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( Sun-ho Lee ),( Kiju Chang ),( Ki Seok Seo ),( Yun Kyung Cho ),( Eun Mi Song ),( Sung Wook Hwang ),( Dong-hoon Yang ),( Byong Duk Ye ),( Jeong-sik Byeon ),( Seung-jae Myung ),( Suk-kyun Yang ),( Sang 대한장연구학회 2020 Intestinal Research Vol.18 No.2
Background/Aims: The use of complementary and alternative medicine (CAM) is a global phenomenon, including inflammatory bowel disease (IBD) patients. We aimed to assess the change in prevalence and patterns of CAM use, and attitudes towards CAM over an 8-year time interval (2006 vs. 2014) among IBD patients in Korea. Methods: A total of 221 IBD patients (CD=142, UC=79) were asked to complete a questionnaire regarding CAM at two time points: at enrollment (2006) and 8 years later (2014/2015). Results: The proportion of patients ever using CAM increased significantly from 60.2% in 2006 to 79.6% in 2014 (P<0.001), while the proportion of current CAM users increased slightly (35.7% to 38.0%, P=0.635); 21.7% used CAM consistently at both time points. The proportion of patients who felt CAM was less effective (P<0.001) and more expensive (P=0.04) than conventional treatments increased over time. Also, the proportion among ever CAM users who perceived a positive effect from CAM significantly decreased in 2014 compared to 2006 (P=0.004). Higher education (adjusted odds ratio [aOR], 2.10), prior side effects to conventional therapies (aOR, 2.23), and prior use of corticosteroids (aOR, 2.51) were associated with CAM use. Interestingly, use of CAM before IBD diagnosis (aOR, 2.73) was significantly associated with consistent CAM use. Conclusions: Although the attitudes toward CAM have become less favorable, the majority of IBD patients have experienced CAM with an overall increase of current CAM users over time. Moreover, more than half of current CAM users used CAM consistently over time. (Intest Res 2020;18:192-199)
Increased Risk of Herpes Zoster Infection in Patients With Inflammatory Bowel Diseases in Korea
Chang, Kiju,Lee, Ho-Su,Kim, Ye-Jee,Kim, Seon-Ok,Kim, Sung-Han,Lee, Sun-Ho,Song, Eun Mi,Hwang, Sung Wook,Park, Sang Hyoung,Yang, Dong-Hoon,Ye, Byong Duk,Byeon, Jeong-Sik,Myung, Seung-Jae,Yang, Suk-Kyun Elsevier 2018 Clinical gastroenterology and hepatology Vol.16 No.12
<P><B>Background & Aims</B></P> <P>Few data are available on risk of herpes zoster (HZ) infection in Asian patients with inflammatory bowel diseases (IBD). We investigated whether patients with IBD in Korea have an increased risk of HZ and sought to identify risk factors for infection.</P> <P><B>Methods</B></P> <P>We performed a nationwide population-based study and a hospital-based, nested case–control study. Using the 2009–2013 data from the Korean national health insurance claims database, we calculated incidence rates and standardized incidence ratios (SIRs) of HZ infection in patients with IBD compared with the entire Korean population. In the nested case–control study, within a hospital-based cohort, 300 patients with IBD and HZ infection were matched with 895 patients with IBD without HZ.</P> <P><B>Results</B></P> <P>In the nationwide population-based study, the incidence rate and SIR of HZ infection in patients with IBD were 18.34/1000 person-years and 1.48 (95% CI, 1.42–1.54), respectively. The SIR for HZ infection was higher in patients with Crohn’s disease than in patients with ulcerative colitis (1.90 vs 1.36; <I>P</I> < .001) and higher in male patients than female patients (1.63 vs 1.33; <I>P</I> < .001). The incidence rate of HZ increased with age (<I>P</I> trend < .001), whereas the SIR of HZ infection decreased with age (<I>P</I> trend < .001). In the nested case–control study, corticosteroid use was associated with HZ infection (for ulcerative colitis, adjusted odds ratio, 2.44; 95% CI, 1.18–5.05 and for Crohn’s disease, adjusted odds ratio, 2.70; 95% CI 1.25–5.83).</P> <P><B>Conclusions</B></P> <P>In a population-based study in Korea, we found patients with IBD to have an increased risk for HZ infection—especially among patients who are male, younger, or have Crohn’s disease. Corticosteroid use increases risk of HZ infection in patients with IBD.</P>
Colonic Pseudo-obstruction With Transition Zone: A Peculiar Eastern Severe Dysmotility
Eun Mi Song,Jong Wook Kim,Sun-Ho Lee,Kiju Chang,Sung Wook Hwang,Sang Hyoung Park,Dong-Hoon Yang,Kee Wook Jung,Byong Duk Ye,Jeong-Sik Byeon,Suk-Kyun Yang,Hyo Jeong Lee,Chang Sik Yu,Chan Wook Kim,Seong 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.1
Background/Aims Previous studies from Korea have described chronic intestinal pseudo-obstruction (CIPO) patients with transition zone (TZ) in the colon. In this study, we evaluated the pathological characteristics and their association with long-term outcomes in Korean colonic pseudo-obstruction (CPO) patients with TZ. Methods We enrolled 39 CPO patients who were refractory to medical treatment and underwent colectomy between November 1989 and April 2016 (median age at symptoms onset: 45 [interquartile range, 29–57] years, males 46.2%). The TZ was defined as a colonic segment connecting a proximally dilated and distally non-dilated segment. Detailed pathologic analysis was performed. Results Among the 39 patients, 37 (94.9%) presented with TZ and 2 (5.1%) showed no definitive TZ. Median ganglion cell density in the TZ adjusted for the colonic circumference was significantly decreased compared to that in proximal dilated and distal non-dilated segments in TZ (+) patients (9.2 vs 254.3 and 150.5, P < 0.001). Among the TZ (+) patients, 6 showed additional pathologic findings including eosinophilic ganglionitis (n = 2), ulcers with combined cytomegalovirus infection (n = 2), diffuse ischemic changes (n = 1), and heterotropic myenteric plexus (n = 1). During follow-up (median, 61 months), 32 (82.1%) TZ (+) patients recovered without symptom recurrence after surgery. The presence of pathological features other than hypoganglionosis was an independent predictor of symptom recurrence after surgery (P = 0.046). Conclusions Hypoganglionosis can be identified in the TZ of most Korean CPO patients. Detection of other pathological features in addition to TZ-associated hypoganglionosis was associated with poor post-operative outcomes.
정윤창(Yoon Chang Jeong),박주아(Ju A Park),한승철(Seung Chul Han),강기주(Kiju Kang) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.06
Shellular 연속되는 부드러운 박막으로 구성되며 최소곡면 형상에 10<sup>-2</sup>g/cc 이하의 극저밀도를 가진 다공질 재료로서, 중공 트러스로 구성된 종래의 micro-architectured material 과 달리 stretching dominated 변형하여 세계 최고의 강도를 가진다. Shellular의 제작방법은 최소곡면 형상의 template 제조, 균일한 두께의 금속 박막의 무전해 도금, 일부 연삭 후 template 식각 과정으로 이루어진다. 충분한 내압강도를 갖는 shellular 압력용기의 제작을 위하여, 본 연구에서는 충분한 연성을 갖는 구리 박막 무전해 도금공정의 확립, 제작된 구리 박막의 인장실험을 통한 기계적 물성과 연성 확인, 최종적으로 확립된 구리 도금법을 통한 압력용기 제작을 진행한다. 나아가 제작된 압력용기의 내압특성을 확인하고 이를 FEA 결과와 비교한다. 확립된 구리 무전해 도금은 70 도의 고온에서 진행되므로 니켈 합금의 무전해도금보다 template의 손상을 일으키기 쉽다 또한 도금과정에서 필연적으로 수소를 발생시키므로 도금박막에 결함과 취성을 유발하는 경향이 있다. 이러한 문제점을 극복하기 위한 도금공정의 개선을 시도하였다. 그 결과를 검증하기 위해서 최종적으로 형성된 구리 박막의 인장실험의 결과를 제시하였다.