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이병석,박기현,박찬규,허갑범,이현철,임승길,조용욱,김유곤 대한내분비학회 1988 Endocrinology and metabolism Vol.3 No.2
Ovarian hyperstimulation syndrome (OHS) is a rare complication in the use of human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) for ovulation induction. The pathophysiology is unclear and treatments are mainly conservative. We presented a case of ovulation induction with HMG and HCG in secondary amenorrhea due to hypogonadotropic hypogonadism after brain surgery for craniopharyngeoma with abscess formation. A brief review on the literatures was made in comment.
황체화된 인간 과립세포에서 Apoptosis 관련 유전자인 bcl-2와 TRPM-2의 발현
이병석,최은아,장경환,김진영,배상욱,박기현,조동제,이국,김재욱,송찬호,Lee, B.S.,Choi, E.A.,Chang, K.H.,Kim, J.Y.,Bae, S.W.,Park, K.H.,Cho, D.J.,Lee, K.,Kim, J.W.,Song, C.H. 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.2
Apoptosis, programmed cell death, is posulated to occur in granulosa cells in ovarian follicular atresia. bcl-2 gene serves as protector from apoptosis and, thus, is associated with increased cell survival. TRPM-2 gene expression has been implicated as a trigger of apoptosis in rat prostate, uterus and mammary gland. Our objective was to determine if bcl-2 and TRPM-2 are expressed in luteinized human GC and, therefore, have regulatory functions for apoptosis in GC. Human GC were obtained via oocyte retrival from the infertile patients stimulated with exogeneous gonadotropins while undergoing IVF. GC were isolated from follicular fluid using Percoll gradient centrifugation. The GC were further purified with anti-CD45 magnetic beads to remove contaminating WBC's. RT-PCR were performed to analyze the mRNA expression of bcl-2 and TRPM-2 in the GC. The PCR primers were designed to amplify a 195 bp fragment of bcl-2 and a 174 bp fragment of TRPM-2. The PCR products were electrophoresed on 4% agarose gel. Three separate experiments indicated that both bcl-2 and TRPM-2 are concurrently expressed in human GC. We cultured granulosa cells with FSH (1 ng/ml) for 1 day to investigate the relative changes of TRPM-2 mRNA level with RNAse protection assay. When we cultured GC with serum free medium for 1 day TRPM-2 mRNA level increased with 1.3 fold, however it was decreased 0.64 fold with FSH. Therefore we conclude that bcl-2 and TRPM-2 are concurrently expressed and that the interaction of their products may be involved in GC apoptosis. And TRPM-2 may be regulated with FSH.
이병석 한국보험학회 2003 保險學會誌 Vol.65 No.-
자동차손해배상보장법 제3조 단서 제2호 소정의 사유에 관한 논점에는 두 가지가 있는 듯하다. 하나는 자동차승객이 사망한 경우라면 당해 사고가 설령 운행자 자신에게는 과실이 없고 제3자의 불법행위에 의하여 발생하였다고 하더라도 당해 운행자는 손해배상책임을 면할 수 없다는 판례의 논리에 관한 것이고, 또 하나는 이러한 논리에 입각하여 있었던 이른바 위헌시비에 관한 것이 그것이다. 전자에 관해서는 이제까지 異論이 없었고, 후자에 관해서는 합헌으로 결정된 바 있다. 이러한 논점의 근저에는 공통적으로 자배법 제3조 단서 제2호 소정의 사유가 운행자의 면책사유라는 인식을 깔고 있다. 그러나 자배법 제3조 단서 제2호 소정의 사유는 운행자의 免責事由라기 보다 애당초 책임이 없는 無責事由에 속한다. 따라서 자배법 제3조 단서 제2호는 당연히 그 존재이유가 없고, 아울러 기존의 해석논리와 위헌시비는 그 거를 상실한다. 이를 논증한 것이 본 연구이다. Two points should be made about the Automobile Liability Security Law(henceforth ALSL), section 3, clause 2. One is the logic behind the precedent which ruled that a person operating an automobile who brought a passenger to death be responsible for liability, even though the accident was caused by third-party's tort and it was not the driver's fault. The other point is the controversy whether the clause is against constitution. The ruling has never been challenged so far, and the section has been agreed to be constitutional. These views are founded on the belief that ALSL, section 3, clause 2 provided the person operating an automobile with exclusion. ALSL, section 3, clause 2, however, is a cause of exemption rather than exclusion. Accordingly, ALSL, section 3, clause 2 is unnecessary and the controversy is baseless. The study intends to argue for the claim.