간암 환자에 합병된 Citrobacter braakii 패혈증 1례 보고

이해미,배성하,이수남,이정우,신아영,류시영,이수연,윤문희,한선영,한남익,이영석,유진홍 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Citrobacter species is a gram-negative bacilli that can cause opportunistic infections in immunocompromised hosts. Citrobacter braakii refers to the genomospecies 6 of the Citrobacter freundii complex. There are no detailed studies on infections caused by this newly identified specific genetic species in Korea. We herein report a case of a patient with hepatocellular carcinoma who, after undergoing transcatheter arterial chemoembolization, developed biloma which later progressed to C.braakii sepsis and did not respond to treatment. To our knowledge, this is the first reported case in Korea on C. braakii infection resulting in septic shock in a patient with malignancy in Korea.

DTMF 신호를 이용한 전자 보안 시스템

이병수,이순흠,박동규,이동원,이선휘,황유동 순천향대학교 부설 산업기술연구소 1999 순천향 산업기술연구소논문집 Vol.5 No.2

we have developed cost-effective effectronic security system. The system is superior to the day-time alert system which is currently used for banks in Choongchung Province. The system can monitor 512 banks and inform the police of emergency state and its related informations. The developed svstem is under field test at a police station in Choongchung Province.

Application of Antioxidant Transgenic Mice

Sun?Uk Kim,Hee-Young Yang,Sun-Hee Ahn,Suhee Kim,Dae?Yeul Yu,Dong?Seok Lee,Tae-Hoon Lee 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.8

중국 포양호 주변의 농경지 현황 및 수질 오염 부하량

이종식,정구복,윤순강,정광용,于傳驥,劉文祥 한국국제농업개발학회 2002 韓國國際農業開發學會誌 Vol.14 No.4

중국 최대의 담수호로 장강을 통해 서해로 유입되는 포양호의 특성, 주변의 농경지 토양환경, 시기별 포양호 수질변화 및 유입되는 각 수계별 수질오염 부하량 등을 검토하였다. 1. 포양호는 주변 지역의 벼 재배와 홍수 조절에 중요한 역할을 하며 최근 간척과 침척토의 침적 등에 의하여 면적이 매년 축소되고 있다. 2. 아열대 기후에 속하여 연평균 강우량이 1,570㎜ 수준으로 비교적 많으나 연 중 분포가 평준하지 않고 월별 차이가 커서 시기별로 호수의 수표면적 및 저수량의 변화가 대단히 크다. 3. 주변 지역의 농경지는 큰 오염원이 없어 비교적 오염되지 않은 토양이며, 오염도가 심한 농경지는 호수 유역의 전체 농경지 면적중 0.22%로 광산 인근 토양이 구리와 황으로 오염되어 있다. 4. 포양호에 직접 유입되는 COD부하량은 시기별로 홍수기가 371.9톤/일로 갈 수기 273.9톤/일에 비해 많았다. 요인별로는 산업체에서 기인되는 양이 가장 많았으며, 유입되는 수계별로는 감강으로부터 유입되는 오염 부하량이 가장 많았다. Water in Poyang lake, which is one of the biggest lake in China, flows into Yellow Sea through the Changjiang River. In this paper, water quality characteristics and loading amount of contaminants of Poyang Lake area were investigated. Poyang lake has a important role to rice cultivation and flood control in the basin of the lake. However, the area of the lake has been reduced gradually by land reclamation and sedimentation. This area belongs to the subtropical zone and the average rainfall is near 1,570㎜, which is relatively higher than other region in China. The surface area and the volume of storage water of the lake is very changeable following to the big different monthly rainfall. Agricultural field near the lake is not contaminated comparatively because there is little source of contamination near the Poyang lake. About 0.22% of the total agricultural field near the lake were heavily contaminated by copper and sulfur originated from metal mines. Inflow loading amount of COD(chemical oxygen demand). Compared to other sources of contamination such as municipality, livestock, and nature, industrial source of COD to Poyang lake were the greatest. Ganjiang stream was the highest for the loading amount of COD to Poyang lake among 5 streams.

만성 호중구성 백혈병 1례

이영진,최유선 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1

Chronic neutrophilic leukemia is a rare myeloproliferative disorder and characterizes unusual sustained neutrophilia with splenomegaly but no fever, inflammation, cancer or other cause of neutrophilia. The neutrophilic alkaline phosphatase(NAP), vitamin B_12, uric acid, lactate dehydrogenase(LD), and ferritin are elevated but t(9;22), bcr/abl rearragement are or not noted. The patent was 68 year old male who was subtrochanteric fracture of right femur at 5 days ago. The WBC was 76.8 × 10 exp (9)/L (neutrophil 96.7%, lymphocyte 1.3%, monocyte 1.2%, eosinophil 0.8%), RBC 3.00 × 10 exp (12)/L, hemoglobin 88 g/L, hematocrit 25.6%, and platelet 199 × 10 exp (9)/L at admission. The serum alkaline phosphatase, LD, ferritin, NAP score were elevated but protein, albumin, cholesterol decreased. The WBC(especially neutrophil) were progressively increased number and up to 134.3 × 10 exp (9)/L (neutrophil 96.3 %, 129.3 × 10 exp (9)/L) but no evidences of neutrophilic leukocytosis. The PBS revealed neutrophilic leukocytosis with shift to the left, toxic granules, and some dysgranulopoiesis. He had splenomegaly, no fever and chill. The patient was expired after the 22th admission day.

혼합형 자가면역성 용혈성 빈혈을 동반한 전신성 홍반성 루푸스 1예

이승철,김선임,이승훈,이현경,조남국,한성훈,유영진,조종래 인제대학교 2000 仁濟醫學 Vol.21 No.2

A 17-year-women developed mixed warm and cold antibody type autoimmune hemolytic anemia associated with systemic lupus erythematosus. The patients was admitted to our hospital for syncope. Jaundice was observed. Urinalysis revealed protein and hemoglobin. Her hemoglobin was 4.6g/dl and reticulocytes were 10%. Total bilirubin was elevated, while haptoglobin and complement were abnormally reduced. ANA and mitochondrial Ab were detected. The direct and indirect Coombs test were positive. The direct antiglobulin test was positive ; IgG and C3d were detected on the red cell surface. The cold agglutinin(CA) titer was 128. The patients was initially treated with high dose steroid therapy. However the patients did not responded to high dose steroid therapy. We treated the patients with plasmapheresis and synchronized cyclophosphamide therapy. Clinical remission of hematologic complications was achieved in this patients. We report a case of mixed type autoimmune hemolytic anemia with SLE that responded plasma pheresis and synchronized cyclophosphamide therapy.

난소의 소세포암종, 고칼슘혈증형 대세포 변종 : 1예 보고 A Case Report

이종실,이종학,김유경,박선후,고경혁 대한병리학회 2001 Journal of Pathology and Translational Medicine Vol.35 No.4

Isolation and characterization of BrMDR1 a novel MDR-type ATP-binding cassette (ABC) transporter in Brassica rapa L.

Sun-Yong Lee1,Yu-Jin Jung,Kwon-Kyoo Kang 한국자원식물학회 2009 한국자원식물학회지 Vol.22 No.3

A cDNA clone encoding a MDR-like ABC transporter protein was isolated from Brassica rapa seedlings, through rapid amplification of cDNA ends (RACE). This gene (named as Brmdr 1; GenBank accession no.: DQ296184 ) had a total length of 4222 bp with an open reading frame of 3900 bp, and encoded a predicted polypeptide of 1300 amino acids with a molecular weight of 143.1 kDa. The BrMDR1 protein shared 71.0, 62.5, 60.0 and 58.2% identity with other MDR proteins isolated from Arabidopsis thaliana (AAN28720), Coptis japonica (CjMDR), Gossypium hirsutum (GhMDR) and Triticum aestivum (TaMDR) at amino acid level, respectively. Southern blot analysis showed that Brmdr1 was a low-copy gene. Expression pattern analysis revealed that Brmdr1 constitutively expressed in the root, stem petals and stamens, but with lower expression in leaves and open flowers. The domains analysis showed that BrMDR1 protein possessed two transmembrane domains (TMDs) and two nucleotide binding domains (NBDs) arranging in TMD1-NBD1-TMD2-NBD2 direction, which is consistent with other MDR transporters. Within NBDs three characteristic motifs common to all ABC transporters, Walker A , Walker B and C motif, were found. These results indicate that BrMDR1 is a MDR-like ABC transporter protein that may be involved in the transport and accumulation of secondary metabolites.

Cis-AB 혈액형 4례

이영진,최유선 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1

The ABO groups are important for blood transfusion and inheritance. The child is receive ABO gene by each parents' ABO gene in chromosome 9. But rare blood groups show unusual inheritance of ABO group on the same chromosome by cross over or mutation. The cis AB group is unusual genetic transmission which have AB and O group child from AB and O group parents. So cis AB group give rise to paternity problem, and discrepancy between cell and serum group. I experienced 4 cases of cis AB and report cases with some literature.

항결핵 치료과정에서 호전되었다가 악화된 뇌 결핵종 1예 보고

이대훈,유진홍,강미자,김홍기,김선화,고동훈,천지성,유원종 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.3

In spite of nationmide tuberculosis control program, tuberculosis is still prevalent in Korea. Accordingly, tuberculous meningitis also poses one of the main trouble some problems. Recently, We experienced a perplexing case of tuberculous menin-gitis and tubercdoma in a 24-year old female patient. She was admitted to our hospital owing to meningeal irritation sign, aphasia, VI nerve palsy, and ,fever. CSF analysis showed a finding consistent with that of presumptive tuberculous meningitis.. Initial MRI of the brain revealed a large mass(tuhercu1oma) on left parieto-temporal area. Antitubeculous regimen(1soniazid (INH), rifampin(RMP), ethambutol(EMB), pyrazinamide(PZA)} of meningeal dose was given immediately, and her symptoms and signs were dramatically disappeared with a few days after treatment. She was discharged with improved condition and under maintenance treatment of tuberculosis. Follow-up one year after treatment. revealed that the previous lesion was nearly diminished. She showed no symptom at all until she recognized a total blindness of sudden onset on her left eye a t the 18th month of treatment. Brain MRI checked at that time showed multiple masses of tuberculoma scattered over the brain base and one of them invaded left optic nerve. In our opinion, the cause of relapse in this patient might he explained by the selection and ultimate replication of a minor population of resistant strain. Although such relapse is an extremely rare event, we think that we should always pay attention to this possible resistance problem every time we meet patients with tuberculous meningitis.