c-형강 및 ebb & flow 방식에 따른 경제성 분석

강승원(Seung Won Kang),박천호(Chun Ho Pak),조용성(Yong Sung Cho) 한국원예학회 2007 원예과학기술지 Vol.25 No.3

관비재배와 저면관수인 ebb & flow, C-형강의 재배방식에 따른 고품질분화 생산을 위한 재배농가의 경제성을 분석하였다. 이를 위해 화훼농가의 비용구조를 분석하였고 자본 회수기간 및 내부수익률의 추정, 관수에 따른 인건비 절감 효과를 분석하여 재배방식에 따른 경제성을 비교하였다. 10a(991.7m²) 규모의 자동온실에 대해 관비재배방식을 선택한 시클라멘 재배농가의 총 비용은 9,993.8만원으로 추정되며, 이 중 시설비는 74%(7,410만원)를 점하고 연간 2,583.8만원의 경영비를 지출할 것으로 예상된다. 반면, C-형강방식을 선택한 재배농가는 초기 시설비용으로 약 8,520.0만원(총비용의 약 70%)을 지출하고, 매년 경영비로 3,597.0만원을 지출할 것으로 추정된다. 한편, 투자자금에 대한 자본회수 기간을 분석한 결과 10a 규모의 자동온실에서 시클라멘을 재배하는 농가에서 관비재배방식 혹은 C-형강방식을 선택할 경우에는 초기시설투자비 회수기간이 약 4 년 정도 소요될 것으로 예측되며, ebb & flow 방식을 선택할 경우에는 약 5년 정도의 시간이 소요될 것으로 예상된다. 또한, 내부 수익률을 추정한 결과 ebb & flow시설과 C-형강시설을 5년과 6년씩 사용한다고 가정할 경우, ebb & flow시설의 내부 수익률은 각각 9%와 14%로 나타났고, C-형강시설의 경우에는 각각 13%와 17%로 나타나 시중의 저축성예금 수신금리 4.82%와 비교하여 경제성이 높은 것으로 분석되었다. Economical efficiency for production of high quality-potted plants was analyzed by types of irrigation system such as conventional fertigation, ebb & flow, and C-channel as subirrigation systems. After cost structure was analyzed, payback period of capital, internal rate return (IRR), and effects of reduced labor cost were estimated. The gross cost of cyclamen-producing farmers using hydroponic systems in automated greenhouses (10a) was about 100 million won. Of the gross cost, installation and operation costs occupied 74% and 25%, respectively. In the C-channel subirrigation system, gross cost was 120 million won approximately. Installation and operation costs occupied 70% and 30%, respectively. Payback period of capital was 4 years for fertigated irrigation and C-channel subirrigation system, whereas it was 5 years for ebb & flow. IRR of ebb & flow and C-channel subirrigation systems was higher than the interest rates of 4.82%, indicating economic efficiency.

Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

Effects of Crude Oil on Marine Microbial Communities in Short Term Outdoor Microcosms

Seung Won Jung,박준상,Oh Youn Kown,Jung-Hoon Kang,심원준,Young-Ok Kim 한국미생물학회 2010 The journal of microbiology Vol.48 No.5

To assess the effects of crude oil spills on marine microbial communities, 10 L outdoor microcosms were manipulated over an exposure period of 8 days. The responses of microbial organisms exposed to five crude oil concentrations in 10 to 10,000 ppm (v/v) were monitored in the microcosms. The abundance of microalgae and copepods decreased rapidly upon the addition of crude oil at concentrations over 1,000 ppm, whereas the total density of heterotrophic bacteria increased dramatically at the higher concentrations. Bacterial diversity, determined by denaturing gradient gel electrophoresis, was increased at higher concentrations. In particular, the intensity of the bands representing Jannaschia sp. and Sulfitobacter brevis increased with the addition of oil. These results indicate that crude oil spills with concentrations over 1,000 ppm seriously affected the structure of the microbial communities.

A Feasibility Study of Application of Laccase-based Time-Temperature Indicator to Kimchi Quality Control on Fermentation Process

Kang, You Jin,Kang, Jin-Won,Choi, Jung-Hwa,Park, Soo Yeon,Rahman, A.T.M. Mijanur,Jung, Seung Won,Lee, Seung Ju The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.6

Kimchi, in factories or during transportation, is usually stacked on shelves at different heights, which affects temperature and thus kimchi quality. In this study, a time-temperature indicator (TTI) was used to control such quality variations. A case study was conducted to evaluate the validity of using the TTI; one group of small packages of young kimchi had the TTI attached whereas the other group did not. They were stored on shelves of different heights (i.e., top, middle, and bottom) in a laboratory fermentor. The samples with TTIs were individually fermented until the color of the TTIs reached a threshold level, whereas the samples without TTIs were collectively fermented for a predetermined time at a given temperature. The qualities of fermented samples including pH, acidity, microbial counts, and reducing sugars were analyzed. The samples with TTIs had more uniform qualities that were closer to the targets than those without TTIs. These results suggest that TTIs are practical tools to control kimchi quality in terms of temperature variation.

Endogenous n-3 Polyunsaturated Fatty Acids Are Beneficial to Dampen CD8+ T Cell-Mediated Inflammatory Response upon the Viral Infection in Mice

Kang, Kyung Won,Kim, Seyoung,Cho, Yong-Bin,Ryu, Seung Rok,Seo, Young-Jin,Lee, Sang-Myeong MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.18

<P>Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have been known to exert anti-inflammatory effects on various disease states. However, its effect on CD8+ T cell-mediated immunopathology upon viral infection has not been well elucidated yet. In this study, we investigated the possible implication of n-3 PUFAs in CD8+ T cell responses against an acute viral infection. Infection of FAT-1 transgenic mice that are capable of synthesizing n-3 PUFAs from n-6 PUFAs with lymphocytic choriomeningitis virus (LCMV) resulted in significant reduction of anti-viral CD8+ T cell responses. Interestingly, expansion of adoptively transferred wild-type (WT) LCMV-specific T cell receptor (TCR) transgenic CD8+ (P14) T cells into FAT-1 mice was significantly decreased. Also, activation of anti-viral CD4+ helper T cells was reduced in FAT-1 mice. Importantly, P14 cells carrying the fat-1 gene that were adoptively transferred into WT mice exhibited a substantially decreased ability to proliferate and produce cytokines against LCMV infection. Together, n-3 PUFAs attenuated anti-viral CD8+ T cell responses against an acute viral infection and thus could be used to alleviate immunopathology mediated by the viral infection.</P>

Lipid Metabolism Pathway Genes and Lung Cancer: ACADSB rs12220683G>C is Associated with Better Survival Outcome in Patients with Non-small Cell Lung Cancer

( Seung Soo Yoo ),( Sook Kyung Do ),( Jin Eun Choi ),( Hyo-gyoung Kang ),( Mi Jeong Hong ),( Jang Hyuck Lee ),( Won Kee Lee ),( Young Woo Do ),( Ji Eun Park ),( Sun Ha Choi ),( Hyewon Seo ),( Yong Hoo 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0

HCV, Alcoholic : O-022 ; Hepatitis C virus infection enhances tumor necrosis factor-alpha-induced cell death via suppression of nuclear factor-kappaB

( Won Seok Kang ),( Jun Seong Park ),( Seung Wook Ryu ),( Woo Il Kim ),( Dong Yeop Chang ),( Dong Ho Lee ),( Do Youn Park ),( Youn Hee Choi ),( Kyung Sun Choi ),( Kwang Hyub Han ),( Chul Hee Choi ),( 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Hepatitis C virus (HCV) infection results in liver injury and long-term complications such as liver cirrhosis and hepatocellular carcinoma. Liver injury in HCV infection is believed to be caused by host immune responses, not by viral cytopathic effects. Tumor necrosis factor-α (TNF-α) plays a pivotal role in the inflammatory processes of hepatitis C. TNF-α induces cell death that can be ameliorated by nuclear factor kappaB (NF-κB) activation. We investigated the regulation of TNF-α signal transduction in HCV-infected cells and identified HCV proteins responsible for sensitization to TNF-α-induced cell death. Methods: We studied the effect of HCV infection on TNF-α signal transduction using an in vitro HCV infection model (JFH-1, genotype 2a) with Huh-7 and Huh-7.5 cells. Results: We found that TNF-α-induced cell death significantly increased in HCV-infected cells. HCV infection diminished TNF-α-induced phosphorylation of IKK and IκB, which are upstream regulators of NF-κB activation. HCV infection also inhibited nuclear translocation of NF-κB and expression of NF-κB-dependent anti-apoptotic proteins such as Bcl-xL, XIAP and c-FLIPL. Decreased levels of Bcl-xL, XIAP, and c-FLIP mRNA and protein were also observed in livers with chronic hepatitis C. Transfection with plasmids encoding each HCV protein revealed that core, NS4B, and NS5B attenuated TNF-α-induced NF-κB activation and enhanced TNF-α-induced cell death. Conclusions: HCV infection enhances TNF-α-induced cell death by suppressing NF-κB activation, through the action of core, NS4B, and NS5B. This mechanism may contribute to immune-mediated liver injury in HCV infection.

Radioimmunotherapy with (131) I-rituximab for patients with relapsed/refractory B-cell non-Hodgkin's lymphoma (NHL).

Kang, Hye J,Lee, Seung S,Kim, Kyeong M,Choi, Tae H,Cheon, Gi J,Kim, Won S,Suh, Cheolwon,Yang, Sung H,Lim, Sang M Blackwell Pub. Asia 2011 Asia-Pacific journal of clinical oncology Vol.7 No.2

<P>Aim:??To evaluate the efficacy and safety of radioimmunotherapy (RIT) with radioiodinated human/murine chimeric anti-CD20 monoclonal antibody rituximab ((131) I-rituximab) for treating Korean patients with relapsed or refractory B-cell non-Hodgkin's lymphomas (NHL). Methods:??All patients received unlabeled rituximab 70?g immediately prior to the administration of a therapeutic dose (median dose: 7.3 GBq) of (131) I-rituximab. The tumor response was evaluated 1?onth later by contrast enhanced (18) F-fludeoxyglucose positron emission tomography-computed tomography. Results:??Between May 2004 and October 2006, 24 patients received single treatment with (131) I-rituximab. The overall response rate (ORR) was 29%; 46% (three complete responses, two partial responses (PR) for patients with low grade B-cell NHL (LGL) and 9% (one PR) for patients with diffuse large B-cell lymphoma (DLBCL). After a median follow-up of 55?onths, the median progression-free survival (PFS) for all the patients was 2.2?onths. The median overall survival (OS) was 11.3?onths. There were statistically significant differences between the LGL and the DLBCL for the median PFS (4.5?onths vs 1.3?onths, respectively, P????.0007) and the median OS (30.3?onths vs 6.5?onths, respectively, P????.0295). Grades 3-4 thrombocytopenia and neutropenia occurred in 33% (8/24) and 21% (5/24) of the patients, respectively. Conclusion:??RIT with (131) I-rituximab seems to be effective and tolerable for patients with refractory LGL, although this treatment had modest activity in patients with refractory DLBCL. Further studies are warranted to determine the efficacy of (131) I-rituximab for treating the patients with DLBCL.</P>

Atrial fibrillation in acute myocardial infarction

( Seung Wook Bak ),( Jin Woo Park ),( Seung Jin Jun ),( Yohan Ku ),( Won Yu Kang ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

Background: Atrial fibrillation (AF) is the most commonly encountered clinical arrhythmia. However, The impact of AF in acute myocardial infarction (AMI) on future major cardiac adverse events is uncertain in Korean population. Methods: Between November 2005 and November 2007, 12,928 patients were registered in the Korean Acute Myocardial Infarction Registry (KAMIR). Patients were divided into 2 groups according to presence of AF: Group I (who had not AF, n=12,350) and Group II (who had AF, n=578). In-hospital mortality, mortality in 1 year, and overall mortality were compared between groups. Also, we examined independent predictors for mortality in AF groups. Results: The incidence of AF in AMI was 4.7%. AF group was significantly older (Group I: 62.5±12.7, Group II: 68.5±11.6, p<0.001) and more likely to have lower systolic blood pressure (Group I: 130.0±30.2, Group II: 122.1±31.7, p<0.001) and lower ejection fraction (Group I: 51.7±12.6, Group II: 48.7±13.1, p<0.001). There was no significant statistical differences in the prevalence of diabetes, hypertension, dyslipidemia, and angiographic findings (p>0.05). There was significant difference in failure rate in percutaneous coronary intervention (1.6% vs. 3.8%, p=0.004), In-hospital mortality (4.2% vs 10.8%, p<0.001), mortality in 12 months (4.8% vs 9.7%, p=0.002), and overall mortality (12.1% vs. 27.8%, p<0.001). However, AF was not a independent predictors in overall mortality. In multivaritate analysis, age (OR 1.094, CI: 1.047~1.142, p<0.001), blood pressure (OR 0.979, CI: 0.964~0.994), left ventricular ejection fraction (OR 0.931, CI: 0.900~0.965, p<0.001), percutaneous coronary intervention (OR 2.409, CI: 1.036~5.60, p=0.041) were independent predictors for overall mortality in AF with AMI patients. Conclusion: Although has poor prognosis, AF in AMI is not a independent predictor for mortality. Age, blood pressure, left ventricular ejection fraction, percutaneous coronary intervention are independant predictors in AF with AMI patients.

The effect of susceptibility variants, identified in never-smoking female lung cancer cases, on male smokers

( Seung Soo Yoo ),( Hyo-gyoung Kang ),( Jin Eun Choi ),( Mi Jeong Hong ),( Sook Kyung Do ),( Jang Hyuck Lee ),( Won Kee Lee ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eung 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.4

Background/Aims: Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in male smokers. Methods: This study included 714 lung cancer patients and 626 healthy controls. The polymorphisms were genotyped using SEQUENOM MassARRAY iPLEX assay or Taq-Man assay. Results: Two polymorphisms were associated with the risk of lung cancer in male smokers, as in female never smokers. Male smokers carrying the rs4975616 variant allele had a significantly decreased risk of lung cancer (in a codominant model: odds ratio, 0.77; 95% confidence interval, 0.61 to 0.96; p = 0.02). The rs9387478 polymorphism also reduced lung cancer risk in male smokers (in a codominant model: odds ratio, 0.85; 95% confidence interval, 0.73 to 0.997; p = 0.046). In a stratified analysis, the association between these polymorphisms and the risk of lung cancer was predominant in lighter smokers and for cases of adenocarcinoma. Conclusions: These results suggest that a subset of polymorphisms known to be associated with the risk of lung cancer in female never smokers is also associated with the risk of lung cancer in male smokers.