[논문]부산시 영도의 세 지역내 식물 집단 구조

허홍욱,이송진,최금자,허만규 부산대학교 환경문제연구소 2004 環境硏究報 Vol.22 No.-

Plant Population Structure of three areas in Young-do of Busan

사람의 혈관 내피세포에 대한 Rickettsia typhi의 감염

안욱수,이강순,송호연 순천향대학교 1994 논문집 Vol.17 No.4

R. typhi, the etiologic agent of murine typhus, has known to cause fever, headache, maculopapular rash and vasculitis of small blood vessel. The skin rash and vasculitis are thought to be the results of endothelial cell injury from the infection with R. typhi in vivo. R. typhi showed ability to cause cellular injury of cultured human endothelial cells. The endothelial cells used in this experiment wee obtained by collagenase treatment of human umbilical cord veins. These cells were conformed to be endothelial cell by the presence of von Willebrand factor through the immunofluorescent antibody technique and Weibel-Palade bodies under the electron microscopy. Ultrastructural study revealed that there were no evidences of entry and/or escape from endothelial cells of R. typhi in 24 hours through 48 hours after infection. On the contrary, numerous particles implicating R. typhi were observed in large vacuole within endothelial cells at 48 hours after inoculations. Estimating the severe injury of endothelial cells by infection of R. typhi, the endothelial cells seems to be the primary target cells in human disease caused by R. typhi infection.

자궁암세포(HeLa)에 대한 사군자탕과 수종 항암제의 병용투여 효과

은재순,김현욱,소준노,오찬호,이송재 又石大學校 1993 論文集 Vol.15 No.-

The studies were conducted to investigate the combined effects of Sa Kunja Tang(SKT) and several anti-cancer drugs. The effects of SKT and several anti-cancer drugs on the proliferation of HeLa cells, human cervical cell line, was estimated by MTT colorimetric assays. The SKT extract inhibited the proliferation of HeLa cell at 10^-4g/ml. The inhibitory action of the mitomycin C(MMC), mercaptopurine(MCP) and 5-fluorouracil(5-Fu) treated group, respectively, on the proliferation of HeLa cell was increased by the SKT. When the mice were treated by the MMC, the number of leukocyte was decreased significantly at the 1st and 3rd day, but recovered at the 7th day. In the groups of the MMC treated with the SKT, the number of leukocytes was increased significantly than the group of the MMC treated only at the 3rd day. The SKT extract decreased the thymus weight of mice. The SKT extract increased the number of plaque forming cells(PFC), but the MMC treated group decreased the number of PFC. The combined treatment of MMC and the SKT increased the number of PFC significantly than the MMC treated group. The SKT extract increased the proliferation of T cells, but the MMC treated group decreased the proliferation of T cells. The combined treatment of MMC and the SKT increased T cell proliferation significantly than the MMC treated group. In conclusion, the results presented in this paper suggest that the SKT extract can decrease the dose of anti-cancer drugs on HeLa cell, and recover the side dffects of the MMC, such as leukopenia and immunosuppresion, without any intercalating the anti-proliferative action of the MMC in vivo.

대학생들의 환경문제 의식에 관한 연구

허만규,이송진,허홍욱 한국환경과학회 2003 한국환경과학회지 Vol.12 No.3

This study was attempted to analyze sophomores' consciousness for environmental problems. In order to achieve this purpose, a method of questionnaire was administered to total 387 students selected from four universities in Busan. There were surveyed questions as follows, the conception of environmental problems, the condition of dwelling place and surrounding of home, the problems of environmental pollution, knowledge and concern for environmental problems, necessity of environmental education of school, and the environmental policy in Korea. Most students responded that the most serious environmental problem is water pollution. Most respondents have recognition the necessity of schooling for environmental education, whereas current-contents of environmental education are not enough to modify students' attitude and behavior.

Chlorpromazine이 백서 해마에서 전기경련 충격에 의한 MAPK 타이로신 인산화에 미치는 영향

주연호,정성훈,전송희,강웅구,김용식,김상욱,박주배 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.2

Object : In order to examine the interaction mechanisms of electroconvulsive shock(ECS) and antipsychotic drug at the level of molecular biology, we observed the effect of chlorpromazine pre-treatment on the activation of mitogen activated protein kinase(MAPK) induced by electroconvulsive shock(ECS) in rat hippocampus Method : Male Sprague-Dawley rats were divided into 2 groups. To the experimental group chlorpromazine(20㎎/㎏) was given intraperitoneally, and to the control distilled water was given instead. Thirty minutes later, ECS was given and the hippocampus was dissected out 2 minutes thereafter. Immunoblotting with antiphosphotyrosine antibody was carried out, and the signal intensity at 42kDa band was quantitized using densitometer. The obtained result was compared by student t-test between the experimental and the control group. The absolute amount of MAPK was measured by immunoblotting with anti-MAPK antibody. Result : The tyrosine phosphorylation of MAPK reached peak at 2 minutes after ECS. However, in the chlorpromazine pre-treated group, the peak level of MAPK tyrosine phosphorylation was significantly attenuated(t=-3.12, df=14, p=0.008) compared to the control. In contrast to this, the absolute amount of MAPK did not differ between the pretreated and the control group. Conclusion : Chlorpromazine attenuated the tyrosine phosphorylation of MAPK by ECS. This finding seems to be related to the fact that chlorpromazine pre-treatment changed the cfos expression by ECS in rat brain. Antipsychotic drug and ECS might interact at the level of MAPK signal transduction system, and this might explained the observed synergistic effect of two treatment modality.

Effects of Natural Zeolite on Mechanical and Thermal Properties of Epoxy Composite System

Song, Young Wook,Kim, Sang Wook 서울시립대학교 산업기술연구소 1996 산업기술연구소논문집 Vol.4 No.-

The natural zeolite was introduced to diglycidyl ether of bisphenol A(DGEBA)/4,4'-methylene dianiline(MDA)/hydroquinone-phenyl glycidyl ether (HQ-PGE) system to modify mechanical and thermal properties of epoxy resin as an inorganic filler. In mechanical properties, the tensile strength of a system with 10 phr of natural zeolite decreased about 17 % than that of a system without natural zeolite. Also, the impact strength of a system with the natural zeolite decreased than that of the system without natural zeolite. Both properties decreased with the increment of natural zeolite contents. In case of thermal properties, glass transition temperature(Tg) and decomposition temperature(Td) of the composites system were seldom affected by natural zeolite and its contents.

Colonic Pseudo-obstruction With Transition Zone: A Peculiar Eastern Severe Dysmotility

Eun Mi Song,Jong Wook Kim,Sun-Ho Lee,Kiju Chang,Sung Wook Hwang,Sang Hyoung Park,Dong-Hoon Yang,Kee Wook Jung,Byong Duk Ye,Jeong-Sik Byeon,Suk-Kyun Yang,Hyo Jeong Lee,Chang Sik Yu,Chan Wook Kim,Seong 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.1

Background/Aims Previous studies from Korea have described chronic intestinal pseudo-obstruction (CIPO) patients with transition zone (TZ) in the colon. In this study, we evaluated the pathological characteristics and their association with long-term outcomes in Korean colonic pseudo-obstruction (CPO) patients with TZ. Methods We enrolled 39 CPO patients who were refractory to medical treatment and underwent colectomy between November 1989 and April 2016 (median age at symptoms onset: 45 [interquartile range, 29–57] years, males 46.2%). The TZ was defined as a colonic segment connecting a proximally dilated and distally non-dilated segment. Detailed pathologic analysis was performed. Results Among the 39 patients, 37 (94.9%) presented with TZ and 2 (5.1%) showed no definitive TZ. Median ganglion cell density in the TZ adjusted for the colonic circumference was significantly decreased compared to that in proximal dilated and distal non-dilated segments in TZ (+) patients (9.2 vs 254.3 and 150.5, P < 0.001). Among the TZ (+) patients, 6 showed additional pathologic findings including eosinophilic ganglionitis (n = 2), ulcers with combined cytomegalovirus infection (n = 2), diffuse ischemic changes (n = 1), and heterotropic myenteric plexus (n = 1). During follow-up (median, 61 months), 32 (82.1%) TZ (+) patients recovered without symptom recurrence after surgery. The presence of pathological features other than hypoganglionosis was an independent predictor of symptom recurrence after surgery (P = 0.046). Conclusions Hypoganglionosis can be identified in the TZ of most Korean CPO patients. Detection of other pathological features in addition to TZ-associated hypoganglionosis was associated with poor post-operative outcomes.

Resection and Observation for Brain Metastasis without Prompt Postoperative Radiation Therapy

Song, Tae-Wook,Kim, In-Young,Jung, Shin,Jung, Tae-Young,Moon, Kyung-Sub,Jang, Woo-Youl The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.6

Objective : Total resection without consecutive postoperative whole brain radiation therapy is indicated for patients with a single or two sites of brain metastasis, with close follow-up by serial magnetic resonance imaging (MRI). In this study, we explored the effectiveness, usefulness, and safety of this follow-up regimen. Methods : From January 2006 to December 2015, a total of 109 patients (76 males, 33 females) underwent tumor resection as the first treatment for brain metastases (97 patients with single metastases, 12 with two metastases). The mean age was 59.8 years (range 27-80). The location of the 121 tumors in the 109 patients was supratentorial (n=98) and in the cerebellum (n=23). The origin of the primary cancers was lung (n=45), breast (n=17), gastrointestinal tract (n=18), hepatobiliary system (n=8), kidney (n=7), others (n=11), and unknown origin (n=3). The 121 tumors were totally resected. Follow-up involved regular clinical and MRI assessments. Recurrence-free survival (RFS) and overall survival (OS) after tumor resection were analyzed by Kaplan-Meier methods based on clinical prognostic factors. Results : During the follow-up, MRI scans were done for 85 patients (78%) with 97 tumors. Fifty-six of the 97 tumors showed no recurrence without adjuvant local treatment, representing a numerical tumor recurrence-free rate of 57.7%. Mean and median RFS was 13.6 and 5.3 months, respectively. Kaplan-Meier analysis revealed the cerebellar location of the tumor as the only statistically significant prognostic factor related to RFS (p=0.020). Mean and median OS was 15.2 and 8.1 months, respectively. There were no significant prognostic factors related to OS. The survival rate at one year was 8.2% (9 of 109). Conclusion : With close and regular clinical and image follow-up, initial postoperative observation without prompt postoperative radiation therapy can be applied in patients of brain metastasi(e)s when both the tumor(s) are completely resected.

Behçet's disease and genes within the major histocompatibility complex region.

Song, Yeong Wook,Kang, Eun Ha Springer-Verlag Tokyo 2012 Modern Rheumatology Vol.22 No.2

<P>The role of genetic background in the development of Behçet's disease (BD) is best reflected by the strong association between HLA-B*51 and BD that has been demonstrated across various ethnic groups. The contributions made by other HLA or non-HLA genes to disease susceptibility have been suggested by the results of a number of gene association studies, although the true associations between the genes located within the major histocompatibility complex (MHC) region and BD have often been doubted due to the possibility of linkage disequilibrium of those genes with HLA-B*51. The presence of a true susceptibility gene in the vicinity of HLA-B*51 has also been extensively investigated because of the limited evidence that directly relates HLA-B*51 to the pathogenesis of BD. However, recent genome-wide association studies have confirmed that HLA-B*51 is primarily associated with BD and that there are multiple susceptibility loci other than HLA-B*51. In this review, we discuss BD-associated genes within the MHC region and their biological roles in the pathogenesis of BD.</P>

Development of a refractive index measurement system for vacuum pressure measurement

Song Han Wook,Kim Jong Ho,Woo Sam Yong 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.78 No.2

Many studies have recently been conducted to replace the mercury manometer that has been used as a national standard because of the prohibition of mercury. In particular, ‘the new realization of the Pascal’ by using photon technology shows some comparable results in terms of performance compared to the existing primary pressure standard based on the mercury manometer. In this study, we describe the development of a refractive index measuring system for precise vacuum pressure measurements to develop a mercury-free standard. If the refractive index of a medium is to be measured using a laser interferometer, designing a cavity as a pressure medium and a laser as a light source is important. We designed a Fabry–Perot (FP) cavity structure having two channels to calculate an arbitrary pressure by comparing the laser resonance frequency in a vacuum state, which served as a reference pressure, and that in an arbitrary pressure state. Zerodur was used as the material for the cavity. The cavity was designed to be a rectangular parallelepiped with a width of 50 mm and a length of 150 mm considering the wavelength (633 nm) of the He–Ne laser used as a light source, the pressure range to be implemented, and the implementation range of a single mode. We independently fabricated a single-mode (SM) He–Ne laser instead of a commercially available laser to modulate the frequency freely and to achieve a single polarization regardless of the quantum number. With our system, the beat frequency was measured to the internal pressure of a cavity. A 1 MHz beat frequency was found to be approximately equal to a pressure of 1 Pa.