권역심뇌혈관질환센터 사업의 비용-편익 분석

김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.1

Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.

HPV에 감염된 자궁경부 상피세포의 Keratin 아형 변화에 관한 연구

기근홍,이영미,장원재,임용,임성철,김창원,전호종 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

The human papillomavirus (HPV) are wide spread in the world, causing proliferation of epidermal and mucosal surface. Certain papillomaviral types are oncogenic in vivo and in vitro. HPV DNA has been detected in most of cervical lesions such as condyloma acuminata, dysplasias, and invasive carcinomas. The materials for this study consisted of 5 dysplasias. 5 squamous cell carcinomas, and 5 exocervix for control, that resected for definite treatment of uterine disease at Chosen University Hospital from January, 1991 to December, 1993. All cases were performed of in situ hybridization for HPV DNA type 6/11, 16, and 18. And also immununohistochemical stain for panel of monoclonal cytokeratin (CK) antibodies were done. The result obtained is as fallows : 1. HPV DNA type 6/11 are detected in all dysplasias. HPV DNA type 16 and 18 are detected in squamous cell carcinomas. 2. Stratifed squamous epithelium of exocervix are positive staining for CK 1, CK 5/6, CK 8, CK 13, CK 14, and CK 19. HPV DNA type 6/11 infected cells are positive for CK 1, CK 13, CK 14, CK 17, CK 18, and CK 19. HPV DNA type 16/18 infected cells are positive for CK 1, CK 5/6, CK 10, CK 13, CK 14, CK 17, CK 18, and CK 19. In conclusion, HPV infection of uterine cervix is associated with change of normal cytokeratin expression pattern. Dysplastic cells are changed of CK 5/6, CK 8, CK 17 and CK18. Squamous cell carcinoma cells are changed of CK 8, CK 17, and CK 18.

소아 대퇴골 간부 골절에 대한 조기 고수상 석고 고정술

이한용,유기원,정진영,손문익,김창기,강용구 대한골절학회 2003 대한골절학회지 Vol.16 No.1

목 적 : 소아 대퇴골 간부 골절의 여러 가지 치료 방법 중 조기 고수상 석고 고정술의 유용성을 알아보고자 시행하였다. 대상 및 방법 : 대퇴골 간부 골절로 1997년 1월부터 2000년 12월까지 보존적 방법으로 치료를 시행받았던 10세 미만의 소아 중 심각한 동반 손상이 없고, 추시 기간이 최소 12개월이었던 환아를 대상으로 하였다. 총 27명, 27예 이었으며, 조기 고수상 석고 고정군(조기군)이 12예, 견인 후 고수상 석고 고정군(견인군)이 15예 이었다. 두 군에 대하여 각각 수상 시 연령, 성별, 수상 기전 등의 기본 자료를 분석하였으며, 재원 기간, 견인 및 고수상 석고 고정 기간, 재원 기간 동안의 방사선 촬영횟수, 고수상 석고 고정 직후와 최종 추시 소견에서의 각 변형 및 하지 부동 등의 임상적 및 방사선학적 자료와 입원 기간 중의 총 진료비를 비교 분석하였다. 결 과 : 평균 연력은 조기군은 4.2세, 견인군은 5.3세 이었으며, 전체 연구 대상 중 남아가 24예로 88%를 차자하였고, 수상 기전은 교통사고가 20예(71%)로 가장 많았다. 재원 기간은 조기군이 평균 7.8일 이었으며, 견인군은 25.8일로 나타나 유의한 차이를 보였다. 수상 일로부터 석고 제거가지의 기간 즉 침상 안정기간은 각각 44.2일과 65.1일 이었다. 재원 기간 중 방사선 촬영 횟수는 조기군은 수상 직후 및 고정 후 각각 1회의 방사선 촬영을 하였으며, 견인군은 견인 및 정복의 정도를 파악하기 위하여 평균 6.9회의 방사선 검사를 시행하였다. 두 군 모두 최종 추시 때의 관절 운동 각도는 정상 범위에 속하였고, 고수상 석고 고정 직후와 최종 추시 소견 상 각 변형은 허용 범위 내에 있었으며, 하지 부동이 각 군에서 3예 씩 발생하였다. 총 입원 진료비는 견인군이 재원 기간의 증가로 인하여 약 2.4배의 비용이 더 필요하였다. 결 론 : 소아 대퇴골 간부 골절에 대한 조기 고수상 석고 고정술은 견인 후 고수상 석고 고정술과 비교하여 임상적 및 방사선학적 결과에서 유의한 차이가 없었으며, 재원 기간의 단축과 고정 기간의 감소를 통한 의료비 절감 및 환자 순응도를 높일 수 있었고, 방사선 촬영 횟수 감소로 소아 생식기에 대한 위험을 줄일 수 있었으므로 유용한 치료 방법이라고 판단되었다. Purpose : To evaluate an efficacy of immediate closed reduction and hip spica casting in pediatric patients with femoral shaft fractures. Materials and Methods : 27 cases of 27 pediatric patients who had seen treated conservatively for the femoral shaft fractures under 10 years of age were retrospectively reviewed. The cases with serious associated injuries were excluded. The hospital stay, duration of traction and hip spica cast, frequencies of plain radiographs, clinical and radiological outcomes at the final follow-up, and financial aspects were evaluated comparatively between the groups of immediate hip spica casting(12 cases) and traction-casting(15 cases). Results : The patients treated with immediate hip spica casting had a mean hospital stay of 7.8 days, compared with a mean of 25.8 days for those treated with traction and casting. The mean duration of immobilization were 44.2 days in the group of immediate hip spica casting, and 65.1 days in the group of traction and casting. The radiologic examinations were performed 2 times and 6.9 times respectively. The clinical and radiological outcomes at the final follow-up were good in both groups. Insignificant leg length discrepancies were seen in 3 cases each group. The total charges of traction and casting was 2.4 times higher than that of immediate hip spica casting. Conclusion : The immediate hip spica casting seems to be an effective method of treatment in femoral shaft fractures without serious associated injuries under 10 years of age because there are several advantages such as satisfactory result, shortened hospitalization and immobilization, reduction of total charges, and lowered the risk of radiologic exposures.

β-CuZn 합금의 항복강도 이상거동에 미치는 변형률 속도와 온도의 영향

이기안,장영원,이종수 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.3

A series of tensile and load relaxation behaviors in B2 type β-CuZn alloy have been examined to clarify the strain rate & the temperature dependence of yield stress anomaly. It has been found in tensile tests that the region showing anomalous peak of yield stress moves to a higher stress and higher temperature region with increasing strain rate. The anomalous yielding region below peak temperature(T_p) revealed slightly positive strain rate dependence, while the region above T_p showed considerably positive strain rate dependence. The slip lines formed below peak temperatures (T_P) were clearly visible with naked eye(coarse slip lines), and became finer near T_p(fine slip lines), while they disappeared completely above T_p. Based on the different tendency of temperature and strain rate dependence of anomalous yielding as the above-mentioned results, two types of deformation modes were suggested and incorporated into the flow curve analysis, which was in accord well with the experimental results. The slightly positive strain rate dependence of yield stress anomaly indicated that the yield stress anomaly in β-CuZn alloy mainly seemed to be attributed to the vacancy hardening.

일산화탄소 중독이 생쥐 신장의 Alkaline phosphatase 활성에 미치는 영향

이홍식,배기원 보건장학회 1975 보건장학회보연구논문집 Vol.4 No.-

단면의 성질을 적용한 크기와 회전 변화에 불변인 영상 검사 시스템

이용중,김태원,김기대,류재엽 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

The purpose of this paper is to develop image inspection system endows an automatic operating and measuring that the moment values are invariant with respect to variable object size and rotation. In this paper, using these moment feature vector with Hu's 7 invariant moment is also given. The charasteristics of section which is applied in the mechanics used moment descriptor of invariant moment detection algorithm for image inspection system. Corresponding rates between 94% and 96% have been achived for all object tested.

毛澤東의 軍事思想 小考

李基遠 동국대학교 행정대학원 1975 행정논집 Vol.6 No.-

염산 독세핀 외용제의 피부 전달 시스템을 위한 제제 설계 및 평가

이은미,김정수,경기열,이계원,지웅길 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-

Doxepin hydrochloride(Dox) is a dibenzoxepin-derivative tricyclic antidepressant and used topically for the short-term relief of moderately severe pruritus associated with atopy dermatitis. Dox topical emulsion(or liposome) formulations were evaluated with respect to their rheological properities, permeation through excised skin of hairless mouse and in vitro/in vivo accumulation in the skin. The apparent viscosity was increased according to the concentration of glycerin and decreased with an increase in the concentration of phosphatidylcholine(PC). The permeation rate of formulation increased with a high concentration of PC and showed no relationship with the change of formulations. Amount of accumulated drug in the excised skin of hairless mouse was decreased with a high concentration of glycerin, but increased according to PC concentration.

급성 일산화탄소 중독 및 회복기의 흰쥐 전립선 Acid phosphatase 활성도의 변화

배기원,유진화,이흥식 대한해부학회 1976 Anatomy & Cell Biology Vol.9 No.2

졸 - 겔법에 의한 다공성 알루미나 미분체 제조에 관한 연구 : 2 . 물과 알콕시드의 비가 알루미나 미분체의 결정화 공정에 미치는 영향 2 . The Effect of [ H2O ] / [ Al - alkoxide ]on The Crystallization Mechanism of As - Prepared Particles

이성원,박형상,윤호성,황운연,구기갑,유승준,김용렬,이정운 한국화학공학회 2001 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.39 No.2

알루미늄 알콕시드의 반응속도를 제어하기 위한 혼합용매와 입자제조 과정에서의 응집을 방지하기 위한 분산제로 HPC를 첨가하는 방법에 의하여 구형의 다공성 알루미나 미분체를 제조하였으며, XRD, FT-IR 및 TG-DTA 분석을 통하여 공정변수로 선정한 물과 알루미늄 알콕시드의 비가 제조된 미분체의 결정화 공정에 미치는 영향에 대하여 고찰하였다. 축중합 반응에 첨가된 물과 Al-알콕시드의 비는 제조된 미분체 및 하소 공정을 거친 미분체의 결정구조에 영향을 미침을 알 수 있었다. [H₂O]/[ASB]의 비가 증가할수록 제조된 미분체는 비정질의 Al(OH)₃로부터 점진적으로 AlO(OH)의 화학조성을 갖는 의사-보헤마이트로 결정성이 바뀌었다. 그리고 건조 공정을 거친 미분체의 결정성이 좋을수록 δ와 θ-Al₂O₃는 저온에서 생성되었으나, α-Al₂O₃는 고온에서 생성되었다. 이와 같은 결과는 Al^(3+)이온의 결정 내에서의 배위체 변화와 관계됨을 알 수 있었다. 그리고 [H₂O]/[ASB]=2의 조건에서 제조된 입자는 다른 시료와 달리 600℃에서 η-Al₂O₃로 1,100℃에서 α-Al₂O₃2로 상전이 되었다. Spherical porous alumina particles were prepared by mixed solvent to control the reaction rate of Al-alkoxide and the particle shape with hydroxy-propyl cellulose(HPC). HPC was used as a dispersant to prevent aggregation during the formation of particles. The effect of [H₂O]/[ASB] ratio on the crystallization reactions of as-prepared particles was studied by XRD, FT-IR, and TG-DTA analysis. The mole ratio of water and Al-alkoxide added in the condensation reaction had an important effect on the crystal structure of as-prepared particles and the calcined particles. As the [H₂O]/[ASB] ratio increase, the crystal structure of as-prepared particles was continuously varied from amorphous Al(OH)₃ to pseudo-boehmite with chemical composition of AIO(OH). The samples which have higher crystallinite after drying process were transformed into the δ- and θ-Al₂O₃ at lower calcination temperature, but these sample were transformed into α-Al₂O₃ at higher calcination temperature. This result was thought to be the transformation of the coordination number of Al^(3+) ion in the crystal structure. The particles prepared by [H₂O]/[ASB]=2 condition crystallized to α-Al₂O₃at 600℃ and converted to η-Al₂O₃at 1,100℃ without intermediate phases.