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젊은 성인에서 신체 만족도에 따른 문제해결양식, 대인관계문제와 우울증상과 자살사고와의 관련성
차승민,김태성,강문희,권명진,김정란,왕성근,지익성 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2
Objectives:The aim of this study was to evaluate that problem solving styles, interpersonal problems, depression and suicidal ideation according to body image satisfaction. Methods:One hundred and nineteen young healthy normal subjects filled out administered the Body Dysmorphic Disorder Examination-Self Report (Korean version of BDDE-SR K-BDDE-SR), Problem Solving Style Scale(Korean version PSS), Korean Inventory of Interpersonal Problem(KIIP), Korean version of the Depression Anxiety Stress Scale(KDASS-21), Korean version of Beck Scale for Suicidal Ideation(Korean version SSI) and Korean version of Reynolds Suicidal Ideation Questionnaire(Korean version SIQ) for a month. Results:Out of the 119 subjects, 39%(N=46) was male and 61%(N=73) was female. In high K-BDDE-SR group (higher than 67), helplessness was significantly higher than low K-BDDE-SR group(lower than 67), and problem-solving confidence, creative style, approach style were significantly lower than low K-BDDE-SR group. Also, Higher level of all KIIP factors in High K-BDDE-SR group was significantly differ than low K-BDDE-SR group. In High K-BDDE-SR group, K-DASS-21, SSI, and SIQ were significantly higher than low K-BDDE-SR group. Using multiple regression analysis contributing variance toward the total factor score of K-BDDE-SR of participants were K-DASS-21 and SIQ. Conclusion:Our results indicates that high tendency of dissatisfied body images have differences in helplessness, problem-solving confidence, approach style, interpersonal problems, depression and suicidal ideation compared to low tendency of dissatisfied body images. It is necessary to study body dysmorphic disorder patients group in the future.
흰쥐에서 니켈 및 카드뮴의 동시노출이 간에 미치는 영향
차봉석,왕승준,장세진 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1
목적 : 이 연구는 적출간 관류법을 이용하여 영화니켈과 염화카드뮴의 동시 노출로 인하여 간에 나타나는 효과를 확인하는 데에 있다. 방법 : 간독성의 지표로서 AST, ALT, LDH의 농도 및 관류속도를 이용하였고 생존력에 대한 지표로서 산소소모율을 측정하였다. 300(±50) g의 흰쥐를 노출군(비노출군 및 50 μM/ 200 μM의 각 농도별 염화니켈과 염화카드뮴의 개별 투여군 및 동시 투여군)별로 5마리씩 총 35마리를 할당하였다. 간을 통과한 관류액을 채취하여 생화학적 간독성 지표를 측정했고 집단간의 시간의 경과에 따른 측정치의 비교를 위해 반복 측정된 2요인 분산분석을 실시하였다. 개별 투여군과 동시 투여군의 생화학적 지표간의 평균을 비교함으로써 상승효과에 대한 가능성을 확인했다. 결과 : 개별 투여군 및 동시 투여군 모두에서 AST, ALT, LDH가 증가했다. 관류속도 및 산소 소모율은 시간의 경과에 따라 감소했으나 통계적으로 유의한 차이를 보이지는 못했다. AST, ALT, LDH, 산소소모율이 일정 시간대 이후로 개별 노출군의 합보다 동시 노출군에서의 측정치가 더욱 크게 증가하였다. 결론 : 간독성에 대한 생화학적 지표의 변화를 확인함으로써 두 물질의 동시노출로 인한 복합적 효과는 상승효과일 가능성이 높은 것으로 보인다. Objectives : This research was intended to verify hepatic effect of simutaneously com-bined exposure of nickel chloride and cadmium chloride with IPRL (Isolated Perfumed Rat Liver) method. Methods : AST(aspartate aminotransferase), ALT(alanine aminotransferase), LDH (lac-tate dehydrogenase) and perfusion flow rate were used as the indicator of hepatotoxicity and oxygen consumption rate were used as the indicator of viability. 300(±50) g - weighted rats were allocated randomly to each group (control group, 50 μM·200 μM sera-rately exposure group of NiCl₂and CdCl₂, simultaneously combined exposure group of NiCl₂and CdCl₂by 5, totally 35. Buffer which got out of liver was sampled and then biochemical indicator of hepatotoxlcity was measured. In order to verify difference among groups, two way - repeated ANOVA was used. With comparing mean summation of sepa-rate exposure group with mean of simultaneous exposure group, possibility that combined effect could be synergistic effect was verified. Results : AST, ALT, LDH increased in both of separate exposure group and simultaneous exposure group. Perfusion flow rate and oxygen consumption rate decreased but statlstically significant difference among groups was not found. In each exposure group, AST, ALT, 7DH, oxygen consumption rate of simultaneous exposure group increased more than sum of separate exposure group after any sampling time. Conclusions : It was found that simultaneous combined effect could be synergistic effect through the biochemical indicator of hepatotoxicity.
정신분열병에 대한 Risperidone의 효과 및 안전성에 관하여
신석철,왕성근,지익성,이선우,이규광,이봉희,이진영,황선희,신용재,배경도,김정란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1
In order to evaluate the efficacy and safety of risperidone, 10 patients with chronic schizophrenia were examined for 8 weeks in a silgle-open study. After the wash-out period of 1 week, risperidone was administered. Efficacy was evaluated by means of Positive and Negative syndrome Scale for Schizophernia(PANSS) and Clinical Global Impression(CGI). Safety assessment included the Extrapyramidal Symptom Rating Scale(ESRS), vital signs, body weight, ECG, and laboratory tests. The results were as follows 1) On the PANSS total score, there was significant improvement of total score after 1 week (P<.05) of administratiom. 2) On the PANSS positive and negative subscal, there were significant improvement of posotive and negative scores after 2 weeks (P<.05) of administration. 3) On the PANSS general psychopatholgy subscals, there were significant improvement of general psychopathologyscores after 1 week (P<.05) of administratiom. 4) On the CGI, there was significant decreasement of clinical impression of severity of schizophrenia score after 2 week (P<.05) of administration. 5) A statistically significant increase in body weight (P<.05) was observed after 8 weeks of administration. 6) EPS reached the peak at the end of the 1st week of administration of risperidone (11.8± 24.25) but they were easily relieved by addition of benztropine and clonazepam. There was not significant change in laboratory tests, vital sign, ECG after 8 weeks of administration. These results suggest that Risperidone is an effective antipsychotics and clinically safe except for increased body weight in chronic schizophrenia.
다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예
최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.
왕승진 ( Seung Jin Wang ),이형재 ( Hyoung Jae Lee ),조정용 ( Jeong Yong Cho ),장미영 ( Mi Young Jang ),박근형 ( Keun Hyung Park ),문제학 ( Jae Hak Moon ) 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2012 한국식품저장유통학회지 Vol.19 No.1
The antioxidant activities of makgeolli and other alcoholic beverages were compared. Based on the same volume (70 μL eq.) of the alcoholic beverages, the 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid ammonium salt) (ABTS+) radical-scavenging activities were as follows: whisky > makgeolli crude extract (MCE) > rice wine (RW) > clarified makgeolli (CM) > soju. Based on the same alcohol concentration (6%) of the alcoholic beverages, however, makgeolli showed the highest activity. In addition, based on the same volume (70 μL eq.), the inhibition effects against the formation of cholesteryl ester hydroperoxide (CE-OOH) were as follows: soju > whisky > RW > MCE > CM. Based on the same alcohol concentration (6%), however, the inhibition effects against the formation of CE-OOH were as follows: RW > MCE > soju > whisky > CM. Therefore, it was suggested that makgeolli may contain radical-scavenging- and metal-ion-chelate-type antioxidants and may increase the antioxidant activity in the blood.
미송톱밥을 이용한 꽃송이버섯 재배의 최적 배지 조성과 버섯의 β-glucan 함량 비교
완승진 ( Seung Jin Wang ),김현석 ( Hyun Seok Kim ),위안진 ( An Jin Wi ),윤병선 ( Byung Sun Yoon ),박화식 ( Whoa Shig Park ),박형호 ( Hyeong Ho Park ),오득실 ( Deuk Sil Oh ) 한국목재공학회 2014 목재공학 Vol.42 No.4
최근 다양한 언론매체 및 국내외 연구논문들을 통해 꽃송이버섯의 기능성이 부각되고 있다. 이에 꽃송이버섯의 농가 대량재배 일반화를 위하여 최적톱밥 입자크기 및 β-glucan 함량이 높은 재배법 연구를 수행한 결과 T7 (1∼2 mm25%, 2∼4 mm 50%, 4 mm 이상 25%) 배지와 같이 입자크기가 일정비율로 혼합된 배지에서 11.5 ± 1.0 cm/44 days로 비교적 우수한 균사생장을 보였으며 자실체생산 역시 대조구보다 높은 142.9 ± 17.7 g의 생중량으로 상품성이 있는 꽃부분이 85%의 비율을 차지하였다. 배지조성 조건에 따른 β-glucan 함량은 모든 자실체에서 꽃부분에 비해 기부가 1.4∼2.4배의 높은 함량을 보였고 이 중 이스트 300 ppm이 첨가된 PCF300 (미송 + 옥수수분말 + 소맥분 + 이스트 300 ppm) 배지의 꽃송이버섯 기부가 59.5%로 가장 높은 β-glucan 함량을 나타냈다. 그러나 꽃부분에서는 비교적 낮은 33.0%의 함량을 보여 꽃부분의 β-glucan 함량을 높일 수 있는 추가적인 연구가 필요할 것으로 사료된다. 따라서 본 연구결과를 토대로 꽃송이버섯 재배시 T7조건인 1∼2 mm 미송톱밥 25%, 2∼4 mm 미송톱밥 50%, 4 mm 이상 미송톱밥 25%의 비율로 톱밥입자 크기를 조절한후 옥수수분말과 소맥분을 첨가하여 배지조제후 이스트 300 ppm첨가하면 β-glucan 함량이 높은 꽃송이버섯 생산이 가능할 것으로 사료된다. Functional effects of cauliflower mushroom (Sparassis latifolia) have been magnified by various media and internal and external research papers, recently. So, optimum condition of wood chip particle size and cultivation method of high β-glucan content for bulk cultivation generalization of cauliflower mushroom farms researched. As a result, T7 (1∼2 mm 25%, 2∼4 mm 50%, over 4 mm 25%) media as mixed media of certain ratio of particle size, showed excellent growth at 11.5 ± 1.0 cm / 44 days. Also, production of fruit body found higher than control and marketable pileus part took 85% ratio. The β-glucan content at media composition condition showed 1.4∼2.4 times higher content in stipe part than pileus part. Also, PCF300 medium found 59.5% highest β-glucan content in stipe part. While β-glucan content showed 33.0% low content in pileus part. Therefore it needed additional study that β-glucan content improved in pileus part. In conclusion, production of high β-glucan content cauliflower mushroom was possible by T7condition (wood chip particle size: 1∼2 mm 25%, 2∼4 mm 50% and over 4 mm 25%, composition: cor\ our and 300 ppm yeast)