Acute exacerbation of interstitial lung disease; subgroup analysis for causes, risk factors for mortality rate, and steroid responsiveness

( Seung Hyun Yong ),( Ah Young Leem ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Moo Suk Park ),( Hye Jin Jang ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Interstitial Lung Disease (ILD) has known as a poor prognosis disease, particularly idiopathic pulmonary fibrosis (IPF). Corticosteroid is widely used for treatment of acute exacerbation (AE)-ILD. This study aims to clarify efficacy of corticosteroid use, and compare the mortality rate depending on the subgroups of ILD. Materials and Methods: We collected the data from the patients who have diagnosed ILD and visited emergency room (ER) with the respiratory symptoms from January 1, 2016 to December 31, 2018. We classified AE-ILD patients into 3 groups depending on methylprednisolone dose per kilogram. Also, we compared the mortality of IPF patients to that of non-IPF patients. Results: A total case of AE-ILD visited ER from 2016 to 2018 was 209 cases, including IPF cases (n=122) and non-IPF cases (n=87). We divided total patients (n=209) into three groups depending on steroid use, and these include group 1 of 0-0.49 mg/kg (n=78), group 2 of 0.5-0.99 mg/kg (n=58), and above 1.0 mg/kg (n=41), each. We found poor prognosis from the cases of IPF compared to non-IPF cases (p=0.029, OR 2.463). Furthermore, there was significant differences of mortality rate according to steroid dose (p=0.036, OR 1.712), CRP elevation (p=0.016, OR 1.004), and intubated case (p=0.000, OR 8.152). Also, we categorized IPF (n=122) to non-IPF cases (n=87) and analyzed the mortality rate. Most of the patients were death from ILD itself (n=23, 63.9%), Pneumonia(n=8, 22.2%), and Lung cancer (n=5, 13.9%). Bacterial infection (n=26) was dominant cause of AE, followed by fungal infection (n=15), and viral infection (n=10). Conclusions: This retrospective analysis of corticosteroid treatment shows more fatal outcome when we use high dose steroid in AE-ILD cases, and there was significant difference in mortality rate depending on the subgroup of ILD and medical background, such as intubation status, higher CRP level, and IPF cases.

여대생의 흡연에 대한 태도 및 요인 분석 : 김천대학 여대생 중심

송애랑 ; 박지원 김천대학교 2004 김천대학교 논문집 Vol.25 No.-

The purpose of this study was to explore the attitudes about smoking and factor analysis among college women. The subject were 347 female students selected by random sampling from Gimcheon College in Korea. The data were collected by survey methods a period of 7days. The data were analyzed by SPSS 10.0 version, T-test. F-test and factor analysis. Analysis of the data resulted in identification of 8 factors in general group and 5 factors in smoking group. Major factor were involved in curiosity, viewpoint of smoking, health belief, friend-relationship, image, body weight loss, fault, and viewpoint of opposite sex The characteristics of smoking behavior: 1. The meaning of smoking behavior in college women is justifiable orregretable. 2. Smoking behavior is related to the perception of harmfulness to health, influence of 2nd generation. 3. Smoking in college women is not caused by antagonism toward male smokers. 4. The first smoking time was middle school students It is suggested that the results of this study may contribute to the development of strategies for the purpose of decreasing smoking behav-ior among female college students.

정신분열병의 유전적 고위험군에서 인지, 정서 및 사회기능 연구

이경진,위휘,유소영,이애라,송지연,하태현,홍경수,김명선,권준수 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objectives : Vulnerability marker in biological relatives of schizophrenia may be very useful in identifying the propensity for the development of schizophrenia. This study suggests that the relatives at risk for genetically developing schizophrenia have impairments in several domains of cognition, social function and affective function as a vulnerability marker. Methods : A neurocognitive function test, a social function test and an affective function test were administered to fifteen healthy relatives from families with two or more patients with schizophrenia (geneticallly high risk subjects). Fifteen healthy controls matched for age and gender were recruited in this study. Results : Compared to the control subject, the genetic high risk subjects performed significantly more poorly in the selective attention and recall memory of neurocognitive function. The high dsk subjects also had lower scores in independence-performance and independence-competence of the social function test and emotion control of the affective function test. Conclusion : Selective attention, recall memory, independence-performance, independence-competence and emotion control ability may be a valuable marker for genetic study of schizophrenia.

정신분열병의 임상적 고위험군의 특징 : '서울청년클리닉'의 자연 추적 관찰 예비연구

유소영,이경진,강도형,이승재,하태현,위휘,이애라,송지연,김성년,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

Objectives : The aims of this study were to identify the intake and following process for subjects at high risk of transition to schizophrenia and to examine the neurocognitive, social, and emotional functions of the subjects compared with healthy controls. Methods : Symptomatic individuals judged at high risk for schizophrenia ('clinical high risk') within Youth Clinic were assessed and followed up. They performed a neurocognitive function test, a social function test and an affective function test. Twenty healthy controls were recruited in this study. Results : Among eighty-two subjects contacted through the Youth clinic, sixteen subjects were judged as the clinical high risk group. Fourteen subjects among the clinical high risk group showed deficits in several domains of neurocognitive functions, such as visual recall memory, verbal short term memory and executive function. Social and affective functions are also impaired in the Cli-nical high risk group compared with healthy controls. Two of 15 subjects (13%) developed a psychotic disorder within 6 months. Conclusion : This study illustrates the state of follow-up study for a clinical high risk group. Despite low numbers and short durations, some impairment of several functions in the clinical high risk group suggests possible predictors of psychosis.

Neurogenesis in the hippocampus is increased by Passiflora incarnate ethanol extracts administration in DBA/2 mice

Ji Ae Song,Hye Kyung Baek,Do Eun Kim,Eunseol Min,Shin-Gyeom Kim,Tae-Hee Kim,Hae-Hyeog Lee,Sun Shin Yi 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.08

Clinical Outcomes of Endoscopic Hemostasis for Bleeding in Patients with Unresectable Advanced Gastric Cancer

Song, In Ji,Kim, Hyun Ju,Lee, Ji Ae,Park, Jun Chul,Shin, Sung Kwan,Lee, Sang Kil,Lee, Yong Chan,Chung, Hyunsoo The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.4

Purpose: Bleeding is one of the most serious complications of advanced gastric cancer (AGC) and is associated with a poor prognosis. This study aimed to evaluate the clinical outcomes of endoscopic hemostasis for bleeding in patients with unresectable AGC. Materials and Methods: This study included 106 patients with bleeding associated with gastric cancer who had undergone endoscopic hemostasis between January 2010 and December 2013. Clinical characteristics, treatment outcomes, including rates of successful endoscopic hemostasis and rebleeding, risk factors for rebleeding, and overall survival (OS) were investigated. Results: Successful initial hemostasis was achieved in 83% of patients. Rebleeding occurred in 28.3% of patients within 30 days. The median OS after initial hemostasis was lower in patients with rebleeding than in those without rebleeding (2.7 and 3.9 months, respectively, P=0.02). There were no significant differences in disease status and rebleeding rates among patients with partial response or stable disease (n=4), progressive disease (n=64), and first diagnosis of disease (n=38). Univariate and multivariate analyses (P=0.038 and 0.034, respectively) revealed that transfusion of ${\geq}5$ units of RBCs was a significant risk factor for rebleeding. Conclusions: Despite favorable success rates of endoscopic hemostasis for bleeding associated with gastric cancer, the 30-day rebleeding rate was 28.3% and the median OS was significantly lower in patients with rebleeding than in those without rebleeding. Massive transfusion (${\geq}5$ units of RBCs) was the only significant risk factor for rebleeding. Patients with bleeding associated with AGC who have undergone massive transfusion should be observed closely following endoscopic hemostasis. Further research on approaches to reduce rebleeding rate and prevent death is needed.

The Enzyme-ball Gold Nanocluster Based Fluorescent Probe for Sensitive Detection of Hydrogen Peroxide

Ji-Ae SONG,Yeong Joong KIM,Byung-Keun OH 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.4

Conservation of the Lacquer Artifacts Excavated from Suchon-ri, Gongju, Korea

Song, Ji Ae,Jeong, Ah-reum,Kwon, Hyeok-nam,Han, Woo-rim,Lee, Hyun-sang The Korean Society Of Conservation Science For Cul 2018 보존과학회지 Vol.34 No.6

In November 2011, various artifacts were excavated from the No. 8 stone-lined tomb in Suchon-ri, Gongju by the Chungnam Institute of History and Culture. These included artifacts with lacquered mainframe and silvery metal ornament. These were recovered together with soil and underwent conservation treatment. In this paper, we discuss the scientific analysis and conservation treatment of the lacquered artifacts excavated from the Suchon-ri site. Among our findings is that the artifacts have three layers of lacquer coating and the metal parts are primarily composed of Ag. As the artifacts were recovered with soil from the site, the soil was removed from underneath and inside the artifacts. The inside of the lacquerware was reinforced with rayon paper using 3% funori, and the metal was treated with acrylic resin after removing the acrylic resin previously used to recover the artifact, followed by cleaning. The metal was also internally reinforced with gauze. Finally, the interior reinforcement was made using PVA and resin in pulp and attached with funori to preserve the shape of the lacquerware, and the exposed rayon was finished with acrylic paint. The main advantages of this study are its review of conservation treatment strategies for lacquer artifacts whose numbers have recently increased, and the application of new conservation treatment methods.

Conservation of the Lacquer Artifacts Excavated from Suchon‐ri, Gongju, Korea

Ji Ae Song,Ah-reum Jeong,Hyeok-nam Kwon,Woo-rim Han,Hyun-sang Lee 한국문화재보존과학회 2018 보존과학회지 Vol.34 No.6

In November 2011, various artifacts were excavated from the No. 8 stone-lined tomb in Suchon-ri, Gongju by the Chungnam Institute of History and Culture. These included artifacts with lacquered mainframe and silvery metal ornament. These were recovered together with soil and underwent conservation treatment. In this paper, we discuss the scientific analysis and conservation treatment of the lacquered artifacts excavated from the Suchon-ri site. Among our findings is that the artifacts have three layers of lacquer coating and the metal parts are primarily composed of Ag. As the artifacts were recovered with soil from the site, the soil was removed from underneath and inside the artifacts. The inside of the lacquerware was reinforced with rayon paper using 3% funori, and the metal was treated with acrylic resin after removing the acrylic resin previously used to recover the artifact, followed by cleaning. The metal was also internally reinforced with gauze. Finally, the interior reinforcement was made using PVA and resin in pulp and attached with funori to preserve the shape of the lacquerware, and the exposed rayon was finished with acrylic paint. The main advantages of this study are its review of conservation treatment strategies for lacquer artifacts whose numbers have recently increased, and the application of new conservation treatment methods.

Species of Korean Furniture in the Late Choseon Dynasty (I)

Song, Ji-Ae,Park, Won-Kyu Korea Furniture Society 2010 한국가구학회지 Vol.21 No.6

서울역사박물관 소장 후기 조선시대 (주로 19세기) 목가구 82점에 사용된 수종을 목재해부학적으로 식별한 결과, 총 22종의 수종이 나왔다. 침엽수는 소나무류, 잣나무류, 전나무속, 은행나무, 가문비나무속, 비자나무, 편백나무속, 외래산소나무로 8종이 분석되었으며, 활엽수는 느티나무, 피나무속, 오동나무속, 오리나무속, 참죽나무, 가래나무속, 감나무속, 배나무속, 자작나무속, 밤나무속, 사시나무속, 느릅나무속, 음나무 등 13종이, 그리고 외떡잎식물로 대나무 1종이 확인되었다. 수종의 점유율로 보면 소나무류(43%), 느티나무(9%), 오동나무속(7%), 피나무속(7%) 순이었다. 한 수종만 쓰인 가구가 37점(45%)으로 가장 많았으며 최대 6수종까지 한 가구를 제작하는데 사용되었다. 지역별 반닫이에 사용된 수종의 특징을 조사한 결과, 북부지방에서 제작된 반닫이는 피나무속과 소나무류가, 중남부지역에서 제작된 반닫이는 모두 공통적으로 소나무류와 느티나무가 사용되었다. 부재 용도에 따라 골재와 판재에는 소나무류, 느티나무, 참죽나무 등 대체로 단단하고 강도가 강한 목재가, 그리고 화장재로는 아름다운 무늬를 가지거나 독특한 재색을 가지거나, 가공하기 용이한 산공재 등 다양한 수종이 사용되었다. 서랍재의 재료는 가볍고, 변형이 적어야 하므로 비중이 낮고, 변형률이 적은 오동나무속 또는 피나무속이 사용되었다. 황해도 반닫이와 박천 반닫이에는 추운 지역에서 자라는 피나무속이 사용되어 산지가 북한임이 제시되었다. The purpose of this study was to analyze the species of 82 furniture in the late Choseon Dynasty (mainly, 19th century), which are housed in the Seoul Museum of History. Total of 22 species were found. The species shared 43% as hard pine(Diploxylon), 9% as Zelkova serrata Makino, 7% as Paulownia spp., 7% as Tilia spp., 6% as soft pine(Haploxylon), 5% as Ginkgo biloba Linn., 4% as Cedrela sinensis A. Juss., 3% as Diospyros spp., 3% as Abies spp., 2% as Alnus spp., 2% as Picea spp., 1% as bamboo, 1% as Populus spp., 1% as Betula spp., 1% as Juglans spp. The other minor ones were Torreya nucifera Sieb. et Zucc., Pyrus spp., Castanea spp., Ulmus spp. and Kalopanax oictuse (Thunb.) Nakai. Thirty seven furniture (45% in total) was made of single species, 19 (23%) of two species, 16 (20%) of three species and 10(12%) of 4 to 6 species. For frames and panels, hard and strong woods, such as hard pines, Zelkova and Cedrela, were used. For drawer, however, light woods having low shrinkage, such as Paulownia and Tilia, were used. The origin of woods could be specified by the habitats of the species identified. Both Hwanghaedo- and Parkcheon- Chests used basswood (Tilia), which grow in the cold regions, indicating the origin of woods as North Korea.