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조영석,권기현,이준철,나소영,이효진,홍우정,이유선,김군순,송민호,김영건,노흥규 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2
Prediction of thrapeutic response to radioiodine in Graves' disease is poorly understood. Although thyrotropin binding inhibitor immunoglobulin(TBII) level is a strong index for relapse after antithyroid drug medication, conflicting results are reported regarding its prognostic significance in Graves' disease treated with RAI. This study is dengned to evaluate possible relationship between post-treatment hypothyroidism and TBII in Graves' disease treated with RAI. Fourty two patient with Graves' disease after radioiodine treatment were studied retrospectively. The subject were divided into hypothyroid group and euthyroid or hyperthyroid group. We evaluated the association of hypothyroidism and TBII with radioiodine treatment dose. The mean age of hypothyroid group was 48±11 years and euthyroid or hyperthyroid group was 47±12 years. There was no difference in two groups. And there was no significant difference in post- treatment TBII between two groups(49.9±28.5%, 29.9±14.3%, p-value >0.05). The treatment-dose had no influence on post-treatment thyroid state. Euthyroid or hyperthyroid group was done with 13.6±6.9mCi and hypothyroid group was 17.0±10.4mCi(p-value > 0.05). TBII had no prognostic significance on long-term hypothyrodism in Graves' disease treated with radioiodine. And, treatment-dose had no influence on post-treatment thyroid state.
2축 편심축력을 받는 고강도 콘크리트 기둥의 등가응력블럭 수정
박준용,유석형,반병열,신성우 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)
The characteristics of stress distribution of non rectangular compressed area in the RC columns are different to those of rectangular compressed area. Nevertheless, in ACI 318-99 code, the design tables for columns subjected to axial loads with bidirectional eccentricities are based on the parameters recommended for rectangular stress block(RSB) of rectangular compressed areas. In this study the characteristics of stress distribution through both angle and depth of neutral axis are observed and formulated rationally. And the modified parameters of rectangular stress block(MRSB) for non rectangular compressed area is proposed. And the computer program using MRSB for the biaxial bending analysis of RC columns in developed and the results of MRSB are compared to RSB and experimental results respectively.
철근 콘크리트 구조물의 거푸집 존치기간 단축에 따른 경제성 평가
김철,오성진,유석형,이광수,신성우 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1
By means of increasing specified strength of concrete, the setting period of slab form can be reduced. When the form of slab is set, construction stage can be classified as follows; the allowable period of upper story work and the setting period of form and support of slab. Six full size scaled specimens with variables such as concrete strength and loading time are fabricated. Structural behavior and serviceability is examined at each construction stage. Test results show that the form of slab can be removed 2 days early without any damage of serviceability in case of increasing of concrete strength. This results were applied to a 15 story RC apartment, which were accomplished construction sequence analysis. As a results, the models are satisfied with structural safety, serviceability. Decrement of indirect cost showed greatly more relatively than increment of direct cost as result that achieve construction cost analysis of in case shortened 30 day's term of work at removal of forms early stage by concrete intensity promotion.
이화운,김유근,정우식,오은주,임헌호,노순아,반수진,최현정,김민선,김헌숙 부산대학교 환경문제연구소 2002 環境硏究報 Vol.20 No.-
In the view of the results investigated the effect of air pollutants that is emitted from a new generator facilities, the total estimated concentration which is the summation of a contributional concentration and observational concentration is much less than that of atmospheric environment criterion for the air pollutants. So we can predict that the operation of the new generator facilities with mitigation equipment don't seriously affect around environment. At the same time, we compared the contributional concentration of before mitigation equipment with that of after it to examine the decreasing amount due to mitigation equipment. The result showed that the concentration of SO2, NO2 and PM-10 is reduced to 25%, 30% and 26% of original value, respectively.
정성필,이석우,양영모,하영록,김승환,유인술 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3
Background: This study was designed to review the cases of patients who had undergone diffusion-weighted magnetic resonance imaging(DWI) in the emergency department(ED), and to investigate its clinical usefulness and current indications. Methods: We analyzed the cases of 152 consecutive patients who underwent DWI in the ED from Jan to Mar 2001. DWI was obtained with the use of a multislice, single-shot, spin-echo plana imaging technique(GE SignaR). Imaging time was less than one minute. The medical records, the DWI films and the computed topography results were reviewed. We investigated the chief complaint, initial findings of physical examination, final diagnosis, decision-making department, interval from admission to imaging, and DWI findings. Results: DWI showed positive findings of high signal intensity in 84 patients(55.3%). Among the 68 patients who yielded a negative result, false negative occurred with 12 patients(17.6%): 10 lacunar infarctions, a pons infarction, and a brainstem infarction. Eleven patients were determined as having a cerebral hemorrhage, all of whom showed the abnormal finding of a mixed signal in DWI. The sensitivity and the specificity of DWI to rule out stroke were 85.5% and 98%, respectively. Current indications for DWI in our ED are age older than 60, alert mental status, and one of the symptoms or signs among lateralyzing sign, language disturbance, and dizziness/vertigo. Conclusion: DWI was highly specific to rule out stroke, so emergency care professionals should be familiar with this new technology. Further prospective study is required to determine the proper indications and clinical usefulness of DWI in the ED.
알카리성 부여제 도포에 의한 중성화된 콘크리트의 알카리성 회복성능에 관한 실험적 연구
김무한,권영진,강석표,유재강,이강우 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1
Concrete is the most commonly used material in construction field and it is the permanent construction material with respect to civil property. But, if concrete loses its alkalinity by CO2 gas, it loses its structural characteristics and results in total collapse in construction field. Therefore. it is needed to be studied the alkali-recovery performance by alkalization agent on carbonated concrete by accelerated carbonation test. In this paper, we investigate recovery performance by impregnating alkalization agent in carbonated concrete, then we evaluate alkali maintenance performance by pH survey in each kinds of finishing materials. The results of this paper can be summarized as follows. 1)Carbonated concrete under pH 10 was recovered its alkalinity to pH 11 at first stage by spreading alkalization agent on its outer surface. 2)After spreading alkalization agent, there is a difference due to types of moreover effect of anti-rust paint and ordinary cement paste were excellent.
야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로
조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6
Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.
Inhibitory actions of the antidepressant/antipanic drug phenelzine on brain GABA transaminase
Yoo, Byung-Kwon,Hong, Joung-Woo,Suk, Jae-Wook,Ahn, Jee-Yin,Yoo, Jeong-Suk,Lee, Kil-Soo,Cho, Sung-Woo,Choi, Soo-Young The Pharmaceutical Society of Korea 1996 Archives of Pharmacal Research Vol.19 No.6
Brain GABA transaminase is inactivated by preincubation with antidepressant/antipanic drug pheneizine (${\beta}$ethylphenylhydrazine) (mixing molar ratio 10:1) at pH 7.4. The reaction of enzyme with phenelzine was monitored by absorption and fluorescence spectroscopic methods. The inactive enzyme was fully reconstituted by addition of cofactor pyridoxal-5-phosphate. This result implies that the blocking of 1 mol of pyridoxal-5-phosphate per enzyme dimer is needed for inactivation of the enzyme. The time course of the reaction is significantly affected by the substrate .alpha.-ketoglutarate, which afforded complete protection against the loss of catalytic activity. The kinetic studies shows that phenelzine reacts with the cofactor of enzyme with a second-order rate constant of $2.1{\times}10^3M^{-1}s^{-1}$. It is postulated that the antidepressant/antipanic drug phenelzine is able to elevate the neurotransmitter GABA levels in central nervous system by inhibitory action on GABA degradative enzyme GABA transaminase.
흰쥐에서 신델라 겔 (송아지 제단백혈액추출물 : 황산미크로노마이신=20:1 복합제제)의 30일간 반복투여 경피독성시험
남석우(Suk Woo Nam),성대석(Dae Suk Sung),유세근(Se Keun Yoo),장만식(Man Sik Chang),최완수(Wahn Soo Choi),정영국(Young Kuk Chung),김규봉(Kyu Bong Kim),한정환(Jeung Whan Han),홍성렬(Sung Youl Hong),이향우(Hyang Woo Lee) 대한약학회 1997 약학회지 Vol.41 No.2
This study was conducted to investigate the subacute transdermal toxicity of Syndella gel, a new topical drug containing deproteinized dialysate of calf''s blood and micronomicin sulfate in Sprague-Dawley rats. Three doses (1.97, 3.94, 7.88 g/kg) of Syndella gel was daily treated transdermally to male and female rats for 30 days. No death was occurred in either control or treated rats. No significant toxic clinical signs and body weight change were not observed at any doses in the male or female rats treated. There were no significant alterations in hematologic and biochemical parameters in both sexes, however slight increase of potassium concentration was observed in 3.94g/kg and 7.88 g/kg female groups. No significant necrotic changes were not observed in examined organs. This study showed that up to 7.88g/kg Syndella gel did not induce subacute transdermal toxicity.