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김혜라,차승익,신경민,임재광,오세림,김민정,이용대,김미영,이재희,김창호 대한결핵및호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.3
Background: Bronchial anthracofibrosis (BAF), which is associated with exposure to biomass smoke in inefficiently ventilated indoor areas, can take the form of obstructive lung disease. Patients with BAF can mimic or present with an exacerbation of chronic obstructive pulmonary disease (COPD). The purpose of the current study was to investigate the prevalence of BAF in Korean patients with COPD exacerbation as well as to examine the clinical features of these patients in order to determine its clinical relevance. Methods: A total of 206 patients with COPD exacerbation were divided into BAF and non-BAF groups, according to computed tomography findings. We compared both clinical and radiologic variables between the two groups. Results: Patients with BAF (51 [25%]) were older, with a preponderance of nonsmoking women; moreover, they showed a more frequent association with exposure to wood smoke compared to those without BAF. However, no differences in the severity of illness and clinical course between the two groups were observed. Patients in the BAF group had less severe airflow obstruction, but more common and severe pulmonary hypertension signs than those in the non-BAF group. Conclusion: Compared with non-BAF COPD, BAF may be associated with milder airflow limitation and more frequent signs of pulmonary hypertension with a more severe grade in patients presenting with COPD exacerbation.
매든-줄리안 진동 원격상관에 따른 S2S모형의 계절내 북반구 중위도 예측성 변화
김혜라,손석우,김혜미 한국기상학회 2021 한국기상학회 학술대회 논문집 Vol.2021 No.4
본 연구에서는 S2S 프로젝트에 참여중인 모형의 과거기후 모의자료를 기반으로 열대 계절내 변동성인 매든-줄리안 진동(Madden-Julian oscillation; MJO)이 북반구 겨울철 중·고위도 예측성에 주는 영향을 확인하였다. MJO예측성 및 중·고위도 예측성이 가장 높은 것으로 알려진 ECMWF 모형의 겨울철 대류권 순환 및 지표온도 예측성을 이상상관계수(ACC)를 이용하여 분석한 결과, 초기화 시기의 MJO강도가 예측 4주차의 중·고위도 예측성에 유의한 영향을 줄 수 있음이 확인되었다. 모형 초기화 시기의 MJO 강도가 평년 기준으로 상위(하위) 3분위 값 이상(이하)인 경우 4주차 순환 예측성은 태평양에서 북미에 이르는 지역(Pacific-North America; PNA)에서 평균에 비해 20% 정도 향상(저하)된다. 지표온도 예측성의 경우 북미 지역을 중심으로 정성적으로 일맥상통하는 결과를 얻을 수 있었다. 한편 중·고위도 순환 예측성은 초기화 시기의 MJO의 강도뿐 아니라 위상의 영향을 함께 받는 것으로 나타났다. 초기화 시기의 MJO 강도가 강한 사례 중 당일 위상이 6-7 및 8-1에 해당하는 경우 PNA 지역에서 서유럽에 이르는 지역을 중심으로 예측성 향상이 나타나며, 위상 4-5의 경우 유라시아 지역에 대해서만 예측성 향상 효과가 나타났다. 또한 위상 2-3의 경우에는 뚜렷한 예측성 향상 효과가 나타나지 않으며 오히려 유로-아틀란틱 지역을 중심으로 순환 예측성이 유의하게 낮아지는 양상이 나타났다. 이러한 초기화 시기의 MJO 강도에 따른 중·고위도 예측성 차이는 MJO 자체 예측성 차이로부터 야기된 것으로 해석된다. 초기화 시기의 MJO 강도가 강한 사례의 경우 이변량상관계수(BCOR) 기준의 MJO 예측성이 평균에 비해 2주차까지 높게 유지된다. 또한 위상 별 MJO 예측성 비교 결과, 중·고위도 예측성 향상 효과가 가장 미미한 MJO 위상 2-3 사례의 경우 MJO 예측성이 다른 위상에 비해 뚜렷하게 낮게 나타났다. 상기한 결과가 단일 모형 결과이며 강한 MJO 사례 중 위상 별 사례의 표본 수가 적은 것을 고려하면 추후 다중 모형 분석이 필요할 것으로 사료된다.
김혜라,이정치,김상기,윤병철,서계원,이정길,이채용 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.2
Causative agents of mastitis were isolated from glandular tissues of 101 culled Holstein cow udders and tested with antimicrobials by standardized disc diffusion method. Pathogens most commonly isolated were coagulase-negative staphylococci (43.9%) and streptococci (21.4%). Most of the udders (88.5%) showed mixed infections with more than two species of bacteria. Antimicrobial sensitivity tests revealed that 90.0% and 84.5% of the isolated organisms were susceptible to amoxicillin and gentamicin, while most organisms were resistant to erythromycin. Coliforms were resistant to ampicillin, cephalothin, cefazolin, erythromycin, kanamycin, neomycin, penicillin and tetracycline and streptococci to erythromycin, kanamycin, neomycin, trimethoprim/sulfamethoxazole and tetracycline.
Ethics of Genealogy in Michel Foucault’s Historical Works through the 1970s-1980s
김혜라 대한영어영문학회 2017 영어영문학연구 Vol.43 No.4
Although Michel Foucault’s works through the 1970s and 1980s have been understood in notions of genealogy and ethics, the works during these decades can be understood together within Foucault’s philosophy of history. Even though critics have viewed Foucault’s genealogy as a methodological stepping-stone for his next journey on ethics, the ways in which he understands history reveal that his genealogy, ethics, and history are interwoven with one other within a frame of ‘self-problematization.’ In this paper, I will suggest ‘self-problematization’ -- which is a mode of being ethical through a perpetual polemic attitude that motivates one to transform continually -- as a conceptual tool to grasp Foucault’s philosophy of history. Revisiting Foucault’s works through the 1970s and the 1980s and pondering how the earlier inchoate thoughts of history have been developed within the frame of ‘self-problematization’ in later years, I argue that Foucault’s investigation of history through genealogy becomes ethical, as the concepts of both history and genealogy undergo the continual reconfiguration within themselves.
The prognostic factors influencing overall survival in uterine cervical cancer with brain metastasis
김혜라,이강국,허미화,김진영 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.6
Background/Aims: The occurrence of brain metastasis (BM) has increased due to improved overall survival (OS) in uterine cervical cancer. However, research about prognostic factors and therapeutic guidelines for BM in uterine cervical cancer remains scarce due to the rarity of BM in this type of cancer. The present study evaluated the clinical characteristics and prognostic factors influencing OS in patients with BM from uterine cervical cancer. Methods: A total of 19 BM patients of uterine cervical cancer were analyzed retrospectively from January 1995 to December 2016. Results: The median and mean OS of all patients was 9.6 and 15.4 months. Treatment (vs. palliative care, p < 0.001), fewer than three regimens of chemotherapy before BM (vs. ≥ 3, p < 0.013), and chemotherapy after BM (vs. absence, p < 0.001) significantly increased the OS time. The Karnofsky performance status ≥ 70 (vs. < 70, p = 0.213), single BM (vs. multiple BM, p = 0.157), and small cell carcinoma (vs. others, p = 0.351) had numerically higher OS than others. Dual therapy (vs. single therapy, p = 0.182; vs. no therapy, p = 0.076) were associated with a longer OS time, but the difference did not reach statistical significance. In addition, the graded prognostic assessment (GPA) appeared to be a better prognostic tool than the recursive partitioning analysis. Conclusions: The results of the present study suggest active multimodal treatment including neurosurgery, radiotherapy, and chemotherapy for BM of uterine cervical cancer with single BM, good performance status, histology of small cell carcinoma, and a better GPA.