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정맥주입 전문간호사가 삽입한 말초삽입형 중심정맥관(PICC) 사용 결과에 대한 후향적 분석
박정윤,박광옥,백미경,김세라,권혜리,양수진 대한기초간호자연과학회 2004 Journal of korean biological nursing science Vol.6 No.1
Background : Intravenous(Ⅳ) access is becoming an increasingly important part of health care today. The current drive for clinical effectiveness and cost-effective health care serves to increase the need for reliable vascular access. Venous access devices were developed to overcome problems associated with limited peripheral access and frequent venipuncture in patients with long-term therapy. Although the peripherally inserted central catheter(PICC) have become popular during recent years in USA, its procedure is rare in Korea. Purpose : The goal of this study was to analyze the PICC inserted patient data by Ⅳ CNS intervention. Method : A Total of 62 PICCs were inserted into 51 patients by the Ⅳ CNS during a 10-month period form November, 14, 2002, to October 2, 2W2. Data was obtained retrospectively through chart review. Result : The patient population included 34(54.8%) men and 28(45.2%) women, with a mean age 50.6 years. The main indication for PICC placement was to access vein in poor peripheral venous status(40.3%). The mean served interval for PICC insertions was 16.7 days(range, 2~61 days). The reasons for removal were completed therapy in 18 cases(29.0%), patient death in 13 cases(21.0%), and mechanical or functional PICC problem in 10cases(16.1%). The three PICCs removed for presumed infection, and one had only positive tip cultures(0.2%). Conclusion : PICCs are rapidly growing popularity and required an extended course of Ⅳ therapy.
( Hye Kyung Baek ),( Myung Hwan Yang ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1
Purpose: Although leisure involvement has been regarded as an important moderate variable in the process of leisure participant`s decision making, motivation and resultant outcomes, there is a lack of researches focusing on the interaction effect between the leisure involvement and leisure motivation(Huang, Tsai, & Lee, 2014; Robinson, 1992). Therefore the purpose of the study was to examine the relationship between leisure motivation(autonomous and controlled motivation) and subjective well-being and whether these relationships are moderated by leisure involvement. Method: Participants were 281 leisure activity participants(166 male, 115female) aged 20-65years who reside in Jeju Province. Participants completed Leisure Sport Motivation Scale(Yang, 2004), Involvement Scale(Mcintryre & Pigram`s, 1992), Life Satisfaction Index(Ragheb & Griffith, 1982; Kim & Yang, 1995), and demographic data. Moderation effects are tested with hierarchical moderated regression analysis, where all predictor variables and their interaction term are standardized prior to model estimation to improve interpretation of regression coefficients. Result: Hierarchical moderated regression analysis revealed that overall leisure involvement has a moderating effect on the relationship between the autonomous motivation and subjective well-being. Thus, leisure activity participants with higher involvement had more positive subjective well-being while comparing to that of the low level of leisure involvement. Controlled motivation had no significant effect on leisure involvement and subjective well-being. The findings also revealed that centrality and self-expression as sub-factors of leisure involvement has a moderating effect on the relationship between the autonomous motivation and subjective well-being, but attraction factor had no significant moderating effect. Conclusion: These findings provide empirical support for the contention that autonomous motivation is as antecedent of leisure involvement, and the prediction of a subjective well-being from autonomous motivation differs across levels of a third variable, leisure involvement. This indicates that the higher leisure involvement may enhance the effect of autonomous motivation on subjective well-being.
Baek Hye Kyung,김영준,Lee Yeon Sun,Jo Hye Ri,Park Mi So,Shin Dong Guk,Shim Hyun A 대한침구의학회 2022 대한침구의학회지 Vol.39 No.4
The purpose of this study was to analyze acupuncture treatment methods and acupoints used to treat obstructive sleep apnea (OSA) or obstructive sleep apnea-hypoapnea syndrome (OSAHS). The data were retrieved from January 2010 to May 2022 from the China National Knowledge Infrastructure database. The search terms included “adult,” “obstructive sleep apnea,” “obstructive sleep apnea hypoapnea syndrome,” “acupuncture,” and “electro-acupuncture.” Clinical trials for acupuncture treatment of OSA or OSAHS were included in this review (4 non-randomized controlled studies, 1 was a case report, and 10 randomized controlled studies). For OSA and OSAHS treatment, the acupoints that were most frequently used included REN23, LU7, ST40, EX9, LI11, and DU20. Compared with the control or Western treatment group, the treatment outcome measures of participants in the acupuncture treatment group significantly improved. In some studies, participants in the acupuncture group did not have side effects and the treatment was cost-effective. The data analyzed in this review suggest that acupuncture is an effective treatment for OSA or OSAHS.
Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors
( Kyung Hye Baek ),( Radha Karki ),( Eung Seok Lee ),( Younghwa Na ),( Youngjoo Kwon ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
In order to identify potential calpain and cathepsin inhibitors we prepared 12 dihydroxychalcone analogues and tested their ability to inhibit μ-calpain, m-calpain, cathepsins B and L. In the calpain inhibition test, compound 10 exhibited the most active inhibitory activity against m-calpain with an IC50 value of 25.25±0.901μM. With respect to inhibition of cathepsins B and L, compound 13 exhibited the most potent inhibitory activity on cathepsin L and moderate inhibitory activity on cathepsin B with IC50 values of 2.80±0.100 and 11.47±0.087μM, respectively. Our results suggest the possibility of developing dual calpain and cathepsin inhibitors by properly modulating structures and/or combining the essential aspects of the functional group effective for specific calpain and cathepsin inhibition. ⓒ2013 Elsevier Inc. All rights reserved.