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자매에서 발생한 중증 마이코플라즈마 폐렴에서 스테로이드 치료
김도희,이경일,김명숙,윤유숙,황자영,임정우,강진한,이준성 대한감염학회 2009 감염과 화학요법 Vol.41 No.3
Numerous evidences support the pathogenesis that M. pneumonias pneumonia is associated with cell-mediat-ed immune reaction. We report 2 cases of severe M. pneumoniae pneumonia in previously healthy sisters, who were both admitted during an epidemic of M. pneumoniae pneumonia. The elder sister, who was 16 years old, was admitted with M. pneumoniae pneumonia. She showed no response to treatment with clarithroycin and levo-floxacin, and eventually progressed to severe ARDS, requiring mechanical ventilation. After treatment with hydrocortisone (200 mg/day), there were rapid improvements in clinical manifestations and chest radiographic findings. The younger sister, who was 14 years old, was admitted 10 days later, Presenting with fever but no pneumonic lesions on chest radiograph. Just like her sister, the infection showed no response to clarithromycin. Fever persisted and pneumonic consolidation with mild pleural effusion was noticed in the left lower lobe on the 5th hospital-day. After treatment with oral prednisolone (1 mg/kg), she showed rapid defervescence and on the 8th hospital day, no pneumonic lesions were detectable on chest radiograph. Given the fact that the pathogenesis of pneumonia and extrapulmonary manifestations in M. pneumoniae infection is immune-mediated, an immuno-suppressive therapy would be validated for selected patients with M. pneumoniae infections.
Do, Kyung-Min,Park, Yong-Bok,Bok, Song-Hae,Lee, Mi-Kyung,Jeong, Tae-Sook,Choi, Myung-Sook The Korean Society of Food Science and Nutrition 2001 Preventive Nutrition and Food Science Vol.6 No.1
Ginseng may have antioxidant and pharmacologic effects similar to those of vitamin E. The interactive effect of ginseng and vitamin E was studied with respect to cholesterol metabolism and the antioxidant status. A ginseng supplement (0.1%, wt/wt) with comparable levels of vitamin E was provided with a high-cholesterol (1%, wt/wt) diet to rats for 5 weeks. The amount of vitamin E included in the ginseng-free and ginseng diets was either a low (low-E) or a normal (normal-E) level. The ginseng supplements significantly (p<0.05) altered the concentrations of plasma triglycerides in both the low-vitamin E group and normal-vitamin E group compared to the each ginseng-free group. The hepatic triglyceride and cholesterol content were not significantly (p>0.05) different between groups regardless of the vitamin E level in the diet. The hepatic HMG-CoA reductase activity was significantly (p<0.05) lowered by the ginseng supplement in both the low-vitamin E and the normal-vitamin E groups compared to the ginseng-free group. The HMG-CoA reductase activity was also significantly (p<0.05) lowered with in increase of the dietary vitamin E in the ginseng-free group. The excretion of fecal neutral sterol was significantly (p<0.05) lower in the normal-E ginseng group than th low-E ginseng-free group. Neither dietary ginseng nor vitamin E significantly changed the hepatic antioxidant enzymes activity. This data indicates that ginseng supplements lower the concentration of plasma triglyceride and hepatic HMG-CoA reductase activity regardless of eh dietary vitamin E level. This information may contribute to understanding the interactive effect of ginseng and vitamin E on cholesterol biosynthesis in high cholesterol-fed rats.
Kyung-Min Do,Yong Bok Park,Song-Hae Bok,Mi-Kyung Lee,Tae-Sook Jeong,Myung-Sook Choi 한국식품영양과학회 2001 Preventive Nutrition and Food Science Vol.6 No.1
Ginseng may have antioxidant and pharmacologic effects similar to those of vitamin E. The interactive effect of ginseng and vitamin E was studied with respect to cholesterol metabolism and the antioxidant status. A ginseng supplement (0.1%, wt/wt) with comparable levels of vitamin E was provided with a high-cholesterol (1%, wt/wt) diet to rats for 5 weeks. The amount of vitamin E included in the ginseng-free and ginseng diets was either a low (low-E) or a normal (normal-E) level. The ginseng supplements significantly (p<0.05) altered the concentrations of plasma triglycerides in both the low-vitamin E group and normal-vitamin E group compared to the each ginseng-free group. The hepatic triglyceride and cholesterol contents were not significantly (p>0.05) different between groups regardless of the vitamin E level in the diet. The hepatic HMG-CoA reductase activity was significantly (p<0.05) lowered by the ginseng supplement in both the low-vitamin E and the normal-vitamin E groups compared to the ginseng-free group. The HMG-CoA reductase activity was also significantly (p<0.05) lowered with an increase of the dietary vitamin E in the ginseng-free group. The excretion of fecal neutral sterol was significantly (p<0.05) lower in the normal-E ginseng group than the low-E ginseng-free group. Neither dietary ginseng nor vitamin E significantly changed the hepatic antioxidant enzymes activity. This data indicates that ginseng supplements lower the concentration of plasma triglyceride and hepatic HMG-CoA reductase activity regardless of the dietary vitamin E level. This information may contribute to understanding the interactive effect of ginseng and vitamin E on cholesterol biosynthesis in high cholesterol-fed rats.
Poster Presentation : A Case of an Ovarian Papillary Adenocarcinoma in a Dog
( Kyung Sook Hong ),( Jin Kyu Park ),( Il Hwa Hong ),( Dong Wei Yuan ),( Moon Jung Goo ),( Mi Ran Ki ),( Hye Rim Lee ),( Ok Kyung Hwang ),( Jung Youn Han ),( Ae Ri Ji ),( Tae Hwan Kim ),( Sun Hee Do ) 한국수의병리학회 2008 학술대회 Vol.12 No.2
Do, Sook Kyung,Choi, Sun Ha,Lee, Shin Yup,Choi, Jin Eun,Hong, Mi Jeong,Kang, Hyo-Gyoung,Lee, Won Kee,Lee, Eung Bae,Shin, Kyung Min,Jeong, Ji Yun,Lee, Yong Hoon,Seo, Hyewon,Yoo, Seung Soo,Lee, Jaehee,C Elsevier 2019 Gene Vol.703 No.-
<P><B>Abstract</B></P> <P>This study was conducted to explore whether polymorphisms of glucose transporter 3 (<I>GLUT3</I>) gene affect the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Four single nucleotide polymorphisms (SNPs) in <I>GLUT3</I> were investigated in a total of 782 patients with NSCLC who underwent curative surgery. The association of the SNPs with overall survival (OS) and disease free survival (DFS) was analyzed. Among the four SNPs investigated, <I>GLUT3</I> rs7309332C>T was significantly associated with OS and DFS in multivariate analyses. The SNP was associated with significantly worse OS (adjusted hazard ratio [aHR] = 1.62, 95% confidence interval [CI] = 1.04–2.53, <I>P</I> = 0.03, under recessive model), and worse DFS (aHR = 1.64, 95% CI = 1.18–2.29, <I>P</I> = 0.003, under recessive model). When stratified by tumor histology, the association between the <I>GLUT3</I> rs7309332C>T and OS/DFS was not limited to either squamous cell carcinoma (SCC) or adenocarcinoma (AC), although the significant association remained only in AC for OS (<I>P</I> = 0.40 for SCC and <I>P</I> = 0.04 for OS) and only in SCC for DFS (<I>P</I> = 0.03 for SCC and <I>P</I> = 0.08 for OS). When AC patients were stratified according to <I>EGFR</I> mutation status, the SNP was significantly associated with DFS in patients with <I>EGFR</I> mutant tumors (aHR = 2.47, 95% CI = 1.15–5.30, <I>P</I> = 0.02, under recessive model), but not in those with <I>EGFR</I> wild-type tumors. This study suggests that genetic variation in <I>GLUT3</I> may be useful in predicting survival of patients with early stage NSCLC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>GLUT3</I> variant was significantly associated with survival of NSCLC after surgery. </LI> <LI> The association was not limited to either squamous cell carcinoma or adenocarcinoma. </LI> <LI> The SNP may help identify patients at high risk of poor outcome in early stage NSCLC. </LI> </UL> </P>
왕느릅나무 추출물에 의한 비장세포 생존률 및 NK cell 세포독성 증가
이성도(Sung Do Lee),김덕원(Deok Won Kim),이인환(Inhwan Lee),이종환(Jong-Hwan Lee),현숙경(Sook Kyung Hyun),강경화(Kyung-Hwa Kang),황혜진(HyeJin Hwang),김철민(CheolMin Kim),김병우(Byoung Woo Kim),정경태(Kyung Tae Chung) 한국생명과학회 2016 생명과학회지 Vol.26 No.1
면역에 대한 관심은 점차 증가하는 추세이며, 식물유래 천연물을 이용한 면역기능 증강에 관련된 연구 역시 활발히 진행되고 있다. 왕느릅나무 껍질은 줄기 혹은 뿌리의 껍질을 뜻하며 전통적으로 동·서양 할 것 없이 항염, 진통, 항암, 상처치료에 사용되어 왔다. 본 연구는 왕느릅나무 열수 추출물(Ulmus macrocarpa water extract, UMWE)이 면역기능에 끼치는 영향을 조사하기 위해 실시되었다. 실험은 UMWE를 농도 100 mg/kg 또는 200 mgkg로 식이한 군, UMW를 농도 100 mg/kg 또는 200 mg/kg으로 식이하면서 면역억제물질인 cyclophosphamide (CY, 120 mg/kg)를 투여한 군, CY만을 투여한 군, 아무 것도 처리하지 않은 비처리군, 총 6개 군으로 나누어 2주간 매일 식이하면서 진행하였다. 각 군에서 획득한 비장지수와 비장세포 지수를 비교하였을 때 UMWE 식이가 CY에 의한 비장세포의 감소를 완화시키는 것으로 나타났으며, in vitro 실험에서 MTT방법과 7-amino-actinomycin D 방법을 통해 비장세포의 생존을 유지하며 사멸을 지연하는 것이 확인되었다. 또한, UMWE는 YAC-1에 대한 비장 NK 세포 활성을 면역억제제 CY가 존재하는 조건에서도 정상적으로 유지시켜 면역기능 유지에 영향을 주는 것으로 나타났다. Ulmi cortex is the elm bark or root bark of Ulmus macrocarpa Hance and has been used as an ingredient of traditional medicine for anti-inflammatory, analgesic, anti-cancer and wound healing on both the East and the West. This study investigated whether the Ulmus macrocarpa Hance Water extract (UMWE) has the in vivo and in vitro immune activating effect. Animals were orally administrated for 14 days as follows: no treat group with distilled water, cyclophosphamide (CY) group with 120 mg/kg of CY, UMWE 100+CY group with 100 ㎎/㎏ of UMWE and 120 mg/kg of CY, UMWE 200+CY group with 200 ㎎/㎏ of UMWE and 120 mg/kg of CY, UMWE 100 group with 100 ㎎/㎏ of UMWE and UMWE 200 group with 200 ㎎/㎏ of UMWE. The immunosuppressive drug CY was intraperitoneally injected to induce immune suppression. Spleen indices showed small changes in CY injected groups but splenocyte indices showed greater decrease in the same groups. However, UMWE appeared to relieve CY"s immunosuppression. UMWE also delayed in vitro splenocyte death increasing its longevity. These data obtained by MTT assay and 7-amino-actinomycin D which stains preferentially dead than live cells. UMWE alone did not show cytotoxicity based on its apoptototic effect on splenocytes in vitro and in vivo. Splenic NK cell activity was maintained by UMWE under the presence of CY in vitro. The data indicated that UMWE protects splenocytes from the immunosuppressive drug CY under in vitro and in vivo conditions.