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ICR 웅성 마우스에서 BisphenoI A가 면역계에 미치는 영향
조경혜,박효영 서울여자대학교 자연과학연구소 2003 자연과학연구논문집 Vol.15 No.-
Bisphenol A (2, 2-bis-(4-hydoxyphenyl) propane; BPA) is a widely used endocrine disrupters and has estrogenic activities. Although interests on biological effect of BPA are rising, evidences of its effect on immune system are lacking. We investigated the effects of BPA on immune parameters, and on interruptions between neuroendocrine and immune system in order to elucidate the mechanism. BPA was orally administrated to mice (as a drinking water) at doses of 0.015, 1.5 and 30 mg/ml for 4 weeks. The BPA treatment did not show changes in body weight, spleen weight and distribution of spleen lymphocyte subpopulation. BPA exposure induced prolactin production in the spleen and hypothalamic pituitary adrenal, and increased the activity of splenocyte proliferation in response to Con A (p<0.001). The production of a strong Th-1 type cytokine (IFN-γ) was induced while Th-2 type (IL-4) was suppressed by BPA treatment. These were consistent with RT-PCR results of transcription factor GATA-3 and IRF-1. These findings suggest that stimulation of prolactin production by estrogenic effects of BPA affects cytokine profiles, and lead to the imbalanced cellular immune response. In addition, we hypothesized that prolactin and cytokines are important mediators involved in the network between neuroendocrine and immune systems after exposure of BPA to mice.
EDISON-CFD : 웹 기반의 유체역학 교육ㆍ연구 융합 환경 구축
정영진(Young Jin Jung),진두석(Du-Seok Jin),김규진(Kyu Jin Kim),임재형(Jae Hyoung Lim),남덕윤(Dukyun Nam),문종배(Jongbae Moon),유정록(Jung-Lok Yu),안부영(Bu-Young Ahn),박선례(Sun Rea Park),이종숙(JongSuk Lee),조금원(Kumwon Cho) 한국전산유체공학회 2011 한국전산유체공학회 학술대회논문집 Vol.2011 No.11
In order to improve the standard of education and research environment with simulation, we suggest EDISON (EDucation-research Integration through Simulation On the Net) project. EDISON platform allows professors, researchers, industrial workers, and students to register, use, and share their simulation software and contents based on the cyber infrastructure of supercomputer and network, and recent research achievements. EDISON platform consists of 3 tiers such as application framework, middleware, and infrastructure to provide an amount of simulation and contents service. To construct the problem solving environment with simulation in 5 area (CFD, Chemistry, Physics, Structural dynamics, Computational design), EDISON platform provides a domain specific web simulation and contents service for each area. Especially, EDISON-CFD indicates the EDISON in Computational Fluid Dynamics that support Fluid dynamics education and research.
김형규,권영주,박상은,차대룡,신진호,조원용,김향,이규백,표희정,이영래,조상경,김용섭,서상열 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.5
Autosomal dominant polycystic kidney disease (ADPKD) is one of most common hereditary disorders that is potentially fatal. To elucidate clinical and genetic characteristics of ADPKD in Korea, 166 patients were analyzed retrospectively. The results were as follows ; 1) The male-to-female ratio was 83: 83, and age of patients was 4813(meanSD) years. 6496 of patients have a family history of the ADPKD. 2) Most common symptom was flank and abdominal pain. In urinalysis, proteinuria(42%), hematuria(18%) were found. Other organ involvement included hepatic cysts(58%), pancreatic cysts(8%) and splenic cyst(296). 3) The age at diagnosis was 44% 12 years. Hypertension was observed in 65%, the age of detection was 45% 11 years. Azotemia was observed in 36%, the age of detection was 52±11 years. 4) Echocardiography showed left ventricular hypertrophy 5896(19/33), valve regurgitation 1596(5/33) and mitral valve prolapse 3%(1/33). Cerebrovascular events occurred in 14 patients(8.4%), and 6 patients confirmed cerebral aneurysm rupture. 5) 29 patients(17%) reached end stage renal failure(ESRD), the age was 53±10 years. The provability of being alive and not having ESRD was 88% by age 50, 76% by age 58, and 48% by age 65. Sex and hepatic cyst were not associated significantly with the course of renal function(p$gt;0.05). 6) 15 patients(9%) died, the age of death was 55±12 years. 6 patients died after reaching ESRD. The cause of death were was cancer(4), cerebrovascular event(3), cessation of dialysis(2), sudden death (2), liver cirrhosis(1), sepsis(1), suicide(1) and unknown(1). Results of our study revealed the complications of ADPKD in Korea, hypertension 6596, ESRD 17% and cerebrovascular event 8%. Functional survival was 88M by age 50, 76% by age 58, and 48M by age 65. The extrarenal manifestations are more important contributors to mortality than renal manifestations of ADPKD.
인쇄용 페이스트의 조성변화가 탄소나노튜브 캐소드의 전계방출 특성에 미치는 영향
최우석,신허영,김동희,안병건,정원섭,이동구,조영래,Choi, Woo-Suk,Shin, Heo-Young,Kim, Dong-Hee,Ahn, Byung-Gun,Chung, Won-Sub,Lee, Dong-Gu,Cho, Young-Rea 한국재료학회 2003 한국재료학회지 Vol.13 No.10
The effects of paste materials on field emission properties in a carbon nanotube(CNT) cathode were investigated for high-efficient field emission displays. The major components in CNT paste for screen printing were a metallic Ag-paste, a dielectric glass-frit and CNT ink. The emission current from the cathode by an electron tunneling effect increased with an increase in the dielectric material fraction in the CNT paste, which is related to an increase of field enhancement factor in Fowler-Nordheim equation. The surface treatment used, after soft baking of the screen-printed CNT films, greatly affected the decrease in the turn-on field in CNT cathode and the uniformity of emission sites over the entire CNT film area.