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Chinese hamster 난소세포에서 DNA - 단백질 교차결합과 glutathione S - 전이효소의 발현에 대한 돌연변이원에 의해 유도된 교차적응반응
이동욱,엄경일,오규선,장정현,문용석 한국유전학회 2001 Genes & Genomics Vol.23 No.2
The present study has been undertaken to elucidate whether glutathione S-transferase (GST) is related to cross-adaptive response to DNA-protein crosslink (DPC) induced by ethyl methanesulfonate (EMS) or ultraviolet radiation (UV)-C in Chinese hamster ovary (CHO) cells. DPC was determined by SDS-K^+ precipitation method, and GST was measured by western blot analysis. 2,4-Dinitrophenol (DNP) that depletes cellular ATP and cycloheximide (CHM) that inhibits protein synthesis were used to find whether DNP and CHM affected the expression level of GST and cross-adaptive response to EMS or UV. There is a cross-adaptive response to DPC in cells pretreated with EMS or UV and subsequently treated with UV or EMS, respectively. In cells pretreated with 2 mM EMS and subsequently treated with 5J/㎡ UV, DNP and CHM did not affect cross-adaptive response to DPC and GST. And also, in cells pretreated with 1J/㎡ UV and subsequently treated with 8 mM EMS, CHM did not affect crass-adaptive response to DPC and the expression level of GST. But DNP increased the amount of DPC, and decreased the expression level of GST in UV-pretreated cells. These results suggest that GST are involved in the induction of cross-adaptive response to DPC in CHO cells.
김선형,남상인,엄태준,제갈욱,신현철,권준택 순천향대학교 부설 산업기술연구소 1999 순천향 산업기술연구소논문집 Vol.5 No.1
This paper presents an improved admission policy of 2000 academical year so that more promising students apply for the University. By analyzing the past admission data and the questioned report, a unique admission policy has been suggested as the University feature reflected. One of the major differences compared from the admission policy of the last year is that the entry number limit for the special admission is in creased or newly established such as the entry allocated for recommended students, perfectly attending students, and regionally apportioned students. Also established is the special admission for those licensed students and late educated students.
Clinical Comparison for Colon Polyps between Right and Left Colon in Koreans
( Wook Hyun Um ),( Hyun Gun Kim ),( Seong Ran Jeon ),( Tae Hee Lee ),( Wan Jung Kim ),( Bong Min Ko ),( Jin Oh Kim ),( Joo Young Cho ),( Joon Seong Lee ),( Moon Sung Lee ) 대한장연구학회 2012 Intestinal Research Vol.10 No.4
Background/Aims: Comparative studies of colon polyps between right and left colon in Korean population are limited. We investigated the clinical characteristics of the patients according to polyp location and compared the results of the morphological and histological analysis of right and left colon polyps. Methods: The study was performed prospectively for the patients who underwent colon polypectomy for health check-ups in a single tertiary center. The patients were classified into three groups by the location of the polyps: right group (from the cecum to the splenic flexure), left group (from the descending colon to the anus), and total group. The size, the morphology, the location and the pathology of the polyps were evaluated. Results: From June 2010 to June 2011, Overall 2596 polyps from 950 patients (male=646) were analyzed. Colon polyps were right side-shift with increased patients age (P<0.001). The incidence of polyps was most common in sigmoid colon (26.5%). Polyps less than 5 mm size were more common in left colon (P<0.001) and flat polyps larger than 1 cm in right colon (P=0.006), respectively. In histopathological findings, the distribution of advanced adenoma was not different according to the location, however tubular adenomas and serrated adenomas (P<0.001) were more common in right colon. Female was more distributed in right group, respectively (P<0.001). Conclusions: In a single center study, colon polyps were more distributed in right colon with age and in females. Also flat polyps larger than 1cm, tubular adenoma and serrated adenoma were found in larger proportion in right colon. (Intest Res 2012;10:372-378)
지속성 외래 복막 투석 환자에게 발생한 후복막 지방육종
엄욱현 ( Wook Hyun Um ),이승원 ( Seung Won Lee ),박근호 ( Geun Ho Park ),이승우 ( Seoung Woo Lee ),김수한 ( Soo Han Kim ),김은주 ( Eun Joo Kim ),박현주 ( Hyun Joo Park ),송준호 ( Joon Ho Song ),김문재 ( Moon Jae Kim ),김준미 ( Joo 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.1
Liposarcoma accounts for at least 20% of all soft tissue sarcoma in adults and occur anywhere in the body, although about 14% of cases arise from retroperitoneum. Liposarcoma usually presents as a painless, enlarging mass that can slowly grow over many years. We here report a case of retroperitoneal liposarcoma in a 52 years old female patient undergoing continuous ambulatory peritoneal dialysis. Retroperitoneal liposarcoma was incidentally found by computed tomography which was performed due to ventral hernia and confirmed by ultrasonography guided-biopsy. She was treated successfully by wide surgical resection and transferred to hemodialysis.
Um, Min Young,Lim, Dong Wook,Son, Hyun Jung,Cho, Suengmok,Lee, Changho Elsevier 2018 Journal of Functional Foods Vol.40 No.-
<P><B>Abstract</B></P> <P> <I>Ishige foliacea</I>, a species of edible brown algae, contains specific polyphenols called phlorotannins, which have antioxidant, anti-inflammatory, and anticancer properties. We hypothesized that the phlorotannin-rich fraction of <I>I. foliacea</I> (PRFI) is neuroprotective. We investigated the effects of PRFI on scopolamine-induced memory impairment in mice. PRFI (50 or 100 mg/kg) supplementation for 6 weeks improved scopolamine-induced memory impairment symptoms in the Morris water maze and passive avoidance tests. PRFI reduced acetylcholinesterase activity in the brain and significantly decreased lipid peroxidation levels, but increased glutathione levels and superoxide dismutase activity. Additionally, PRFI up-regulated the expression levels of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B, and phosphorylated extracellular signal-regulated kinase (ERK) and cyclic AMP-response element-binding protein (CREB), which are involved in neuroplasticity in the cerebral cortex and hippocampus. Our results suggest that PRFI prevents scopolamine-induced memory impairment, possibly through oxidative scavenging and ERK-CREB-BDNF pathway regulation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PRFI improved scopolamine-induced memory impairment in mice. </LI> <LI> PRFI decreased AChE activity and restored scopolamine-induced oxidative stress. </LI> <LI> PRFI activated the ERK-BDNF-CREB signalling pathway. </LI> <LI> PRFI is a potent agent for the treatment of memory impairment-related diseases. </LI> </UL> </P>
김현욱(hyun wook Kim),엄기준(Gi Jun Um) 한국공공디자인학회 2023 공공디자인연구 Vol.8 No.-
최근 공공디자인에 대한 관심과 함께, 공공디자인을 통한 지역 정체성 강화에 대한 관심도 높아지고 있다. 본 연구에서는 여러 지역 가운데, 다양한 자연문화유산을 보유하고 있는 강원도 인제군을 특정하여 연구를 진행하였다. 강원도 인제군은 천혜의 자연을 간직한 휴식형 관광지, 익스트림 레포츠 등이 발달하고 있는 지역으로써, 지역정체성 강화를 통해 발전 가능성이 높은 지역이다. 특히 공공디자인의 여러 분야 가운데에서도 공공조형물을 통한 지역정체성 연계 및 강화가 필요하며, 이에 따라 본 연구에서는 인제군의 기초적인 정체성을 분석하고, 이를 기반으로 공공디자인으로써의 공공조형물, 기호학적 측면의 공공조형물을 분석하였다. 분석 결과, 인제군의 ‘하늘내린 인제’라는 브랜드에서 나타나듯이 청정 자연을 표방하고 있으며, 여러 명소들의 공공조형물은 조형물 형태, 안내판 형태, 표지석 형태, 게이트 형태 등으로 구분된다. 디자인 측면에서는 창의성, 일관성, 주변환경과의 조화, 의미와 연계 등의 보완이 필요한 것으로 나타났고, 기호학적 측면에서는 공공조형물의 유형별 의미가 조금씩 다르게 보여졌으며, 지역 정체성 및 장소의 의미에 대한 연관성 고려가 필요한 것으로 나타났다. Recently, along with interest in public design, interest in strengthening regional identity through public design is also increasing. In this study, a study was conducted by specifying Inje-gun, Gangwon-do, which has various natural and cultural heritages among various regions. Inje-gun, Gangwon-do, is an area where rest-type tourist attractions and extreme leisure sports are developing with a high possibility of development through strengthening local identity. In particular, among the various fields of public design, it is necessary to link and strengthen local identity through public sculptures, and this study analyzed the basic identity of Inje-gun and analyzed public sculptures and semiotics in public designs. As a result of the analysis, as shown in Inje-gun's “Skyfall Inje” brand, it advocates clean nature, and public sculptures of various attractions are classified into sculpture shape, guide plate shape, sign stone shape, and gate shape. In terms of design, it was found that creativity, consistency, harmony with the surrounding environment, meaning and linkage were needed, and in terms of semiotics, the meaning of public sculptures was slightly different, and the relevance of local identity and place was considered.