http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Seung Soo Yoo ),( Hyo-gyoung Kang ),( Jin Eun Choi ),( Mi Jeong Hong ),( Sook Kyung Do ),( Jang Hyuck Lee ),( Won Kee Lee ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eung 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.4
Background/Aims: Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in male smokers. Methods: This study included 714 lung cancer patients and 626 healthy controls. The polymorphisms were genotyped using SEQUENOM MassARRAY iPLEX assay or Taq-Man assay. Results: Two polymorphisms were associated with the risk of lung cancer in male smokers, as in female never smokers. Male smokers carrying the rs4975616 variant allele had a significantly decreased risk of lung cancer (in a codominant model: odds ratio, 0.77; 95% confidence interval, 0.61 to 0.96; p = 0.02). The rs9387478 polymorphism also reduced lung cancer risk in male smokers (in a codominant model: odds ratio, 0.85; 95% confidence interval, 0.73 to 0.997; p = 0.046). In a stratified analysis, the association between these polymorphisms and the risk of lung cancer was predominant in lighter smokers and for cases of adenocarcinoma. Conclusions: These results suggest that a subset of polymorphisms known to be associated with the risk of lung cancer in female never smokers is also associated with the risk of lung cancer in male smokers.
The effect of susceptibility variants identified in never-smoking female lung cancer on male smokers
( Seung Soo Yoo ),( Hyo-gyoung Kang ),( Jin Eun Choi ),( Sun Ha Choi ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eungbae Lee ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in male smokers. Two polymorphisms were associated with the risk of lung cancer in male smokers, as in female never smokers. Male smokers carrying the rs4975616 variant allele had a significantly decreased risk of lung cancer (in a codominant model: odds ratio=0.77, 95% confidence interval=0.61-0.96, P=0.02). The rs9387478 polymorphism also reduced lung cancer risk in male smokers (in a codominant model: odds ratio=0.85, 95% confidence interval=0.73-1.00, P=0.05). In a stratified analysis, the association between these polymorphisms and the risk of lung cancer was predominant in lighter smokers and for cases of adenocarcinoma. These results suggest that a subset of polymorphisms known to be associated with the risk of lung cancer in female never smokers is also associated with the risk of lung cancer in male smokers.
( Seung Soo Yoo ),( Hyo-gyoung Kang ),( Jin Eun Choi ),( Sook Kyung Do ),( Won Kee Lee ),( Sun Ha Choi ),( So Yeon Lee ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Yangki Seo 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-
A number of genome-wide association studies have reported several variants that influence the risk of lung cancer in never- smoking females. We evaluated the impact of these variants on survival outcome in never-smoking females with non-small cell lung cancer (NSCLC). In total, 510 never-smoking females with NSCLC who underwent curative surgery were enrolled. Eleven variants associated with lung cancer susceptibility in never-smoking females, were genotyped and their associations with survival outcome were analyzed. Among these 11 variants, TP63 rs7631358 and CSF1R rs10079250 affected survival outcomes. TP63 rs7631358 G>A was associated with a relatively worse overall survival (under a dominant model; hazard ratio = 2.31, 95% confidence interval = 1.18-4.52, P = 0.01). CSF1R rs10079250 A>G was associated with a relatively better disease- free survival (under a codominant model; hazard ratio = 0.70, 95% confidence interval = 0.53-0.93, P = 0.01). These results suggest that TP63 rs7631358 G>A and CSF1R rs10079250 A>G may affect the prognosis of NSCLC in never-smoking females, as well as the risk of lung cancer.
Yoo Hwa Seung,Lee Nam Heon,Cho Jung Hyo,Lee Yeon Weol,Son Chang Gue,Kang Wee Chang,Cho Chong Kwan The Society of Korean Medicine 2005 대한한의학회지 Vol.26 No.4
Objectives: Recently, angiogenesis has gained an increasing interest as a prognostic factor in breast cancer. In this study we aimed to assess the anti angiogenic effects of HAD, a botanical anticancer remedy which has been prescribed in Daejeon University Oriental Hospital in Korea, on patients with breast carcinoma by measuring the serum vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF) and platelets levels. Methods: The study included 26 consecutive breast cancer patients (mean age$\pm$standard deviation: 47.5$\pm$8.7 years) with stage II to IV disease who were treated with HAD (mean duration $\pm$ standard deviation: 264.5$\pm$121.6 days). In addition to routine laboratory and staging procedures, serum VEGF, b-FGF levels and platelet counts were determined as antiangiogenic markers. The antiangiogenic effects of HAD were evaluated by analyzing the differences between the values of the antiangiogenic markers before and after the treatment with HAD. Results: Serum b-FGF concentrations were significantly reduced after the treatment with HAD (P=0.042). Serum VEGF concentrations were found to have a somewhat decreasing change, though the change was not statistically significant (P=0.229). Platelet counts had little changes (P=O.80). Conclusions: It is supposed that HAD has effects on decreasing the serum b-FGF levels related with the clinical outcome of breast cancer patients.
International tourism receipts and economic growth : a cross-country analysis
Hyo-Ju Kim(김효주),Seung-Hoon Yoo(유승훈) 한국무역학회 2008 무역학자 전국대회 발표논문집 Vol.2008 No.8
Evaluating the sources of economic growth is obviously important, and numerous attempts have been made to judge the impact of many different factors on economic growth. Since some empirical studies have reported that International tourism receipts (ITR) is one of the important factors in economic growth, this paper empirically explores the impacts of ITR on economic growth using a cross-country analysis based on data from 102 countries for the year 1995-2005. To this end, a further augmented version of the endogenous growth theory model, explicitly including ITR, is applied. Subject to the appropriate caveats, the results provide further support for several key conclusions of the former studies - investment in physical capital, population growth, and the human capital are important in accounting for economic growth across countries. More importantly, it is concluded that ITR significantly contributes to economic growth. Thus, the suggestion that countries can significantly enhance their economic growth by further increasing ITR seems to be supported by the results of this study.
Occurrence and Prevalence of Honeybee Disease in Apis mellifera and Apis cerana in Korea
Seung-Won Kang,Mi-Sun Yoo,Jin-Hyeong Noh,Hyo Seon Park,il Min,Dong-Min Jeon,Su Chin Park,Mi Seong Lee,Young Un Hong,Sang Young Bang,Eun Hee Jang,Min Kwon Lee,Jong Sik Park,Myeong-Ho Jeong,Kwang Jung,M 한국양봉학회 2012 韓國養蜂學會誌 Vol.27 No.3
Seung Won Cheon,Seung-Guk Park,Sunmi Yoo,Hyo-Eun Kim,Hyunji Kim 대한가정의학회 2021 Korean Journal of Family Medicine Vol.42 No.4
Background: This study aimed to investigate trends in the prevalence of current smokers and motivation to quit among Korean male cancer survivors. Methods: Out of 20,012 men who participated in the Korea National Health and Nutrition Examination Survey V (2010–2012), VI (2013–2015), and VII (2016–2017), 742 cancer survivors were included. A cancer survivor was defined as a person who concurred to the item, “The cancer has been diagnosed by a doctor” in the health questionnaire. Smoking status was classified as current, former, and never smokers. Regarding motivation to quit smoking, we defined those who had a willingness to quit within 6 months as the willing group. Logistic regression analysis was conducted to examine trends in the prevalence of current smokers and the proportion of the willing group among current smokers. Results: Overall, 3.7% of Korean men who participated in the study were cancer survivors. Current smokers constituted 19.5%, 19.1%, and 15.3% of cancer survivors in phases V, VI, and VII respectively which did not show significant changes (P for trend=0.33). However, the proportion of current smokers in the non-cancer group was significantly reduced to 46.6%, 41.2%, and 38.9% in phases V, VI, and VII, respectively (P for trend <0.001). The proportion of those with a motivation to quit smoking did not show a significant trend in the cancer survivors (P for trend=0.964) and non-cancer group (P for trend=0.884). Conclusion: Prevalence of current smokers and motivation to quit in Korean male cancer survivors did not show significant trends.
Significance of Inflammatory Markers in Diabetic Patients with Stable Coronary Artery Disease
( Hyo Jin Lee ),( Sung Ho Her ),( Yun Sun Im ),( Kang Yeon Won ),( Sun Hong Yoo ),( Dong Bin Kim ),( Dong Il Shin ),( Pum Joon Kim ),( Ki Bae Seung ),( Jae Hyung Kim ),( Keon Yeop Kim ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.3
Background/Aims: Patients with diabetes are prone to coronary artery disease (CAD); however, the majority of diabetic patients show normal coronary arteries. We examined differences in the clinical aspects of diabetic patients with insignificant and with significant stenosis of the coronary artery. Methods: A total of 418 consecutive diabetic patients with stable angina who had undergone coronary angiography from January 2004 to March 2007 were included in this study. Patients were subdivided into control and CAD groups and then clinical characteristics and CAD-associated factors were evaluated. Results: A total of 92 (22%) patients were assigned to the control group and 326 (78%) patients were assigned to the CAD group. Using univariate regression analysis, we found that patients with CAD were significantly older (control vs. CAD; 59±21 vs. 64.7±33.7, years, p<0.001), had a longer duration of diabetes (8.2±21.8 vs. 10.2±29.8, years, p=0.027), higher titers of high sensitivity C-reactive protein (hsCRP; 0.3±6.79 vs. 0.9±12.6, mg/dL, p=0.015), and increased hemoglobin A1c (HbA1c) levels (7.1±3.8 vs. 7.5±4.8, %, p=0.007) compared to control patients. Multivariate regression analysis showed that only differences in age, hsCRP, and HbA1c were statistically significant. When patients were subdivided into groups based on hsCRP levels (208 patients in the low group [49.8%], 210 patients in the high group [50.2%]), we found that patients with higher hsCRP levels showed more frequent multivessel disease. Conclusions: In diabetic patients, age, hsCRP, and HbA1c were associated with stable CAD. Among these factors, hsCRP levels were significantly correlated with multivessel involvement in diabetic CAD. Therefore, high hsCRP levels may be a strong predictor for atherosclerotic progression of the coronary arteries in diabetic patients, suggesting that regular screening tests should be performed. (Korean J Intern Med 2009;24:212-219)