Protein transduction domain을 이용한 recombinant human bone morphogenetic protein-2의 골재생효과

정성원,김남희,육종인,김창성,김형준,조규성,Jung, Sung-Won,Kim, Nam-Hee,Yook, Jong-In,Kim, Chang-Sung,Kim, Hyung-Jun,Cho, Kyoo-Sung 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.3

Bone morphogenetic proteins(BMPs) are regarded as members of the transforming growth $factor-{\beta}$ superfamily with characteristic features in their amino acid sequences. A number of studies have demonstrated the biologic activities of BMPs, which include the induction of cartilage and bone formation. Recently there was a attempt to overcome a limitation of mass production, and economical efficieny of rh-BMPs. The method producing PTD by using bacteria have advantages of acquiry a mass of proteins. Hences, a new treatment which deliver protein employed by protein transduction domain(PTD) has been tried. The purpose of this study was to evaluate the bone regenerative effect of TATBMP-2 and TAT-HA2-BMP-2 employed by PTD from HlV-1 TAT protein for protein translocation in the rat calvarial model. An 8mm calvarial, critical size osteotomy defect was created in each of 32 male Spraque-Dawley rats(weight $250{\sim}300g$). The animals were divided into 4 groups of 32 animals each (4 animals/group/healing interval). The defect was treated with TATBMP-2/ACS(Absorbable collagen sponge) (TATBMP-2 0.1mg/ml), TAT-HA2-BMP-2/ACS(TAT-HA2-BMP-2 0.1mg/ml), ACS alone or left untreated for surgical control(negative control). The rats were sacrificed at 2 or 8 weeks postsurgery, and the results were evaluated histologically. The results were as follows: New bone formation were not significantly greater in the TATBMP-2/ACS group relative to negative, and positive control groups. New bone was evident at the defect sites in TAT-HA2-BMP-2/ACS group relative to negative, positive control and TATBMP-2 groups. There were a little bone regeneration in TATBMP-2 groups. While, enhanced local bone formation were observed in TAT-HA2-BMP-2 group. But, The results was not the same in all rat defects. Therefore, further investigations are required to develop a method. which disperse homogenously, and adhere to target cells.

한국적 특수성을 고려한 지역특성과 개인의 건강

정성원,조영태,Jung, Sung-Won,Cho, Young-Tae 대한예방의학회 2005 예방의학회지 Vol.38 No.3

Recently much attention has been paid to the effect of neighborhood characteristics on the health of individuals, independent of individual demographic and/or socioeconomic characteristics. Although many empirical studies of a kind, mostly based on Western society, have appeared on various international journals, few studies have shown empirical evidence of neighborhood characteristics as an independent and significant risk factor of ill health in Korea. This paper discusses possible reasons that neighborhood seems to be neither significant nor substantial regarding its impact on the health of Koreans. Addressing the uniqueness of Korean society regarding the concept of neighborhood, attributes of neighborhoods, and methodological challenges, authors suggest that more sophisticated conceptual and methodological approach, specific to Korean society, should enable to reveal the effect of neighborhood characteristics on individual health in Korea.

백서두개골 결손부에서 BMP전달체의 골재생효과분석

정성원,정지희,채경준,정의원,김창성,조규성,채중규,김종관,최성호,Jung, Sung-Won,Jung, Jee-Hee,Chae, Gyung-Joon,Jung, Ui-Won,Kim, Chang-Sung,Cho, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.4

Bone morphogenetic proteins have been shown to possess significant osteoinSductive potential, but in order to take advantage of this effect for tissue engineering, carrier systems are essential. Successful carrier systems must enable vascular and cellular invasion, allowing BMP to act as a differentiation factor. The carrier should be reproducible, non-immunogenic, moldable, and space-providing, to define the contours of the resulting bone. The purpose of this study was to review available literature, in comparing various carriers of BMP on rat calvarial defect model. The following conclusions were deduced. 1. Bone regeneration of ACS/BMP, ${\beta}-TCP/BMP$, FFSS/BMP, $FFSS/{\beta}-TCP/BMP$, MBCP/BMP group were significantly greater than the control groups. 2. Bone density in the ACS/BMP group was greater than that in ${\beta}-TCP$, FFSS, $FFSS/{\beta}-TCP$ carrier group. 3. Bone regeneration in FFSS/BMP group was less than in ACS/BMP, ${\beta}-TCP/BMP$, MBCP/BMP group. However, New bone area of $FFSS/{\beta}-TCP/BMP$ carrier group were more greater than that of FFSS/BMP group. ACS, ${\beta}-TCP$, FFSS, $FFSS/{\beta}-TCP$, MBCP were used for carrier of BMP. However, an ideal carrier which was reproducible, non-immunogenic, moldable, and space-providing did not exist. Therefore, further investigation are required in developing a new carrier system.

우울증의 진단평가 지침 -우울증 평가도구를 중심으로-

정성원 ( Sung Won Jung ),이은정 ( Eun Jung Lee ),최윤경 ( Yun Kyeung Choi ),성형모 ( Hyung Mo Sung ),김대현 ( Dae Hyeon Kim ),최정식 ( Jeong Shik Choi ),김정범 ( Jung Bum Kim ) 한국정신병리진단분류학회 2009 精神病理學 Vol.18 No.1

Depression is the second most common chronic disease in primary care. However, depression is commonly misdiagnosed, or though diagnosed properly, it is easy to treat inadequate doses or duration of antidepressants. It is of importance to diagnose and treat properly. Because of a wide range of symptoms and comorbidities, it is difficult to make a diagnosis of depression. Rating scales can be useful for the diagnosis of depression. It is feasible that the clinicians assess the patients with depression appropriately and determine therapeutic strategies by rating scales for depression. We have reviewed the purpose of rating scales for depression, including screening, ratings of symptoms, diagnosis, the progress, and the results of treatment. We also have described the actual condition of rating scales in Korea, which were performed by clinical research center for depression. It is restricted within marrow limits to select certain rating scale for depression and poorly known that some scales have been developed. Therefore, it is important task to announce the rating scales for depression so that the clinicians and researchers can be familiar with these scales. It is also important to develop a diversity of scales so that the clinicians can select appropriate scales.

자연언어처리를 위한 기계학습

정성원(Sung Won Jung),권혁철(Hyuk Chul Kwon) 한국정보과학회 2007 정보과학회지 Vol.25 No.3

웹 문서 중 의미 있는 표의 추출

정성원(Sung-Won Jung),이원희(Won-Hee Lee),김영기(Young-gi Kim),권혁철(Hyuck-Chul Kwon) 한국정보과학회 언어공학연구회 2002 한국정보과학회 언어공학연구회 학술발표 논문집 Vol.2002 No.10

진단 및 치료 대장 내시경의 합병증으로 발생한 대장 천공의 치료에 대한 임상적 고찰순천향대학교 의과대학 내과학교실 소화기 연구소, 대전 속편한 내과

정성원 ( Song Won Jung ),유창범 ( Chang Beom Ryu ),송민수 ( Yon Soo Kim ),김연수 ( Min Soo Song ),고봉민 ( Bong Min Ko ),차상우 ( Sang Woo Cha ),류권호 ( Kwon Ho You ),홍수진 ( Soo Jin Hong ),김영석 ( Young Seok Kim ),문종호 ( Jon 대한장연구학회 2004 Intestinal Research Vol.2 No.1

Colonoscopy is used increasingly because the indication for therapeutic colonoscopy has been increased and the technique has been developed continuously as well as colonosopy is useful for diagnosis of colonic disease. Therefore, It is important understanding precisely about the complication of colonoscopy and managing the complication immediately and properly. In particular, colon perforation is the most fatal, emergency case and have needed surgical treatment, generally. Recently, the case treated with endoscopic clipping and conservative management has been reported. but until now, when perforated, wheather the endoscopic clipping or the surgical management at each other case is beneficial is not confirmed.

전통, 근대, 탈근대의 결합―청계천 복원 담론을 중심으로―

정성원(Jung Sung-Won) 동양사회사상학회 2004 사회사상과 문화 Vol.9 No.-

여러 가지 이유로 근대(사회)는 위기에 직면하고 있다. 이에 연구자들은 그 해소 방안에 관심을 가지면서 전통과 근대의 '조화', 근대와 탈근대의 변증법적 '통일'을 제시한다. 이 논문의 목적은 청계천 복원 담론 분석을 통해 이러한 '조화'와 '통일'을 비판적으로 검토하는 데 있다. 다시 말해 우리가 흔히 근대(사회)의 위기 해소 방안을 생각할 때 직면하게 되는 '조화' 내지 '통일'이라는 논리의 실체를 확인하는 데 있다. 만약 이 논문이 그 나름대로의 연구 의의를 가진다면 바로 이 점에 있다. 청계천 복원 담론이 사회학적 분석의 대상이 될 수 있는 것은, 그 담론의 내용이 전통을 매개로 하여 그러한 위기를 풀어내려고 했다는 점에서이다. 뿐만 아니라 탈근대가 이 담론을 통해 근대와의 적극적인 차이를 드러내려는 자세를 보이고 있다는 점에서이다. 다시 말해 청계천 복원 담론은 근대(사회)의 위기 극복이라는 차원에서 전통―근대, 근대―탈근대 결합의 그 타당성과 적실성을 판가름할 수 있는 하나의 리트머스 용지이다. 즉 그 담론은 전통, 근대, 탈근대 등이 상호 교차하고 있는 하나의 논쟁 공간이다. 우리는 이 논문을 통해 기존의 논의에서 주장되고 있는 전통과 근대의 ‘조화’는 근대의 이익, 즉 자본 일반의 확대재생산이라는 차원에서 전통을 일방적으로 선택함으로써, 그러한 조화는 결국 전통과 근대의 대칭성이 아닌 비대칭성을 강화시킬 수밖에 없다는 점을 확인할 수 있다. 뿐만 아니라 근대(사회)가 직면한 위기를 타개하기 위한 차원에서 제시되는 근대와 탈근대의 변증법적 ‘통일’ 또한 논리적 차원에서는 가능하다. 그러나 청계천 복원 담론 분석의 결과는 여전히 양자는 대립각을 세우고 있으며, 특히 근대와 탈근대 공히 강조하는 삶의 질의 문제 해결과 관련해서는 상당한 차이를 드러낸다. 또한 전통과의 결합에 있어서는 다른 이유로 전통을 차별적으로 선택하고 있음을 확인할 수 있었다. 요컨대 근대(사회)의 위기 해소와 관련하여 제시되는 ‘조화’와 ‘통일’의 관점은 일정 부분 한계를 가질 수밖에 없다고 본다. For many reasons, modern society has faced crises. Researchers, concerned with solutions, have suggested a harmony and a dialectic unity between tradition, modernity and postmodernity. The aim of this article is to review critically their harmony and unity through the analysis of Chunggyechun Restoration’s discourses. That is to say, to prove a logical fiction of the harmony and the unity which one encounters at the moment we consider policy of crisis solution in modern society. This point might be a significance of the article. Chunggyechun Restoration’s discourses contain their contents to solve the crises by mediating tradition. Postmodernity also reveals distinctive differences from modernity through the discourses. To say, Chungyechun Restoration’s Discourses are a kind of litmus paper which can read a validity and suitability of combination between tradition and modernity, and modernity and postmodernity. They are a polemic space which tradition, modernity and postmodernity intersect. As a result, this article point that modernity chooses unfairly tradition in the dimension of its interest, the expanding reproduction of capital in general. For such reason, the harmony between tradition and modernity plays a role to reinforce their asymmetry, not their symmetry. The dialectic unity between modernity and postmodernity is also possible in the logical dimension. However, its result of the analysis of discourses is that both of modernity and postmodernity conflict with each other. Especially, policy of life quality on which modernity and postmodernity focus in common has a considerable gap between them. Tradition in the Chunggyechun Restoration’s discourses is used selectively and unevenly. In sum, I argue that the harmony and unity for solutions of modern crises have, to some extent, limits.

2002년 8월 낙동강 홍수 호우특성 분석

정성원(Jung Sung Won),문장원(Moon Jang Won),한명선(Han Myoung Sun),김동희(Kim Dong Hee) 대한토목학회 2002 대한토목학회 학술대회 Vol.2002 No.11

퍼지 집합의 소속함수에 대한 가중치 함수와 비퍼지화에서의 적용

정성원(Sung-Won Jung),이광형(Hyung Lee-Kwang) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.1B

본 논문에서는 퍼지집합의 소속함수에 대한 가중치 함수를 제안한다. 제안하는 가중치 함수는 퍼지집합의 소속함수에 곱해지는 형태로서 적용되어지며, 이것은 소속함수에 대한 사용자의 선호도를 의미한다. 제안하는 가중치 함수의 개념은 기본적으로 소속함수를 사용하는 어떤 퍼지 집합의 응용에서도 적용될 수 있을 것으로 보이나, 본 논문에서는 그 중 한가지 경우로 비퍼지화 방법을 적용 대상으로 선택하였다. 제안하는 가중치 함수가 비퍼지화 방법에 있어서 가지는 의미를 보이며, 기존의 비퍼지화 방법들에서 이러한 가중치 함수의 개념이 어떻게 적용되어 왔는지를 보인다. 또한 기존의 비퍼지화 방법들의 개념에 적용되지 않은 형태의 가중치 함수를 선택하여, 비퍼지화 방법에 특정 가중치 함수를 적용하였을 때의 특성 변화를 보인다. 이러한 일반적인 형태의 가중치 함수를 퍼지집합의 소속함수에 적용함으로서, 다양한 형태의 선호도를 퍼지집합의 형태에 반영할 수 있을 것으로 보인다.