The clinical performance of APTIMA human papillomavirus and Hybrid Capture 2 assays in the triage of lesser abnormal cervical cytologies

Yanli Guo,Ke You,Li Geng,Jie Qiao 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.4

Objective: This study was performed to evaluate the clinical performance of APTIMA human papillomavirus (AHPV) assay and Hybrid Capture 2 (HC2) assay in screening for cervical disease, especially in women with atypical squamous cell of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL). Methods: A total of 411 women diagnosed with ASC-US or LSIL were referred and further triaged by HC2 test. Prior to colposcopy, liquid-based cytology specimens were collected for the AHPV assay. Sensitivity and specificity were established based on the histological findings of cervical intraepithelial neoplasia (CIN). Results: In all 411 subjects, the positive detection rate of AHPV assay was 70.8% (95% confidence interval [CI], 66.4 to 75.2), which was significantly lower than the positive detection rate of 94.9% obtained using HC2 test (95% CI, 92.3 to 96.8). Only one CIN 3-positive case was detected among the 120 AHPV-negative women, which was then confirmed by Pap smear test to be LSIL. The sensitivities of AHPV and HC2 for CIN 3 were similar (94.1% and 100%, respectively). However, AHPV showed a significantly higher specificity than HC2 test (30.2% and 5.3%, respectively; p<0.001). Conclusion: AHPV assay is effective in identifying CIN 3-positive cases because of its high specificity and lower false-negative rate. The use of AHPV for the triage of ASC-US and LSIL might help to reduce the referral rate of colposcopy during cervical cancer screening.

Patterns of endoscopy during COVID-19 pandemic: a global survey of interventional inflammatory bowel disease practice

( Yan Chen ),( Qiao Yu ),( Francis A. Farraye ),( Gursimran S. Kochhar ),( Charles N. Bernstein ),( Udayakumar Navaneethan ),( Kaicun Wu ),( Jie Zhong ),( David A. Schwartz ),( Hao Wu ),( Jing-jing Zh 대한장연구학회 2021 Intestinal Research Vol.19 No.3

Background/Aims: Performance of diagnostic or therapeutic endoscopic procedures in inflammatory bowel disease (IBD) patients can be challenging during a viral pandemic; the main concerns being the safety and protection of patients and health care providers (HCP). The aim of this study is to identify endoscopic practice patterns and outcomes of IBD and coronavirus disease 19 (COVID-19) with a worldwide survey of HCP. Methods: The 20-item survey questionnaire was sent to physician members of the American Society for Gastrointestinal Endoscopy Special Interest Group in Interventional IBD, Chinese IBD Society Endoscopy Interest Group, and the China Crohn’s and Colitis Foundation. Results: A total of 141 respondents submitted valid responses. Nighty-five respondents (67.9%) reported that at least 25% of their scheduled emergent endoscopic procedures were canceled or postponed during the pandemic. Fifty-six respondents (40.0%) have performed emergent endoscopy during the pandemic. A few respondents (9/140, 6.4%) estimated that more than 25% of their patients had worsened disease due to delayed or canceled emergent endoscopy procedures. More than 80% of respondents believed that personal protective equipment (PPE) for the endoscopy team, room sterilization, and pre-procedure screening of patients for COVID-19 were necessary. Out of 140 respondents, 16 (11.4%) reported that several of their patients had COVID-19. Eight clinicians (5.7%) reported that they or their endoscopy colleagues developed work-related COVID-19. Conclusions: Cancellation of elective and emergent endoscopy in IBD care during the pandemic was common. Few respondents reported that their patients’ disease conditions worsened due to the cancellation of the endoscopy procedure. Most respondents voiced the need for proper PPE during the procedure regardless of patients’ COVID-19 status and screening the patients for COVID-19. (Intest Res 2021;19:332-340)

Preliminary Study on Hairy Root Occurrence of Tree Peony Induced by Agrobactrium rhizogenes

Yan Wang,Zhi-de Yang,Kun Miao,Qiao-xiang Tang,Xue-mei Liu 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Robust Predictive Augmented Unscented Kalman Filter

Yan Zhao,Shesheng Gao,Jing Zhang,Qiao-nan Sun 제어·로봇·시스템학회 2014 International Journal of Control, Automation, and Vol.12 No.5

This paper presents a new Unscented Kalman Filtering (UKF) method by using robust model prediction. This method incorporates system driving noise in system state through augmentation of state space dimension to expand the input of system state information. The system model error is constructed by model prediction, and is then used to rectify the UKF process to obtain the estimate of the real system state. The proposed method endows the robustness to the traditional UKF, thus over-coming the limitation that the traditional UKF is sensitive to system model error. Experimental results show that the convergence rate and accuracy of the proposed filtering method is superior to the Ex-tended Kalman Filtering and traditional UKF.

High-resolution Anorectal Manometry in the Diagnosis of Functional Defecation Disorder in Patients With Functional Constipation: A Retrospective Cohort Study

Yan Zhao,Xiaoyang Ren,Wen Qiao,Lei Dong,Shuixiang He,Yan Yin 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.2

Background/Aims High-resolution anorectal manometry (HRAM) has been considered a first-line diagnostic tool for functional defecation disorder. However, clinical studies on HRAM used in constipation patients are very limited and few studies have reported the characteristics of anorectal pressure in Chinese patients. The aim of this study is to investigate the characteristics of motility data in a cohort of Chinese patients with functional constipation. Methods A total of 82 consecutive patients with functional constipation who underwent a standardized HRAM were retrospectively enrolled in this study. The functional defecation disorder was classified into Rao’s types. Results The mean age of 82 patients was 51 years (range, 16–83 years). Indications for anorectal manometry were functional constipation for all patients. The mean resting pressure was 69.2 ± 21.2 mmHg (range, 24.5–126.9 mmHg). The mean maximum squeezing pressure was 198.4 ± 75.6 mmHg (range, 54.2–476.9 mmHg). The mean length of the anal high pressure zone was 3.4 ± 1.0 cm (range, 0.6–4.9 cm). Sixty (73.2%) patients were diagnosed as functional defecation disorder. In attempted defecation, type I was most common (n = 24), followed by type II (n = 12), type III (n = 11), and type IV (n = 13) that were present on HRAM according to Rao’s classification. In all 60 patients with functional defecation disorder, 37 were women and 23 were men. Men were significantly more likely than women to have functional defecation disorder (92.0% vs 64.9%, P = 0.014). Conclusion HRAM could be used as a test for the diagnosis of functional defecation disorder and functional defecation disorder is common in Chinese patients with functional constipation.

Identification of Plasma Biomarkers in Drug-Naïve Schizophrenia Using Targeted Metabolomics

Qiao Su,Fuyou Bi,Shu Yang,Huiming Yan,Xiaoxiao Sun,Jiayue Wang,Yuying Qiu,Meijuan Li,Shen Li,Jie Li 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.9

Objective Schizophrenia (SCZ) is a severe psychiatric disorder with unknown etiology and lacking specific biomarkers. Herein, we aimed to explore plasma biomarkers relevant to SCZ using targeted metabolomics. Methods Sixty drug-naïve SCZ patients and 36 healthy controls were recruited. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale. We analyzed the levels of 271 metabolites in plasma samples from all subjects using targeted metabolomics, and identified metabolites that differed significantly between the two groups. Then we evaluated the diagnostic power of the metabolites based on receiver operating characteristic curves, and explored metabolites associated with the psychotic symptoms in SCZ patients. Results Twenty-six metabolites showed significant differences between SCZ patients and healthy controls. Among them, 12 metabolites were phosphatidylcholines and cortisol, ceramide (d18:1/22:0), acetylcarnitine, and γ-aminobutyric acid, which could significantly distinguish SCZ from healthy controls with the area under the curve (AUC) above 0.7. Further, a panel consisting of the above 4 metabolites had an excellent performance with an AUC of 0.867. In SCZ patients, phosphatidylcholines were positively related with positive symptoms, and cholic acid was positively associated with negative symptoms. Conclusion Our study provides insights into the metabolite alterations associated with SCZ and potential biomarkers for its diagnosis and symptom severity assessment.

Investigation of Co nanoparticle assemblies induced by magnetic field

Yan Li,Xiao Li Zhang,Ri Qiu,Ru Qiao,강영수 한국공업화학회 2008 Journal of Industrial and Engineering Chemistry Vol.14 No.1

Cobalt nanoparticles were synthesized by using cobalt (II) acetate as precursor in an organic solution. Under the inuence of a 0.05 T magneticeld, in a colloidal solution, the cobalt nanoparticles covered with surfactants were assembled into highly constrained linear chains along thedirection of the magnetic eld. After removal of the eld the chains become oppy and then aggregate into pearl necklaces coiled structuresupon gentle agitation. The differences of the magnetic properties between the magnetic eld induced and random cobalt nanoparticles can becharacterized by superconducting quantum interference devise (SQUID).# 2007 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

Experimental and numerical study on shear studs connecting steel girder and precast concrete deck

Shengfang Qiao,Huqing Liang,Jia-Bao Yan,Wanying Wang 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.71 No.4

Shear studs are often used to connect steel girders and concrete deck to form a composite bridge system. The application of precast concrete deck to steel-concrete composite bridges can improve the strength of decks and reduce the shrinkage and creep effect on the long-term behavior of structures. How to ensure the connection between steel girders and concrete deck directly influences the composite behavior between steel girder and precast concrete deck as well as the behavior of the structure system. Compared with traditional multi-I girder systems, a twin-I girder composite bridge system is more simplified but may lead to additional requirements on the shear studs connecting steel girders and decks due to the larger girder spacing. Up to date, only very limited quantity of researches has been conducted regarding the behavior of shear studs on twin-I girder bridge systems. One convenient way for steel composite bridge system is to cast concrete deck in place with shear studs uniformly-distributed along the span direction. For steel composite bridge system using precast concrete deck, voids are included in the precast concrete deck segments, and they are casted with cast-in-place concrete after the concrete segments are erected. In this paper, several sets of push-out tests are conducted, which are used to investigate the heavier of shear studs within the voids in the precast concrete deck. The test data are analyzed and compared with those from finite element models. A simplified shear stud model is proposed using a beam element instead of solid elements. It is used in the finite element model analyses of the twin-I girder composite bridge system to relieve the computational efforts of the shear studs. Additionally, a parametric study is developed to find the effects of void size, void spacing, and shear stud diameter and spacing. Finally, the recommendations are given for the design of precast deck using void for twin I-girder bridge systems.

Synthesis and characterization of phenol-formaldehyde resin using enzymatic hydrolysis lignin

Wei Qiao,Shujun Li,Guowan Guo,Shiyan Han,Shixue Ren,Yanli Ma 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1

Enzymatic hydrolysis lignin (EHL) was utilized to partially replace phenol for preparing phenolformaldehyde(PF) resin. The influence of lignin substitution rate on the properties of the lignin-modifiedphenol-formaldehyde (LPF) resin was investigated. Lignin substitution of 60 wt% did not deteriorate theadhesive strength of PF resin. FTIR analysis of the resins revealed that the incorporation of EHL made nobig difference in chemical structure, but led to a deteriorated thermal resistance. The comparisonbetween LPF and bio-ethanol production residue-modified phenol-formaldehyde (RPF) resins elucidatedthat the purification processwas beneficial for its higher substitution application and better performanceof adhesive.

Characterization of the Pressure Drop during Condensation in Channels of Multi-Channel Cylinder Dryer Using Homogeneous and Separated Flow Models

Lijie Qiao,Jixian Dong,Huan Liu,Bo Wang,Sha Wang,Yan Dong,Haozeng Guo 한국펄프·종이공학회 2021 펄프.종이기술 Vol.53 No.4