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이영래 한국작물보호협회 1981 자연과 농업 Vol.2 No.11
재배환경의 변화에 따른 병충해의 복합적인 격발에도 불구하고 전염원 초기 박멸대책 추진, 상습지의 중점관리 및 예방위주의 적기 동시공동방제추진으로 가장 염려했던출수기의 목도열의 발생이 없이 깨끗한 출수기를 맞게 된것은 오직 증산해야겠다는 영농의욕의 결과이다. 그러나 유통구조개선 및 질소비료 과용등 방제행정의 개선점도 지적되고있어 이에 대한 대책이 조속히 강구돼야 할 것이다.
이영래,Eun-Mi Noh,Eun-Yong Jeong,윤석권,Young-Ju Jeong,Jong-Hyeon Kim,권강범,김병수,Sung-Ho Lee,박창식,김종석 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.8
Cordycepin (3'-deoxyadenosine) has been shown to exhibit many pharmacological activities, including anti-cancer, anti-inflammatory, and anti-infection activities. However, the anti-skin photoaging effects of cordycepinhave not yet been reported. In the present study, we investigated the inhibitory effects of cordycepin on matrix metalloproteinase-1 (MMP-1) and -3 expressions of the human dermal fibroblast cells. Western blot analysis and real-time PCR revealed cordycepin inhibited UVB-induced MMP-1 and -3 expressions in a dose-dependent manner. UVB strongly activated NF-κB activity, which was determined by IκBα degradation, nuclear localization of p50 and p65 subunit, and NF-κB binding activity. However, UVB-induced NF-κB activation and MMP expression were completely blocked by cordycepin pretreatment. These findings suggest that cordycepin could preventUVB-induced MMPs expressions through inhibition of NF-κB activation. In conclusion, cordycepin might beused as a potential agent for the prevention and treatment of skin photoaging.