주의력결핍 과잉운동장애 환아에서 주의력 과제와 관련된 대뇌의 기능적 국소화

신동원,송동호,전덕인,남궁기,이만홍,이홍식,민성길 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 주의력결핍 과잉운동장애는 주의력에 결함이 있는 장애이다. 주의력에 주로 관여하는 부위는 전두엽과 두정엽으로서 이전 연구에서 주의력결핍 과잉운동장애 환자의 전두엽과 두정엽의 이상에 대하여 보고되어 왔으나, 대부분 안정상태에서 정상인과 비교한 연구들이다. 이에 본 연구는 주의력결핍 과잉운동장애 환자가 주의를 요하는 과제를 실행하는 동안 활성화되는 뇌의 양상을 정량화 뇌파를 이용하여 파악하고, 활성화 양상에 있어 정상인과의 차이점을 확인해 주의력결핍 과잉운동장애 환자의 주의력 결함과 관계된 뇌의 국소적 병태를 밝히고자 하였다. 또한 주의력결핍 과잉운동장애 환자의 주의력 결함과 관계된 뇌의 국소적 병태를 밝히고자 하였다. 또한 주의력결핍 과잉운동장애의 치료제인 methylphenidate를 주의력결핍 과잉운동장애 환자에게 투여하여 주의력 과제 중에 활성화되는 뇌 양상의 변화를 알아보고, 치료제가 주의력을 높이는 기전에 대한 이해를 넓히고자 하였다. 방 법 : 연구 대상자는 환자 20명, 정상인 20명으로 총 40명이었다. 두 군은 성별, 나이, 손잡이, 지능에 있어서 차이가 없도록 선발되었다. 정상인은 안정 상태와 주의력 과제를 실행하는 동안 정량화 뇌파를 측정하였다. 환자군은 methylphenidate를 투여한 상태와 투여하지 않은 상태에서 각각 안정 상태와 주의력 과제를 실행하는 동안 정량화 뇌파를 측정하였다. 결 과 : 본 연구의 결과는 다음과 같다. 1) 집중력 검사상, 정상대조군이 투약 전 환자군에 비해 목표자극에 대한 정반응 시간과 목표 자극에 대한 정반응 시간의 표준편차에 있어 유의하게 낮은 점수를 보여 집중력이 좋음을 알 수 있었다. 환자군은 누락 오류, 목표 자극에 대한 평균 정반응 시간, 표준편차에 있어 투약 전에 비해 투약 후에 유의하게 낮은 점수를 얻어, 투약 후 집중력이 유의하게 호전됨을 확인하였다. 정상 대조군과 투약 후 환자군 사이에 집중력 검사상 차이는 없었다. 2) 안정상태에서 얻은 정량화 뇌파의 모든 파 영역에서 환자군은 정상군에 비해 유의하게 뇌파의 전위가 증가해 있었다. 3) 정량화 뇌파의 delta 파 영역에서 뇌파를 분석한 결과, 정상 대조군의 경우, 주의력 과제 중에는 안정상태에 비하여 두정-후두엽 부위의 전위가 유의하게 증가하였으나, 환자군에서는 주의력 과제 중에 유의하게 전위가 증가하는 부위가 없어, 국소화한 뇌 활성 변화를 관찰할 수 없었다. 4) Theta 파 영역에서, 정상 대조군의 경우, 주의력 과제 중에는 안정상태에 비해 우측 전두엽, 우측 측두엽, 양측 두정-후두엽 부위에서 전위가 유의하게 증가하였다. 그러나 환자군에서 투약하기 전에는 유의하게 증가하는 부위가 없었다. 환자군에서 투약 후에는 우측 전두엽, 우측 측두엽, 양측 두정-후두엽 부위에서 유의하게 전위가 증가해, 정상 대조군과 유사한 뇌활성도의 변화 양상을 보였다. 5) Alpha 파 영역에서, 정상 대조군의 경우, 주의력 과제 중에는 안정상태와 비교해 두정-후두엽 부위만이 유의하게 뇌파가 증가하는 반면, 투약하지 않은 환자군의 경우 광범위한 부위에서 유의하게 뇌파가 증가하여 뇌 활성 변화 부위가 국소화되지 않았다. 6) Beta 파 영역에서, 정상 대조군의 경우 안정상태에 비해 주의력 과제 중에는 좌측 전두엽과 Cz 부위만이 유의하게 전위가 증가하는 반면, 투약 하지 않은 환자군의 경우 거의 모든 뇌부위에서 전위가 유의하게 증가해 뇌의 활성 변화 부위가 국소화되지 않았다. 투약한 후에는 좌측 전두엽과 양측 측두엽의 뇌파가 유의하게 증가해 국소화한 뇌 활성 변화 양상을 보였다. 결 론 : 주의력결핍 과잉운동장애 환자는 안정상태에서 정상인과 비교해 뇌파상 비정상적으로 활성화되어 있다. 정상인의 경우, 공간 자극에 관계된 주의력 과제 실행시 주로 전두엽과 두정-후두엽이 활성화되었으나 주의력결핍 과잉운동장애 환자는 국소적인 뇌활성화에 실패하였다. 주의력결핍 과잉운동장애 환자의 주의력 결함은 전두엽과 두정-후두엽 부위의 병태와 관련이 있을 것으로 사료된다. Objectives : The attentional deficit is a core symptom in attention deficit hyperactivity disorder. The major brain areas related to attention are frontal and parietal lobes. Abnormalities of frontal and parietal lobes in attention deficit hyperactivity disorder have been reported in previous researches. But, most of the researches are based on comparing patients and controls while they are in resting condition. Further research on functional changes related to performance of attentional task is needed to understand the attentional dysfunction in attention deficit hyperactivity disorder. In this study, the localized functional changes of the brains related to attentional task in patients with attention deficit hyperactivity disorder and the differences of them between patients and normal controls were examined. Also the effect of the methylphenidate on functional changes related to attentional task in patients with attention deficit hyperactivity disorder was examined. Method : Quantitative electroencephalography(QEEG) was applied to examine the fuctional changes related to attentional task. Subjects of this study consisted of 20 patients with attention deficit hyperactivity disorder and 20 controls who were matched age, sex, handedness, intelligence. QEEG was recorded on eye open resting condition, and on performing computerized attentional task. In cases of patients, after taking of methylphenidate, QEEG was recorded on both conditions. Results : 1) In attention test, normal controls had better scores in response time and variabilities of response time than those of patients with attention deficit hyperactivity disorder without taking methylphenidate. After taking medication, scores of omission, response time and variabilities of response time were significantly improved, comparing to scores without taking medication. No differences were recognized between the controls and patients with taking medication in scores of attention test. 2) In resting condition, spectral EEG revealed baseline activity levels of patients were significantly increased comparing to those of controls. 3) Analysis of delta wave revealed that amplitudes of controls were significantly elevated in parieto-occipital area during performance of attentional task. But in patients, localized activated area related to attentional task was not remarkable. 4) Theta activity of controls were significantly elevated in right frontal, right temporal, and both parieto-occipital areas during performance of attentional task. But in patients without taking medication, localized activated area related to attentional work was not remarkable. After taking medication, right frontal, right temporal, and both parieto-occipital areas were significantly activated. 5) Alpha activities of controls were significantly increased in parieto-occipital area during performance of attentional task, but those of patient without taking medication were increased in broad area. 6) Beta activities of controls were significantly increased in frontal area during attentional performance, but those of patients without taking medication were significantly increased in most of the brain areas. After taking medication, significantly increased activities related to attentional task were recognized in left frontal, and both temporal areas. Localized activated patterns similar to those of controls were recognized. Conclusion : Based on the results of this research, it is suggested that patients with attention deficit hyperactivity disorder have increased baseline brain activity. In controls, brains showed localized response to a attentional stimuli, and functional changes related to attentional stimuli were recognized in frontal, and parieto-occipital areas. But, patients failed in showing appropriate localized activated response to attentional stimuli. It is concluded that frontal and parieto-occipital areas have some deficit responsible for the attentional dysfunction of attention deficit hyperactivity disorder.

자기조절학습전략을 통한 읽기 중재가 주의력결핍과잉행동장애 아동의 읽기 이해력과 읽기 태도에 미치는 영향

이후희,황순영 한국정서ㆍ행동장애아교육학회 2011 정서ㆍ행동장애연구 Vol.27 No.1

본 연구는 자기조절학습전략을 통한 읽기 중재가 주의력결핍과잉행동장애 아동의 읽기 이해력과 읽기 태도에 미치는 영향을 밝히고자 하는 데 있다. 이를 위해 P시의 초등학교 3~4학년에 재학 중이면서 전문의에 의해 주의력결핍과잉행동장애로 판정받고, 6개월 이상 약물치료를 받은 아동 6명을 연구대상으로 하였다. 연구설계는 사전검사, 20회기의 실험처치 후 사후검사로써 단일집단 전후검사설계(one-group pretest-post test design)로 이루어졌다. 자료 분석 방법으로는 비모수적 방법인 Wilcoxon의 부호 순위 검정을 이용하였다. 본 연구의 결과는 첫째, 자기조절학습전략을 통한 읽기 중재가 주의력결핍과잉행동장애 아동의 읽기 이해력을 향상시켰다. 낱말이해, 문장배열, 짧은 글 이해에서 유의미한 차이가 있었으며, 그 중에서도 짧은 글 이해 영역에 대한 변화 점수가 가장 높은 것으로 나타났다. 반면에 문장완성, 어휘선택에서는 유의미한 차이가 나타나지 않았다. 둘째, 자기조절학습전략을 통한 읽기 중재가 주의력결핍과잉행동장애 아동의 읽기 태도를 향상시켰다. 따라서 연구 결과를 종합하여 볼 때 자기조절학습전략을 통한 읽기 중재가 주의력결핍과잉행동장애 아동의 읽기 이해력과 읽기 태도를 향상시키는 데 효과적인 교수 방법임을 알 수 있다. The purpose of this study is to reading effects of self-regulated learning strategy on reading comprehension and reading attitude of children with attention deficit hyperactivity disorder. The subjects were six children with attention deficit hyperactivity disorder in the third or fourth grade who were identified as children with attention deficit hyperactivity disorder by psychiatrist. The intervention program consisted of twenty sessions for ten weeks. Each program session took forty minutes. Then a researcher carried out pre- and post-tests to determine how self-regulated learning strategy was effective in reading comprehension and reading attitude of children with attention deficit hyperactivity disorder. Results of the study are two. First, using reading comprehension, self-regulated learning strategy were effective on the participants with attention deficit hyperactivity disorder. After the program, the score of reading comprehension was higher than that of pre-test. It seems to be the effect of the program. Second, through the results of the pre- and post-tests using reading attitude toward recreation and reading attitude toward learning, we realized that self-regulated learning strategy was supportive to help the children with attention deficit hyperactivity disorder. The tests showed that self-regulated learning strategy was effective reading attitude toward recreation and reading attitude toward learning.

소아 주의력결핍 및 과잉행동장애 (ADHD)의 한의학적 치료에 대한 국내외 연구 동향

안혜리,구은진,이혜림 대한한방소아과학회 2019 대한한방소아과학회지 Vol.33 No.3

Objectives: The purpose of this study to analyze the effect of Korean medicine therapy of Attention deficit hyperactivity disorders. Methods: Electronic research articles were selected by using NDSL, OASIS, KISS, KMBASE, K-portal, Pubmed, Cochrane, and Ebscohost. Results: We analyzed fifteen studies about Korean medicine treatment of Attention deficit hyperactivity disorders. There are eleven studies on the acupuncture treatment, and the most commonly used acupoints were GV20 and EX-HN1. There are eight studies on the herb medicine treatment. The most commonly used herbal materials are Root of Rehmanniae Radix et Rhizoma Preparata, Root of Rehmanniae Radix et Rhizoma Preparata, Sclerotium of Poria cocos Wolf, and Rhizome of Acori Gramineri Rhizoma. Syncope and hematomas were common side effects of the acupuncture treatment. Also, the acupuncture needle can be stuck or bent during the treatment. In most studies, Attention deficit hyperactivity disorders was improved when treated with Korean medicine. Conclusions: More studies are needed to demonstrate the effectiveness of Korean medicine in Attention deficit hyperactivity disorders. This study can be used for various studies of Attention deficit hyperactivity disorders.

우울감을 주소로 내원한 환자들에서 주의력 결핍/ 과잉행동장애 증상의 공존율 분석

정미영,박서영,김정호,임우영,이연정 한국정신신체의학회 2019 정신신체의학 Vol.27 No.2

Objectives:Cognitive dysfunction, including inattention, is often observed in patients with depression. Inattentive symptoms in patients with depression is similar to those among attention deficit/hyperactivity disorder (ADHD) patients. It is important to diagnose the two diseases accurately, because the treatment varies depending on the cause of inattention. This study aimed to investigate the coexistence rate of ADHD and the correlation between ADHD symptoms and depression in patients with depression. Methods:Participants in this study were 158 outpatients presenting with depression, who visited the psychiatric department from March 2015 to July 2018. Participants divided into a depression and a non-depression group according to the Korean version of the Center for Epidemiological Studies-Depression Scale (CES-D) score and were administered the following : a sociodemographic variables form (age, sex, academic background, occupation), the self-reporting test for adult ADHD (Adult Attention Deficit/Hyperactivity Disorder self-report scale-V 1.1; ASRS V1.1), and the Korean version of the Connors adult ADHD rating scale (K-CAARS). Descriptive statistical analysis, crossover analysis, t-tests, and Pearson’s correlation coefficient were conducted on the data. Results:The coexistence rate of adult ADHD symptom was as high as 36.7% in patients with depression (p<0.001). In K-CAARS, the depression group (Inattention=1.80, Hyperactivity=1.92, Impulsivity=1.56, Selfconcept= 2.06) showed higher average scores on ADHD symptoms than the non-depressive group (Inattention= 1.28, Hyperactivity=1.25, Impulsivity=1.09, Self-concept=1.42, p<0.001). Conclusions:This study confirmed that ADHD symptoms coexist in the depression group. When evaluating the symptoms of patients who complain of depression, it is suggested that they should be accurately diagnosed and appropriately treated with interest to the coexistence of ADHD symptoms and the possibility for ADHD diagnosis. 연구목적우울증 환자들에게서는 부주의를 포함한 인지기능 저하는 흔히 동반된다. 우울증 환자들에게서 나타나는부주의 증상은 주의력결핍/과잉행동장애(Attention Deficit/Hyperactivity Disorder, ADHD)에게서 나타나는증상과 유사한 양상을 보인다. 부주의 증상의 원인에 따라 치료가 달라지므로 두 질환을 정확히 진단하는 것이중요하다. 본 연구에서는 우울감을 주소로 내원한 환자들에서 ADHD 증상의 공존율과 증상 별 상관관계를 알아보고자 한다. 방 법2015년 3월~2018년 7월까지 우울감을 주소로 순천향대학교 부속 서울병원 정신건강의학과 외래에 내원한158명의 환자를 대상으로 하였다. 모든 대상자들은 사회인구학적 특성(연령, 성별, 학력, 직업), 한국판 역학연구센터 우울척도(The Center for epidemiological Studies-Depression Scale, CES-D), 성인 주의력결핍과잉행동장애 자기보고척도(Adult Attention Deficit/Hyperactivity Disorder self-report scale-V 1.1, ASRS-V 1.1), 한국판 코너스 성인 ADHD 평정척도(Korean-Conners’ Adult ADHD Rating Scale, K-CAARS)를 수행하였다. 우리는 우울증군과 비우울증군을 CES-D점수로 분류하였으며, 자료처리는 기술통계분석, 교차분석, t-tests, 피어슨 상관분석을 실시하였다. 결 과성인 ADHD 증상 공존율은 우울증군에게서 36.7%로 높았다(p-value<0.001). K-CAARS에서 ADHD 증상정도는 우울증군(Inattention=1.80, Hyperactivity=1.92, Impulsivity=1.56, Self-concept=2.06)이 비우울증군(Inattention=1.28, Hyperactivity=1.25, Impulsivity=1.09, Self-concept=1.42) 보다 높게 나타났다(p-value< 0.001). 결 론본 연구에서는 ADHD 증상이 우울군에서 공존한다는 것을 확인하였다. 우울감을 호소하는 환자의 증상을평가할 때, ADHD 증상의 공존 여부와 ADHD 진단 가능성에 관심을 가지고 정확하게 진단하고 적절한 치료를 병행해 나가야 한다고 제안한다.

Associations among High Risk for Sleep-disordered Breathing, Related Risk Factors, and Attention Deficit/Hyperactivity Symptoms in Elementary School Children

김경민,Jee Hyun Kim,Dohyun Kim,Myung-Ho Lim,Hyunjoo Joo,Seung Jin Yoo,Eun Jung Kim,Mina Ha,Ki-Chung Paik,Hojang Kwon 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.4

Objective: Habitual snoring is a common problem in children. We evaluated the association between a high risk for sleep-disordered breathing and attention deficit/hyperactivity symptoms. Methods: Parents of 13,560 children aged 6 to 12 years responded to questionnaires including items on habitual snoring and the Korean attention deficit/hyperactivity disorder rating scale. The snoring score comprised the number of “yes” responses to habitual-snoring items, and a high risk for sleep-disordered breathing was defined as a snoring score ≥ 2. Results: The odds ratio (OR) of a high risk for sleep-disordered breathing was significantly higher in boys (OR = 1.47; p < 0.001), overweight children (OR = 2.20; p < 0.001), and children with current secondhand-smoking exposure (OR = 1.38; p < 0.001). The Korean attention deficit/hyperactivity disorder rating scale score increased significantly with the snoring score (0 vs. 1, B = 1.56, p < 0.001; 0 vs. 2, B = 2.44, p < 0.001; 0 vs. 3, B = 2.48, p < 0.001; 0 vs. 4, B = 3.95; p < 0.001). Conclusion: Our study confirms several risk factors of sleep-disordered breathing, namely male sex, overweight, and exposure to tobacco smoking, and found a positive association between habitual snoring and attention deficit/hyperactivity symptoms.

Aripiprazole in ADHD with Tic Disorder and in ADHD with Tourette Disorder: Two Case Reports

임명호,Jin Kyung Kang,박태원,백기청,김현우 대한정신약물학회 2007 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.5 No.2

We report the effect of aripiprazole in attention deficit hyperactivity disorder (ADHD) with tic disorder and in ADHD with Tourette disorder, which are very common in clinical settings, but are not supported by theory. We administered 15 mg of the dopamine partial agonist aripiprazole, which led to the obvious improvement of symptoms in ADHD patients with tic disorder or Tourette disorder. We report the effect of aripiprazole in attention deficit hyperactivity disorder (ADHD) with tic disorder and in ADHD with Tourette disorder, which are very common in clinical settings, but are not supported by theory. We administered 15 mg of the dopamine partial agonist aripiprazole, which led to the obvious improvement of symptoms in ADHD patients with tic disorder or Tourette disorder.

주의력결핍과잉운동장애 아동의 뇌청각 사건유발전위

최진숙,주은정 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.2

In the present study, the authors hoped to determine whether the children with Attention Deficit Hyperactivity Disorder differed from normals in Auditory Event Related Potential study. The study was performed by selective attentional tasks. Study subjects were grouped into attention deficit hyperactivity disorder group(N=9) and normal control group(N=8) according to clinical information, DSM-III-R diagnostic criteria, several psychological tests. During the selective attentional tasks, subject were submitted to odd-ball test with auditory stimuli of the two different frequencies, under the two conditions of attention or ignorance. Test was performed twice, the first under the condition that should be attend to auditory stimuli and count the target sound, the second condition with reading. The results are as follows : 1) Considering the average value of auditory event related potential wave components over all conditions, the amplitude of wave components at each electrode site was different. Amplitude of N2 wave was larger at anterior portion of the brain and the amplitude of P3b was larger at posterior portion of the brain. 2) At Pz electrode site, amplitude of N2 wave to target and non-target sound was different between boys with attention deficit hyperactivity disorder and normal controls. Amplitude of N2 wave in attention deficit hyperactivity disorder was smaller than normal controls. 3) At Fz, Cz, Pz electrode site, amplitude of P3b wave elicited by target sound was larger than by non-target sound. This discrepancy was not interrelated with subjects group factor or attentiation factor. 4) Amplitude of N2 wave at Fz, Cz electrode site was different according to attend condition. Amplitude of N2 wave under the condition attended to auditory stimuli was larger than under the ignore condition. This discrepancy was not interrelated with subject group factor or stimulus factor. 5) Amplitude of P3b wave at Pz was significantly different according to attention. Amplitude of P3b was greater at attend condition. This discrepancy was not influenced by subject group factor or stimulus type factor. In conclusion, some findings of this study were suggestive there are differences in brain auditory event related potential between the two groups(ADHD vs controls). Further study is necessary to prove and conclude it.

청지각 훈련(The Listening Program)이 주의력결핍 과잉행동장애 아동의 감각처리 및 주의집중력에 미치는 영향

이찬화,유은영,박혜연,이지연 대구대학교 특수교육재활과학연구소 2022 특수교육재활과학연구 Vol.61 No.1

The purpose of this study was to investigate the changes in the children's attention and sensory processing level after applying auditory perception training to children with attention deficit/hyperactivity disorder. The subjects of this study were three children with attention deficit hyperactivity disorder, and the study design applied the ABA design of a single subject experimental design. The research process was conducted in a total of 23 sessions,and consisted of 4 sessions during the baseline period, 15 sessions during the intervention period, and 4 sessions during the re-baseline period. Auditory perception training was provided 15 times during the intervention period, 5 times a week, and 2 modules were listened to. To measure the change in the level of attention, the FAIR attention test was used. As a result of the study, after applying the auditory perception training, 2 out of 3 subjects had an effect on improving attentional ability, and the improvement in auditory processing ability was found in all subjects, but statistical significance was found only in 2 subjects. As a result of the SSP test, overall sensory processing ability was improved in all subjects, and subject 2 was able to confirm the tendency to change from problem category to suspicious category after intervention and maintain. Through the results of this study, it is significant in that auditory perception training is an effective intervention method for attention and sensory processing ability of children with attention deficit hyperactivity disorder.

Comorbid Depressive Disorders in ADHD: The Role of ADHD Severity, Subtypes and Familial Psychiatric Disorders

Michela Di Trani,Francesca Di Roma,Andriola Elda,Leone Daniela,Parisi Pasquale,Miano Silvia,Donfrancesco Renato 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.2

Objective To evaluate the presence of Major Depressive Disorder (MDD) and Dysthymic Disorder (DD) in a sample of Italian children with Attention Deficit Hyperactivity Disorder (ADHD) and to explore specific features of comorbid depressive disorders in ADHD. Methods Three hundred and sixty-six consecutive, drug-naïve Caucasian Italian outpatients with ADHD were recruited and comorbid disorders were evaluated using DSM-IV-TR criteria. To evaluate ADHD severity, parents of all children filled out the ADHD Rating Scale. Thirty-seven children with comorbid MDD or DD were compared with 118 children with comorbid conduct disorder and 122 without comorbidity for age, sex, IQ level, family psychiatric history, and ADHD subtypes and severity. Results 42 of the ADHD children displayed comorbid depressive disorders: 16 exhibited MDD, 21 DD, and 5 both MDD and DD. The frequency of hyperactive-impulsive subtypes was significantly lower in ADHD children with depressive disorders, than in those without any comorbidity. ADHD children with depressive disorders showed a higher number of familial psychiatric disorders and higher score in the Inattentive scale of the ADHD Rating Scale, than children without any comorbidity. No differences were found for age, sex and IQ level between the three groups. Conclusion Consistent with previous studies in other countries, depressive disorders affect a significant proportion of ADHD children in Italy. Patient assessment and subsequent treatment should take into consideration the possible presence of this comorbidity, which could specifically increase the severity of ADHD attention problems.

아동의 모발 내 무기물 농도와 주의력결핍 및 과잉행동장애와의 상호연관성에 관한 연구

유연아,정문호 한국환경보건학회 2004 한국환경보건학회지 Vol.30 No.1

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most general childhood problems occurs locally and internationally, but the causes of ADHD are not cleared yet. Therefore, this study tried to examine some parts of the causes of ADHD closely, and finally contribute to the medical treatment of ADHD and its precautionary measures, by measuring and comparing concentration of minerals in hairs of the patients of ADHD and their control group's children. which can analyze the relevance to ADHD and the mineral content in human bodies, and mutual relations between toxic minerals and essential minerals in human bodies. After collection of hairs from 200 children(5 to 7-year-old, boys: 159 girls:41) diagnosed as ADHD by medical specialists based on the standard of DSM-IV diagnosis and their control group's 177 children(boys: 138 girls:39), the mineral concentration of samples was measured through ICP-MS and compared. And correlations between toxic minerals and essential minerals in human bodies among patients group was analyzed. All the toxic minerals(Pb, Hg, Al, Cd, As) of hairs analyzed in the study showed more higher range of concentration in patients group in comparison with their control group. Among them, the concentration of Pb(3.27 $\pm$ 3.82 ppm) and As(0.16 $\pm$ 0.15 ppm) in patients group were significantly high compared to their control group. And in this study Pb among toxic minerals showed negative correlation with Zn(r = -0.43), Mg(r = -0.15) among essential minerals. Cd among toxic minerals showed negative correlation with Zn(r = -0.20) among essential minerals. As among toxic minerals showed negative correlation with Ca(r = -0.14) among essential minerals.