 연구대상자의 일반적인 특성을 살펴보면, 여자 노인보다 남자 노인의 참여수가 약간 높았고, 65~74세의 중ㆍ고령 노인의 비율이 가장 높게 나타났다. 연구대상자 대부분 고졸 이상이었고, 대학원 이상의 학력을 소지하신 노인들도 참여하신 것으로 나타나 전반적으로 연구대상자 대부분 높은 학력을 소지하신 분들이 참여했음을 알 수 있다. 둘째, 연구대상자의 실버유아보조강사교육 참여 동기는 유아들에게 관심이 있어서와 새로운 정보와 지식을 얻기 위해서가 대부분으로 참여하신 노인들은 실버유아보조강사교육을 통해 노인들의 자기개발기회와 유아에게 경륜이 포함된 전문분야 교육을 제공하고자 히는 욕구가 있다고 볼 수 있다. 실버유아보조강사교육 참여한 후 교육에 참여한 노인들 대부분은 만족함을 나타났고, 만족한 이유로는 새로운 정보를 얻을 수 있어서와 여가시간을 유용하게 할 수 있어 서로 나타난 것으로 보아 실버유아보조강사교육 프로그램은 노인들의 특성과 사회적인 요구의 특성을 잘 고려한 프로그램으로서 만족도가 높은 프로그램이라고 할 수 있다. 셋째, 연구대상자들에게 추후 실버유아보조강사교육이 실시될 경우의 요구사항으로는 근무기간은 10일, 교육시간은 4시간 이내를 요구하는 것으로 나타났고, 희망파견근무횟수로는 주 3회로 나타났고, 희망파견근무시간은 2~3시간으로 나타났다. 또한 실버유아보조강사교육 후 파견근무를 참여하고 싶은 노인 97%로 대부분의 노인들이 실버유아보조강사를 희망하고 있다는 것을 알 수 있었다.

감각운동 중심 영아교육 프로그램이 영아의 운동능력 발달에 미치는 효과

주영은 한국보육학회 2008 한국보육학회지 Vol.8 No.3

The sensorimotor skills of infants start to grow in their first 6 to 12 months after birth. So sensorimotor-centered infant education programs should be prepared to facilitate their development of motor skills. The purpose of this study was to develop a sensorimotor-centered infant education program to expedite the development of the motor skills of 6 to 12 months old, as they usually made a rapid progress in motor skills. And it's also intended to apply it in a daycare center to identify its effect on the motor skills who were 6 to 12 months old. To identify the effect of the program on their motor skills development, both groups took tests in motor skills before and after the experiment, and their caregivers were interviewed three times to see if there were any changes in their views. For data handling, Mann-Whitney U-Test was used, which was a nonparametric test to be suitable for a small number of subjects. The results were as follows: First, the experimental group that was exposed to the sensorimotor-centered infant education program showed a significantly better improvement in post-motor skills, including gross and fine motor skills, than the control group that wasn't. Therefore the sensorimotor-centered infant education program could be said to have a positive impact on the development of their motor skills. Second, the caregivers expressed satisfaction when they received theoretical and practical education about the development of motor skills and they got confident of infant education. And there was a favorable change in their ways of interacting with infants in the course of acquiring how to respond to them. 본 연구는 운동능력 발달이 급속히 이루어지는 6~12개월 영아를 대상으로 운동능력을 발달시키기 위한 감각운동 중심 영아교육 프로그램을 개발하고 이를 어린이집 보육현장에 적용하여 6~12개월 영아의 운동능력 발달에 미치는 효과를 검증하는데 목적이 있다. 영아의 운동능력 발달에 미치는 효과를 알아보기 위하여 프로그램 실시 전·후 실험집단 및 비교집단 영아를 대상으로 운동능력을 측정하는 검사를 실시하였고, 교사의 인식변화를 알아보기 우하여 면담을 3회 실시하였다. 수집된 자료는 연구대상 사례수기가 적은경우에 적합한 비모수통계방법인 맨 휘트니(Mann-Whitney) U-test를 실시하여 분석하였다. 연구결과, 첫째, 감각운동 중심 영아교육 프로그램이 영아의 운동능력 발달에 긍정적인 영향을 미친 것으로 나타났다. 둘째, 교사들은 운동능력 발달에 대한 이론과 실제 활동으로 구성된 교사교육을 통해 만족감과 영아교육에 대한 자신감을 갖게 되었고, 영아의 요구에 민감하게 반응하는 방법을 익히게 되면서 교사들의 상호작용 방법이 긍정적으로 변화된 것으로 나타났다.

14. 美國의 'No-Fault' 自動車保險에 관한 考察

朱榮殷 연세법학회 1990 연세법학 Vol.1 No.-

保險募集人의 法的 地位

朱榮殷 연세법학회 1992 연세법학 Vol.2 No.-

Evaluation of the Impact Acceleration Forces Attainable by Use of Mini-Trampoline

주영은,Dean, Ward,Choo, Young-Eun 대한생리학회 1982 대한생리학회지 Vol.16 No.2

수직뛰기 운동을 위한 mini-trampoline은 운동중 인체에 미치는 중력가속도를 변화시킴으로써 그 효과를 나타낸다고 하므로, mini-trampoline 운동중에 피검자가 받는 중력가속도를 다음과 같은 방법으로 측정하였다. 피검자로 하여금 mini-trampoline상에서 최대의 높이로 수직뛰기를 반복시키고, 그 뒷벽에는 3인치 간격의 눈금을 표시하여 뛰는 높이를 알 수 있게 하였다. 수직뛰기를 하는 동안에 super-8 mm 영사기로 초당 48 frames의 속도로 촬영한 후 각 frame에 나타난 피검자의 두정부 높이를 알아내었다. 수직뛰기하는 동안 시간에 대한 머리높이의 면화를 graph에 그려서 상승뛰기 운동시의 최대속도를 계산하였다. 이 결과로 부터 Arizona State University의 Crash Survival Investigator's School에서 고안한 다음의 공식을 사용하여 중력가속도(G)를 계산하였다. $$G={\frac{0.7854{\cdot}V^2}{32.2S}}$$ V = 상승운동시 나타난 최대속도 (fps) S = 하강운동시 정지거리 (ft) 본 연구에서 V는 약 9fps 였고, S는 0.61 ft 였으며 따라서 G는 $3.24+G_z$였다. 인체가 친밀 수 있는 증력가속도의 한계가 $+G_z$방향으로 0.1초동안 20G이며 $-G_z$방향으로 0.1초 동안 15G임을 고러할 때 mini-trampoline운동으로써 얻을 수 있는 중력가속도는 인체에 유해할 만큼 큰 것이 아니라는 것을 알 수 있다. It has been hypothesized that the effectiveness of the popular mini-trampoline as a conditioning device is due to the increased gravitational forces which are imparted to every cell in the body during its use. This study evaluated a means of determining the acceleration forces on a subject using a minitrampoline. By cinematic evaluation, a plot of the changes in distance over time was obtained. Using the formulas developed at the Arizona State University Crash Survival Investigators' School, the maximum acceleration forces were determined to be approximately $3.2+G_z$.

포스타 전시 발표 : 소화기 ; 위암종에서 Tissue inhibitors of Metalloproteinases(TIMPs)의 발현

주영은,조천영,김명성,오원태,서강석,김현수,유종선,김세종 대한내과학회 1998 대한내과학회 추계학술대회 Vol.1998 No.1