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      • KCI등재

        MicroRNA-1 in Cardiac Diseases and Cancers

        Jianhua Wu 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.5

        MicroRNAs (miRs) are endogenous ≈22-nt non-coding RNAs that participate in the regulation ofgene expression at post-transcriptional level. MiR-1 is one of the muscle-specific miRs, aberrant expressionof miR-1 plays important roles in many physiological and pathological processes. In thisreview, we focus on the recent studies about miR-1 in cardiac diseases and cancers. The findingsindicate that miR-1 may be a novel, important biomarker, and a potential therapeutic target in cardiacdiseases and cancers.

      • KCI등재

        Enhanced Nitrogen Photo Fixation Performance of Transition Metal-Doped Urchin-Like W18O49 Under Visible-Light Irradiation

        Jianhua Ge,Jing Xu,Yujie Liu,Long Zhang,Lan Wang,Dehan Wu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.11

        Nitrogen photo fixation mediated by various photocatalysts has received extensive concerns in recent years. In this work, a general strategy is proposed to enhance nitrogen photo fixation performance with some W18O49-based photocatalysts under visible-light irradiation. A series of photocatalysts were successfully synthesized in the presence of some noble-metal-free transition metals (Fe, Co and Ni) to modify the urchin-like W18O49. The resulting photocatalysts were systematically characterized using XRD, SEM, EDS, XPS, PL, N2 adsorption–desorption isotherms, and DRS. Structural characterization of the photocatalysts revealed that the crystal morphology features were preserved, optional harvesting properties were enhanced, BET specific surface area was extended, and migration efficiency of the photo-induced charge carriers was significantly improved in the modified-W18O49 materials. Therefore, a progressed nitrogen photo fixation performance was observed. The maximum production of NH4 + was approximately reached to 2752 μg · g -1 catal. under the optimum reaction conditions. Furthermore, a plausible nitrogen photo fixation mechanism in the presence of the synthesized composites is also proposed.

      • KCI등재

        Subsidence estimation of breakwater built on loosely deposited sandy seabed foundation: Elastic model or elasto-plastic model

        Jianhua Shen,Huaicheng Wu,Yuting Zhang 대한조선학회 2017 International Journal of Naval Architecture and Oc Vol.9 No.4

        In offshore area, newly deposited Quaternary loose seabed soils are widely distributed. There are a great number of offshore structures has been built on them in the past, or will be built on them in the future due to the fact that there would be no very dense seabed soil foundation could be chosen at planed sites sometimes. However, loosely deposited seabed foundation would bring great risk to the service ability of offshore structures after construction. Currently, the understanding on wave-induced liquefaction mechanism in loose seabed foundation has been greatly improved; however, the recognition on the consolidation characteristics and settlement estimation of loose seabed foundation under offshore structures is still limited. In this study, taking a semi-coupled numerical model FSSI-CAS 2D as the tool, the consolidation and settlement of loosely deposited sandy seabed foundation under an offshore breakwater is investigated. The advanced soil constitutive model Pastor- Zienkiewics Mark III (PZIII) is used to describe the quasi-static behavior of loose sandy seabed soil. The computational results show that PZIII model is capable of being used for settlement estimation problem of loosely deposited sandy seabed foundation. For loose sandy seabed foundation, elastic deformation is the dominant component in consolidation process. It is suggested that general elastic model is acceptable for subsidence estimation of offshore structures on loose seabed foundation; however, Young's modulus E must be dependent on the confining effective stress, rather than a constant in computation.

      • SCIESCOPUSKCI등재

        Subsidence estimation of breakwater built on loosely deposited sandy seabed foundation: Elastic model or elasto-plastic model

        Shen, Jianhua,Wu, Huaicheng,Zhang, Yuting The Society of Naval Architects of Korea 2017 International Journal of Naval Architecture and Oc Vol.9 No.4

        In offshore area, newly deposited Quaternary loose seabed soils are widely distributed. There are a great number of offshore structures has been built on them in the past, or will be built on them in the future due to the fact that there would be no very dense seabed soil foundation could be chosen at planed sites sometimes. However, loosely deposited seabed foundation would bring great risk to the service ability of offshore structures after construction. Currently, the understanding on wave-induced liquefaction mechanism in loose seabed foundation has been greatly improved; however, the recognition on the consolidation characteristics and settlement estimation of loose seabed foundation under offshore structures is still limited. In this study, taking a semi-coupled numerical model FSSI-CAS 2D as the tool, the consolidation and settlement of loosely deposited sandy seabed foundation under an offshore breakwater is investigated. The advanced soil constitutive model Pastor-Zienkiewics Mark III (PZIII) is used to describe the quasi-static behavior of loose sandy seabed soil. The computational results show that PZIII model is capable of being used for settlement estimation problem of loosely deposited sandy seabed foundation. For loose sandy seabed foundation, elastic deformation is the dominant component in consolidation process. It is suggested that general elastic model is acceptable for subsidence estimation of offshore structures on loose seabed foundation; however, Young's modulus E must be dependent on the confining effective stress, rather than a constant in computation.

      • A cellulose synthase-like protein is required for osmotic stress tolerance in <i>Arabidopsis</i>

        Zhu, Jianhua,Lee, Byeong-Ha,Dellinger, Mike,Cui, Xinping,Zhang, Changqing,Wu, Shang,Nothnagel, Eugene A.,Zhu, Jian-Kang Blackwell Publishing Ltd 2010 The Plant journal Vol.63 No.1

        <P>Summary</P><P>Osmotic stress imposed by soil salinity and drought stress significantly affects plant growth and development, but osmotic stress sensing and tolerance mechanisms are not well understood. Forward genetic screens using a root-bending assay have previously identified <I>salt overly sensitive</I> (<I>sos</I>) mutants of Arabidopsis that fall into five loci, <I>SOS1</I> to <I>SOS5.</I> These loci are required for the regulation of ion homeostasis or cell expansion under salt stress, but do not play a major role in plant tolerance to the osmotic stress component of soil salinity or drought. Here we report an additional <I>sos</I> mutant, <I>sos6-1,</I> which defines a locus essential for osmotic stress tolerance<I>. sos6-1</I> plants are hypersensitive to salt stress and osmotic stress imposed by mannitol or polyethylene glycol in culture media or by water deficit in the soil. <I>SOS6</I> encodes a cellulose synthase-like protein, AtCSLD5. Only modest differences in cell wall chemical composition could be detected, but we found that <I>sos6-1</I> mutant plants accumulate high levels of reactive oxygen species (ROS) under osmotic stress and are hypersensitive to the oxidative stress reagent methyl viologen. The results suggest that SOS6/AtCSLD5 is not required for normal plant growth and development but has a critical role in osmotic stress tolerance and this function likely involves its regulation of ROS under stress.</P>

      • KCI등재

        Identification of acidic species extracted from heavy crude oil by fourier transform ion cyclotron resonance mass spectrometry

        Bencheng Wu,Jianhua Zhu,Xiaohui Li,Yanzhao Huang,Hui Cheng 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.6

        Acidic species were extracted from heavy crude oil by alcohol-alkali solution and ion exchange resin. Theacidic species in the obtained extracts and extracted crude oil were characterized by negative-ion ESI FT-ICR MS. Theanalytical results indicated that some class species, O2, O1, N1, N1O1, N1O2, N1S1 and O2S1 etc., were identified in thenegative-ion spectrum, in which O2, O1 and N1 class showed much higher abundance than others. Compared to O1 andN1 class, O2 class could be extracted from heavy crude oil by using the two methods more efficiently, which meansthat a great majority of O2 class can be extracted; meanwhile, almost half of O1 and N1 class still remained in residualphase. Detailed analysis demonstrated that alcohol-alkali method was effective for extracting O2, O1 and N1 class withlower molecular weight; ion exchange method, however, was helpful to extract higher molecular weight O1 and N1class and showed almost equal extraction selectivity to all kind of O2 class.

      • Experimental and numerical analyses on axial cyclic behavior of H-section aluminium alloy members

        Jinzhi Wu,Jianhua Zheng,Guojun Sun,Xinquan Chang 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.81 No.1

        This paper considers the combination of cyclic and axial loads to investigate the hysteretic performance of Hsection 6061-T6 aluminum alloy members. The hysteretic performance of aluminum alloy members is the basis for the seismic performance of aluminum alloy structures. Despite the prevalence of aluminum alloy reticulated shells structures worldwide, research into the seismic performance of aluminum alloy structures remains inadequate. To address this deficiency, we design and conduct cyclic axial load testing of three H-section members based on a reliable testing system. The influence of slenderness ratios and bending direction on the failure form, bearing capacity, and stiffness degradation of each member are analyzed. The experiment results show that overall buckling dominates the failure mechanism of all test members before local buckling occurs. As the load increases after overall buckling, the plasticity of the member develops, finally leading to local buckling and fracture failure. The results illustrate that the plasticity development of the local buckling position is the main reason for the stiffness degradation and failure of the member. Additionally, with the increase of the slenderness ratio, the energy-dissipation capacity and stiffness of the member decrease significantly. Simultaneously, a finite element model based on the Chaboche hybrid strengthening model is established according to the experiment, and the rationality of the constitutive model and validity of the finite element simulation method are verified. The parameter analysis of twenty-four members with different sections, slenderness ratios, bending directions, and boundary conditions are also carried out. Results show that the section size and boundary condition of the member have a significant influence on stiffness degradation and energy dissipation capacity. Based on the above, the appropriate material constitutive relationship and analysis method of H-section aluminum alloy members under cyclic loading are determined, providing a reference for the seismic design of aluminum alloy structures.

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