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Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study
Duo Huang,Emmanuel Wong,Ming-Liang Zuo,Pak-Hei Chan,Wen-Sheng Yue,Hou-Xiang Hu,Ling Chen,Li-Xue Yin,Xin-Wu Cui,Ming-Xiang Wu,Xi Su,Chung-Wah Siu,Jo-Jo Hai 대한혈액학회 2019 Blood Research Vol.54 No.3
BackgroundPrevious Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum peri-od in the Chinese population. We investigated the risk of venous thromboembolism in a “real-world” cohort of pregnant Chinese women with no prior history of venous thromboembolism.MethodsIn this observational study, 15,325 pregnancies were identified in 14,162 Chinese women at Queen Mary Hospital, Hong Kong between January 2004 and September 2016. Demographic data, obstetric information, and laboratory and imaging data were retrieved and reviewed.ResultsThe mean age at pregnancy was 32.4±5.3 years, and the median age was 33 years (interquartile range, 29‒36 yr). Pre-existing or newly diagnosed diabetes mellitus was present in 627 women (4.1%); 359 (0.7%) women had pre-existing or newly detected hypertension. There was a small number of women with pre-existing heart disease and/or rheumatic conditions. Most deliveries (86.0%) were normal vaginal; the remaining were Cesarean section 2,146 (14.0%). The incidence of venous thromboembolism was 0.4 per 1,000 pregnancies, of which 83.3% were deep vein thrombosis and 16.7% were pul-monary embolism. In contrast to previous studies, 66.7% of venous thrombosis occurred in the first trimester.ConclusionChinese women had a substantially lower risk of venous thromboembolism during preg-nancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early preg-nancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization.
You-Duo Wu,Chuang Xue,Li-Jie Chen,WenJie Yuan,Feng-Wu Bai 한국생물공학회 2016 Biotechnology and Bioprocess Engineering Vol.21 No.1
Micronutrient zinc is of great importance for acetone-butanol-ethanol (ABE) fermentation by Clostridium acetobutylicum. The effect of zinc supplementation on toxic metabolites (formic, acetic, butyric acid and butanol) tolerance during ABE fermentation was investigated under various stress-shock conditions without pH control. Great improvements on cell growth, glucose utilization and butanol production were achieved. In the presence of 0.45 g/L formic acid, zinc contributed to 11.28 g/L butanol produced from 55.24 g/L glucose compared to only 5.27 g/L butanol from 29.49 g/L glucose in the control without zinc supplementation. More importantly, relatively higher levels of 7.5 g/L acetic acid, 5.5 g/L butyric acid and 18 g/L butanol could be tolerated by C. acetobutylicum with zinc supplementation while no fermentation was observed under the same stress-shock condition respectively, suggesting that the acids and butanol tolerance in C. acetobutylicum could be significantly facilitated by pleiotropic regulation of micronutrient zinc. Thus, this paper provides an efficient bioprocess engineering strategy for improving stress tolerance in Clostridium species.
( Yan-jun Wang ),( Xiu-qiong Lang ),( Dan Wu ),( Yu-qin He ),( Chun-hui Lan ),( Xiao-xiao ),( Bin Wang ),( Duo-wu Zou ),( Ji-min Wu ),( Yong-bin Zhao ),( Peter W Dettmar ),( Dong-feng Chen ),( Min Yan 대한소화기 기능성질환·운동학회 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.1
Background/Aims To determine the value of salivary pepsin in discriminating sub-types of gastroesophageal reflux disease (GERD) and GERD-related disorders. Methods Overall, 322 patients with different sub-types of GERD and 45 healthy controls (HC) were studied. All patients took Gastroesophageal Reflux Disease Questionnaire (GerdQ) and underwent endoscopy and 24-hour esophageal pH monitoring and manometry. Salivary pepsin concentration (SPC) was detected by using colloidal gold double-antibody immunological sandwich assay. Oral esomeprazole treatment was administrated in the patients with non-erosive reflux disease (NERD) and extra-esophageal symptoms (EES). Results Compared to HC, patients with erosive esophagitis, NERD, EES, EES plus typical GERD symptoms, or Barrett’s esophagus had a higher prevalence of saliva and SPC (all P < 0.001). There was no significant difference in the positive rate for pepsin in patients with functional heartburn or GERD with anxiety and depression, compared to HC. After esomeprazole treatment, the positive rate and SPC were significantly reduced in NERD (both P < 0.001) and in EES (P = 0.001 and P = 0.002, respectively). Of the 64 NERD patients, 71.9% (n = 46) were positive for salivary pepsin, which was significantly higher than the rate (43.8%, n = 28) of pathological acid reflux as detected by 24-hour esophageal pH monitoring (P = 0.002). Conclusions Salivary pepsin has an important significance for the diagnosis of GERD and GERD-related disorders. Salivary pepsin and 24-hour esophageal pH monitoring may complement with each other to improve the diagnostic efficiency.
( Duo-hong Sheng ),( Ye Wang ),( Shu-ge Wu ),( Rui-qin Duan ),( Yue-zhong Li ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.7
SOS response is a conserved response to DNA damage in prokaryotes and is negatively regulated by LexA protein, which recognizes specifically an “SOS-box” motif present in the promoter region of SOS genes. Myxococcus xanthus DK1622 possesses a lexA gene, and while the deletion of lexA had no significant effect on either bacterial morphology, UV-C resistance, or sporulation, it did delay growth. UV-C radiation resulted in 651 upregulated genes in M. xanthus, including the typical SOS genes lexA, recA, uvrA, recN and so on, mostly enriched in the pathways of DNA replication and repair, secondary metabolism, and signal transduction. The UV-irradiated lexA mutant also showed the induced expression of SOS genes and these SOS genes enriched into a similar pathway profile to that of wild-type strain. Without irradiation treatment, the absence of LexA enhanced the expression of 122 genes that were not enriched in any pathway. Further analysis of the promoter sequence revealed that in the 122 genes, only the promoters of recA2, lexA and an operon composed of three genes (pafB, pafC and cyaA) had SOS box sequence to which the LexA protein is bound directly. These results update our current understanding of SOS response in M. xanthus and show that UV induces more genes involved in secondary metabolism and signal transduction in addition to DNA replication and repair; and while the canonical LexA-dependent regulation on SOS response has shrunk, only 5 SOS genes are directly repressed by LexA.
Duo, Zhang Guang,Mu, Wu Jin 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1
This paper implements efficiently the problem of Mechanical Theorem Proving (MTP) in propositional logic according to the Davis & Putnam Rules. Through applying strategies, such as deleting, decomposing, merging and removing sequentially all the atoms and their negations, we can abandon all the used sets of ground clauses, and put forword the refutation procedure determinately step by step. And the conclusion can be obtained within at most m steps. (Here m indicates the number of the atoms in s0, the initial set of ground clauses.) Compared with all the past classical methods in solving the problem of MTP, the method provided by this paper has several advantages: simple, convenient, determinate and highly efficient; and it requires only a lower_level support of environment, for using non_intelligent languages, BASIC for example, may implement the problem of MTP simply and efficiently.
Wan Siying,Wu Duo,Niu Gengyun,Liu Ting,Wei Meicai 한국곤충학회 2022 Entomological Research Vol.52 No.1
Arge nipponensis group is proposed for 12 East Asian species. A key to species of this group is provided. Arge aurora Wei, sp. nov., a widespread species in China is described. It has been misidentified as Arge nipponensis Rohwer, 1910 in China since 1927. Arge nipponensis Rohwer is removed from the faunal list of China. The ovipositor and genitalia of A. nipponensis are described and figured for the first time. The geographic distribution analysis indicated that geographical barriers were probably the key to the distribution of A. aurora and A. nipponensis.
Cuihua Wang,Duo Rong,Wenquan Zhang,Bin Gong,Jianhua Wu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.9
The flow and heat transfer characteristics of magnetic nanofluids in a circular channel under the action of magnetic fields were studied through numerical simulation based on the finite element method. The results show that there are obvious secondary vortices on the cross-section, and a swirling flow is formed in the duct under the coupling effects of the magnetic field, velocity distribution, and thermal variations which destroys the boundary layer, accelerates the mixing of fluids, and enhances heat transfer. In the studied range, the maximum heat transfer coefficient can be increased by 102.65 %, and the maximum comprehensive heat transfer factor J is 1.69 compared to the ferrofluid not affected by the external magnetic field. In addition, the effect of enhancing heat transfer gradually decreases with the increase of θ, until heat transfer is slightly inhibited when the magnetic field is parallel to the flow direction.
ShuJiao Tong,ZongZhi Wu,RuJun Wang,YingQuan Duo 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.8
This paper focuses on an advanced layers of protection analysis (LOPA) method to assess the risk of a chemical process. Based on the chemical accident statistics between 2001 and 2014 in China, an acceptable risk function was built for chemical processes to confirm the acceptable risk value for an accident scenario. The assessment index for an emergency system was developed to assess the protective function of emergency protection based on analytic hierarchy process (AHP), and the probability of failure on demand (PFD) of emergency protection was obtained by fuzzy comprehensive assessment method and fuzzy set theory. The proposed method was applied to a methanol distillation installation. The result showed that the protections, including emergency protection, were sufficient because the probability of mitigation protection (1×10−8) was less than the acceptable risk value (3.04×10−7). The advanced LOPA method was proven to be able to improve the integrity and accuracy of traditional LOPA.
Li-yuan Wang,Jing Wu,Ya-fen Gao,Duo-mao Lin,Jun Ma 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.1
Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT propofol is safe in the hyperlipidemic population for long-term use. Free fatty acids (FFAs) were used to establish high-fat stimulation of HepG2 and Huh7 cells. Subsequently, these cells were treated with propofol at the concentration of 0, 4, or 8 μg/ml for 24 and 48 h. The results indicated that the cell viability was notably decreased when the cells were stimulated with 2 mmol/L FFAs and treated with 12 μg/ml MCT/LCT propofol. Accordingly, we chose 2 mmol/L FFAs along with 4 and 8 μg/ml MCT/LCT propofol for the subsequent experiments. Four and 8 μg/ml MCT/LCT propofol inhibited FFA-induced lipid accumulation in the cells and significantly reversed acetyl coenzyme A carboxylase (ACC) activity. In addition, MCT/LCT propofol not only significantly promoted the phosphorylation of AMPK and ACC, but also reversed the FFA-induced decreased phosphorylation of AMPK and ACC. In conclusion, MCT/LCT propofol reverses the negative effects caused by FFAs in HepG2 and Huh7 cells, indicating that MCT/LCT propofol might positively regulate lipid metabolism.